Bernard Thébaud Sinclair Centre for Regenerative Medicine Ottawa Hospital Research Institute Biography Publications Institution JoVE Articles Bernard Thébaud has not added a biography. If you are Bernard Thébaud and would like to personalize this page please email our Author Liaison for assistance. Publications In Reply Stem Cells Translational Medicine. May, 2016 | Pubmed ID: 27091589 Impact of Bronchopulmonary Dysplasia on Brain and Retina Biology Open. 2016 | Pubmed ID: 26988760 Not Another Steroid Trial: Early Low-dose Hydrocortisone in Preterm Infants Lancet (London, England). Apr, 2016 | Pubmed ID: 26916175 Functional Differences Between Placental Micro- and Macrovascular Endothelial Colony-Forming Cells Stem Cells Translational Medicine. Jan, 2016 | Pubmed ID: 26819255 Corrigendum: The Isolation and Culture of Endothelial Colony-forming Cells from Human and Rat Lungs Nature Protocols. Jan, 2016 | Pubmed ID: 26716702 Preterm Birth: Risk Factor for Early-onset Chronic Diseases CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Dec, 2015 | Pubmed ID: 26644500 Bronchopulmonary Dysplasia and Chronic Lung Disease: Stem Cell Therapy Clinics in Perinatology. Dec, 2015 | Pubmed ID: 26593085 Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society Circulation. Nov, 2015 | Pubmed ID: 26534956 Mesenchymal Stromal Cells in Animal Bleomycin Pulmonary Fibrosis Models: A Systematic Review Stem Cells Translational Medicine. Dec, 2015 | Pubmed ID: 26494779 The Isolation and Culture of Endothelial Colony-forming Cells from Human and Rat Lungs Nature Protocols. Nov, 2015 | Pubmed ID: 26448359 Stem Cells and Their Mediators - Next Generation Therapy for Bronchopulmonary Dysplasia Frontiers in Medicine. 2015 | Pubmed ID: 26284246 Stem Cells for the Prevention of Neonatal Lung Disease Neonatology. 2015 | Pubmed ID: 26044105 Effect of Fatty Acids on Human Bone Marrow Mesenchymal Stem Cell Energy Metabolism and Survival PloS One. 2015 | Pubmed ID: 25768019 Stem Cells in Animal Asthma Models: a Systematic Review Cytotherapy. Dec, 2014 | Pubmed ID: 25442788 Animal Models of Bronchopulmonary Dysplasia. The Term Rat Models American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2014 | Pubmed ID: 25305248 Rac2 is Involved in Bleomycin-induced Lung Inflammation Leading to Pulmonary Fibrosis Respiratory Research. 2014 | Pubmed ID: 24970330 Existence, Functional Impairment, and Lung Repair Potential of Endothelial Colony-forming Cells in Oxygen-induced Arrested Alveolar Growth Circulation. May, 2014 | Pubmed ID: 24710033 Advances in Bronchopulmonary Dysplasia Expert Review of Respiratory Medicine. Jun, 2014 | Pubmed ID: 24666156 Doppler Parameters of Fetal Lung Hypoplasia and Impact of Sildenafil American Journal of Obstetrics and Gynecology. Sep, 2014 | Pubmed ID: 24631434 Progenitor Cells of the Distal Lung and Their Potential Role in Neonatal Lung Disease Birth Defects Research. Part A, Clinical and Molecular Teratology. Mar, 2014 | Pubmed ID: 24619857 Exogenous Hydrogen Sulfide (H2S) Protects Alveolar Growth in Experimental O2-induced Neonatal Lung Injury PloS One. 2014 | Pubmed ID: 24603989 Lung Mesenchymal Stromal Cells in Development and Disease: to Serve and Protect? Antioxidants & Redox Signaling. Nov, 2014 | Pubmed ID: 24350665 Metabolomics of Prematurity: Analysis of Patterns of Amino Acids, Enzymes, and Endocrine Markers by Categories of Gestational Age Pediatric Research. Feb, 2014 | Pubmed ID: 24216540 Stem Cell-based Therapy for Neonatal Lung Disease: It is in the Juice Pediatric Research. Jan, 2014 | Pubmed ID: 24126817 Hypoxia-inducible Factors Promote Alveolar