Adrian Goldman Research Program in Molecular and Integrative Biosciences University of Helsinki Biography Publications Institution JoVE Articles Adrian Goldman has not added a biography. If you are Adrian Goldman and would like to personalize this page please email our Author Liaison for assistance. Publications Evolving a Lipase for Hydrolysis of Natural Triglycerides Along with Enhanced Tolerance Towards a Protease and Surfactants Protein Engineering, Design & Selection : PEDS. Sep, 2019 | Pubmed ID: 31504920 Improving on Nature's Shortcomings: Evolving a Lipase for Increased Lipolytic Activity, Expression and Thermostability Protein Engineering, Design & Selection : PEDS. 09, 2019 | Pubmed ID: 31403166 Structure of the UspA1 Protein Fragment from Moraxella Catarrhalis Responsible for C3d Binding Journal of Structural Biology. Nov, 2019 | Pubmed ID: 31400508 Glutamate Transporters: a Broad Review of the Most Recent Archaeal and Human Structures Biochemical Society Transactions. Aug, 2019 | Pubmed ID: 31383819 Asymmetry in Catalysis by Membrane-bound Pyrophosphatase Demonstrated by a Nonphosphorus Allosteric Inhibitor Science Advances. May, 2019 | Pubmed ID: 31131322 Roles of the Hydrophobic Gate and Exit Channel in Vigna Radiata Pyrophosphatase Ion Translocation Journal of Molecular Biology. Apr, 2019 | Pubmed ID: 30878480 Substrate Polyspecificity and Conformational Relevance in ABC Transporters: New Insights from Structural Studies Biochemical Society Transactions. 12, 2018 | Pubmed ID: 30514765 Defining Dynamics of Membrane-Bound Pyrophosphatases by Experimental and Computational Single-Molecule FRET Methods in Enzymology. 2018 | Pubmed ID: 30149870 A Simple Strategy to Determine the Dependence of Membrane-Bound Pyrophosphatases on K As a Cofactor Methods in Enzymology. 2018 | Pubmed ID: 30149856 Binding of EphrinA5 to RET Receptor Tyrosine Kinase: An in Vitro Study PloS One. 2018 | Pubmed ID: 29889908 Pacing Across the Membrane: the Novel PACE Family of Efflux Pumps is Widespread in Gram-negative Pathogens Research in Microbiology. Sep - Oct, 2018 | Pubmed ID: 29409983 Affimer Proteins Inhibit Immune Complex Binding to FcγRIIIa with High Specificity Through Competitive and Allosteric Modes of Action Proceedings of the National Academy of Sciences of the United States of America. 01, 2018 | Pubmed ID: 29247053 Using a SMALP Platform to Determine a Sub-nm Single Particle Cryo-EM Membrane Protein Structure Biochimica Et Biophysica Acta. Feb, 2018 | Pubmed ID: 28993151 Crystal Structure of a Tripartite Complex Between C3dg, C-terminal Domains of Factor H and OspE of Borrelia Burgdorferi PloS One. 2017 | Pubmed ID: 29190743 Obesity: Receptors Identified for a Weight Regulator Nature. 10, 2017 | Pubmed ID: 28953879 Zebrafish GDNF and Its Co-receptor GFRα1 Activate the Human RET Receptor and Promote the Survival of Dopaminergic Neurons in Vitro PloS One. 2017 | Pubmed ID: 28467503 Insights into the Mechanism of Membrane Pyrophosphatases by Combining Experiment and Computer Simulation Structural Dynamics (Melville, N.Y.). May, 2017 | Pubmed ID: 28345008 The Crystal Structure of PD1, a Haemophilus Surface Fibril Domain Acta Crystallographica. Section F, Structural Biology Communications. 02, 2017 | Pubmed ID: 28177321 Membrane Pyrophosphatases from Thermotoga Maritima and Vigna Radiata Suggest a Conserved Coupling Mechanism Nature Communications. 12, 2016 | Pubmed ID: 27922000 Transport Mechanism of a Glutamate Transporter Homologue GltPh Biochemical Society Transactions. 06, 2016 | Pubmed ID: 27284058 Artificial Membranes for Membrane Protein Purification, Functionality and Structure Studies Biochemical Society Transactions. 