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Dual-Dye optische mapping van harten van RyR2R2474S Knock-in muizen van catecholaminerge polymorfe ventriculaire tachycardie
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Dual-Dye optische mapping van harten van RyR2R2474S Knock-in muizen van catecholaminerge polymorfe ventriculaire tachycardie

Article DOI: 10.3791/65082-v • 09:36 min • December 22nd, 2023
December 22nd, 2023 •
*1,2, *1, 1, 1, 1, 1, 3, 1, 1,2, 1,4, 1
1Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 2Department of Cardiology, the Affiliated Hospital of Southwest Medical University, 3Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 4Department of Pharmacology, University of Oxford
* These authors contributed equally

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Dit protocol introduceert dual-dye optische mapping van muizenharten verkregen van wildtype en knock-in dieren die zijn aangetast door catecholaminerge polymorfe ventriculaire tachycardie, inclusief elektrofysiologische metingen van transmembraanspanning en intracellulaire Ca2+ transiënten met hoge temporele en ruimtelijke resolutie.

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Deze maand in JoVE nummer 202
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