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Cartographie optique à double colorant des cœurs de souris knock-in RyR2R2474S de tachycardie ventriculaire polymorphe catécholaminergique
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Cartographie optique à double colorant des cœurs de souris knock-in RyR2R2474S de tachycardie ventriculaire polymorphe catécholaminergique

Article DOI: 10.3791/65082-v • 09:36 min • December 22nd, 2023
December 22nd, 2023 •
*1,2, *1, 1, 1, 1, 1, 3, 1, 1,2, 1,4, 1
1Key Laboratory of Medical Electrophysiology of Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, 2Department of Cardiology, the Affiliated Hospital of Southwest Medical University, 3Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 4Department of Pharmacology, University of Oxford
* These authors contributed equally

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Ce protocole introduit une cartographie optique à double colorant des cœurs de souris obtenus à partir d’animaux de type sauvage et knock-in atteints de tachycardie ventriculaire polymorphe catécholaminergique, y compris des mesures électrophysiologiques de la tension transmembranaire et des transitoires intracellulaires Ca2+ avec une haute résolution temporelle et spatiale.

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Ce mois-ci dans JoVE numéro 202
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