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Articles by Claudia Repetto in JoVE
JoVE General
استخدام بيوفيدباك في الواقع الافتراضي السريرية : مشروع مقدام
1Applied Technology for Neuro-Psychology Lab, Istituto Auxologico Italiano, 2Psychology Department, Università Cattolica del Sacro Cuore
ويهدف المشروع في الواقع الظاهري نظام متعدد الاستشعار الذكي لعلاج اضطرابات القلق المرتبطة (باسل) في وضع متعددة الاستشعار السياق يدرك نظام الواقع الافتراضي لعلاج الاضطرابات ذات الصلة القلق.
Other articles by Claudia Repetto on PubMed
The Effects of Ageing and Alzheimer's Disease on Semantic and Gender Priming
Normal ageing as well as age-associated pathological conditions, such as Alzheimer's disease, are associated with modifications of language processing. In particular, an impaired performance in semantic tasks, associated with relatively spared syntactic processing, has been suggested to be the hallmark of the language disorder of Alzheimer's disease. The present experiment tests semantic and syntactic aspects of language processing at the same time, using an on-line paradigm, in patients with Alzheimer's disease, compared with elderly and young controls. Normal ageing was associated with a profile of performance, which was slowed but qualitatively comparable with that of young controls. Both gender agreement and congruent sentential semantics resulted in facilitation relative to baseline in young and elderly controls, with no significant interference effects of incongruent grammatical and semantic information. In contrast, Alzheimer's disease patients presented both facilitation and interference effects. These findings suggest that interference effects are amplified by dementia, and may result from defective inhibitory processes due to Alzheimer's disease pathology.
Right Hemisphere Involvement in Non-fluent Primary Progressive Aphasia
We described a 56-years-old man with a diagnosis of "non-fluent primary progressive aphasia" (NfPPA). An accurate neuropsychological, neurological and neuroimaging evaluation was performed in order to assess clinical and behavioural features of the patient. From a neuropsychological point of view, the patient showed a typical cognitive profile of subjects affected by NfPPA: a prominent language deficit, associated with impairments in several cognitive domains after three years from the onset of the symptomatology. The most intriguing feature is that SPECT revealed hypoperfusion in the right frontal cortex, albeit the patient is right-handed. This unexpected finding shows that NfPPA may arise not only from cortical abnormalities in the language-dominant left hemisphere, but also from right hemisphere involvement in a right hander (crossed aphasia).
NeuroVR 1.5 in Practice: Actual Clinical Applications of the Open Source VR System
At CT 2007, we presented NeuroVR (http://www.neurovr.org), a free virtual reality platform based on open-source software. The software allows non-expert users to adapt the content of 14 pre-designed virtual environments to the specific needs of the clinical or experimental setting. Following the feedbacks of the 700 users who downloaded the first version, we developed a new version - NeuroVR 1.5 - that improves the possibility for the therapist to enhance the patient's feeling of familiarity and intimacy with the virtual scene, by using external sounds, photos or videos. The key characteristics that make NeuroVR suitable for most clinical applications are the high level of control of the interaction with the tool, and the enriched experience provided to the patient. Actually, NeuroVR is used in the assessment and treatment of Obesity, Alcohol Abuse, Anxiety Disorders, Generalized Anxiety Disorders, and Cognitive Rehabilitation.
The Use of Biofeedback in Clinical Virtual Reality: the Intrepid Project
In our protocol for the treatment of Generalized Anxiety Disorders we use Virtual reality (VR) to facilitate emotional regulation and the relaxation process. Using a biofeedback biomonitoring system (GSR, HR, Thermal) the patient is made aware of his or her reactions through the modification of some features of the VR environment in real time. Using mental exercises the patient learns to control these physiological parameters and using the feedback provided by the virtual environment is able to gauge his or her success. To test this concept, we planned a randomized controlled trial (NCT00602212), including three groups of 15 patients each (for a total of 45 patients): (1) the VR group, (2) the non-VR group, and (3) the waiting list (WL) group.
Semantic and Gender Priming in Frontotemporal Dementia
Modifications of language processing can be observed both in normal aging and in the most common forms of degenerative dementia, such as Alzheimer's disease and the spectrum of frontotemporal dementias. The present experiment tests at the same time semantic and syntactic aspects of language processing in patients with frontotemporal dementia, using an online paradigm that allows researchers to evaluate the real linguistic competence of the patients.
Virtual Reality in the Treatment of Generalized Anxiety Disorders
Generalized anxiety disorder (GAD) is a common anxiety disorder characterized by 6 months of "excessive anxiety and worry" about a variety of events and situations. Anxiety and worry are often accompanied by additional symptoms like restlessness, being easily fatigued, difficulty concentrating, irritability, muscle tension and disturbed sleep. GAD is usually treated with medications and/or psychotherapy. In particular, the two most promising treatments seem to be cognitive therapy and applied relaxation. In this study we integrated these approaches through the use of a biofeedback enhanced virtual reality (VR) system used both for relaxation and controlled exposure. Moreover, this experience is strengthened by the use of a mobile phone that allows patients to perform the virtual experience even in an outpatient setting. This paper describe the results of a controlled trial (NCT00602212) involving 20 GAD patients randomly assigned to the following groups: (1) the VR and Mobile group (VRMB) including biofeedback; (2) the VR and Mobile group (VRM) without biofeedback; (3) the waiting list (WL) group. The clinical data underlined that (a) VR can be used also in the treatment of GAD; (b) in a VR treatment, patients take advantage of a mobile device that delivers in an outpatient setting guided experiences, similar to the one experienced in VR.
