Translate this page to:
In JoVE (1)
Other Publications (3)
Articles by Ashley L. Fischer in JoVE
MISSION LentiPlex Pooled shRNA Library Screening in Mammalian Cells
Matthew J. Coussens, Courtney Corman, Ashley L. Fischer, Jack Sago, John Swarthout
Here we use a human LentiPlex pooled library and traditional sequencing methods to identify gene targets promoting cell survival. We demonstrate how to set up and deconvolute a LentiPlex screen and validate the results.
Other articles by Ashley L. Fischer on PubMed
Journal of Clinical and Experimental Neuropsychology. Oct, 2009 | Pubmed ID: 19142776
Type 2 diabetes is associated with cognitive deficits, although inconsistently across neuropsychological domains. We examined 3-year longitudinal data from the Victoria Longitudinal Study, comparing diabetes (n = 28) and control (n = 272) older adults on a comprehensive neuropsychological battery. Assessing potential change and stability, we found that (a) baseline diabetes group deficits in semantic speed and speed-intensive executive function were preserved, (b) new average deficits for reaction time and nonspeeded executive function appeared, and (c) no differential short-term change was observed. It is clinically and theoretically important to examine sequential change in multiple domains over time.
Neuropsychology. Jan, 2009 | Pubmed ID: 19210028
Type 2 diabetes may be associated with exacerbated aging-related declines in cognitive neuropsychological performance. The authors examined whether such effects are systematic (i.e., broadly distributed across domains or domain-specific) or moderated by age (i.e., varying across age within older adults). The authors assembled recent cross-sectional data from the Victoria Longitudinal Study (VLS) Sample 3 (Wave 1; initial n = 570; initial age = 53-90 years). Using a comprehensive, multidimensional spectrum of cognitive neuropsychological tests, the authors examined performance differences by diabetes status (diabetes group vs. healthy controls) and age (young-old vs. old-old). Our results showed that healthy controls significantly outperformed the diabetes group only on markers of executive functioning and speed. Notably, the diabetes-related effects were robust across the two late-life age groups. Future research examining longitudinal changes is recommended.
Testing Covariates of Type 2 Diabetes-cognition Associations in Older Adults: Moderating or Mediating Effects?
Neuropsychology. Sep, 2010 | Pubmed ID: 20804243
The general goal of this study was to advance our understanding of Type 2 diabetes (T2D)-cognition relationships in older adults by linking and testing comprehensive sets of potential moderators, potential mediators, and multiple cognitive outcomes.