06, 2016 | Pubmed ID: 27284055 A Method for Detergent-free Isolation of Membrane Proteins in Their Local Lipid Environment Nature Protocols. 07, 2016 | Pubmed ID: 27254461 A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters PloS One. 2015 | Pubmed ID: 26606682 Solution Structure and Biophysical Characterization of the Multifaceted Signalling Effector Protein Growth Arrest Specific-1 BMC Biochemistry. Feb, 2015 | Pubmed ID: 25888394 The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 25659429 Proton/sodium Pumping Pyrophosphatases: the Last of the Primary Ion Pumps Current Opinion in Structural Biology. Aug, 2014 | Pubmed ID: 24768824 Is the Bovine Lysosomal Phospholipase B-like Protein an Amidase? Proteins. Feb, 2014 | Pubmed ID: 23934913 The Structure of the NTPase That Powers DNA Packaging into Sulfolobus Turreted Icosahedral Virus 2 Journal of Virology. Aug, 2013 | Pubmed ID: 23698307 Inorganic Pyrophosphatases: One Substrate, Three Mechanisms FEBS Letters. Jun, 2013 | Pubmed ID: 23684653 Structural Basis for Complement Evasion by Lyme Disease Pathogen Borrelia Burgdorferi The Journal of Biological Chemistry. Jun, 2013 | Pubmed ID: 23658013 Crystallization and Preliminary X-ray Analysis of Membrane-bound Pyrophosphatases Molecular Membrane Biology. Feb, 2013 | Pubmed ID: 22881431 Yersinia Infection Tools-characterization of Structure and Function of Adhesins Frontiers in Cellular and Infection Microbiology. 2012 | Pubmed ID: 23316485 The Structure and Catalytic Cycle of a Sodium-pumping Pyrophosphatase Science (New York, N.Y.). Jul, 2012 | Pubmed ID: 22837527 Human UDP-glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-terminal His-tag on Glucuronidation Kinetics Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2012 | Pubmed ID: 22782802 The Translocation Domain in Trimeric Autotransporter Adhesins is Necessary and Sufficient for Trimerization and Autotransportation Journal of Bacteriology. Feb, 2012 | Pubmed ID: 22155776 Crystal Structure and Role of Glycans and Dimerization in Folding of Neuronal Leucine-rich Repeat Protein AMIGO-1 Journal of Molecular Biology. Nov, 2011 | Pubmed ID: 21983541 Obesity Risk Gene TMEM18 Encodes a Sequence-specific DNA-binding Protein PloS One. 2011 | Pubmed ID: 21980424 The Structure of E. Coli IgG-binding Protein D Suggests a General Model for Bending and Binding in Trimeric Autotransporter Adhesins Structure (London, England : 1993). Jul, 2011 | Pubmed ID: 21742268 Cloning, Expression, Purification, Crystallization and Preliminary X-ray Diffraction Data of the Pyrococcus Horikoshii RadA Intein Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. May, 2011 | Pubmed ID: 21543876 Dual Interaction of Factor H with C3d and Glycosaminoglycans in Host-nonhost Discrimination by Complement Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21285368 A Combined Quantum Chemical and Crystallographic Study on the Oxidized Binuclear Center of Cytochrome C Oxidase Biochimica Et Biophysica Acta. Jul, 2011 | Pubmed ID: 21211513 First Analysis of a Bacterial Collagen-binding Protein with Collagen Toolkits: Promiscuous Binding of YadA to Collagens May Explain How YadA Interferes with Host Processes Infection and Immunity. Jul, 2010 | Pubmed ID: 20439473 Both Domain 19 and Domain 20 of Factor H Are Involved in Binding to Complement C3b and C3d Molecular Immunology. May, 2010 | Pubmed ID: 20378178 Structural Determinants of Growth Factor Binding and Specificity by VEGF Receptor 2 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20145116 Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90: Computational Analysis and Protein Engineering The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19586912 Comparison of GFL-GFRalpha Complexes: Further Evidence Relating GFL Bend Angle to RET Signalling Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Jun, 2009 | Pubmed ID: 19478429 The Immunoglobulin-binding Eib Proteins from Escherichia Coli Are Receptors for IgG Fc Molecular Immunology. May, 2009 | Pubmed ID: 19303642 The Structure of the Conserved Neurotrophic Factors MANF and CDNF Explains Why They Are Bifunctional Protein Engineering, Design & Selection : PEDS. Apr, 2009 | Pubmed ID: 19258449 Recent Inventions on Receptor Tyrosine Kinase RET Modulation Recent Patents on Biotechnology. 