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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic...

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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

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08:15 min

June 6, 2025

DOI: 10.3791/68198-v

Wanqing Ren*¹, Tongzheng Liu*², Jie Liu³, Jianlin Wu¹

¹College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine, ²Innovation Research Institute of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine, ³Office of Shandong College of Traditional Chinese Medicine

This study evaluated the antidepressant efficacy of Qiangzhifang in a rat model of chronic restraint stress-induced depression and elucidated its regulatory effect on HIF-1 and JAK-STAT pathways by network pharmacology and molecular docking analysis.

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