Name: Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia (Video) | JoVE Journal
Uploaded: 2025-05-30T12:40:00.000+00:00
Duration: 4 min 59 s
Description: Learn heat-sensitive moxibustion for treating insomnia in COPD patients using targeted acupoint techniques. This non-pharmacological method improves sleep quality and daily life through traditional Chinese medicine.

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5 minutes

This research was supported by the 2022 &#34;Tianfu Qingcheng Plan&#34; Tianfu Science and Technology Leading Talents Project (Chuan Qingcheng No. 1090) and Sichuan Science and Technology Program (2023ZYD0050). The authors would like to thank Mr. Yi Zhu for participating in our study as a model.

The protocol was approved by the Ethics Committee of the Zigong First People&#39;s Hospital&#160;(No. Ethical (M) 2024-033). This was a before-and-after treatment controlled trial involving patients from the Hospital of Chengdu University of Traditional Chinese Medicine and the to Zigong First People&#39;s&#160;Hospital. Informed consent was obtained from all patients who participated in the study. The details of the reagents and equipment used are listed in the Table of Materials.
1. Patient assessment
<ol>
	<li>Inclusion criteria
	<ol>
		<li>Confirm that patients meet the diagnostic criteria for stable COPD outlined in the Global Strategy for the Prevention, Diagnosis, and Management of COPD15.</li>
		<li>Verify that patients meet the diagnostic criteria for COPD with lung and kidney qi deficiency in Chinese Medicine, as defined by the 2011 Guidelines for Chinese Medicine Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease16. Diagnose COPD with lung and kidney qi deficiency if patients exhibit two primary symptoms and two secondary symptoms (Table 1).</li>
		<li>Ensure that patients meet either the diagnostic criteria for insomnia in Chinese adults17or the International Classification of Sleep Disorders (ICSD)18.</li>
		<li>Select patients aged 50-75 years, regardless of gender.</li>
		<li>Confirm that patients are conscious, mentally competent, and aware of the study.</li>
	</ol>
	</li>
	<li>Exclusion criteria
	<ol>
		<li>Exclude patients with acute exacerbation of COPD.</li>
		<li>Exclude patients with COPD who do not have lung and kidney qi deficiency.</li>
		<li>Exclude pregnant women, children, and other patients for whom the procedure is not suitable.</li>
		<li>Exclude patients who refuse to undergo moxibustion treatment.</li>
		<li>Exclude patients who are allergic to medical devices (e.g., alcohol) or therapeutic drugs (moxa).</li>
		<li>Exclude patients with skin damage or sensory disorders at the treatment site.</li>
		<li>Exclude patients who have received acupuncture, sleeping pills, or treatment other than basic COPD therapy within the past 2 weeks. 
		&#8203;NOTE: The purpose of the patient assessment is to determine whether the patient is in a state suitable for moxibustion treatment.</li>
	</ol>
	</li>
	<li>Dropout criteria
	<ol>
		<li>Withdraw subjects from the study if they meet any of the following criteria:
		<ol>
			<li>Develop a serious adverse reaction during treatment.</li>
			<li>Voluntarily withdraw from the study.</li>
			<li>Experience a serious complication or disease progression during the study.</li>
			<li>Take other medications that may impact the final study results.</li>
		</ol>
		</li>
	</ol>
	</li>
</ol>
2.&#160;Study design
<ol>
	<li>Use a comparative test method before and after treatment in the same patient. Observe patients (n = 12) with COPD complicated by insomnia of the lung and kidney qi deficiency type.</li>
	<li>Provide all included patients with basic treatment for COPD, as outlined in the Global Strategy for the Prevention, Diagnosis, and Management of COPD15, including the following:
	<ol>
		<li>Administer long-term oxygen therapy and ventilation support.</li>
		<li>Ensure that patients receive pharmacological interventions, including cough and sputum suppression and conventional anti-infective therapy with bronchodilators. Use &#946;2-adrenergic (LABA), anti-muscarinic (LAMA) bronchodilators, and inhaled corticosteroids (ICS).</li>
		<li>Provide non-pharmacological interventions, including smoking cessation guidance, sleep education, and supervision of physical activities at an appropriate intensity.</li>
	</ol>
	</li>
	<li>Administer heat-sensitive moxibustion treatment to the patient.</li>
	<li>Implement dietary interventions by instructing patients to avoid excitatory substances (e.g., strong tea), alcohol, and tobacco, and to refrain from overeating before bedtime.</li>