Development and Regeneration American Journal of Respiratory Cell and Molecular Biology. Jan, 2014 | Pubmed ID: 23962064 Intrapulmonary Arteriovenous Anastomoses. Physiological, Pathophysiological, or Both? Annals of the American Thoracic Society. Oct, 2013 | Pubmed ID: 24161053 The Axonal Guidance Cue Semaphorin 3C Contributes to Alveolar Growth and Repair PloS One. 2013 | Pubmed ID: 23840631 Cell Therapy for Lung Diseases: Report from an NIH-NHLBI Workshop November 13-14, 2012 American Journal of Respiratory and Critical Care Medicine. May, 2013 | Pubmed ID: 23713908 The Promise of Stem Cells in Bronchopulmonary Dysplasia Seminars in Perinatology. Apr, 2013 | Pubmed ID: 23582961 Using Cell-Based Strategies to Break the Link Between Bronchopulmonary Dysplasia and the Development of Chronic Lung Disease in Later Life Pulmonary Medicine. 2013 | Pubmed ID: 23401768 Short-term, Long-term and Paracrine Effect of Human Umbilical Cord-derived Stem Cells in Lung Injury Prevention and Repair in Experimental Bronchopulmonary Dysplasia Thorax. May, 2013 | Pubmed ID: 23212278 Exosomes: Cell Garbage Can, Therapeutic Carrier, or Trojan Horse? Circulation. Nov, 2012 | Pubmed ID: 23114790 Stem Cell Conditioned Medium Improves Acute Lung Injury in Mice: in Vivo Evidence for Stem Cell Paracrine Action American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2012 | Pubmed ID: 23023971 Cell-based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia Clinics in Perinatology. Sep, 2012 | Pubmed ID: 22954277 Neonatal Mice Genetically Modified to Express the Elastase Inhibitor Elafin Are Protected Against the Adverse Effects of Mechanical Ventilation on Lung Growth American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2012 | Pubmed ID: 22683569 Preconditioning Enhances the Paracrine Effect of Mesenchymal Stem Cells in Preventing Oxygen-induced Neonatal Lung Injury in Rats Stem Cells and Development. Oct, 2012 | Pubmed ID: 22533467 Lung Injury in Preterm Neonates: the Role and Therapeutic Potential of Stem Cells Antioxidants & Redox Signaling. Oct, 2012 | Pubmed ID: 22400813 Antiproliferative Effects of Local Anesthetics on Mesenchymal Stem Cells: Potential Implications for Tumor Spreading and Wound Healing Anesthesiology. Apr, 2012 | Pubmed ID: 22343474 Critical Role of the Axonal Guidance Cue EphrinB2 in Lung Growth, Angiogenesis, and Repair American Journal of Respiratory and Critical Care Medicine. Mar, 2012 | Pubmed ID: 22161159 Airway Delivery of Soluble Factors from Plastic-adherent Bone Marrow Cells Prevents Murine Asthma American Journal of Respiratory Cell and Molecular Biology. Feb, 2012 | Pubmed ID: 21903873 Growth Factors, Stem Cells and Bronchopulmonary Dysplasia Neonatology. 2011 | Pubmed ID: 21701205 Update in Pediatric Lung Disease 2010 American Journal of Respiratory and Critical Care Medicine. Jun, 2011 | Pubmed ID: 21642257 Antenatal Sildenafil Treatment Attenuates Pulmonary Hypertension in Experimental Congenital Diaphragmatic Hernia Circulation. May, 2011 | Pubmed ID: 21537000 Activation of Akt Protects Alveoli from Neonatal Oxygen-induced Lung Injury American Journal of Respiratory Cell and Molecular Biology. Feb, 2011 | Pubmed ID: 20348209 Patent Ductus Arteriosus in Premature Infants: A Never-closing Act Paediatrics & Child Health. May, 2010 | Pubmed ID: 21532789 L-citrulline Attenuates Arrested Alveolar Growth and Pulmonary Hypertension in Oxygen-induced Lung Injury in Newborn Rats Pediatric Research. Dec, 2010 | Pubmed ID: 20805789 Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension: a Basis for Excessive Cell Proliferation and a New Therapeutic Target