Christophe Prehaud Virology Department Institut Pasteur, Viral Neuroimmunology Laboratory Biography Publications Institution JoVE Articles Christophe Prehaud Christophe Prehaud obtained his Ph.D. degree in 1984 at Paris University (UPMC) on a molecular and genetic study of the Rabies virus glycoprotein (RABV-G). Then, he moved to Oxford-UK (NERC Institute of Virology) as a European Economic Community (EEC) postdoc fellow before undertaking a post doc training in Australia (CSIRO). He joined Institut Pasteur (Paris, France) in 1994 where he works with Dr Monique Lafon in her research unit (Viral NeuroImmunology) on the Neuron-Rabies Virus interaction. Since then, their work demonstrated the key role of the RABV-G in the neuron survival phenotype of virulent RABV strains and allowed to identify the serine-threonine microtubule associated serine-threonine kinase MAST2 as neuronal protein partner of RABV-G. From this basic research project, they identify a short polypeptide molecule that can trigger neuronal survival and axonal neuroregeneration. The use, delivery and optimization of this molecule is currently developed in a translational research program by using in vivo models as well as in cellulo human neuronal cells and BBB-minibrain models. Publications Innovative in Cellulo Method As an Alternative to in Vivo Neurovirulence Test for the Characterization and Quality Control of Human Live Yellow Fever Virus Vaccines: A Pilot Study Biologicals : Journal of the International Association of Biological Standardization. May, 2018 | Pubmed ID: 29580693 एक मानव रक्त मस्तिष्क इंटरफेस मॉडल रोगजनकों या दवाओं और मस्तिष्क के साथ उनकी बातचीत द्वारा बैरियर क्रॉसिंग का अध्ययन करने के लिए Anaelle da Costa*1, Christophe Prehaud*1, Florian Bakoa1, Philippe Afonso2, Pierre-Emmanuel Ceccaldi2, Pierre Lafaye3, Monique Lafon1 1Institut Pasteur, CNRS UMR 3569, Unité de Neuroimmunologie Virale, 2Institut Pasteur, Unité d’Epidémiologie et de Pathophysiologie des Virus Oncogènes, Université Sorbonne Paris Cité/Paris Diderot, 3Institut Pasteur, PFIA, DTPS JoVE 59220 Neuroscience
एक मानव रक्त मस्तिष्क इंटरफेस मॉडल रोगजनकों या दवाओं और मस्तिष्क के साथ उनकी बातचीत द्वारा बैरियर क्रॉसिंग का अध्ययन करने के लिए Anaelle da Costa*1, Christophe Prehaud*1, Florian Bakoa1, Philippe Afonso2, Pierre-Emmanuel Ceccaldi2, Pierre Lafaye3, Monique Lafon1 1Institut Pasteur, CNRS UMR 3569, Unité de Neuroimmunologie Virale, 2Institut Pasteur, Unité d’Epidémiologie et de Pathophysiologie des Virus Oncogènes, Université Sorbonne Paris Cité/Paris Diderot, 3Institut Pasteur, PFIA, DTPS JoVE 59220 Neuroscience