	<li>Exclude other treatment modalities for sleep disorders to ensure the independence of the heat-sensitive moxibustion treatment.</li>
	<li>Take emergency measures promptly in case of acute exacerbation of COPD during treatment. Record the acute exacerbation and treatment process in detail. After the condition improves, consult the patient and reassess to decide whether to continue the trial.</li>
	<li>Withdraw patients from the study if no improvement is observed after 1 week of active treatment.</li>
</ol>
3. Pre-operation preparation
<ol>
	<li>Material preparation
	<ol>
		<li>Ensure the availability of the following items (Figure 1):
		<ol>
			<li>Moxa sticks (long cylindrical strips rolled up with moxa floss as the main ingredient; general specifications: diameter: 16-40 mm) (Figure 1B).</li>
			<li>An ignition device, such as a lighter (Figure 1D).</li>
			<li>A surgical tray (length: 200 mm, width: 125 mm) (Figure 1A).</li>
		</ol>
		</li>
		<li>Ensure medical swabs are within their validity period (Figure 1C).</li>
		<li>Obtain a portable infrared thermometer (Figure 1G).</li>
		<li>Provide tweezers and forceps as necessary (Figure 1E,F). No special requirements are needed, and they should be acceptable to all sterile healthcare personnel. 
		NOTE: The category of ignition devices includes matches, alcohol lamps, and lighters. Select an appropriate device at the user&#39;s discretion. Use the ignition device to extinguish the flame promptly after use. Employ treatment discs to extinguish the fire of moxa sticks and remove ashes.</li>
	</ol>
	</li>
	<li>Environmental preparation
	<ol>
		<li>Equip separate treatment rooms with smoke exhaust or elimination systems. Ensure that the surrounding environment is free of flammable substances to minimize fire hazards.</li>
		<li>Avoid using an oxygen supply device in the room to prevent the risk of combustion. Maintain the ambient temperature between 24-30 &#176;C19.</li>
	</ol>
	</li>
	<li>Operator preparation
	<ol>
		<li>Verify the patient&#39;s basic information. Wear a medical mask and a medical hat.</li>
		<li>Wash hands with soap and water using the seven-step handwashing method, and dry them thoroughly.</li>
	</ol>
	</li>
	<li>Patient preparation
	<ol>
		<li>Skin cleansing
		<ol>
			<li>Instruct the patient to cleanse the surgical area with water 2-3 times before the procedure to remove surface contaminants. Ensure that the cleaning radius exceeds 10 cm. Keep the skin dry after cleansing. 
			NOTE: If conditions permit, use lukewarm water to enhance comfort during cleansing.</li>
		</ol>
		</li>
		<li>Patient education and communication
		<ol>
			<li>Educate the patient on moxibustion sensory expectations. Ensure the patient remains focused during moxibustion.</li>
			<li>Guide the patient to observe and report sensations such as warmth and penetration. Establish real-time communication between the practitioner and the patient.</li>
		</ol>
		</li>
	</ol>
	</li>
</ol>
4. Operating procedure
NOTE: Ensure that all practitioners involved in treatment delivery are certified acupuncturists with a minimum of one year of independent clinical experience. To ensure the accuracy and reproducibility of acupoint localization, all practitioners must complete a standardized training program before the study. This program should include (1) a comprehensive review of acupoint anatomy and localization techniques based on established textbooks, (2) hands-on practice sessions following a standardized protocol to ensure consistent technique application, and (3) a final assessment to confirm proficiency in acupoint identification. Additionally, a calibration test was conducted to evaluate inter-rater reliability, allowing only practitioners who achieved a Cohen&#39;s Kappa score of &#8805;0.8 to participate in the study. The treatment was conducted in accordance with the National Standard of the People&#39;s Republic of China for Technical Practice of Acupuncture and Moxibustion, Part 1: Moxibustion (GB/T 21709.1-2008)20, and the Standardized Manipulations of Heat-sensitive Moxibustion Therapy21.
<ol>
	<li>Patient positioning
	<ol>
		<li>Instruct the patient to assume a prone position. Select positions based on acupoint topography to ensure optimal exposure.</li>
	</ol>
	</li>
	<li>Selection and positioning of acupuncture points
	<ol>
		<li>Identify the following points in accordance with the Nomenclature and Location of Meridian Points (GB/T 12346-2021)22&#160;(Figure 2): Xinshu (BL15), Danshu (BL19), Pishu (BL20), Feishu (BL13), Shenshu (BL23)23,24,25.
