Name: Demystifying Venous Excess Ultrasound (VExUS): Image Acquisition and Interpretation (Video) | JoVE Journal
Uploaded: 2025-05-16T14:00:00.000+00:00
Duration: 5 min 49 s
Description: Learn VExUS image acquisition and interpretation using point-of-care ultrasound to assess venous congestion. This method helps clinicians predict organ dysfunction and improve patient outcomes through timely evaluation.

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5 minutes

All procedures performed in studies involving human participants adhered to the ethical standards of the institutional research committee and the Declaration of Helsinki, including its later amendments or comparable ethical standards. Written informed consent was obtained from the human participants. The scanning technique encompassed transducer selection, machine settings, patient positioning, B-mode scanning, and image acquisition. Patients with unclear volume status, suspected venous congestion, heart failure, acute kidney injury (AKI), and/or chronic kidney disease (CKD) were included in the study, while those with end-stage kidney disease on dialysis, known cirrhosis or portal vein thrombosis, or any condition preventing safe probe usage over the abdomen were excluded. The details of the reagents and equipment used are listed in the Table of Materials.
1. Transducer selection
<ol>
	<li>Select a low-frequency transducer: the sector array (aka &#34;phased array&#34;; 1-5 MHz) transducer can be selected for its smaller footprint21; the curvilinear transducer (2-5 MHz) can serve as a substitute. 
	NOTE: On some machines, the curvilinear probe will de-activate EKG gating, whereas the sector array probe will permit EKG gating. But if EKG gating is available with either the curvilinear or sector array probe, it is preferable to use the curvilinear to maximize visualization of the color Doppler signal.</li>
</ol>
2. Machine settings
<ol>
	<li>For all views, set the depth such that the target of the scan will appear in the middle third of the ultrasound screen (the typical setting is between 16-20 cm).</li>
	<li>For all views, set the gain such that the lumen of blood vessels appears anechoic (black), the vessel walls appear hyperechoic (bright), and the surrounding structures appear intermediate between these extremes.</li>
</ol>
3. Patient and sonographer positioning
<ol>
	<li>For most of the exam, position the patient supine.
	<ol>
		<li>When imaging the inferior vena cava (IVC), ask the patient to lift their feet onto the bed (i.e., flex their hips) to relax their abdominal muscles and allow for image optimization.</li>
		<li>When imaging the right kidney, reposition the patient in the left lateral recumbent position for better visualization of the right kidney.</li>
	</ol>
	</li>
	<li>Before scanning, expose the patient&#39;s lower chest and abdomen.</li>
	<li>Position the ultrasound machine so that the sonographer&#39;s dominant hand can hold the ultrasound probe. This allows for finer manipulation of the ultrasound probe and frees up the non-dominant hand for operating the ultrasound machine. For example, right-handed sonographers should position themselves with the patient on their right side and vice versa.</li>
</ol>
4. Mode, presets, and setup
<ol>
	<li>Select two-dimensional (2-D) mode, also called brightness mode (B-mode).</li>
	<li>Select the Cardiac preset.</li>
	<li>Set up EKG gating by plugging the leads into the ultrasound machine and placing the leads in the standard orientation on the patient&#39;s skin. 
	NOTE: The VExUS exam can be performed in either the Cardiac or Abdominal preset, but on many machines, the Abdominal preset will de-activate EKG gating, whereas the Cardiac preset will permit EKG gating. So, if EKG gating is available on a given machine, it is preferable to use whichever preset permits EKG gating.</li>
</ol>
5. Inferior vena cava (IVC) imaging
<ol>
	<li>Gel
	<ol>
		<li>Apply gel to the ultrasound probe directly to maximize scanning efficiency prior to acquiring each image.</li>
	</ol>
	</li>
	<li>Subxiphoid view
	<ol>
		<li>Place the probe beneath the xiphoid process with the indicator pointing cranially (Figure 1).</li>
		<li>Adjust the probe position until the IVC is seen in its maximal anteroposterior diameter (Figure 2).</li>
		<li>While keeping the IVC in the center of the screen, rotate the probe 90 degrees counterclockwise to obtain a short-axis view of the IVC (Figure 3).</li>
