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Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

Article DOI: 10.3791/55845-v • 09:57 min • June 4th, 2017
June 4th, 2017 •
1, 1, 1, 1
1Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University

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Stem cells are promising therapeutic carriers to treat brain tumors due to their intrinsic tumor tropism. Non-invasive intranasal stem cell delivery bypasses the blood brain barrier and demonstrates strong potential for clinical translation. This article summarizes the basic principles of intranasal stem cell delivery in a mouse model of glioma.

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Intranasal Delivery Therapeutic Stem Cells Glioblastoma Mouse Model Preclinical Neuro-oncology Blood-brain Barrier Non-invasive Treatment Brain Malignancies Brain Disorders Culturing Glioma Cells Serum Supplemented Medium Serum-free Medium Cell Culture Incubator Confluency Calcium And Magnesium-free PBS Trypsin
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