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Industry 4.0 has fundamentally transformed products, services, and processes through the integration of advanced technologies such as the Internet of Things, Big Data, Cyber Security, Cloud Computing, Additive Manufacturing, and Advanced Robotics1,2. With the rise of Artificial Intelligence (AI), Industry 4.0 integrates AI technology with various advanced technologies, reshaping the manufacturing and operations landscapes3. However, while Industry 4.0 significantly improves productivity and creates new job opportunities for workers, it also brings challenges such as increased cognitive demands, higher work risks, and the need for continuous skill enhancement4. To address the issue of neglecting human factors during the rapid development of Industry 4.0, the European Commission proposed the concept of Industry 5.0, emphasizing three core elements: human centrality, sustainability, and resilience5,6. Industry 5.0 emphasizes the collaboration between humans and AI, improving productivity while ensuring human health and environmental sustainability, thus achieving sustainable economic growth7. Horvat et al. investigated data from 1334 manufacturing companies, and the study results indicate that human-centric Industry 5.0 enhances the manufacturer's ability to innovate in products, with employee participation being an important factor, reflecting the importance of human-centric Industry 5.08.
Industry 5.0 emphasizes the combination of human creativity and technological precision, giving rise to the concept of Operator 5.09. Operator 5.0 places the operators within human-centered production systems, involving sociotechnical systems, social sustainability, and resilience engineering10. Mattsson and Kurdve propose that Operator 5.0 includes 9 factors: cognitive/physical ability to perform task, overall digital skills, universal design, minimize unexpected events, productivity and quality, safety, standards, instructions, and training materials11. Peruzzini et al., based on Operator 5.0, proposed the Augmented Digital Twin (ADT) that integrates machines, robots, environments, interfaces, and people, thereby developing human-centric smart manufacturing systems12. Yaqot et al. proposed the enhanced human-automation symbiosis (EHAS) framework, emphasizing achieving human-automation symbiosis through physical and sensory enhancement, cognitive and emotional enhancement, communication and collaboration enhancement, digital ethics, digital citizenship, privacy, and human rights enhancement13.
The transition from Industry 4.0 to Industry 5.0 represents a shift from technology-centric manufacturing to value-centric manufacturing14. Higher education must confront the challenges brought by Industry 5.0 and reform existing curricula to train the future workforce. University programs must consider the competencies required for Operator 5.0 to prepare students receiving an engineering education for their future career development.
The implementation of Operator 5.0 education has led to changes in the teaching objectives of operations management courses. As a core function of modern enterprise management, operations management encompasses the entire process from raw material procurement to the delivery of final products or services. It covers multiple dimensions such as supply chain management, production planning and scheduling, work study, inventory management, and quality control. The teaching goal of operations management courses is to enable students to understand how to optimize resource allocation, improve efficiency, reduce costs, and ensure that the quality and delivery speed of products or services meet market demands. In particular, the work-study component helps students deeply understand and master theoretical knowledge of operators in operations management, analyze complex case studies, and propose innovative and practical solutions through hands-on learning.
The assembly line, as the most typical production situation in manufacturing, is the major application field for Operator 5.0-related technology. Industry 5.0 requires assembly lines to handle specific production needs. Operator 5.0, through the merging of human creativity and technology empowerment, enables the shift of assembly lines from mass manufacturing to mass customization. Operator 5.0 can swiftly alter assembly line procedures utilizing digital twins and simulation tools to satisfy unique product requirements, achieving the flexibility and adaptability of the assembly line15. Operator 5.0 can simulate the movements and weariness of assembly line workers through digital twins, optimizing workstation design, representing the concept of Human-in-the-loop in smart manufacturing16. Therefore, in the education of Operator 5.0, taking the improvement of the assembly line as an example, Figure 1A illustrates the main steps currently involved in identifying and addressing issues in an assembly line. Current practices do not adequately consider work-related musculoskeletal disorders (WMSDs) during the early stages of engineering design. Physical ergonomic risk factors include awkward postures, force exertion, material handling, stationary positions, and repetition17. When these risks are present in actual production operations, they not only cause WMSDs among workers but also prolong production cycles and increase operational costs for enterprises when corrective measures are implemented. Boysen et al. provided a systematic review of assembly line balancing issues, highlighting human factors as a critical factor in improving assembly line performance18. Therefore, in the era of Industry 5.0, the importance of human factors in operations management has become even more pronounced, playing a significant role in contemporary business strategies19,20.