		<li>Cine clip acquisition: For machines configured for retrospective image acquisition, click on acquire after step 5.2.3. For machines configured for prospective image acquisition, click on acquire before step 5.2.3.</li>
	</ol>
	</li>
	<li>Right flank view
	<ol>
		<li>In patients with contraindications to subxiphoid imaging, place the probe along the right anterior axillary line in the body&#39;s coronal plane with the probe indicator pointing cranially (Figure 4).</li>
		<li>Adjust the probe position until the IVC is seen in its maximal anteroposterior diameter.</li>
		<li>While keeping the IVC in the center of the screen, rotate the probe 90 degrees counterclockwise to obtain a short-axis view of the IVC.</li>
		<li>Cine clip acquisition: For machines configured for retrospective image acquisition, click on acquire after step 5.3.3. For machines configured for prospective image acquisition, click on acquire before step 5.3.3.</li>
	</ol>
	</li>
	<li>IVC assessment
	<ol>
		<li>If IVC is &#62;2 cm in anterior-to-posterior maximal diameter (Figure 5), proceed to step 6.</li>
		<li>If IVC is &#60;= 2 cm (Figure 3), VExUS is not indicated. Use clinical judgment or other tools to assess volume status.</li>
	</ol>
	</li>
</ol>
6. Hepatic vein Doppler
<ol>
	<li>Gel
	<ol>
		<li>Apply gel to the ultrasound probe directly to maximize scanning efficiency prior to acquiring each image.</li>
	</ol>
	</li>
	<li>Right flank view
	<ol>
		<li>Place the probe along the right anterior axillary line in the body&#39;s coronal plane with the probe indicator pointing cranially (Figure 4).</li>
		<li>Adjust the probe position until the hepatic vein is visualized emptying into the IVC near the cavo-atrial junction (Figure 6).</li>
		<li>Select the color Doppler mode on the ultrasound machine.</li>
		<li>Move the color box so that the majority of the vessel is within its borders.</li>
		<li>Select PW Doppler mode on the ultrasound machine.</li>
		<li>Move the Doppler gate so that it is located within the lumen of the hepatic vein.</li>
		<li>Activate PW Doppler.</li>
		<li>Ask the patient to hold their breath at end-expiration.</li>
		<li>Allow a full screen of PW Doppler tracing to occur, and then click on Freeze (or equivalent) (Figure 7).</li>
		<li>Click on Acquire (or equivalent) to save still images of flow tracing.</li>
	</ol>
	</li>
</ol>
7. Portal vein Doppler
<ol>
	<li>Gel
	<ol>
		<li>Apply gel to the ultrasound probe directly to maximize scanning efficiency prior to acquiring each image.</li>
	</ol>
	</li>
	<li>Right flank view
	<ol>
		<li>Place the probe along the right anterior axillary line in the body&#39;s coronal plane with the probe indicator pointing cranially (Figure 4).</li>
		<li>Adjust the probe position until the portal vein is visualized (Figure 8).</li>
		<li>Select the color Doppler mode on the ultrasound machine.</li>
		<li>Move the color box so that most of the vessel is within its borders.</li>
		<li>Select PW Doppler mode on the ultrasound machine.</li>
		<li>Move the Doppler gate so that it is located within the lumen of the portal vein.</li>
		<li>Activate PW Doppler.</li>
		<li>Ask the patient to hold their breath at end-expiration.</li>
		<li>Allow a full screen of PW Doppler tracing to occur, and then click on Freeze (or equivalent) (Figure 9).</li>
		<li>Click on Acquire (or equivalent) to save still images of flow tracing.</li>
	</ol>
	</li>
</ol>
8. Imaging of renal parenchymal veins
<ol>
	<li>Gel
	<ol>
		<li>Apply gel to the ultrasound probe directly to maximize scanning efficiency prior to acquiring each image.</li>
	</ol>
	</li>
	<li>Right flank view
	<ol>
		<li>Place the probe along the right anterior axillary line in the body&#39;s coronal plane with the probe indicator pointing cranially (Figure 4).</li>
		<li>Adjust the probe position until the right kidney is seen in the long-axis view.</li>
		<li>Select the color Doppler mode on the ultrasound machine.</li>
		<li>Enlarge the color Doppler box to contain most of the renal cortex (Figure 10).</li>
		<li>Select PW Doppler mode on the ultrasound machine.</li>
		<li>Move the Doppler gate to a location within the renal cortex that has a color Doppler reading.</li>
		<li>Activate PW Doppler.</li>
		<li>Ask the patient to hold their breath at end-expiration.</li>
		<li>Allow a full screen of PW Doppler tracing to occur, and then click on Freeze (or equivalent) (Figure 11).</li>
		<li>Click on Acquire (or equivalent) to save still images of flow tracing.</li>
	</ol>
	</li>
</ol>

