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A Closed-chest Model to Induce Transverse Aortic Constriction in Mice
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A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Article DOI: 10.3791/57397-v • 08:10 min • April 5th, 2018
April 5th, 2018 •
*1, *1, 2, 1, 2, 3, 1, 4
1Department of Anaesthesiology, University Hospital Bonn, 2Department of Cardiac Surgery, University Hospital Bonn, 3Institute of Physiology 2, University of Bonn, 4Department of Medicine - Cardiology, University Hospital Bonn
* These authors contributed equally

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Summary
Automatic Translation

Here, we present a protocol of Transverse Aortic constriction (TAC) via a lateral thoracotomy. This technique is a minimally invasive, closed chest surgical procedure aiming to simulate pressure overload and heart failure in mice utilizing standard TAC laboratory settings.

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Transverse Aortic Constriction Closed-chest Model Mice Left Ventricular Myocardial Hypertrophy Minimal Invasive Technique Respiratory Problems Inflammatory Response Immunology Cardiac Macrophagia Rib Cage Intact Trauma Minimized Body Weight Adaptation Surgical Trauma Reduction Measurement Deviation Reduction Anesthesia Induction Box Narcosis Maintenance Nylon Suture Fixation Reflex Absence Check Adhesive Tape Fixation Rectal Probe Insertion Depilatory Cream Application
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