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Journal / Cancer Research / 프로그래밍된 죽음 리간드 1 발현 이미징을 위한 68갈륨 표지 D-펩타이드 PET 추적자 …
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Cancer Research

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JoVE Journal Cancer Research
프로그래밍된 죽음 리간드 1 발현 이미징을 위한 68갈륨 표지 D-펩타이드 PET 추적자 개발
Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry
Journal (Cancer Research)
Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry
Flow Cytometric Analysis of Apoptotic Biomarkers in Actinomycin D-Treated SiHa Cervical Cancer Cells
Journal (Cancer Research)
Flow Cytometric Analysis of Apoptotic Biomarkers in Actinomycin D-Treated SiHa Cervical Cancer Cells
 
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프로그래밍된 죽음 리간드 1 발현 이미징을 위한 68갈륨 표지 D-펩타이드 PET 추적자 개발

Article DOI: 10.3791/65047-v • 09:06 min • February 3rd, 2023
February 3rd, 2023 •
*1, *2, 1, 2, 2, 4, *2,3, *3, *1, *2
1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
* These authors contributed equally

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이 연구는 [68Ga] D-도데카펩티드 길항제의 양전자 방출 단층 촬영 이미징을 기반으로 전신에서 프로그래밍된 죽음 리간드 1의 분포를 평가하는 비침습적 실시간 방법을 개발했습니다. 이 기술은 기존의 면역조직화학에 비해 장점이 있으며 면역관문 차단 요법의 혜택을 받을 적절한 환자를 식별하는 효율성을 향상시킵니다.

Tags

Cancer Research Programmed Death-Ligand 1 Expression Immune Checkpoint Blockade Therapy PD-1 PD-L1 Inhibitors Tumor Cells Immunohistochemistry (IHC) Positron Emission Tomography (PET) Radiolabeled Tracers Dextrorotary (D)-peptides Proteolytic resistance Metabolic Half-s 68Ga-labeled PD-L1-targeted D-peptide D-dodecapeptide Antagonist (DPA) Tumor-bearing mouse stability imaging ability
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