Colleen Brophy Department of Surgery Vanderbilt University Medical Center Biography Publications Institution JoVE Articles Colleen Brophy has not added a biography. If you are Colleen Brophy and would like to personalize this page please email our Author Liaison for assistance. Publications The Cell Permeant Phosphopetpide mimetic of VASP Alleviates Motor Function Deficits After Experimental Subarachnoid Hemorrhage Journal of Molecular Neuroscience : MN. Jan, 2024 | Pubmed ID: 38214771 Evaluation of Common Clinical and Hemodynamic Parameters to Pulmonary Capillary Wedge Pressures in Patients Undergoing Right Heart Catheterization Medical Research Archives. Nov, 2023 | Pubmed ID: 38249786 The Effect of Fluid Pre-loading on Vital Signs and Hemodynamic Parameters in a Porcine Model of Lipopolysaccharide-Induced Endotoxemia Cureus. Aug, 2023 | Pubmed ID: 37692606 Blocking P2X7 Receptor with AZ 10606120 Exacerbates Vascular Hyperpermeability and Inflammation in Murine Polymicrobial Sepsis Physiological Reports. Jun, 2022 | Pubmed ID: 35668576 Comparison of Clinical Symptoms and Bioimpedance to Pulmonary Capillary Wedge Pressure in Heart Failure American Heart Journal Plus : Cardiology Research and Practice. Mar, 2022 | Pubmed ID: 35600671 Noninvasive Venous Waveform Analysis Correlates With Pulmonary Capillary Wedge Pressure and Predicts 30-Day Admission in Patients With Heart Failure Undergoing Right Heart Catheterization Journal of Cardiac Failure. Dec, 2022 | Pubmed ID: 34555524 Therapeutic MK2 Inhibition Blocks Pathological Vascular Smooth Muscle Cell Phenotype Switch JCI Insight. Oct, 2021 | Pubmed ID: 34622803 Respiratory Non-Invasive Venous Waveform Analysis for Assessment of Respiratory Distress in Coronavirus Disease 2019 Patients: An Observational Study Critical Care Explorations. Oct, 2021 | Pubmed ID: 34617035 Vasorelaxing Cell Permeant Phosphopeptide Mimetics for Subarachnoid Hemorrhage European Journal of Pharmacology. Jun, 2021 | Pubmed ID: 33737008 Hemodynamic Parameters in the Assessment of Fluid Status in a Porcine Hemorrhage and Resuscitation Model Anesthesiology. Apr, 2021 | Pubmed ID: 33635950 Physiology and Clinical Utility of the Peripheral Venous Waveform JRSM Cardiovascular Disease. 2020 | Pubmed ID: 33194174 A Brief Report on the Effects of Vasoactive Agents on Peripheral Venous Waveforms in a Porcine Model JRSM Cardiovascular Disease. 2020 | Pubmed ID: 32864123 Non-Invasive Venous Waveform Analysis (NIVA) for Volume Assessment During Complex Cranial Vault Reconstruction: A Proof-of-concept Study in Children PloS One. 2020 | Pubmed ID: 32640004 Non-invasive Venous Waveform Analysis (NIVA) for Volume Assessment in Patients Undergoing Hemodialysis: an Observational Study BMC Nephrology. May, 2020 | Pubmed ID: 32448178 Cell-free Hemoglobin Increases Inflammation, Lung Apoptosis, and Microvascular Permeability in Murine Polymicrobial Sepsis PloS One. 2020 | Pubmed ID: 32012200 Non-Invasive Venous Waveform Analysis (NIVA) for Monitoring Blood Loss in Human Blood Donors and Validation in a Porcine Hemorrhage Model Journal of Clinical Anesthesia. May, 2020 | Pubmed ID: 31786067 Observational Study of Noninvasive Venous Waveform Analysis to Assess Intracardiac Filling Pressures During Right Heart Catheterization Journal of Cardiac Failure. Feb, 2020 | Pubmed ID: 31574315 An Anionic, Endosome-escaping Polymer to Potentiate Intracellular Delivery of Cationic Peptides, Biomacromolecules, and Nanoparticles Nature Communications. Nov, 2019 | Pubmed ID: 31676764 Normal Saline Solutions Cause Endothelial Dysfunction Through Loss of Membrane Integrity, ATP Release, and Inflammatory Responses Mediated by P2X7R/p38 MAPK/MK2 