This study aimed to explore potential drug-drug interactions between eugenol (EUG) and repaglinide (RPG) in patients with type 2 diabetes mellitus (T2DM).
Research Article
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| Name | Company | Catalog Number | Comments |
|---|---|---|---|
| acetonitrile | Merck, Germany | 34851 | ≥99.9% |
| chromatographic column | Phenomenex, USA | 00G-4041-E0 | 250 mm × 4.6 mm, particle size 5 μm |
| DAS | Beijing Bozhiyin, China | - | 3.0 |
| EUG | MUST Bio-technology, China | A0074 | purity ≥99% |
| GraphPad Prism | GraphPad Software, USA | - | 9.0.0 |
| High Performance Liquid Chromatography | Shimadzu Corporation, Japan | 228-45147-42 | RF-20A |
| ketoconazole | Merck, Germany | K1003 | Purity 99.0-101.0% |
| Male Sprague-Dawley rats | Shanghai Animal Center, China | - | 200–250 g |
| NADPH | Merck, Germany | 10107824001 | 97% (dry weight) |
| OneTouch Ultra2 blood glucose meter | Life Scan Inc., USA | https://shop.onetouch.com/onetouch-sup-reg-sup-ultra-sup-reg-sup-2-meter/product/OTSUS05_0019 | - |
| PBS | Merck, Germany | P4474 | ph 7.4 |
| RLM | Merck, Germany | M9066 | - |
| RPG | Merck, Germany | R9028 | purity ≥98% |
| STZ | Merck, Germany | S0130 | ≥98% (HPLC) |
| EUG, eugenol; RPG, repaglinide; RLM, rat liver microsomes; NADPH, β-Nicotinamide adenine dinucleotide phosphate; STZ, streptozotocin; PBS, phosphate-buffered saline. |
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