Charles L. Sawyers Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Charles L. Sawyers has not added a biography. If you are Charles L. Sawyers and would like to personalize this page please email our Author Liaison for assistance. Publications A Rectal Cancer Organoid Platform to Study Individual Responses to Chemoradiation Nature Medicine. Oct, 2019 | Pubmed ID: 31591597 Herceptin: A First Assault on Oncogenes That Launched a Revolution Cell. Sep, 2019 | Pubmed ID: 31519311 FOXA1 Mutations Alter Pioneering Activity, Differentiation and Prostate Cancer Phenotypes Nature. 07, 2019 | Pubmed ID: 31243370 Publisher Correction: The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. Jul, 2019 | Pubmed ID: 31152158 Genomic Correlates of Clinical Outcome in Advanced Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019 | Pubmed ID: 31061129 Amplifies Androgen Receptor Output in Human Prostate Cancer and Contributes to Antiandrogen Resistance ELife. Jan, 2019 | Pubmed ID: 30644358 Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade JAMA Oncology. Apr, 2019 | Pubmed ID: 30589920 SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2019 | Pubmed ID: 30587545 Strategies to Identify and Target Cells of Origin in Prostate Cancer Journal of the National Cancer Institute. Mar, 2019 | Pubmed ID: 30312421 American Association for Cancer Research Project Genomics Evidence Neoplasia Information Exchange: From Inception to First Data Release and Beyond-Lessons Learned and Member Institutions' Perspectives JCO Clinical Cancer Informatics. 12, 2018 | Pubmed ID: 30652542 Immunogenomic Analyses Associate Immunological Alterations with Mismatch Repair Defects in Prostate Cancer The Journal of Clinical Investigation. 10, 2018 | Pubmed ID: 30179225 Tumor Copy Number Alteration Burden is a Pan-cancer Prognostic Factor Associated with Recurrence and Death ELife. 09, 2018 | Pubmed ID: 30178746 Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 30109253 Patient Derived Organoids to Model Rare Prostate Cancer Phenotypes Nature Communications. 06, 2018 | Pubmed ID: 29921838 The Long Tail of Oncogenic Drivers in Prostate Cancer Nature Genetics. 05, 2018 | Pubmed ID: 29610475 Challenges in Validating Candidate Therapeutic Targets in Cancer ELife. 02, 2018 | Pubmed ID: 29417929 Targeting DNA Repair in Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 04, 2018 | Pubmed ID: 29369701 Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting European Urology. 05, 2018 | Pubmed ID: 29258679 Positron Emission Tomography/Computed Tomography-Based Assessments of Androgen Receptor Expression and Glycolytic Activity As a Prognostic Biomarker for Metastatic Castration-Resistant Prostate Cancer JAMA Oncology. Feb, 2018 | Pubmed ID: 29121144 Deletion of 3p13-14 Locus Spanning FOXP1 to SHQ1 Cooperates with PTEN Loss in Prostate Oncogenesis Nature Communications. 10, 2017 | Pubmed ID: 29057879 Regulation of the Glucocorticoid Receptor Via a BET-dependent Enhancer Drives Antiandrogen Resistance in Prostate Cancer ELife. 09, 2017 | Pubmed ID: 28891793 Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA Vs Guideline-Based Germline Testing JAMA. 09, 2017 | Pubmed ID: 28873162 Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making JCO Precision Oncology. Jul, 2017 | Pubmed ID: 28825054 ERF Mutations Reveal a Balance of ETS Factors Controlling Prostate Oncogenesis Nature. 06, 2017 | Pubmed ID: 28614298 Sharing Clinical and Genomic Data on Cancer - The Need for Global Solutions The New England Journal of Medicine. 05, 2017 | Pubmed ID: 28538124 SOX2 Promotes Lineage Plasticity and Antiandrogen Resistance in TP53- and RB1-deficient Prostate Cancer Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059768 Rb1 and Trp53 Cooperate to Suppress Prostate Cancer Lineage Plasticity, Metastasis, and Antiandrogen Resistance Science (New York, N.Y.). 01, 2017 | Pubmed ID: 28059767 Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells That Can Initiate Human Prostate Cancer and Predict Poor Outcome Cell Reports. 12, 2016 | Pubmed ID: 27926864 A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon PloS One. 2016 | Pubmed ID: 27536883 Facilitating a Culture of Responsible and Effective Sharing of Cancer Genome Data Nature Medicine. 