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Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
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Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery

DOI:
10.3791/57229-v

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09:12 min

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March 27, 2018

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, , , , , ,
1Department of Surgery,University of Minnesota, 2Cardiology,Minneapolis VA Medical Center

Chapters

  • 00:04Title
  • 00:49Hibernation Surgery
  • 03:30Off Pump Coronary Artery Bypass
  • 06:53Results: Representative Cardiac Magnetic Resonance Imaging (MRI) and Wall Thickening Measurement
  • 07:49Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol presents a surgical large animal model of chronic, single vessel ischemia that results in regional abnormalities but does not create infarct, known as hibernating myocardium. Following establishment of chronic ischemia, animals are treated with off-pump LIMA-LAD coronary artery bypass graft surgery to revascularize the ischemic tissue.

Tags

Surgical Swine ModelChronic Cardiac IschemiaOff-pump Coronary Artery Bypass Graft SurgeryCardiothoracic SurgeryHibernating MyocardiumLeft Anterior Descending ArteryCoronary Artery ConstrictorBypass GraftRevascularizationAtherosclerotic Disease

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