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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Article DOI: 10.3791/57117-v • 10:31 min • April 20th, 2018
April 20th, 2018 •
1,2,3, 1,2,3, 1,2,4, 5, 2,3, 6, 2, 2, 1,3, 6
1CIBERCV, Instituto de Salud Carlos III, 2Department of Physiology, Universitat de València, 3INCLIVA, 4Department of Electronic Engineering, Universidad Politécnica de Valencia, 5UCIM, Universitat de València, 6Department of Physiotherapy, Universitat de València

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Summary
Automatic Translation

We describe methods to develop an experimental model of diet-induced metabolic syndrome (MetS) in rabbits using a high-fat, high-sucrose diet. Animals developed central obesity, mild hypertension, pre-diabetes, and dyslipidemia, thus reproducing the main components of human MetS. This chronic model will allow acquisition of knowledge underlying mechanisms of disease progression.

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Metabolic Syndrome Model High Fat Diet High Sucrose Diet Organ Remodeling Pathophysiology Clinical Markers Therapeutic Approaches Rabbit Model Acclimation Period Control Group MetS Group Chow Intake Sucrose Solution Concentration Caloric Intake
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