		<ol>
			<li>Xinshu (BL15): Locate on the back, under the spinous process of the 5th thoracic vertebra, 1.5 cun from the posterior midline.</li>
			<li>Danshu (BL19): Locate on the back, under the spinous process of the 10th thoracic vertebra, 1.5 cun from the posterior midline.</li>
			<li>Pishu (BL20): Locate on the back, below the spinous process of the 11th thoracic vertebra, 1.5 cun from the posterior midline.</li>
			<li>Feishu (BL13): Locate on the back, below the spinous process of the 3rd thoracic vertebra, 1.5 cun from the posterior midline.</li>
			<li>Shenshu (BL23): Locate on the back, below the spinous process of the 2nd lumbar vertebra, 1.5 cun from the posterior midline.</li>
		</ol>
		</li>
	</ol>
	</li>
	<li>Acupoint localization methods
	<ol>
		<li>Use both the Bone-Length Measurement Method and the Finger-Cun Measurement Method26&#160;to determine acupoint locations.
		<ol>
			<li>Apply the Bone-Length Measurement Method, which stipulates that the distance from the posterior midline to the inner edge of the scapula is 3 cun (Figure 2).</li>
			<li>Apply the Finger-Cun Measurement Method, where four fingers are aligned together, using the width of the patient&#39;s second knuckle as the standard, with the total transverse width of four fingers equating to 3 cun (Figure 3).</li>
		</ol>
		</li>
	</ol>
	</li>
	<li>Heat-sensitive moxibustion procedure
	<ol>
		<li>Thermal-sensitized acupoint positioning: Center the positioning on traditional acupoints (see step 4.2 and 4.3). Apply meridian moxibustion, gyratory moxibustion, sparrow-pecking moxibustion, and mild moxibustion to the upper, lower, left, and right areas of localized acupoints for heat-sensitized acupoint exploration.
		<ol>
			<li>Ignite the moxa stick: Grip the moxa stick at its proximal third (top-middle segment). Ignite using a single-flame lighter at a 45&#176; angle to ensure controlled combustion.</li>
			<li>Perform the following moxibustion techniques.
			<ol>
				<li>Meridian moxibustion (Figure 4): Hold the moxa stick about 1/3 of the way up the middle and position the lit end perpendicularly above the meridian, 2-3 cm from the skin. Move the moxa stick at an even speed along the Foot Taiyang Bladder Meridian route for 2-3 min. 
				NOTE: Repeat the process until the skin is warm and flushed without burning pain. Use a portable infrared thermometer to ensure a skin temperature of 41-42 &#176;C27. The Foot Taiyang Bladder Meridian runs from the head to the feet along the posterior body.</li>
				<li>Sparrow-pecking moxibustion (Figure 5): Hold the moxa stick about 1/3 of the way up the middle. Place the lit end perpendicularly above the acupuncture point, maintaining a 2-3 cm distance from the skin. Move the moxa stick in a vertical pecking motion, keeping a constant distance. 
				NOTE: Ensure the skin is warm and flushed without causing burning pain. Use a portable infrared thermometer to confirm a skin temperature of 41-42 &#176;C.</li>
				<li>Gyratory moxibustion (Figure 6): Hold the moxa stick about 1/3 of the way up the middle. Position the burning end perpendicularly above the acupuncture point, 2-3 cm from the skin. Rotate the moxa stick in a circular motion with a radius of 2.5 cm around the acupuncture point. 
				NOTE: Ensure the skin is warm and flushed without burning pain. Use a portable infrared thermometer to confirm a skin temperature of 41-42 &#176;C.</li>
				<li>Mild moxibustion (Figure 7): Hold the moxa stick about 1/3 of the way up the middle. Position the burning end perpendicularly 2-3 cm above the acupuncture point. 
				NOTE: Ensure the skin is warm and flushed without burning pain. Use a portable infrared thermometer to confirm a skin temperature of 41-42 &#176;C. Adjust the moxa stick&#39;s distance based on the patient&#39;s sensation. Use the index finger to assess temperature and prevent burns.</li>
			</ol>
			</li>
			<li>Marking heat-sensitive acupoints: Maintain communication with the patient. Ask about sensations and identify thermal sensitization when the patient reports heat penetration, expansion, transmission, local non-heat with distant heat, superficial non-heat with deep heat, or any non-thermal sensations. Record the exact locations28,29(Table 2).</li>
			<li>Selection of heat-sensitized acupoints : Select the two most distinctly felt acupoints for the next step. 
			NOTE: Selection principle: (1) Prioritize heat-sensitive acupoints with non-heat sensations; (2) Prefer acupoints where heat-sensitive moxibustion sensation reaches the affected area; (3) Choose acupoints with the strongest heat-sensitive response30.</li>
