Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Baihan Zeng; Luming Qi; Sha Wu; Nannan Liu; Jie Wang; Kaidi Nie; Lina Xia; Shuguang Yu

doi:10.3791/65071

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Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

JoVE Journal
Medicine

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JoVE Journal Medicine

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

1,832 Views

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11:06 min

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April 07, 2023

DOI:

10.3791/65071-v

DOI:

10.3791/65071-v

•

11:06 min

April 07, 2023

•

4 Views

Baihan Zeng*^1,2,3, Luming Qi*^1,2,3, Sha Wu*^1,2,3, Nannan Liu^1,2,3, Jie Wang^1,2,3, Kaidi Nie^1,2,3, Lina Xia^1,2,3, Shuguang Yu^2,3

¹School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine, ²State Administration of Traditional Chinese Medicine Key Laboratory of Traditional Chinese Medicine, Regimen and Health,Chengdu University of Traditional Chinese Medicine, ³Key Laboratory of Traditional Chinese Medicine Regimen and Health of Sichuan Province

Summary

The present protocol describes an integrated strategy for exploring the key targets and mechanisms of Fructus Phyllanthi against hyperlipidemia based on network pharmacology prediction and metabolomics verification.

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Network Pharmacology Metabolomics Fructus Phyllanthi Hyperlipidemia Traditional Chinese Medicine Active Ingredients Therapeutic Target Database Protein-protein Interaction Network UniProt Cytoscape Hub Genes Drug Component-disease Target Network

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

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