Andrés A. Trabanco

Publications

• Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
  Journal of the American Chemical Society. May, 2020  |   Pubmed ID: 32379965
• Hydrosulfonylation of Alkenes with Sulfonyl Chlorides Under Visible Light Activation
  Angewandte Chemie (International Ed. in English). Jul, 2020  |   Pubmed ID: 32286720
• Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
  Journal of the American Chemical Society. 01, 2020  |   Pubmed ID: 31881153
• MGluR2 Positive Allosteric Modulators: an Updated Patent Review (2013-2018)
  Expert Opinion on Therapeutic Patents. 07, 2019  |   Pubmed ID: 31242055
• Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
  Angewandte Chemie (International Ed. in English). 06, 2019  |   Pubmed ID: 31020767
• Progress Toward Allosteric Ligands of Metabotropic Glutamate 7 (mGlu7) Receptor: 2008-present
  MedChemComm. Feb, 2019  |   Pubmed ID: 30881607
• Computationally Guided Identification of Allosteric Agonists of the Metabotropic Glutamate 7 Receptor
  ACS Chemical Neuroscience. 03, 2019  |   Pubmed ID: 30216043
• Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization
  Journal of Medicinal Chemistry. 01, 2019  |   Pubmed ID: 29494768
• Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2
  Journal of Medicinal Chemistry. 08, 2017  |   Pubmed ID: 28704052
• Industrial Medicinal Chemistry Insights: Neuroscience Hit Generation at Janssen
  Drug Discovery Today. 10, 2017  |   Pubmed ID: 28669605
• Acylguanidine Beta Secretase 1 Inhibitors: A Combined Experimental and Free Energy Perturbation Study
  Journal of Chemical Theory and Computation. Mar, 2017  |   Pubmed ID: 28103438
• Application of Free Energy Perturbation for the Design of BACE1 Inhibitors
  Journal of Chemical Information and Modeling. 09, 2016  |   Pubmed ID: 27500414
• Towards Selective Phosphodiesterase 2A (PDE2A) Inhibitors: a Patent Review (2010 - Present)
  Expert Opinion on Therapeutic Patents. Aug, 2016  |   Pubmed ID: 27321640
• Molecular Mechanism of Positive Allosteric Modulation of the Metabotropic Glutamate Receptor 2 by JNJ-46281222
  British Journal of Pharmacology. Feb, 2016  |   Pubmed ID: 26589404
• A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors
  Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2015  |   Pubmed ID: 26140617
• N-Bridged 5,6-bicyclic Pyridines: Recent Applications in Central Nervous System Disorders
  European Journal of Medicinal Chemistry. Jun, 2015  |   Pubmed ID: 25542766
• QSAR Design of Triazolopyridine MGlu2 Receptor Positive Allosteric Modulators
  Journal of Molecular Graphics & Modelling. Sep, 2014  |   Pubmed ID: 25086773
• Dihydrothiazolopyridone Derivatives As a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu5) Receptor
  Journal of Medicinal Chemistry. Sep, 2013  |   Pubmed ID: 23947773
• Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the MGlu2 Receptor and Its Radioligand [3H]JNJ-40068782
  The Journal of Pharmacology and Experimental Therapeutics. Sep, 2013  |   Pubmed ID: 23766542
• MGluR2 Positive Allosteric Modulators: a Patent Review (2009 - Present)
  Expert Opinion on Therapeutic Patents. May, 2013  |   Pubmed ID: 23452205
• A Practical Entry to β-aryl-β-alkyl Amino Alcohols: Application to the Synthesis of a Potent BACE1 Inhibitor
  Organic & Biomolecular Chemistry. Sep, 2012  |   Pubmed ID: 22810961
• Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
  Journal of Medicinal Chemistry. Mar, 2012  |   Pubmed ID: 22352782
• New Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 (mGluR2): Identification and Synthesis of N-propyl-8-chloro-6-substituted Isoquinolones
  Bioorganic & Medicinal Chemistry Letters. Feb, 2011  |   Pubmed ID: 21232953
• Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2
  Current Medicinal Chemistry. 2011  |   Pubmed ID: 21110815