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Network Pharmacology Prediction and Experimental Validation of Trichosanthes–Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
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JoVE Journal Medicine
Network Pharmacology Prediction and Experimental Validation of Trichosanthes–Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Network Pharmacology Prediction and Experimental Validation of Trichosanthes–Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

DOI:
10.3791/64847-v

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13:18 min

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March 03, 2023

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, , ,
1Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, 2Traditional Chinese Medicine Department,Peking University People’s Hospital

Chapters

  • 00:04Introduction
  • 01:09Network Pharmacological Prediction
  • 07:14Detection of Cell Viability
  • 09:24Drug Intervention and Sample Collection
  • 10:30Results: Effects of Different Concentrations of Trichosanthes-Fritillaria thunbergii Extract
  • 12:47Conclusion

Summary

Automatic Translation

Automatic Translation

This study reveals the mechanism of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma based on network pharmacology and experimental verification. The study also demonstrates that the PI3K/AKT signaling pathway plays a vital role in the action of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma.

Tags

Keywords: Network PharmacologyTraditional Chinese MedicineMulticomponentTarget PredictionBiological ValidationLung AdenocarcinomaTrichosanthesFritillaria ThunbergiiHERB DatabaseSMILESSwiss ADMESimilarity Ensemble ApproachGeneCardsOMIM

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