Circulation. Jun, 2010 | Pubmed ID: 20529999 Mesenchymal Stem Cells in Chronic Lung Disease: Culprit or Savior? American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2010 | Pubmed ID: 20363850 Defective Angiogenesis in Hypoplastic Human Fetal Lungs Correlates with Nitric Oxide Synthase Deficiency That Occurs Despite Enhanced Angiopoietin-2 and VEGF American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2010 | Pubmed ID: 20348277 If Your Placenta Doesn't Have It, Chances Are Your Lungs Don't Have It Either: the "vascular Hypothesis" of Bronchopulmonary Dysplasia Starts in Utero The Journal of Pediatrics. Apr, 2010 | Pubmed ID: 20303437 The Effect of Early-life Stress on Airway Inflammation in Adult Mice Neuroimmunomodulation. 2010 | Pubmed ID: 20203529 Expression and Function of Phosphodiesterases in Nitrofen-induced Congenital Diaphragmatic Hernia in Rats Pediatric Pulmonology. Apr, 2010 | Pubmed ID: 20196107 Adrenomedullin Promotes Lung Angiogenesis, Alveolar Development, and Repair American Journal of Respiratory Cell and Molecular Biology. Aug, 2010 | Pubmed ID: 19738161 Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats American Journal of Respiratory and Critical Care Medicine. Dec, 2009 | Pubmed ID: 19713449 Pulmonary Hypertension Associated with Congenital Diaphragmatic Hernia Cardiology in the Young. May, 2009 | Pubmed ID: 19419607 A Novel Mouse Model of Ureaplasma-induced Perinatal Inflammation: Effects on Lung and Brain Injury Pediatric Research. Apr, 2009 | Pubmed ID: 19127208 Blunted Hypoxic Pulmonary Vasoconstriction in Experimental Neonatal Chronic Lung Disease American Journal of Respiratory and Critical Care Medicine. Aug, 2008 | Pubmed ID: 18511704 Developmental Absence of the O2 Sensitivity of L-type Calcium Channels in Preterm Ductus Arteriosus Smooth Muscle Cells Impairs O2 Constriction Contributing to Patent Ductus Arteriosus Pediatric Research. Feb, 2008 | Pubmed ID: 18091358 Endometrial Regenerative Cells: a Novel Stem Cell Population Journal of Translational Medicine. 2007 | Pubmed ID: 18005405 Angiogenesis in Lung Development, Injury and Repair: Implications for Chronic Lung Disease of Prematurity Neonatology. 2007 | Pubmed ID: 17575472 Oxygen Activates the Rho/Rho-kinase Pathway and Induces RhoB and ROCK-1 Expression in Human and Rabbit Ductus Arteriosus by Increasing Mitochondria-derived Reactive Oxygen Species: a Newly Recognized Mechanism for Sustaining Ductal Constriction Circulation. Apr, 2007 | Pubmed ID: 17353442 Decreased Lung Fibroblast Growth Factor 18 and Elastin in Human Congenital Diaphragmatic Hernia and Animal Models American Journal of Respiratory and Critical Care Medicine. May, 2007 | Pubmed ID: 17303798 Bronchopulmonary Dysplasia: Where Have All the Vessels Gone? Roles of Angiogenic Growth Factors in Chronic Lung Disease American Journal of Respiratory and Critical Care Medicine. May, 2007 | Pubmed ID: 17272782 A Mitochondria-K+ Channel Axis is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth Cancer Cell. Jan, 2007 | Pubmed ID: 17222789 A Method for Increasing Jet Nebulizer Delivery Efficiency for Aerosol Drug Delivery in Ventilated Newborns: an in Vitro Study Respiratory Care. Nov, 2006 | Pubmed ID: 17067406 An Abnormal Mitochondrial-hypoxia Inducible Factor-1alpha-Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension Circulation. Jun, 2006 | Pubmed ID: 16735674 A Central Role for Oxygen-sensitive K+ Channels and Mitochondria in the Specialized Oxygen-sensing System Novartis Foundation Symposium. 