		</ol>
		</li>
		<li>Double-point mild moxibustion (Figure 8)
		<ol>
			<li>Confirm heat-sensitized acupoints. Hold the moxa stick about 1/3 of the way up the middle and ignite both simultaneously. Hold a moxa stick in each hand, directing them at the two selected acupoints, keeping a 2-3 cm distance from the skin. 
			NOTE: Ensure the operation area is warm, with local skin flushing but no burning pain. Use a portable infrared thermometer to maintain a skin temperature of 41-42 &#176;C.</li>
			<li>Continue moxibustion for 40 min31,32.</li>
		</ol>
		</li>
	</ol>
	</li>
	<li>Extinguishing the moxa stick and cleaning residues
	<ol>
		<li>Place the burning end of the moxa stick into a water-filled treatment tray to extinguish the fire.</li>
		<li>Use pliers to remove large ash pieces. Wipe any remaining stains with gauze.</li>
	</ol>
	</li>
	<li>Treatment frequency: Administer treatment once every 2 days for 4 weeks.</li>
	<li>Post-treatment care
	<ol>
		<li>Instruct the patient to avoid touching or using cold water for 2 h.</li>
		<li>Keep the treated area at a comfortable temperature.</li>
		<li>Advise seeking medical attention if adverse symptoms occur. 
		NOTE: Small blisters will naturally absorb. If large blisters form, puncture with a sterile syringe, apply antibiotic ointment, and keep the area clean to prevent infection.</li>
	</ol>
	</li>
</ol>
5. Adverse event prevention and countermeasures
<ol>
	<li>Preventive measures
	<ol>
		<li>Prior to the study, ensure thorough communication with patients and their families, providing detailed explanations of the treatment rationale, procedures, and necessary precautions. This fosters cooperation and understanding.</li>
		<li>Adhere strictly to the prescribed surgical protocols. If the patient&#39;s condition worsens, terminate the trial and implement appropriate therapeutic measures. Adjust the treatment plan following the global strategy for the prevention, diagnosis, and management of COPD, reassessing the patient once their condition improves.</li>
		<li>Document all adverse reactions occurring during treatment, including burns, dermatological reactions, and severe pain.</li>
	</ol>
	</li>
	<li>Possible adverse events and countermeasures
	<ol>
		<li>Burns: If a burn occurs due to prolonged or excessive heat exposure, immediately rinse the affected area with running cold water and apply a sterile gauze dressing or ointment. Seek medical attention if necessary.</li>
		<li>Skin rash: In case of a rash following moxibustion, apply an external anti-allergic ointment or administer oral anti-allergic medication as needed.</li>
		<li>Severe pain: If the patient experiences intense pain, stop the procedure immediately and immerse the affected area in cold water to relieve discomfort. If the pain persists or worsens, administer pain medication as required.</li>
	</ol>
	</li>
</ol>
6. Efficacy evaluation
<ol>
	<li>Primary outcome measures
	<ol>
		<li>Assess treatment efficacy using the Pittsburgh Sleep Quality Index (PSQI)33and the COPD Assessment Test (CAT)34.</li>
		<li>Provide the PSQI questionnaire to patients 1 day before enrollment and 4 weeks after the treatment. Ensure that the total score is recorded, with higher scores indicating poorer sleep quality.</li>
		<li>Provide the CAT questionnaire before enrollment and after 4 weeks of the treatment. Record the total score, noting that higher scores indicate poorer quality of life. 
		NOTE: Consider a &#8805;2-point reduction in CAT score as the Minimal Clinically Important Difference (MCID), indicating a clinically meaningful improvement35.</li>
	</ol>
	</li>
	<li>Secondary outcome measures
	<ol>
		<li>Collect blood samples from patients 1 day before enrollment and 4 weeks after the treatment.</li>
		<li>Measure serum levels of interleukin-6 (IL-6) and 5-hydroxytryptamine (5-HT) using enzyme-linked immunosorbent assay (ELISA). Record and analyze the results to evaluate changes in IL-6 and 5-HT levels after treatment30.</li>
	</ol>
	</li>
</ol>
7. Data statistics and analysis
<ol>
	<li>Perform all statistical analyses using statistical analysis and graphing software.</li>
	<li>Describe data measurements statistically using mean &#177; standard deviation.</li>
	<li>Use paired t-tests to compare differences before and after treatment, as this is a stand-alone before-and-after control study.</li>
	<li>Consider a p-value &#8804;0.05 as statistically significant for the tested differences.</li>
</ol>

