Charles L. Sawyers Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Charles L. Sawyers has not added a biography. If you are Charles L. Sawyers and would like to personalize this page please email our Author Liaison for assistance. Publications A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation Nature Medicine. Oct, 2019 | Pubmed ID: 31591597 Herceptin: A First Assault on Oncogenes That Launched a Revolution Cell. Sep, 2019 | Pubmed ID: 31519311 FOXA1 Mutations Alter Pioneering Activity, Differentiation and Prostate Cancer Phenotypes Nature. 07, 2019 | Pubmed ID: 31243370 Publisher Correction: The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. Jul, 2019 | Pubmed ID: 31152158 Genomic Correlates of Clinical Outcome in Advanced Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019 | Pubmed ID: 31061129 Amplifies Androgen Receptor Output in Human Prostate Cancer and Contributes to Antiandrogen Resistance ELife. Jan, 2019 | Pubmed ID: 30644358 Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade JAMA Oncology. Apr, 2019 | Pubmed ID: 30589920 SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2019 | Pubmed ID: 30587545 Strategies to Identify and Target Cells of Origin in Prostate Cancer Journal of the National Cancer Institute. Mar, 2019 | Pubmed ID: 30312421 American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives JCO Clinical Cancer Informatics. 12, 2018 | Pubmed ID: 30652542 Immunogenomic Analyses Associate Immunological Alterations with Mismatch Repair Defects in Prostate Cancer The Journal of Clinical Investigation. 10, 2018 | Pubmed ID: 30179225 Tumor Copy Number Alteration Burden is a Pan-cancer Prognostic Factor Associated with Recurrence and Death ELife. 09, 2018 | Pubmed ID: 30178746 Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 30109253 Patient Derived Organoids to Model Rare Prostate Cancer Phenotypes Nature Communications. 06, 2018 | Pubmed ID: 29921838 The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. 05, 2018 | Pubmed ID: 29610475 Challenges in Validating Candidate Therapeutic Targets in Cancer ELife. 02, 2018 | Pubmed ID: 29417929 Targeting DNA Repair in Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 04, 2018 | Pubmed ID: 29369701 Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting European Urology. 05, 2018 | Pubmed ID: 29258679 Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity As a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer JAMA Oncology. Feb, 2018 | Pubmed ID: 29121144 Deletion of 3p13-14 Locus Spanning FOXP1 to SHQ1 Cooperates with PTEN Loss in Prostate Oncogenesis Nature Communications. 10, 2017 | Pubmed ID: 29057879 Regulation of the Glucocorticoid Receptor Via a BET-dependent Enhancer Drives Antiandrogen Resistance in Prostate Cancer ELife. 09, 2017 | Pubmed ID: 28891793 Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA Vs Guideline-Based Germline Testing JAMA. 09, 2017 | Pubmed ID: 28873162 Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making JCO Precision Oncology. Jul, 2017 | Pubmed ID: 28825054 ERF Mutations Reveal a Balance of ETS Factors Controlling Prostate Oncogenesis Nature. 06, 2017 | Pubmed ID: 28614298 Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions The New England Journal of Medicine. 05, 2017 | Pubmed ID: 28538124 SOX2 Promotes Lineage Plasticity and Antiandrogen Resistance in TP53- and RB1-deficient Prostate Cancer Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059768 Rb1 and Trp53 Cooperate to Suppress Prostate Cancer Lineage Plasticity, Metastasis, and Antiandrogen Resistance Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059767 Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells That Can Initiate Human Prostate Cancer and Predict Poor Outcome Cell Reports. 