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<li>Koratala, A., Argaiz, E. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Femoral+vein+Doppler+for+guiding+ultrafiltration+in+end-stage+renal+disease%3A+A+novel+addition+to+bedside+ultrasound%5BTitle%5D)+AND+%22CASE%22%5BJournal%5D)">Femoral vein Doppler for guiding ultrafiltration in end-stage renal disease: A novel addition to bedside ultrasound.</a> CASE. 8 (10), 475-483 (2024).</li>
<li>Kumar, A., Bharti, A. K., Hussain, M., Kumar, S., Kumar, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Correlation+of+internal+jugular+vein+and+inferior+vena+cava+collapsibility+index+with+direct+central+venous+pressure+measurement+in+critically-ill+patients%3A+An+observational+study%5BTitle%5D)+AND+%22Indian+J+Crit+Care+Med%22%5BJournal%5D)">Correlation of internal jugular vein and inferior vena cava collapsibility index with direct central venous pressure measurement in critically-ill patients: An observational study.</a> Indian J Crit Care Med. 28 (6), 595-600 (2024).</li>
<li>Kim, Y. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Artificial+intelligence+in+medical+ultrasonography%3A+Driving+on+an+unpaved+road%5BTitle%5D)+AND+%22Ultrasonography%22%5BJournal%5D)">Artificial intelligence in medical ultrasonography: Driving on an unpaved road.</a> Ultrasonography. 40 (3), 313-317 (2021).</li>
<li>Argaiz, E. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((VExUS+Nexus%3A+Bedside+assessment+of+venous+congestion%5BTitle%5D)+AND+%22Adv+Chronic+Kidney+Dis%22%5BJournal%5D)">VExUS Nexus: Bedside assessment of venous congestion.</a> Adv Chronic Kidney Dis. 28 (3), 252-261 (2021).</li>
<li>Rola, P., Haycock, K., Spiegel, R., Beaubien-Souligny, W., Denault, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((VExUS%3A+Common+misconceptions%2C+clinical+use+and+future+directions%5BTitle%5D)+AND+%22Ultrasound+J%22%5BJournal%5D)">VExUS: Common misconceptions, clinical use and future directions.</a> Ultrasound J. 16 (1), 49(2024).</li>
</ol>

YSB reports receiving honoraria from the American Society of Anesthesiologists for Editorial Board work on Point-of-Care Ultrasound and from OpenAnesthesia.org for creating educational content related to POCUS. The remaining authors have no disclosures.

Critical steps 
VExUS was developed in post-cardiac surgery patients to quantify venous congestion non-invasively, but the utility has expanded for its use to assist in the evaluation of venous congestion and assessment of fluid status in multiple clinical contexts. To perform the exam properly, several critical steps must be considered. First, to maximize the diagnostic yield of the exam, one must consider the requirements of the VExUS exam when selecting a transducer and preset23. ...

