Osteoporosis involves osteoblast/clast imbalance and impaired autophagy. The review links dysregulated autophagy to bone loss and highlights TCM multi-target benefits via PI3K/AKT/mTOR, AMPK/mTOR, PINK1/Parkin pathways.
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Review Article
* These authors contributed equally
Osteoporosis involves osteoblast/clast imbalance and impaired autophagy. The review links dysregulated autophagy to bone loss and highlights TCM multi-target benefits via PI3K/AKT/mTOR, AMPK/mTOR, PINK1/Parkin pathways.
Osteoporosis, a common and high-incidence bone disease, is characterized by low bone density and degradation of bone microstructure. Its pathogenesis is intricate, with the imbalance of osteoblast and osteoclast functions being a core element and abnormal autophagy also serving as a key pathogenic factor. This paper delves into the intrinsic link between the pathological mechanisms of osteoporosis and autophagy. It comprehensively outlines the manifestations of bone metabolic imbalance, interprets the normal physiological role of autophagy in bone metabolism, and explores the abnormal changes and mechanisms of autophagy in osteoporosis. Furthermore, the paper focuses on the cutting-edge research progress in treating osteoporosis with traditional Chinese medicine (TCM) by targeting autophagy-related pathways, including the PI3K/AKT/mTOR, AMPK/mTOR, and PINK1/Parkin signaling pathways. It highlights the unique advantages of TCM in multi-target and multi-pathway intervention, clarifies future research directions, and aims to establish a more comprehensive and systematic strategy for preventing and treating osteoporosis with TCM.
Osteoporosis (OP) has emerged as a pervasive global health crisis, currently affecting over 200 million individuals worldwide. Characterized by systemic impairment of bone mass and micro-architectural deterioration, this "silent epidemic" dramatically increases skeletal fragility, leading to susceptibility to fractures that impose a staggering burden on healthcare systems and significantly diminish patient quality of life1,2. As the global population ages, the incidence of OP-related fractures is projected to rise exponentially, necessitating a deeper understanding of its molecular underpinnings and th....
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The relationship between the pathogenesis of osteoporosis and autophagy
The manifestation of bone metabolism imbalance in osteoporosis: Osteoporosis (OP) can be divided into two major types based on its etiological characteristics: primary and secondary. Primary OP is associated with a variety of factors, including aging, genetic background, and environmental influences, while secondary OP has more definitive causes, mainly resulting from specific diseases or the use of certain medications7. Currently, it is widely accepted in the field of modern medicine that the regulation mechanism of bone metabolism imbalance is the k....
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In summary, autophagy plays a crucial role in the pathogenesis and progression of osteoporosis. Dysregulation of autophagy inevitably disrupts the balance of bone metabolism, negatively impacting the function and number of osteoblasts and osteoclasts (Figure 1), ultimately leading to severe consequences such as bone loss and structural damage.
In stark contrast to the single-target intervention of traditional Western medicine, traditional Chinese .......
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The authors declare that they have no competing financial interests or personal relationships that could have influenced the work reported in this paper.
Scientific Research Project of Sichuan Provincial Administration of Traditional Chinese Medicine (GrantNos. 2024MS276,25ZDIZX017,2024Ms152);
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