12, 2016 | Pubmed ID: 27926864 A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon PloS One. 2016 | Pubmed ID: 27536883 Facilitating a Culture of Responsible and Effective Sharing of Cancer Genome Data Nature Medicine. 05, 2016 | Pubmed ID: 27149219 Organoid Culture Systems for Prostate Epithelial and Cancer Tissue Nature Protocols. Feb, 2016 | Pubmed ID: 26797458 Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins Molecular Pharmaceutics. Feb, 2016 | Pubmed ID: 26725682 Identification of Different Classes of Luminal Progenitor Cells Within Prostate Tumors Cell Reports. Dec, 2015 | Pubmed ID: 26628377 Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer Nature Reviews. Cancer. Dec, 2015 | Pubmed ID: 26563462 All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care Through the Global Alliance for Genomics and Health Cancer Discovery. Nov, 2015 | Pubmed ID: 26526696 Androgen Receptor Upregulation Mediates Radioresistance After Ionizing Radiation Cancer Research. Nov, 2015 | Pubmed ID: 26432404 Identification of an Oncogenic RAB Protein Science (New York, N.Y.). Oct, 2015 | Pubmed ID: 26338797 Integrative Clinical Genomics of Advanced Prostate Cancer Cell. May, 2015 | Pubmed ID: 26000489 Feedback Suppression of PI3Kα Signaling in PTEN-mutated Tumors is Relieved by Selective Inhibition of PI3Kβ Cancer Cell. Jan, 2015 | Pubmed ID: 25544636 Identifying Actionable Targets Through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling Molecular Cancer Therapeutics. Jan, 2015 | Pubmed ID: 25381262 MAGI-2 Scaffold Protein is Critical for Kidney Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25271328 Cabozantinib Resolves Bone Scans in Tumor-naïve Mice Harboring Skeletal Injuries Molecular Imaging. 2014 | Pubmed ID: 25248353 Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: a Policy Statement from the American Association for Cancer Research Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2014 | Pubmed ID: 25204554 Organoid Cultures Derived from Patients with Advanced Prostate Cancer Cell. Sep, 2014 | Pubmed ID: 25201530 Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures Cell. Sep, 2014 | Pubmed ID: 25201529 CDK9-mediated Transcription Elongation is Required for MYC Addiction in Hepatocellular Carcinoma Genes & Development. Aug, 2014 | Pubmed ID: 25128497 Copy Number Alteration Burden Predicts Prostate Cancer Relapse Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25024180 Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade Cell. Dec, 2013 | Pubmed ID: 24315100 "N of 1" Case Reports in the Era of Whole-genome Sequencing The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24135144 Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers Cancer Discovery. Nov, 2013 | Pubmed ID: 24027196 Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-resistant Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2013 | Pubmed ID: 24002508 ETS Factors Reprogram the Androgen Receptor Cistrome and Prime Prostate Tumorigenesis in Response to PTEN Loss Nature Medicine. Aug, 2013 | Pubmed ID: 23817021 Perspective: Combined Forces Nature. Jun, 2013 | Pubmed ID: 23803949 Developing Standards for Breakthrough Therapy Designation in Oncology Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23719260 Overcoming Mutation-based Resistance to Antiandrogens with Rational Drug Design ELife. Apr, 2013 | Pubmed ID: 23580326 β4 Integrin Signaling Induces Expansion of Prostate Tumor Progenitors The Journal of Clinical Investigation. Feb, 2013 | Pubmed ID: 23348745 89Zr-转铁蛋白与脑肿瘤负担的影像。 Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2013 | Pubmed ID: 23236019 The 2011 Gordon Wilson Lecture: Overcoming Resistance to Targeted Cancer Drugs Transactions of the American Clinical and Climatological Association. 