05, 2016 | Pubmed ID: 27149219 Organoid Culture Systems for Prostate Epithelial and Cancer Tissue Nature Protocols. Feb, 2016 | Pubmed ID: 26797458 Applying ⁸⁹Zr-Transferrin To Study the Pharmacology of Inhibitors to BET Bromodomain Containing Proteins Molecular Pharmaceutics. Feb, 2016 | Pubmed ID: 26725682 Identification of Different Classes of Luminal Progenitor Cells Within Prostate Tumors Cell Reports. Dec, 2015 | Pubmed ID: 26628377 Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer Nature Reviews. Cancer. Dec, 2015 | Pubmed ID: 26563462 All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care Through the Global Alliance for Genomics and Health Cancer Discovery. Nov, 2015 | Pubmed ID: 26526696 Androgen Receptor Upregulation Mediates Radioresistance After Ionizing Radiation Cancer Research. Nov, 2015 | Pubmed ID: 26432404 Identification of an Oncogenic RAB Protein Science (New York, N.Y.). Oct, 2015 | Pubmed ID: 26338797 Integrative Clinical Genomics of Advanced Prostate Cancer Cell. May, 2015 | Pubmed ID: 26000489 Feedback Suppression of PI3Kα Signaling in PTEN-mutated Tumors is Relieved by Selective Inhibition of PI3Kβ Cancer Cell. Jan, 2015 | Pubmed ID: 25544636 Identifying Actionable Targets Through Integrative Analyses of GEM Model and Human Prostate Cancer Genomic Profiling Molecular Cancer Therapeutics. Jan, 2015 | Pubmed ID: 25381262 MAGI-2 Scaffold Protein is Critical for Kidney Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25271328 Cabozantinib Resolves Bone Scans in Tumor-naïve Mice Harboring Skeletal Injuries Molecular Imaging. 2014 | Pubmed ID: 25248353 Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: a Policy Statement from the American Association for Cancer Research Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2014 | Pubmed ID: 25204554 Organoid Cultures Derived from Patients with Advanced Prostate Cancer Cell. Sep, 2014 | Pubmed ID: 25201530 Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures Cell. Sep, 2014 | Pubmed ID: 25201529 CDK9-mediated Transcription Elongation is Required for MYC Addiction in Hepatocellular Carcinoma Genes & Development. Aug, 2014 | Pubmed ID: 25128497 Copy Number Alteration Burden Predicts Prostate Cancer Relapse Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25024180 Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade Cell. Dec, 2013 | Pubmed ID: 24315100 "N of 1" Case Reports in the Era of Whole-genome Sequencing The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24135144 Androgen Receptor Signaling Regulates DNA Repair in Prostate Cancers Cancer Discovery. Nov, 2013 | Pubmed ID: 24027196 Phase I Study of ARN-509, a Novel Antiandrogen, in the Treatment of Castration-resistant Prostate Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2013 | Pubmed ID: 24002508 ETS Factors Reprogram the Androgen Receptor Cistrome and Prime Prostate Tumorigenesis in Response to PTEN Loss Nature Medicine. Aug, 2013 | Pubmed ID: 23817021 Perspective: Combined Forces Nature. Jun, 2013 | Pubmed ID: 23803949 Developing Standards for Breakthrough Therapy Designation in Oncology Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23719260 Overcoming Mutation-based Resistance to Antiandrogens with Rational Drug Design ELife. Apr, 2013 | Pubmed ID: 23580326 β4 Integrin Signaling Induces Expansion of Prostate Tumor Progenitors The Journal of Clinical Investigation. Feb, 2013 | Pubmed ID: 23348745 Imaging Tumor Burden in the Brain with 89Zr-Transferrin Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2013 | Pubmed ID: 23236019 The 2011 Gordon Wilson Lecture: Overcoming Resistance to Targeted Cancer Drugs Transactions of the American Clinical and Climatological Association. 2012 | Pubmed ID: 23303979 Annotating MYC Status with 89Zr-transferrin Imaging Nature Medicine. Oct, 2012 | Pubmed ID: 23001181 Distinct Patterns of Dysregulated Expression of Enzymes Involved in Androgen Synthesis and Metabolism in Metastatic Prostate Cancer Tumors Cancer Research. Dec, 2012 | Pubmed ID: 22971343 JNK and PTEN Cooperatively Control the Development of Invasive Adenocarcinoma of the Prostate Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22753496 Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-specific Antigen Cancer Discovery. Apr, 2012 | Pubmed ID: 22576209 Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-hairpin RNA Library Screening PloS One. 2012 | Pubmed ID: 22509301 Converting Cancer Therapies into Cures: Lessons from Infectious Diseases Cell. Mar, 2012 | Pubmed ID: 22424221 ARN-509: a Novel Anti-androgen for Prostate Cancer Treatment Cancer Research. Jan, 2012 | Pubmed ID: 22266222 Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-existing Resistance in Chronic Myeloid Leukemia PloS One. 2011 | Pubmed ID: 22140458 TMPRSS2-ERG Status in Circulating Tumor Cells As a Predictive Biomarker of Sensitivity in Castration-resistant Prostate Cancer Patients Treated with Abiraterone Acetate European Urology. Nov, 2011 | Pubmed ID: 21802835 Noninvasive Measurement of Androgen Receptor Signaling with a Positron-emitting Radiopharmaceutical That Targets Prostate-specific Membrane Antigen Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606347 Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-deficient Prostate Cancer Cancer Cell. May, 2011 | Pubmed ID: 21575859 FAS and NF-κB Signalling Modulate Dependence of Lung Cancers on Mutant EGFR Nature. Mar, 2011 | Pubmed ID: 21430781 MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to MTOR Inhibitors PloS One. 2011 | Pubmed ID: 21394210 ETV1 is a Lineage Survival Factor That Cooperates with KIT in Gastrointestinal Stromal Tumours Nature. Oct, 2010 | Pubmed ID: 20927104 Constitutively Active Androgen Receptor Splice Variants Expressed in Castration-resistant Prostate Cancer Require Full-length Androgen Receptor Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823238 Integrative Genomic Profiling of Human Prostate Cancer Cancer Cell. Jul, 2010 | Pubmed ID: 20579941 Coordinate Transcriptional Regulation by ERG and Androgen Receptor in Fusion-positive Prostate Cancers Cancer Cell. May, 2010 | Pubmed ID: 20478521 Antitumour Activity of MDV3100 in Castration-resistant Prostate Cancer: a Phase 1-2 Study Lancet. Apr, 2010 | Pubmed ID: 20398925 Structure-activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-resistant Prostate Cancer (CRPC) Journal of Medicinal Chemistry. Apr, 2010 | Pubmed ID: 20218717 Clonal Hematopoiesis in Philadelphia Chromosome-negative Bone Marrow Cells of Chronic Myeloid Leukemia Patients Receiving Dasatinib Leukemia Research. Jun, 2010 | Pubmed ID: 19804904 Lessons Learned from the Development of Kinase Inhibitors Clinical Advances in Hematology & Oncology : H&O. Sep, 2009 | Pubmed ID: 20020670 Shifting Paradigms: the Seeds of Oncogene Addiction Nature Medicine. Oct, 2009 | Pubmed ID: 19812578 Proteasomal and Genetic Inactivation of the NF1 Tumor Suppressor in Gliomagenesis Cancer Cell. Jul, 2009 | Pubmed ID: 19573811 Finding and Drugging the Vulnerabilities of RAS-dependent Cancers Cell. May, 2009 | Pubmed ID: 19490885 Cooperativity of TMPRSS2-ERG with PI3-kinase Pathway Activation in Prostate Oncogenesis Nature Genetics. May, 2009 | Pubmed ID: 19396167 Development of a Second-generation Antiandrogen for Treatment of Advanced Prostate Cancer Science (New York, N.Y.). May, 2009 | Pubmed ID: 19359544 Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-sensitive and Castrate-resistant Prostate Cancer Cancer Research. Feb, 2009 | Pubmed ID: 19176386 Translational Research: Are We on the Right Track? 2008 American Society for Clinical Investigation Presidential Address The Journal of Clinical Investigation. Nov, 2008 | Pubmed ID: 18982165 The Nuclear Factor-kappaB Pathway Controls the Progression of Prostate Cancer to Androgen-independent Growth Cancer Research. Aug, 2008 | Pubmed ID: 18701501 A Prostatic Intraepithelial Neoplasia-dependent P27 Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression Cancer Cell. Aug, 2008 | Pubmed ID: 18691549 Targeting the Androgen Receptor Pathway in Prostate Cancer Current Opinion in Pharmacology. Aug, 2008 | Pubmed ID: 18674639 The Cancer Biomarker Problem Nature. Apr, 2008 | Pubmed ID: 18385728 Something Lost--something Gained: the ASCI Begins Its Second Century The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18382722 Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-deficient Glioblastoma PLoS Medicine. Jan, 2008 | Pubmed ID: 18215105 Sequential ABL Kinase Inhibitor Therapy Selects for Compound Drug-resistant BCR-ABL Mutations with Altered Oncogenic Potency The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17710227 Phosphorylation of the ATP-binding Loop Directs Oncogenicity of Drug-resistant BCR-ABL Mutants Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17164333 Biology of Progressive, Castration-resistant Prostate Cancer: Directed Therapies Targeting the Androgen-receptor Signaling Axis Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005 | Pubmed ID: 16278481 Inhibition of Drug-resistant Mutants of ABL, KIT, and EGF Receptor Kinases Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16046538 A Novel Pyridopyrimidine Inhibitor of Abl Kinase is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and is Effective Against STI571-resistant Bcr-abl Mutants Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2003 | Pubmed ID: 12684394 Prostata Organoid kulturer som værktøjer til at oversætte genotyper og Mutational profiler til farmakologiske reaktioner Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research
Prostata Organoid kulturer som værktøjer til at oversætte genotyper og Mutational profiler til farmakologiske reaktioner Kyrie J. Pappas1, Danielle Choi1, Charles L. Sawyers1,2, Wouter R. Karthaus1 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 2Howard Hughes Medical Institute JoVE 60346 Cancer Research