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JoVE Journal Chemistry
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Article DOI: 10.3791/58986-v • 10:17 min • April 23rd, 2019
April 23rd, 2019 •
1, 1, 1, 1, 2, 3, 3, 1
1Department of Chemistry and Chemical Biology, McMaster University, 2Agilent Technologies Inc., 3Seroclinix Corporation

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Summary
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Here we describe a high-throughput method for comprehensive drug surveillance that allows for the improved resolution and detection of large panels of drugs of abuse and their metabolites, with quality control based on multisegment injection-capillary electrophoresis-mass spectrometry.

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High-throughput Comprehensive Drug Surveillance Multisegment Injection-capillary Electrophoresis-mass Spectrometry Urine Drug Screening Routine Analysis Drugs Of Abuse Work Place Testing Therapeutic Drug Monitoring Amino Assays Target Analysis MSI-CE-MS Rapid Screening Unlimited Drug Panel Metabolites High Accuracy Minimal Sample Workup Affordable Screening Method Patient Outcomes Adherence Drug Dosage Regimes Illicit Drug Usage Multiplexed Separation Platform Targeted Metabolite Profiling Non-targeted Metabolite Profiling Biological Samples Morning Urine Samples Prescription Drug History Minus 80 Degree Celsius Storage Deuterated Internal Standards
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