The authors have nothing to disclose.

Insomnia in patients with COPD can be attributed to several factors, including frequent awakenings due to hypoxemia and hypercapnia during sleep36, nocturnal respiratory symptoms, and the use of COPD medications, which may affect sleep patterns. Additionally, anxiety and depression are significant contributors to insomnia. The prevalence of depression in COPD patients has been reported to be as high as 80%, while anxiety affects up to 74% of patients37,<sup class...

Chronic Obstructive Pulmonary Disease (COPD) is a significant global health concern. It is a heterogeneous lung disease characterized by persistent and progressive airflow obstruction due to abnormalities in the airways and/or alveoli. Clinical symptoms include coughing, sputum production, dyspnea, and chest tightness. The global prevalence of COPD among individuals aged 30-79 years has been reported to be 10.3%, with a prevalence of 8.6% in China1,2.
COPD is frequently associated with comorbid conditions, including cardiovascular disease, osteoporosis, and pulmonary hypertension. The presence of comorbidities increases the risk of morbidity and mortality, leading to a higher likelihood of hospitalization and increased healthcare costs. Furthermore, comorbidities significantly impact the clinical status and prognosis of patients with COPD, complicating disease management3,4.
Sleep disorders are a common consequence of COPD and often occur alongside nocturnal COPD symptoms, particularly cough and dyspnea. Studies indicate that approximately 40% of patients with COPD experience sleep disorders5, including obstructive sleep apnea (OSA), insomnia, and restless legs syndrome (RLS). The prevalence of OSA, RLS, and insomnia in patients with COPD has been reported to be 29.1%, 21.6%, and 29.5%, respectively6. The incidence of insomnia in patients with COPD is approximately three times higher than in the general population7. Additionally, hospitalized COPD patients experience an average reduction of 34 min of sleep per night and have a 22.5% lower probability of achieving normal sleep efficiency compared to those without COPD8.
A variety of traditional sedatives and hypnotics, including benzodiazepines, imidazopyridines, and, to a lesser extent, antidepressants, have been used to treat insomnia in COPD patients. While clinical trials suggest that these medications can be effective, their safety is not always assured9,10.
Moxibustion has been shown to stimulate meridian Qi through heat and bioactive substances produced during combustion, thereby regulating physiological functions, treating diseases, and promoting overall health. Contemporary research suggests that the thermal stimulation from moxibustion plays a key role in disease treatment. The heat applied to the dermal level enhances blood flow, optimizes microcirculation, and facilitates vasodilation11. Additionally, volatile oils released during the combustion of wormwood can have a calming effect on the brain, regulate neurotransmitter imbalances, and increase cerebral levels of 5-hydroxytryptamine (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA)12,13.
Heat-sensitive moxibustion is a novel therapeutic approach that differs from traditional moxibustion. It involves the application of moxa heat to heat-sensitive acupoints, offering notable benefits for the treatment of insomnia14. This article presents a demonstration of heat-sensitive moxibustion for treating insomnia in a patient with COPD.

