Chrisostomos Prodromou School of Life Sciences University of Sussex Biography Publications Institution JoVE Articles Chrisostomos Prodromou has not added a biography. If you are Chrisostomos Prodromou and would like to personalize this page please email our Author Liaison for assistance. Publications HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease Sub-cellular Biochemistry. 2023 | Pubmed ID: 36520314 Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant Biomolecules. Jun, 2022 | Pubmed ID: 35883461 Advances Towards Understanding the Mechanism of Action of the Hsp90 Complex Biomolecules. Apr, 2022 | Pubmed ID: 35625528 Two-colour Single-molecule Photoinduced Electron Transfer Fluorescence Imaging Microscopy of Chaperone Dynamics Nature Communications. Nov, 2021 | Pubmed ID: 34845214 Structure of the TELO2-TTI1-TTI2 Complex and Its Function in TOR Recruitment to the R2TP Chaperone Cell Reports. Jul, 2021 | Pubmed ID: 34233195 The Structure-function Relationship of Oncogenic LMTK3 Science Advances. Nov, 2020 | Pubmed ID: 33188023 Clinical and Functional Analyses of AIPL1 Variants Reveal Mechanisms of Pathogenicity Linked to Different Forms of Retinal Degeneration Scientific Reports. Oct, 2020 | Pubmed ID: 33067476 Editorial: The Role of Heat Shock Proteins in Neuroprotection Frontiers in Pharmacology. 2020 | Pubmed ID: 32848805 Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90-Client Interactions Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2020 | Pubmed ID: 32167602 Structural Mechanism for Regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP Co-chaperone Revealed by Cryo-EM Science Advances. May, 2019 | Pubmed ID: 31049401 Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90 Cell Reports. Jan, 2019 | Pubmed ID: 30699359 Advances on the Structure of the R2TP/Prefoldin-like Complex Advances in Experimental Medicine and Biology. 2018 | Pubmed ID: 30484153 Author Correction: RPAP3 Provides a Flexible Scaffold for Coupling HSP90 to the Human R2TP Co-chaperone Complex Nature Communications. Jul, 2018 | Pubmed ID: 30065299 Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection Frontiers in Molecular Biosciences. 2018 | Pubmed ID: 29930942 RPAP3 Provides a Flexible Scaffold for Coupling HSP90 to the Human R2TP Co-chaperone Complex Nature Communications. Apr, 2018 | Pubmed ID: 29662061 Bioassay to Test the Pathogenicity of Missense Human Variants Journal of Medical Genetics. Aug, 2018 | Pubmed ID: 29632148 Multi-chaperone Function Modulation and Association with Cytoskeletal Proteins Are Key Features of the Function of AIP in the Pituitary Gland Oncotarget. Feb, 2018 | Pubmed ID: 29507682 The Integrity and Organization of the Human AIPL1 Functional Domains is Critical for Its Role As a HSP90-dependent Co-chaperone for Rod PDE6 Human Molecular Genetics. Apr, 2018 | Pubmed ID: 29351602 The Stoichiometric Interaction of the Hsp90-Sgt1-Rar1 Complex by CD and SRCD Spectroscopy Frontiers in Molecular Biosciences. 2017 | Pubmed ID: 29387685 Tumor Suppressor Tsc1 is a New Hsp90 Co-chaperone That Facilitates Folding of Kinase and Non-kinase Clients The EMBO Journal. 12, 2017 | Pubmed ID: 29127155 Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System Cell Reports. Oct, 2017 | Pubmed ID: 29091774 The Integrity and Organization of the Human AIPL1 Functional Domains is Critical for Its Role As a HSP90-dependent Co-chaperone for Rod PDE6 Human Molecular Genetics. Nov, 2017 | Pubmed ID: 28973376 The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System Structure (London, England : 1993). Jul, 2017 | Pubmed ID: 28648606 HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients Cell Reports. Jun, 2017 | Pubmed ID: 28636940 The Structure of FKBP38 in Complex with the MEEVD Tetratricopeptide Binding-motif of Hsp90 PloS One. 2017 | Pubmed ID: 28278223 Mechanisms of Hsp90 Regulation The Biochemical Journal. Aug, 2016 | Pubmed ID: 27515256 The FNIP Co-chaperones Decelerate the Hsp90 Chaperone Cycle and Enhance Drug Binding Nature Communications. 06, 2016 | Pubmed ID: 27353360 Cooperation of Local Motions in the Hsp90 Molecular Chaperone ATPase Mechanism Nature Chemical Biology. Aug, 2016 | Pubmed ID: 27322067 Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations The Journal of Clinical Endocrinology and Metabolism. Aug, 2016 | Pubmed ID: 27253664 Dihydropyridine Derivatives Modulate Heat Shock Responses and Have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. May, 2016 | Pubmed ID: 27163800 Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors Cell Reports. Feb, 2016 | Pubmed ID: 26804907 C-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells Cell Reports. Aug, 2015 | Pubmed ID: 26235616 Tah1 Helix-swap Dimerization Prevents Mixed Hsp90 Co-chaperone Complexes Acta Crystallographica. Section D, Biological Crystallography. May, 2015 | Pubmed ID: 25945584 Structural Basis for Phosphorylation-dependent Recruitment of Tel2 to Hsp90 by Pih1 Structure (London, England : 1993). Jun, 2014 | Pubmed ID: 24794838 Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-competitive Inhibitors Molecular Cell. Jan, 2014 | Pubmed ID: 24462205 Synthesis of 19-substituted Geldanamycins with Altered Conformations and Their Binding to Heat Shock Protein Hsp90 Nature Chemistry. Apr, 2013 | Pubmed ID: 23511419 ATP-competitive Inhibitors Block Protein Kinase Recruitment to the Hsp90-Cdc37 System Nature Chemical Biology. May, 2013 | Pubmed ID: 23502424 Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-terminal α-7 Helix of the TPR Domain of AIP is Sufficient for Pituitary Adenoma Predisposition PloS One. 2012 | Pubmed ID: 23300914 CDK-dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-cycle Progression Cell. Dec, 2012 | Pubmed ID: 23217712 Co-crystalization and in Vitro Biological Characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 Inhibitors PloS One. 2012 | Pubmed ID: 22984537 Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50(CDC37)-AHA1 Chaperone Machine Molecular Cell. Aug, 2012 | Pubmed ID: 22727666 Charged Linker Sequence Modulates Eukaryotic Heat Shock Protein 90 (Hsp90) Chaperone Activity Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22315411 The 'active Life' of Hsp90 Complexes Biochimica Et Biophysica Acta. Mar, 2012 | Pubmed ID: 21840346 Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity Molecular Cell. Mar, 2011 | Pubmed ID: 21419342 Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors Molecular Cell. Jul, 2010 | Pubmed ID: 20670895 בדיקת מלכיט ירוק לגילוי מעכבי חלבון הלם חום 90 Sayan Dutta Gupta1, Dae-Geun Song1, SueJung Lee1, Jae Wook Lee1, Jin-Soo Park1, Chrisostomos Prodromou2, Cheol-Ho Pan1 1Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), 2School of Life Sciences, University of Sussex JoVE 64693 Biochemistry
בדיקת מלכיט ירוק לגילוי מעכבי חלבון הלם חום 90 Sayan Dutta Gupta1, Dae-Geun Song1, SueJung Lee1, Jae Wook Lee1, Jin-Soo Park1, Chrisostomos Prodromou2, Cheol-Ho Pan1 1Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), 2School of Life Sciences, University of Sussex JoVE 64693 Biochemistry