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Journal / Biochemistry / En in vivo østrogenmangel muse model til…
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Biochemistry

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JoVE Journal Biochemistry
En in vivo østrogenmangel muse model til screening eksogene østrogen behandlinger af hjerte-kar-dysfunktion efter overgangsalderen
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En in vivo østrogenmangel muse model til screening eksogene østrogen behandlinger af hjerte-kar-dysfunktion efter overgangsalderen

Article DOI: 10.3791/59536-v • 06:27 min • August 13th, 2019
August 13th, 2019 •
1, 2, 1
1Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences & Peking Union Medical College, 2Shandong University of Traditional Chinese Medicine

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Klinisk, østrogenmangel hos menopausale kvinder kan forværre forekomsten af lipid forstyrrelser og åreforkalkning. Vi etablerede en in vivo østrogenmangel model ved bilateral ovariektomi via en dobbelt dorsal-lateral indsnit i ApoE-/- mus. Musemodellen er anvendelig til screening eksogene østrogen behandlinger af hjerte-kar-dysfunktion efter overgangsalderen.

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Biokemi ovariektomi åreforkalkning dobbelt dorsal-lateral Incision udskiltes administration intima-medie tykkelse ekkokardiografi
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