<table><tbody><tr><td>Adobe Photoshop 2021</td><td>Adobe Systems</td><td></td><td></td></tr><tr><td>Forcep</td><td>Cofoe Medical Technology Co.,ltd.</td><td>Hunan Medical Device&amp;nbsp; Registration Certificate:&amp;nbsp; No.20160012</td><td></td></tr><tr><td>IBM SPSS Statistics 25</td><td>IBM</td><td></td><td></td></tr><tr><td>Lighter</td><td>Ningbo Qiant Technology Co., Ltd</td><td>Chaofan-CF2</td><td></td></tr><tr><td>Medical swabs</td><td>Cofoe Medical Technology Co.,ltd.</td><td>Hunan Medical Device&amp;nbsp; Registration Certificate:&amp;nbsp; No.20192140881</td><td></td></tr><tr><td>Moxa sticks</td><td>Nanyang Xian Herb Pharmaceutical Co., Ltd</td><td>XC23T07019</td><td></td></tr><tr><td>Surgical tray</td><td>Jiangsu Kangjian Medical Apparatus Co.,Ltd.</td><td>Medium Size</td><td></td></tr><tr><td>Thermometer</td><td>Cofoe Medical Technology Co.,ltd.</td><td>Hunan Medical Device&amp;nbsp; Registration Certificate:&amp;nbsp; No.20182070190</td><td></td></tr><tr><td>Tweezer</td><td>Cofoe Medical Technology Co.,ltd.</td><td>Hunan Medical Device&amp;nbsp; Registration Certificate:&amp;nbsp; No.20180176</td><td></td></tr></tbody></table>

heat-sensitive moxibustion as a traditional chinese medicine therapy for chronic obstructive pulmonary disease combined with insomnia

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Chronic Obstructive Pulmonary Disease (COPD) is a global health concern and a heterogeneous lung disease characterized by persistent, progressive airflow obstruction due to airway and/or alveolar abnormalities. COPD is associated with various comorbidities, including insomnia, which is a common underlying condition. Chronic insomnia exacerbates morbidity, increases hospitalization rates and healthcare costs, and reduces the quality of life in patients with COPD.
Heat-sensitive moxibustion is an emerging therapy that utilizes heat generated by ignited moxa materials. This technique involves suspending moxibustion over heat-sensitive acupoints to stimulate various sensations, such as heat penetration, expansion, transfer, local non-heat with distant heat, superficial non-heat with deep heat, and non-thermal sensations. These effects, along with meridian Qi conduction, enhance the therapeutic efficacy of moxibustion, making it a distinctive Chinese medicine therapy for insomnia. This study evaluated the efficacy of heat-sensitive moxibustion in patients with COPD and comorbid insomnia. The results demonstrated that heat-sensitive moxibustion significantly reduced Pittsburgh Sleep Quality Index (PSQI) and COPD Assessment Test (CAT) scores, indicating improvements in sleep quality and overall quality of life. Additionally, serum levels of interleukin-6 (IL-6) were decreased, while 5-hydroxytryptamine (5-HT) levels were increased, suggesting a potential mechanism underlying the observed therapeutic effects. This article provides a detailed protocol for standardizing the use of heat-sensitive moxibustion in the treatment of COPD with insomnia and presents clinical outcomes supporting its efficacy.

This protocol outlines a before-and-after controlled trial investigating the efficacy of heat-sensitive moxibustion in improving sleep quality and overall quality of life in patients with COPD-related insomnia. A total of 12 patients (Table 3) diagnosed with COPD and insomnia were included in the study and received heat-sensitive moxibustion treatment.
Analysis of individual and total scores bef...

This protocol presents the clinical efficacy of heat-sensitive moxibustion in treating chronic obstructive pulmonary disease (COPD) combined with insomnia and outlines the procedure for heat-sensitive moxibustion.

Chronic Obstructive Pulmonary Disease (COPD) is a global health concern and a heterogeneous lung disease characterized by persistent, progressive airflow ...

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Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia (Video) | JoVE Journal

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

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