2012 | Pubmed ID: 23303979 Annotating MYC Status with 89Zr-transferrin Imaging Nature Medicine. Oct, 2012 | Pubmed ID: 23001181 Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors Cancer Research. Dec, 2012 | Pubmed ID: 22971343 JNK and PTEN Cooperatively Control the Development of Invasive Adenocarcinoma of the Prostate Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22753496 Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-specific Antigen Cancer Discovery. Apr, 2012 | Pubmed ID: 22576209 Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-hairpin RNA Library Screening PloS One. 2012 | Pubmed ID: 22509301 Converting Cancer Therapies into Cures: Lessons from Infectious Diseases Cell. Mar, 2012 | Pubmed ID: 22424221 监察局-509: 前列腺癌治疗的新型 Anti-androgen。 Cancer Research. Jan, 2012 | Pubmed ID: 22266222 健身所赋予的 BCR-ABL 激酶域突变确定预先存在耐药慢性粒细胞白血病的风险。 PloS One. 2011 | Pubmed ID: 22140458 TMPRSS2 ERG 去势抵抗前列腺癌患者治疗 Abiraterone 醋酸敏感性的预测生物标记物作为循环肿瘤细胞中的地位。 European Urology. Nov, 2011 | Pubmed ID: 21802835 雄激素受体信号与正电子自产的目标前列腺特异性膜抗原的无创性测量。 Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606347 肌醇和雄激素受体信号转导中 Pten 基因缺陷型前列腺癌的相互反馈调节。 Cancer Cell. May, 2011 | Pubmed ID: 21575859 FAS 和 NF-κ B 信号调制突变体表皮生长因子对肺癌的依赖。 Nature. Mar, 2011 | Pubmed ID: 21430781 MYC 前列腺肿瘤发生与 AKT 进行合作,并改变了对 MTOR 抑制剂的敏感性。 PloS One. 2011 | Pubmed ID: 21394210 ETV1 是沿袭存活的因素,在胃肠道间质肿瘤工具包与合作。 Nature. Oct, 2010 | Pubmed ID: 20927104 一积极的雄激素受体拼接变种在前列腺癌药物去势耐表示需要全长雄激素受体。 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823238 人类前列腺癌的综合基因组分析。 Cancer Cell. Jul, 2010 | Pubmed ID: 20579941 协调的 ERG 和雄激素受体在融合阳性前列腺癌中的转录调控。 Cancer Cell. May, 2010 | Pubmed ID: 20478521 具有抗癌活性的 MDV3100 去势抵抗前列腺癌: 1-2 期临床研究。 Lancet. Apr, 2010 | Pubmed ID: 20398925 去势抵抗前列腺癌 (不动产) 的乙内酰硫脲雄激素受体拮抗剂的构效关系。 Journal of Medicinal Chemistry. Apr, 2010 | Pubmed ID: 20218717 慢性粒细胞白血病患者 Dasatinib 费城染色体阴性骨髓细胞无性系造血功能。 Leukemia Research. Jun, 2010 | Pubmed ID: 19804904 从发展的激酶抑制剂的经验教训。 Clinical Advances in Hematology & Oncology : H&O. Sep, 2009 | Pubmed ID: 20020670 模式发生变化: 癌基因成瘾的种子。 Nature Medicine. Oct, 2009 | Pubmed ID: 19812578 蛋白酶体和 NF1 在 Gliomagenesis 中的抑癌基因灭活。 Cancer Cell. Jul, 2009 | Pubmed ID: 19573811 查找与 RAS 相关癌症的安全漏洞。 Cell. May, 2009 | Pubmed ID: 19490885 前列腺发生 PI3 激酶通路的激活与 TMPRSS2 ERG 的协同性。 Nature Genetics. May, 2009 | Pubmed ID: 19396167 第二代 Antiandrogen 治疗晚期前列腺癌的发展。 Science (New York, N.Y.). May, 2009 | Pubmed ID: 19359544 组蛋白化酶是雄激素受体功能需要激素敏感和去势术后抗前列腺癌。 Cancer Research. Feb, 2009 | Pubmed ID: 19176386 转化研究: 我们是否在正确的轨道上吗?2008 美国学会临床调查总统地址。 The Journal of Clinical Investigation. Nov, 2008 | Pubmed ID: 18982165 核因子 KappaB 通路控制雄激素独立增长的前列腺癌的恶化。 Cancer Research. Aug, 2008 | Pubmed ID: 18701501 前列腺上皮内瘤变依赖 P27 Kip1 检查站诱导衰老及抑制细胞增殖和肿瘤。 Cancer Cell. Aug, 2008 | Pubmed ID: 18691549 针对前列腺癌雄激素受体途径。 Current Opinion in Pharmacology. Aug, 2008 | Pubmed ID: 18674639 癌症生物标记物的问题。 Nature. Apr, 2008 | Pubmed ID: 18385728 东西东西迷失--获得: ASCI 开始其第二个世纪。 The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18382722 雷帕霉素在一个阶段中的抗肿瘤活性我审判胶质母细胞瘤 Pten 基因缺陷复发的患者。 PLoS Medicine. Jan, 2008 | Pubmed ID: 18215105 序贯 ABL 激酶抑制剂治疗选择复合耐药 BCR-ABL 基因突变与改变瘤效力。 The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17710227 磷酸化的 ATP 结合循环指示 BCR-ABL 耐药突变的致癌性。 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17164333 逐步、 去势抵抗前列腺癌生物学: 定向疗法针对雄激素受体信号轴。 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005 | Pubmed ID: 16278481 ABL、 套件和表皮生长因子受体激酶的耐药突变体的抑制作用。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16046538 一种新型的 Pyridopyrimidine 抑制剂 Abl 激酶是 Picomolar 抑制剂 Bcr Abl 驱动的 K562 细胞,有效针对耐 STI571 Bcr-abl 突变体。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2003 | Pubmed ID: 12684394 前列腺有机体培养作为工具,将基因型和突变谱转化为药理反应 Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research
前列腺有机体培养作为工具,将基因型和突变谱转化为药理反应 Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research