Christian Siebold

Publications

• A Calcium-sensing Receptor Mutation Causing Hypocalcemia Disrupts a Transmembrane Salt Bridge to Activate β-arrestin-biased Signaling
  Science Signaling. Feb, 2018  |   Pubmed ID: 29463778
• Multiple Ligand Binding Sites Regulate the Hedgehog Signal Transducer Smoothened in Vertebrates
  Current Opinion in Cell Biology. Apr, 2018  |   Pubmed ID: 29268141
• RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling
  Trends in Cell Biology. 05, 2017  |   Pubmed ID: 28007423
• Cholesterol Activates the G-protein Coupled Receptor Smoothened to Promote Hedgehog Signaling
  ELife. 10, 2016  |   Pubmed ID: 27705744
• Structural Basis of Smoothened Regulation by Its Extracellular Domains
  Nature. 07, 2016  |   Pubmed ID: 27437577
• Structural Basis for Integration of GluD Receptors Within Synaptic Organizer Complexes
  Science (New York, N.Y.). Jul, 2016  |   Pubmed ID: 27418511
• Initiation of T Cell Signaling by CD45 Segregation at 'close Contacts'
  Nature Immunology. May, 2016  |   Pubmed ID: 26998761
• Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases
  Developmental Cell. Dec, 2015  |   Pubmed ID: 26651291
• Secreted HHIP1 Interacts with Heparan Sulfate and Regulates Hedgehog Ligand Localization and Function
  The Journal of Cell Biology. Jun, 2015  |   Pubmed ID: 26056142
• Repulsive Guidance Molecule is a Structural Bridge Between Neogenin and Bone Morphogenetic Protein
  Nature Structural & Molecular Biology. Jun, 2015  |   Pubmed ID: 25938661
• Structure and Function of the Smoothened Extracellular Domain in Vertebrate Hedgehog Signaling
  ELife. Oct, 2013  |   Pubmed ID: 24171105
• Structural Insights into Proteoglycan-shaped Hedgehog Signaling
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013  |   Pubmed ID: 24062467
• Structure of the Repulsive Guidance Molecule (RGM)-neogenin Signaling Hub
  Science (New York, N.Y.). Jul, 2013  |   Pubmed ID: 23744777
• Restoring P53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-phosphorylated Nuclear IASPP
  Cancer Cell. May, 2013  |   Pubmed ID: 23623661
• Structural Insights into Semaphorins and Their Receptors
  Seminars in Cell & Developmental Biology. Mar, 2013  |   Pubmed ID: 23253452
• Neuropilins Lock Secreted Semaphorins Onto Plexins in a Ternary Signaling Complex
  Nature Structural & Molecular Biology. Dec, 2012  |   Pubmed ID: 23104057
• Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling
  Developmental Cell. Nov, 2011  |   Pubmed ID: 22000855
• A Dual Binding Mode for RhoGTPases in Plexin Signalling
  PLoS Biology. Aug, 2011  |   Pubmed ID: 21912513
• Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
  Nature Structural & Molecular Biology. Jul, 2011  |   Pubmed ID: 21743455
• Recording Information on Protein Complexes in an Information Management System
  Journal of Structural Biology. Aug, 2011  |   Pubmed ID: 21605682
• Automation of Large Scale Transient Protein Expression in Mammalian Cells
  Journal of Structural Biology. Aug, 2011  |   Pubmed ID: 21571074
• Structure of HLA-A*0301 in Complex with a Peptide of Proteolipid Protein: Insights into the Role of HLA-A Alleles in Susceptibility to Multiple Sclerosis
  Acta Crystallographica. Section D, Biological Crystallography. May, 2011  |   Pubmed ID: 21543847
• Proteoglycan-specific Molecular Switch for RPTPσ Clustering and Neuronal Extension
  Science (New York, N.Y.). Apr, 2011  |   Pubmed ID: 21454754
• Structural Basis of Semaphorin-plexin Signalling
  Nature. Oct, 2010  |   Pubmed ID: 20877282
• Interactions Between Hedgehog Proteins and Their Binding Partners Come into View
  Genes & Development. Sep, 2010  |   Pubmed ID: 20844013
• Structural Plasticity of Eph Receptor A4 Facilitates Cross-class Ephrin Signaling
  Structure (London, England : 1993). Oct, 2009  |   Pubmed ID: 19836338
• Crystal Structure of the GluR2 Amino-terminal Domain Provides Insights into the Architecture and Assembly of Ionotropic Glutamate Receptors
  Journal of Molecular Biology. Oct, 2009  |   Pubmed ID: 19651138
• Structural Insights into Hedgehog Ligand Sequestration by the Human Hedgehog-interacting Protein HHIP
  Nature Structural & Molecular Biology. Jul, 2009  |   Pubmed ID: 19561611
• Receptor Protein Tyrosine Phosphatase Micro: Measuring Where to Stick
  Biochemical Society Transactions. Apr, 2008  |   Pubmed ID: 18363557
• Biochemical and Structural Studies of ASPP Proteins Reveal Differential Binding to P53, P63, and P73
  Structure (London, England : 1993). Feb, 2008  |   Pubmed ID: 18275817
• Structure and Functional Analysis of the IGF-II/IGF2R Interaction
  The EMBO Journal. Jan, 2008  |   Pubmed ID: 18046459
• Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-clamp Mechanism
  Science (New York, N.Y.). Aug, 2007  |   Pubmed ID: 17761881
• Structure of the Fungal Beta-glucan-binding Immune Receptor Dectin-1: Implications for Function
  Protein Science : a Publication of the Protein Society. Jun, 2007  |   Pubmed ID: 17473009
• Mutations in Alpha-tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans
  Cell. Jan, 2007  |   Pubmed ID: 17218254
• MHC Class II Proteins and Disease: a Structural Perspective
  Nature Reviews. Immunology. Apr, 2006  |   Pubmed ID: 16557259
• Molecular Analysis of Receptor Protein Tyrosine Phosphatase Mu-mediated Cell Adhesion
  The EMBO Journal. Feb, 2006  |   Pubmed ID: 16456543
• MICAL (分子与 （英文版） 进行交互），催化区域的高分辨率结构域的 Flavoenzyme 信号分子。
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005  |   Pubmed ID: 16275925
• Multiple Sclerosis: MHC Associations and Therapeutic Implications
  Expert Reviews in Molecular Medicine. Feb, 2005  |   Pubmed ID: 15710050
• Crystal Structure of HLA-DQ0602 That Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004  |   Pubmed ID: 14769912