Signaling Pathways PloS One. 2019 | Pubmed ID: 31412063 Corrigendum to "Peripheral IntravenousVolume Analysis (PIVA) for Quantitating Volume Overload in Patients Hospitalized with Acute Decompensated Heart Failure-A Pilot Study" Journal of Cardiac Failure Vol. 24 No. 8, Pp. 525-532 Journal of Cardiac Failure. Jul, 2019 | Pubmed ID: 31345283 Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue Tissue Engineering. Part A. Mar, 2019 | Pubmed ID: 30132374 Peripheral Intravenous Volume Analysis (PIVA) for Quantitating Volume Overload in Patients Hospitalized With Acute Decompensated Heart Failure-A Pilot Study Journal of Cardiac Failure. Aug, 2018 | Pubmed ID: 29777760 Excipients for the Lyoprotection of MAPKAP Kinase 2 Inhibitory Peptide Nano-polyplexes Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2018 | Pubmed ID: 29709529 Vascular Surgical Stretch Injury Leads to Activation of P2X7 Receptors and Impaired Endothelial Function PloS One. 2017 | Pubmed ID: 29136654 Limiting Injury During Saphenous Vein Graft Preparation For Coronary Arterial Bypass Prevents Metabolic Decompensation Scientific Reports. Oct, 2017 | Pubmed ID: 29079734 Heparin-functionalized Polymer Graft Surface Eluting MK2 Inhibitory Peptide to Improve Hemocompatibility and Anti-neointimal Activity Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2017 | Pubmed ID: 28987880 P2X7R Antagonism After Subfailure Overstretch Injury of Blood Vessels Reverses Vasomotor Dysfunction and Prevents Apoptosis Purinergic Signalling. Dec, 2017 | Pubmed ID: 28905300 Unregulated Saphenous Vein Graft Distension Decreases Tissue Viscoelasticity Perfusion. Sep, 2017 | Pubmed ID: 28820033 Calcification of Human Saphenous Vein Associated with Endothelial Dysfunction: A Pilot Histopathophysiological and Demographical Study Frontiers in Surgery. 2017 | Pubmed ID: 28232909 Hyperlactemia Predicts Surgical Mortality in Patients Presenting With Acute Stanford Type-A Aortic Dissection Journal of Cardiothoracic and Vascular Anesthesia. Feb, 2017 | Pubmed ID: 27493094 Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes Cellular and Molecular Bioengineering. Sep, 2016 | Pubmed ID: 27818713 Use of Brilliant Blue FCF During Vein Graft Preparation Inhibits Intimal Hyperplasia Journal of Vascular Surgery. Aug, 2016 | Pubmed ID: 27763268 The Case for Endothelial Preservation Pressure-Regulated Distension in the Preparation of Autologous Saphenous Vein Conduits in Cardiac and Peripheral Bypass Operations Frontiers in Surgery. 2016 | Pubmed ID: 27713879 Aortic Arch Involvement Worsens the Prognosis of Type B Aortic Dissections Journal of Vascular Surgery. Nov, 2016 | Pubmed ID: 27397897 Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein PloS One. 2016 | Pubmed ID: 27136356 Peripheral Venous Waveform Analysis for Detecting Hemorrhage and Iatrogenic Volume Overload in a Porcine Model Shock (Augusta, Ga.). Oct, 2016 | Pubmed ID: 27070329 Preoperative Predictors of 30-Day Mortality and Prolonged Length of Stay After Above-Knee Amputation Annals of Vascular Surgery. Feb, 2016 | Pubmed ID: 26616501 Brilliant Blue FCF is a Nontoxic Dye for Saphenous Vein Graft Marking That Abrogates Response to Injury Journal of Vascular Surgery. Jul, 2016 | Pubmed ID: 25704409 The Influence of VKORC1 and CYP2C9 Mutations on Warfarin Response After Total Hip and Knee Arthroplasty Journal of Orthopaedics. Dec, 2015 | Pubmed ID: 27047214 An Optimized Preparation Technique for Saphenous Vein Graft The American Surgeon. Jul, 2015 | Pubmed ID: 26140874 MK2 Inhibitory Peptide Delivered in Nanopolyplexes Prevents Vascular Graft Intimal Hyperplasia Science Translational Medicine. Jun, 2015 | Pubmed ID: 26062847 Endosomolytic