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Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
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Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Article DOI: 10.3791/64847-v • 13:18 min • March 3rd, 2023
March 3rd, 2023 •
1, 1, 1, 2
1Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, 2Traditional Chinese Medicine Department, Peking University People's Hospital

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Summary
Automatic Translation

This study reveals the mechanism of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma based on network pharmacology and experimental verification. The study also demonstrates that the PI3K/AKT signaling pathway plays a vital role in the action of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma.

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Network Pharmacology Prediction Experimental Validation Trichosanthes-Fritillaria Thunbergii Action Mechanism Lung Adenocarcinoma Traditional Chinese Medicine Multicomponent Target Characteristics Network And Biological Research Technology Demonstration Threshold Reduction Systematic Analytical Technology Interaction Network Multifactors Single Pathway Prediction Database Drug-protein Relationship Prediction Subsequent Experiments Verification HERB Database Gua Liu Zhebimu Drug Components Canonical SMILES Structure Oral Bioavailability Drug-like Values HERB Group Database Swiss ADME Database Active Components Prediction
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