Assessment of the hemodynamic circuit at the bedside is fundamental to the daily care of acutely ill patients. The deleterious effects of fluid overload are increasingly recognized even outside of more obvious clinical syndromes such as heart failure, and there are now multiple studies showing that positive fluid balance is associated with increased mortality1. There is a growing body of evidence that shows that even low levels of venous congestion are associated with organ dysfunction2. Similarly, timely decongestion is associated with improved outcomes3. This multiorgan, dynamic circuit involves the right and left heart, systemic vascular resistance, pulmonary artery pressures, and sequential right-sided venous return, culminating in the vena cava. It is complex, and its accurate assessment remains challenging for bedside clinicians. Clinicians from a variety of specialties make decisions regularly based on this assessment. Conventional bedside tools and physical exam maneuvers, including assessment of jugular venous pressure, are almost always available but remain unreliable4,5,6,7,8,9. Point of care ultrasound (POCUS) is a limited ultrasound examination performed at the bedside and is interpreted by the treating physician to answer focused clinical questions. It is integrated in real-time with the patient&#39;s history, physical examination, and other available data to aid in diagnosis and management. Over the last several years, ultrasound has solidified itself as an extension of the physical exam10, improving clinicians&#39; ability to detect venous congestion11,12. Additionally, POCUS can guide decongestive therapy, which can potentially positively affect patient outcomes2,3.
One specific protocol using ultrasound that has been validated to help with hemodynamic assessment is the venous excess ultrasound score, or VExUS. First described by Beaubien-Souligny et al.13 in 2020, this scoring system was originally validated in post-cardiac surgery patients as a reliable predictor of acute kidney injury (AKI). Over the past several years, VExUS has also been shown to help with intravascular volume assessment in multiple other clinical contexts14,15,16,17. VExUS evaluates multiple intra-abdominal veins to screen for sonographic signs associated with congestion. These sonographic signs of congestion appear and progress in incremental fashion as venous congestion worsens, allowing VExUS to both screen for congestion and potentially track its response to therapy over time.
While the individual components of the VExUS exam have long been in use18,19,20, their combination, as well as their use to monitor therapy over time, remain underutilized, partly due to providers&#39; lack of familiarity with how to perform the exam. We believe that this gap in knowledge is one major factor that has prevented wider-scale adoption of VExUS as the primary alternative to gold-standard invasive cardiac monitoring of venous pressures.
To attempt to address this knowledge gap, this article describes an instructional protocol for performing the VExUS exam, which can serve as a step-by-step guide for bedside clinicians. This protocol draws on the collective experience of a group of physicians representing multiple medical specialties (nephrology, critical care, internal medicine, and anesthesiology) from multiple academic medical centers to describe a standardized approach to VExUS image acquisition and interpretation.