Caputo et al. introduced the theory of concurrent engineering into workplace design, proposing that ergonomic evaluations be considered at the stage of process design, thereby potentially preventing ergonomic risks in the design phase21. In the era of Industry 4.0, there is insufficient attention to the core role of ergonomics in production operations, making it difficult to fully adapt to the requirements of ergonomics in Industry 5.022. Therefore, guided by the concept of Industry 5.0, the teaching practice of operations management needs to incorporate more ergonomics content. Taking the assembly line improvement issue as an example, Figure 1B shows that in the case of clear improvement objectives and targets, the measurement of time and ergonomic risks in each process is carried out simultaneously, and ergonomic evaluations are considered at the stage of process design in parallel with concurrent engineering thinking for assembly line improvement.

Figure 1: Two types of assembly line improvement processes. (A) The traditional assembly line improvement process, and (B) the one integrating human factors. Please click here to view a larger version of this figure.
In the Operator 5.0 framework and evolving demands of Industry 5.0, the workforce needs to acquire relevant digital skills to effectively engage in new work and tasks. 62% of manufacturing companies reported that the lack of employees with appropriate skills is a major obstacle to the success of digital transformation23. Hansen et al. surveyed 30 companies pursuing digital transformation and found that the success of digital transformation during the transition from Industry 4.0 to Industry 5.0 depends on the cultivation of worker capabilities24. Future professionals need to master advanced digital capabilities to effectively interact with intelligent systems25. Hermawati et al. assessed the current state of ergonomics education and found that there is a gap between current ergonomics education and the requirements of Industry 5.026. Therefore, it is crucial to train new skills according to the requirements of Industry 5.0, and it is necessary to develop students' digital competencies7.
The emergence of digital twins incorporating ergonomic risk evaluation has enabled the integrated design of workplace design and ergonomic evaluation through digital simulation, applying the concept of concurrent engineering. This achieves human-centric digital design in the context of Industry 5.0. Caputo et al. proposed a digital twin model that includes ergonomic evaluation for workplace design, which was validated on a Fiat Chrysler Automobiles (FCA) assembly line using both Ergonomic Assessment Worksheet (EAWS) and Ovako Working Posture Analysing System (OWAS) assessment methods21,27. The studies mentioned above utilized the Methods-Time Measurement (MTM) process language in their analyses. MTM is a type of Predetermined Time System (PTS) that decomposes manual operational procedures into basic elements of motions, taking work conditions into account to determine the time required for a task. Breznik et al. employed the MTM Universal Analysis System (MTM-UAS) along with simulation software to address the assembly line balancing problem (ALBP)28.
In response to the aforementioned requirements in operations management—integrating physical ergonomic risk factors during the initial engineering design phase and developing students' digital competency—this study uses the assembly line improvement problem as an example. It incorporates ergonomic evaluation into a digital twin model to demonstrate how engineering education can adapt to the demands of Industry 5.0, fostering the development of Operator 5.0 through human-centric design and digital capability building.
In summary, against the backdrop of the transition from Industry 4.0 to human-centric Industry 5.0, this paper explores the integration of human factors into operations management education. Using the example of guiding students in assembly line design within teaching practices, it incorporates ergonomic risk evaluation to help students understand the essence of Operator 5.0. By demonstrating the process of integrating ergonomics into operations management education, this study aims to provide new insights and directions for both education and practice in the field of operations management in the era of Industry 5.0.
This protocol presents experimental procedures for measuring and improving time and ergonomic risks in assembly line design. The procedure can be summarized in five steps: 1) Collection of production status, 2) Problem analysis in the production process, 3) Establishment of the digital factory, 4) Model optimization, and 5) Effectiveness verification of the digital factory. If any one of these requirements in the five steps is not met, the process is incomplete and insufficient to prove effectiveness.