2006 | Pubmed ID: 16686435 Adult Bone Marrow-derived Stem Cells for the Lung: Implications for Pediatric Lung Diseases Pediatric Research. Apr, 2006 | Pubmed ID: 16549555 Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-induced Lung Injury: Evidence That Angiogenesis Participates in Alveolarization Circulation. Oct, 2005 | Pubmed ID: 16230500 Sildenafil Improves Alveolar Growth and Pulmonary Hypertension in Hyperoxia-induced Lung Injury American Journal of Respiratory and Critical Care Medicine. Sep, 2005 | Pubmed ID: 15947285 Hypoxic Pulmonary Vasoconstriction: Redox Regulation of O2-sensitive K+ Channels by a Mitochondrial O2-sensor in Resistance Artery Smooth Muscle Cells Journal of Molecular and Cellular Cardiology. Dec, 2004 | Pubmed ID: 15572043 Oxygen-sensitive Kv Channel Gene Transfer Confers Oxygen Responsiveness to Preterm Rabbit and Remodeled Human Ductus Arteriosus: Implications for Infants with Patent Ductus Arteriosus Circulation. Sep, 2004 | Pubmed ID: 15353504 Preferential Expression and Function of Voltage-gated, O2-sensitive K+ Channels in Resistance Pulmonary Arteries Explains Regional Heterogeneity in Hypoxic Pulmonary Vasoconstriction: Ionic Diversity in Smooth Muscle Cells Circulation Research. Aug, 2004 | Pubmed ID: 15217912 O2 Sensing in the Human Ductus Arteriosus: Redox-sensitive K+ Channels Are Regulated by Mitochondria-derived Hydrogen Peroxide Biological Chemistry. Mar-Apr, 2004 | Pubmed ID: 15134333 Reductions in the Incidence of Nitrofen-induced Diaphragmatic Hernia by Vitamin A and Retinoic Acid American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2004 | Pubmed ID: 14729516 In Vivo Gene Transfer of the O2-sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats Circulation. Apr, 2003 | Pubmed ID: 12695303 Etiology of Congenital Diaphragmatic Hernia: the Retinoid Hypothesis Pediatric Research. May, 2003 | Pubmed ID: 12621107 The Assessment of IgG Avidity in the Evaluation of Perinatal Herpes Simplex Virus Infection Journal of Perinatology : Official Journal of the California Perinatal Association. Dec, 2002 | Pubmed ID: 12478453 O2 Sensing in the Human Ductus Arteriosus: Regulation of Voltage-gated K+ Channels in Smooth Muscle Cells by a Mitochondrial Redox Sensor Circulation Research. Sep, 2002 | Pubmed ID: 12242265 Altered Guanylyl-cyclase Activity in Vitro of Pulmonary Arteries from Fetal Lambs with Congenital Diaphragmatic Hernia American Journal of Respiratory Cell and Molecular Biology. Jul, 2002 | Pubmed ID: 12091244 Sildenafil Reverses O2 Constriction of the Rabbit Ductus Arteriosus by Inhibiting Type 5 Phosphodiesterase and Activating BK(Ca) Channels Pediatric Research. Jul, 2002 | Pubmed ID: 12084842 Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs Jennifer J.P. Collins1,2, Marius A. Möbius1,3,4, Bernard Thébaud1,2,5 1Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, 2University of Ottawa, 3Department of Neonatology and Pediatric Critical Care Medicine, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 4DFG Research Center and Cluster of Excellence for Regenerative Therapies (CRTD), Technische Universität, Dresden, 5Children's Hospital of Eastern Ontario Research Institute JoVE 53782 Biology
Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs Jennifer J.P. Collins1,2, Marius A. Möbius1,3,4, Bernard Thébaud1,2,5 1Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, 2University of Ottawa, 3Department of Neonatology and Pediatric Critical Care Medicine, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 4DFG Research Center and Cluster of Excellence for Regenerative Therapies (CRTD), Technische Universität, Dresden, 5Children's Hospital of Eastern Ontario Research Institute JoVE 53782 Biology
