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A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts

Article DOI: 10.3791/65101-v • 07:56 min • February 17th, 2023
February 17th, 2023 •
1,2, 1, 1, 1,2
1Cardiovascular Surgery, First Medical Center, Chinese PLA General Hospital, 2Medical School of Chinese PLA

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Summary
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This protocol presents a model of long-term ventricular fibrillation in rat hearts induced by continuous stimulation with low-voltage alternating current. This model has a high success rate, is stable, reliable, and reproducible, has a low impact on cardiac function, and causes only mild myocardial injury.

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Long-term Ventricular Fibrillation Rat Hearts Langendorff Apparatus Small Animal Model Cardiac Surgery Krebs-Henseleit Buffer Perfusion System Oxygen And Carbon Dioxide Gas Temperature Control Physiological Signal Recorder
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