<table><tbody><tr><td>5500P Ultrasound System</td><td>Philips</td><td>HC795143</td><td>Used to obtain a subset of the Figures and Videos</td></tr><tr><td>Affiniti 70 Ultrasound System</td><td>Philips</td><td>HC795210</td><td>Used to obtain a subset of the Figures and Videos</td></tr><tr><td>Curvilinear Transducer (C1-5-D)</td><td>GE</td><td>5409287-R</td><td>1-5 MHz, also called the abdominal probe</td></tr><tr><td>Curvilinear Transducer (C5-1)</td><td>Philips</td><td>HC989605412041</td><td>2-5 MHz, also called the abdominal probe</td></tr><tr><td>Curvilinear Transducer (C5-1)</td><td>SonoSite</td><td>https://www.sonosite.com/products/ultrasound-transducers/c5-1</td><td>1-5 MHz, also called the abdominal probe</td></tr><tr><td>Curvilinear Transducer (C5-2s)</td><td>Mindray</td><td>https://lysis.cc/products/mindray-c5-2s</td><td>1-5 MHz, also called the abdominal probe</td></tr><tr><td>Edge 1 Ultrasound Machine</td><td>SonoSite</td><td></td><td>Used to obtain a subset of the Figures and Videos</td></tr><tr><td>Handheld Probe (Butterfly iQ3)</td><td>Butterfly</td><td>https://www.butterflynetwork.com/iq3?srsltid=AfmBOorvY6WqHGbdeWW&lt;br/&gt; gtefztEJa8pt_xbwSOc6hQuB2s-Kb0wRlsCLR</td><td>Used to obtain a subset of the Figures and Videos</td></tr><tr><td>LOGIQ P9 Ultrasound System</td><td>GE</td><td>H42752LS</td><td>Used to obtain a subset of the Figures and Videos</td></tr><tr><td>Lumify Handheld Ultrasound</td><td>Philips</td><td></td><td>Used to obtain a subset of the Figures and Videos</td></tr><tr><td>Phased-Array Transducer (3Sc-D)</td><td>GE</td><td>https://services.gehealthcare.in/gehcstorefront/p/5863286</td><td>1-5 MHz, also called the cardiac probe</td></tr><tr><td>Phased-Array Transducer (P4-2s)</td><td>Mindray</td><td>https://lysis.cc/products/mindray-p4-2s</td><td>1-5 MHz, also called the cardiac probe</td></tr><tr><td>Phased-Array Transducer (P5-1)</td><td>SonoSite</td><td>https://www.sonosite.com/in/products/ultrasound-transducers/p5-1</td><td>1-5 MHz, also called the cardiac probe</td></tr><tr><td>Phased-Array Transducer (S4-1)</td><td>Philips</td><td>HC989605389271</td><td>1-5 MHz, also called the cardiac probe</td></tr><tr><td>TE7 Max Ultrasound System</td><td>Mindray</td><td>https://www.mindray.com/na/products/ultrasound/point-of-care/te-series/te-7-max-portable-ultrasound-machine/</td><td>Used to obtain a subset of the Figures and Videos</td></tr></tbody></table>

demystifying venous excess ultrasound (vexus): image acquisition and interpretation

Demystifying Venous Excess Ultrasound (VExUS): Image Acquisition and Interpretation

Providers in many medical specialties must accurately assess the hemodynamic circuit to deliver appropriate patient care. Venous congestion is increasingly implicated in a range of multiorgan complications. However, hemodynamic assessment remains challenging because of the complex physiology involved and inconsistent diagnostic accuracy of conventional bedside tools and physical exam maneuvers. While right heart catheterization is regarded as the gold standard for measuring systemic venous pressure, it is invasive and not easily repeatable, and thus, there remains a need for non-invasive alternatives. Even point-of-care ultrasound examinations of the internal jugular vein or inferior vena cava have significant limitations in terms of accuracy of intravascular volume assessment and correlation with central venous pressure. To improve bedside clinicians' accuracy at assessing venous congestion, a protocol was developed and validated that utilizes pulsed-wave (PW) Doppler signals of veins in the liver and kidney to grade the degree of venous congestion present in patients. Although this scoring system, called Venous Excess Ultrasound (VExUS), is being increasingly adopted within certain subspecialties of medicine, such as nephrology and critical care, it remains underutilized in medicine as a whole. This is likely due, at least in part, to knowledge gaps and lack of training in this emerging modality. To address this educational gap, this article will describe VExUS image acquisition and interpretation.

The first step to the VExUS exam involves imaging the inferior vena cava (IVC) to determine if there are signs of elevated right atrial pressures that would qualify the patient for the remainder of the exam. When imaging the IVC, it is important to view it from both the longitudinal and transverse perspectives to see the vessel in its maximal dimension. If the IVC is greater than 2 cm in its maximal anteroposterior diameter, then the remainder of the examination can be performed.
The next step...