2008 | Pubmed ID: 19075852 The Structure of the Glial Cell Line-derived Neurotrophic Factor-coreceptor Complex: Insights into RET Signaling and Heparin Binding The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18845535 Structure of the Actin-depolymerizing Factor Homology Domain in Complex with Actin The Journal of Cell Biology. Jul, 2008 | Pubmed ID: 18625842 Mutation Analysis in UGT1A9 Suggests a Relationship Between Substrate and Catalytic Residues in UDP-glucuronosyltransferases Protein Engineering, Design & Selection : PEDS. Sep, 2008 | Pubmed ID: 18502788 The First Aspartic Acid of the DQxD Motif for Human UDP-glucuronosyltransferase 1A10 Interacts with UDP-glucuronic Acid During Catalysis Drug Metabolism and Disposition: the Biological Fate of Chemicals. Mar, 2008 | Pubmed ID: 18048489 The Human UDP-glucuronosyltransferase: Identification of Key Residues Within the Nucleotide-sugar Binding Site Molecular Pharmacology. Sep, 2007 | Pubmed ID: 17578897 Crystal Structure of the N-terminal NC4 Domain of Collagen IX, a Zinc Binding Member of the Laminin-neurexin-sex Hormone Binding Globulin (LNS) Domain Family The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17553797 Structure of Streptococcus Agalactiae Serine/threonine Phosphatase. The Subdomain Conformation is Coupled to the Binding of a Third Metal Ion The FEBS Journal. Jun, 2007 | Pubmed ID: 17521332 Structure of the Streptococcus Agalactiae Family II Inorganic Pyrophosphatase at 2.80 A Resolution Acta Crystallographica. Section D, Biological Crystallography. Jun, 2007 | Pubmed ID: 17505113 Interactions with Other Human UDP-glucuronosyltransferases Attenuate the Consequences of the Y485D Mutation on the Activity and Substrate Affinity of UGT1A6 Pharmacogenetics and Genomics. Feb, 2007 | Pubmed ID: 17301691 A Complete Structural Description of the Catalytic Cycle of Yeast Pyrophosphatase Biochemistry. Feb, 2007 | Pubmed ID: 17260952 A Trimetal Site and Substrate Distortion in a Family II Inorganic Pyrophosphatase The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17095506 Crystal Structure of the Second PDZ Domain of SAP97 in Complex with a GluR-A C-terminal Peptide The FEBS Journal. Nov, 2006 | Pubmed ID: 17069616 Reindeer Beta-lactoglobulin Crystal Structure with Pseudo-body-centred Noncrystallographic Symmetry Acta Crystallographica. Section D, Biological Crystallography. Nov, 2006 | Pubmed ID: 17057340 Crystallization and Preliminary Crystallographic Analysis of Two Streptococcus Agalactiae Proteins: the Family II Inorganic Pyrophosphatase and the Serine/threonine Phosphatase Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Sep, 2006 | Pubmed ID: 16946472 Structure of Complement Factor H Carboxyl-terminus Reveals Molecular Basis of Atypical Haemolytic Uremic Syndrome The EMBO Journal. Apr, 2006 | Pubmed ID: 16601698 Crystal Structure of a Glycyl Radical Enzyme from Archaeoglobus Fulgidus Journal of Molecular Biology. Mar, 2006 | Pubmed ID: 16414072 Intracellularly Truncated Human Alpha2B-adrenoceptors: Stable and Functional GPCRs for Structural Studies Journal of Receptor and Signal Transduction Research. 