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Myocardial Infarction and Functional Outcome Assessment in Pigs
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Myocardial Infarction and Functional Outcome Assessment in Pigs

Article DOI: 10.3791/51269-v • 12:03 min • April 25th, 2014
April 25th, 2014 •
1,2, 1, 1, 1, 1, 1, 1,2, 1,2, *1, *1
1Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 2Interuniversity Cardiology Institute of the Netherlands
* These authors contributed equally

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Summary
Automatic Translation

This protocol describes the porcine myocardial infarction (MI) model using a 90 min closed-chest coronary balloon occlusion of the left anterior descending artery (LAD), followed by reperfusion. Furthermore, the protocol for several outcome parameters, such as cardiac function, hemodynamics, microvascular resistance, and infarct size, are also presented.

Tags

Myocardial Infarction Functional Outcome Assessment Pigs Cardiovascular Therapeutics First-in-man Trials Ethical And Legal Roadmap Safety And Efficacy Aspects Large Animal Model Human Scenario Porcine MI Model Closed-chest Coronary Balloon Occlusion Left Anterior Descending Artery (LAD) Reperfusion Myocardial Ischemia Left Ventricle Infarction Anterior Wall Septal Wall Inferoseptal Wall Outcome Measures Cardiac Systolic Function Cardiac Diastolic Function Hemodynamics Coronary Flow Velocity Microvascular Resistance Infarct Size Validation Of Novel Cardioregenerative Biologics Acute Ischemic Insult Subacute Setting Chronic MI Scar Formation
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