Point-of-care ultrasound (POCUS) is often used to assess the hemodynamic circuit and detect the presence of venous congestion. The Venous Excess Ultrasound (VExUS) scoring system was developed to aid clinicians in predicting the impact of venous congestion on organ dysfunction. This article aims to describe VExUS image acquisition and interpretation.

Providers in many medical specialties must accurately assess the hemodynamic circuit to deliver appropriate patient care. Venous congestion is ...

demystifying-venous-excess-ultrasound-vexus-image-acquisition

Research

JoVE Journal

Medicine

The goal of this study is to use magnetic resonance venography with long-circulating gadolinium-based contrast agent and direct thrombus imaging for quantitative evaluation of DVT volume in a multicenter, clinical trial setting. Inter- and intra-observer variability assessments were conducted, and reproducibility of the protocol was determined.

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

We describe an imaging protocol that enables the clinician to visualize, in real-time, the patient's intravascular and extravascular space volumes and set diuresis and fluid removal parameters accordingly for the safe and efficient treatment of pulmonary edema.

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Troubleshooting FoCUS Image Acquisition: Patient Positioning, Transducer Manipulation, and Image Optimization

Traditionally, lower extremity deep venous thrombosis (DVT) is diagnosed by radiology-performed venous duplex ultrasound. Providers appropriately trained in focused point-of-care ultrasound (POCUS) can perform a rapid bedside examination with high sensitivity and specificity in critically ill patients. We describe the scanning technique for focused POCUS DVT lower extremity examination.

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Point-of-care ultrasound evaluation of the inferior vena cava (IVC) is commonly utilized to identify, among other things, the volume status. Imaging should be performed systematically to ensure repeatability. This manuscript reviews the methods and pitfalls of sonographic IVC examination.

Image Acquisition Method for the Sonographic Assessment of the Inferior Vena Cava

Varicocele relies heavily on angiographic diagnostic techniques for disease-related examination and assessment. In order to diagnose varicocele better, we combined supine and standing positions for varicocele imaging, and contrast-enhanced ultrasound is used for patients with inconspicuous reflux. This approach facilitates the early detection, diagnosis, and treatment of varicocele.

Combined Supine and Standing Imaging for Varicocele: An Improved Diagnostic Approach

This protocol allows for the in vivo quantification of venous compliance and distensibility using catheterization and 3D angiography as a survival procedure allowing for a variety of potential applications.

Quantifying Inferior Vena Cava Compliance and Distensibility in an In Vivo Ovine Model Using 3D Angiography

Here, we present a protocol for bedside POCUS application in ARDS management within the ICU. It details standardized techniques for lung, cardiac, diaphragm, venous, and gastric assessments to guide ventilation, predict weaning, and prevent complications.

The Application of Point-of-Care Ultrasonography (POCUS) in the Management of Acute Respiratory Distress Syndrome (ARDS) in the Intensive Care Unit

The overall goal is to enable clinicians to insert a central venous catheter under real-time ultrasound guidance via the right supraclavicular fossa view of the lower part of the superior vena cava. This view is useful for different catheter insertion sites, thrombosis detection before insertion and ultrasound guided correction of misplaced catheters.

The Supraclavicular Fossa Ultrasound View for Central Venous Catheter Placement and Catheter Change Over Guidewire

This protocol describes the consecutive implantation of an osmotic pump to induce abdominal aortic aneurysm by angiotensin II release in apolipoprotein E (ApoE) deficient mice and of a vascular access port with a jugular vein catheter for repeated drug treatment. Monitoring of aneurysm development by 3D ultrasound is effectively conducted despite dorsal implants.

Drug Treatment by Central Venous Catheter in a Mouse Model of Angiotensin II Induced Abdominal Aortic Aneurysm and Monitoring by 3D Ultrasound

Learn VExUS image acquisition and interpretation using point-of-care ultrasound to assess venous congestion. This method helps clinicians predict organ dysfunction and improve patient outcomes through timely evaluation.

Demystifying Venous Excess Ultrasound (VExUS): Image Acquisition and Interpretation

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