2005 | Pubmed ID: 16149769 G-protein-coupled Receptor Domain Overexpression in Halobacterium Salinarum: Long-range Transmembrane Interactions in Heptahelical Membrane Proteins Proteins. Aug, 2005 | Pubmed ID: 15971205 Functional Studies with Membrane-bound and Detergent-solubilized Alpha2-adrenergic Receptors Expressed in Sf9 Cells Biochimica Et Biophysica Acta. Jun, 2005 | Pubmed ID: 15893292 The Structure of the Bacteriophage PRD1 Spike Sheds Light on the Evolution of Viral Capsid Architecture Molecular Cell. Apr, 2005 | Pubmed ID: 15837420 G Protein-coupled Receptors Show Unusual Patterns of Intrinsic Unfolding Protein Engineering, Design & Selection : PEDS. Feb, 2005 | Pubmed ID: 15790574 Unusual Twinning in an Acetyl Coenzyme A Synthetase (ADP-forming) from Pyrococcus Furiosus Acta Crystallographica. Section D, Biological Crystallography. Mar, 2005 | Pubmed ID: 15735347 The First Cysteine-rich Domain of the Receptor GFRalpha1 Stabilizes the Binding of GDNF The Biochemical Journal. May, 2005 | Pubmed ID: 15610063 Structural Studies of Metal Ions in Family II Pyrophosphatases: the Requirement for a Janus Ion Biochemistry. Nov, 2004 | Pubmed ID: 15533045 The Structure of GFRalpha1 Domain 3 Reveals New Insights into GDNF Binding and RET Activation The EMBO Journal. Apr, 2004 | Pubmed ID: 15044950 The Yersinia Adhesin YadA Collagen-binding Domain Structure is a Novel Left-handed Parallel Beta-roll The EMBO Journal. Feb, 2004 | Pubmed ID: 14765110 Functional Expression and Direct Visualization of the Human Alpha 2B -adrenergic Receptor and Alpha 2B -AR-green Fluorescent Fusion Protein in Mammalian Cell Using Semliki Forest Virus Vectors Protein Expression and Purification. Dec, 2003 | Pubmed ID: 14965773 The Structure of Pseudomonas P51 Cl-muconate Lactonizing Enzyme: Co-evolution of Structure and Dynamics with the Dehalogenation Function Protein Science : a Publication of the Protein Society. Sep, 2003 | Pubmed ID: 12930985 The Structural Basis of Receptor-binding by Escherichia Coli Associated with Diarrhea and Septicemia Journal of Molecular Biology. Aug, 2003 | Pubmed ID: 12909017 Structural Studies of Yersinia Adhesin YadA Advances in Experimental Medicine and Biology. 2003 | Pubmed ID: 12756733 Structure of Escherichia Coli Pyruvate Formate-lyase with Pyruvate Acta Crystallographica. Section D, Biological Crystallography. Dec, 2002 | Pubmed ID: 12454503 Expression, Purification and Crystallization of a Collagen-binding Fragment of Yersinia Adhesin YadA Acta Crystallographica. Section D, Biological Crystallography. Jun, 2002 | Pubmed ID: 12037311 3-Carboxy-cis,cis-muconate Lactonizing Enzyme from Neurospora Crassa: MAD Phasing with 80 Selenomethionines Acta Crystallographica. Section D, Biological Crystallography. May, 2002 | Pubmed ID: 11976482 The Structure of Neurospora Crassa 3-carboxy-cis,cis-muconate Lactonizing Enzyme, a Beta Propeller Cycloisomerase Structure (London, England : 1993). Apr, 2002 | Pubmed ID: 11937053 Screening för Thermotoga maritima membran-bundna Pyrofosfatashämmare Keni Vidilaseris*1, Niklas G. Johansson*2, Ainoleena Turku2, Alexandros Kiriazis2, Gustav Boije af Gennäs2, Jari Yli-Kauhaluoma2, Henri Xhaard2, Adrian Goldman1,3 1Research Program in Molecular and Integrative Biosciences, University of Helsinki, 2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds JoVE 60619 Biochemistry
Screening för Thermotoga maritima membran-bundna Pyrofosfatashämmare Keni Vidilaseris*1, Niklas G. Johansson*2, Ainoleena Turku2, Alexandros Kiriazis2, Gustav Boije af Gennäs2, Jari Yli-Kauhaluoma2, Henri Xhaard2, Adrian Goldman1,3 1Research Program in Molecular and Integrative Biosciences, University of Helsinki, 2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds JoVE 60619 Biochemistry