Christopher L. Axelrod Integrated Physiology and Molecular Medicine Laboratory Pennington Biomedical Research Center Biography Publications Institution JoVE Articles Christopher L. Axelrod Christopher Axelrod is the director of the Integrative Physiology and Molecular Medicine laboratory at Pennington Biomedical Research Center in Baton Rouge, Louisiana. His research applies a bioenergetic lens to understanding the pathogenesis and treatment of complex metabolic diseases such as insulin resistance, obesity, type 2 diabetes, non-alcoholic fatty liver disease, and cancer. Research interests include the development and testing of mitochondrial targeted pharmacotherapies, redox homeostasis in aging and disease, and therapeutic applications of metabolic surgery. Publications CRISPR/Cas9-engineered Drosophila Knock-in Models to Study VCP Diseases Disease Models & Mechanisms. Jul, 2021 | Pubmed ID: 34296742 CRISPR/Cas9-engineered Drosophila Knock-in Models to Study VCP Diseases Disease Models & Mechanisms. Jul, 2021 | Pubmed ID: 34160014 Lipids Activate Skeletal Muscle Mitochondrial Fission and Quality Control Networks to Induce Insulin Resistance in Humans Metabolism: Clinical and Experimental. Aug, 2021 | Pubmed ID: 34090870 Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults with Type 2 Diabetes The Journal of Clinical Endocrinology and Metabolism. Apr, 2021 | Pubmed ID: 33870426 Roux-en-Y Gastric Bypass Restores Islet Function and Morphology Independent of Body Weight in ZDF Rats American Journal of Physiology. Endocrinology and Metabolism. Jan, 2021 | Pubmed ID: 33427046 BAM15-mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control EMBO Molecular Medicine. 07, 2020 | Pubmed ID: 32519812 Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling Diabetes. 08, 2020 | Pubmed ID: 32409493 β-Hydroxybutyrate is Reduced in Humans with Obesity-related NAFLD and Displays a Dose-dependent Effect on Skeletal Muscle Mitochondrial Respiration in Vitro American Journal of Physiology. Endocrinology and Metabolism. 07, 2020 | Pubmed ID: 32396388 Lipids and Ketones Dominate Metabolism at the Expense of Glucose Control in Pulmonary Arterial Hypertension: a Hyperglycaemic Clamp and Metabolomics Study The European Respiratory Journal. 04, 2020 | Pubmed ID: 32108049 Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD Medicine and Science in Sports and Exercise. 07, 2020 | Pubmed ID: 32028458 UCC118 Supplementation Reduces Exercise-induced Gastrointestinal Permeability and Remodels the Gut Microbiome in Healthy Humans Physiological Reports. 11, 2019 | Pubmed ID: 31758610 Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats Obesity Surgery. 07, 2019 | Pubmed ID: 30809769 Exercise Training Remodels Human Skeletal Muscle Mitochondrial Fission and Fusion Machinery Towards a Pro-elongation Phenotype Acta Physiologica (Oxford, England). 04, 2019 | Pubmed ID: 30408342 Mitochondrial Dynamics in Skeletal Muscle Insulin Resistance and Type 2 Diabetes Translational Research : the Journal of Laboratory and Clinical Medicine. 12, 2018 | Pubmed ID: 30153426 Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates Elizabeth R. M. Zunica1,2,3, Christopher L. Axelrod1, L. Anne Gilmore2,4, John P. Kirwan1,3 1Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 2Clinical Oncology and Metabolism, Pennington Biomedical Research Center, 3Department of Nutrition, Case Western Reserve University, 4Department of Clinical Nutrition, University of Texas Southwestern Medical Center JoVE 62875 Cancer Research
Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates Elizabeth R. M. Zunica1,2,3, Christopher L. Axelrod1, L. Anne Gilmore2,4, John P. Kirwan1,3 1Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 2Clinical Oncology and Metabolism, Pennington Biomedical Research Center, 3Department of Nutrition, Case Western Reserve University, 4Department of Clinical Nutrition, University of Texas Southwestern Medical Center JoVE 62875 Cancer Research
