Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

So we study complex carbohydrates, or glycans, in the innate immune system and immune-related disorders, focusing currently on sepsis and cancer. Our work involves analytical methods and systems glycobiology, including glycomics and glycoproteomics methods, for the detailed characterization of the human glycoprotein. Glycoproteomics has experienced tremendous advances over the past decades, and progress is no longer limited by the shortage of high quality mass spectrometry data available.

Rather, the challenge is to interpret and generate biological knowledge from the spectral data. The glycomics-guided glycoproteomics method enables glyco scientists to obtain deep and accurate insight into the glycoproteome and hard barriers with human health indices, Glycoproteomics is uniquely capable of generating site-specific insights into the glycoproteome. But glycopeptide rates remain high.