Nano-Polyplex Platform Technology for Cytosolic Peptide Delivery To Inhibit Pathological Vasoconstriction ACS Nano. Jun, 2015 | Pubmed ID: 26004140 Preservation Solution Impacts Physiologic Function and Cellular Viability of Human Saphenous Vein Graft Surgery. Aug, 2015 | Pubmed ID: 26003912 Prediction of In-hospital Mortality After Ruptured Abdominal Aortic Aneurysm Repair Using an Artificial Neural Network Journal of Vascular Surgery. Jul, 2015 | Pubmed ID: 25953014 Peripheral Venous Waveform Analysis for Detecting Early Hemorrhage: a Pilot Study Intensive Care Medicine. Jun, 2015 | Pubmed ID: 25862041 Race As a Predictor of Delay from Diagnosis to Endarterectomy in Clinically Significant Carotid Stenosis Journal of Vascular Surgery. Jul, 2015 | Pubmed ID: 25776188 Brilliant Blue FCF As an Alternative Dye for Saphenous Vein Graft Marking: Effect on Conduit Function JAMA Surgery. Nov, 2014 | Pubmed ID: 25251505 Pressure Control During Preparation of Saphenous Veins JAMA Surgery. Jul, 2014 | Pubmed ID: 24759942 Surgical Vein Graft Preparation Promotes Cellular Dysfunction, Oxidative Stress, and Intimal Hyperplasia in Human Saphenous Vein Journal of Vascular Surgery. Jul, 2014 | Pubmed ID: 23911244 Role of Cyclic Nucleotide-dependent Actin Cytoskeletal Dynamics:Ca(2+)](i) and Force Suppression in Forskolin-pretreated Porcine Coronary Arteries PloS One. 2013 | Pubmed ID: 23593369 Cell-permeant Peptide Inhibitors of Vasospasm and Intimal Hyperplasia Vascular. Feb, 2013 | Pubmed ID: 23104826 Intimal Thickness Associated with Endothelial Dysfunction in Human Vein Grafts The Journal of Surgical Research. Mar, 2013 | Pubmed ID: 22763213 Teaching in the Operating Room: Results of a National Survey Journal of Surgical Education. 2012 | Pubmed ID: 22910164 Role of the Renin-angiotensin System in the Pathogenesis of Intimal Hyperplasia: Therapeutic Potential for Prevention of Vein Graft Failure? Annals of Vascular Surgery. Nov, 2012 | Pubmed ID: 22445245 Women in Academic Surgery: the Pipeline is Busted Journal of Surgical Education. 2012 | Pubmed ID: 22208838 Surgical Skin Markers Impair Human Saphenous Vein Graft Smooth Muscle and Endothelial Function The American Surgeon. Jul, 2011 | Pubmed ID: 21944360 Detrimental Effects of Mechanical Stretch on Smooth Muscle Function in Saphenous Veins Journal of Vascular Surgery. Feb, 2011 | Pubmed ID: 21146345 A Novel Cell Permeant Peptide Inhibitor of MAPKAP Kinase II Inhibits Intimal Hyperplasia in a Human Saphenous Vein Organ Culture Model Journal of Vascular Surgery. Dec, 2010 | Pubmed ID: 20864298 The Small Heat Shock Protein, HSPB6, in Muscle Function and Disease Cell Stress & Chaperones. Jan, 2010 | Pubmed ID: 19568960 Design of a Bioactive Cell-penetrating Peptide: when a Transduction Domain Does More Than Transduce Journal of Peptide Science : an Official Publication of the European Peptide Society. Oct, 2009 | Pubmed ID: 19691016 Cell Permeant Peptide Analogues of the Small Heat Shock Protein, HSP20, Reduce TGF-beta1-induced CTGF Expression in Keloid Fibroblasts The Journal of Investigative Dermatology. Mar, 2009 | Pubmed ID: 18787533 Author Spotlight: Exploring Venous Waveforms for Non-Invasive Respiratory Monitoring in Pigs Bret D. Alvis1,2, Colleen Brophy3, Joyce Cheung-Flynn3, Marisa Case1, Kyle Hocking2,3 1Department of Anesthesiology, Vanderbilt University Medical Center, 2Department of Biomedical Engineering, Vanderbilt University, 3Department of Surgery, Vanderbilt University Medical Center JoVE 65963 Medicine Adult and Pediatric Porcine Model of Acute Volume Overload Bret D. Alvis1,2, Jenna Helmer Sobey1, Lexie Vaughn3, Christina Jelly1, Dawson Wervey4, Joyce Cheung-Flynn3, Marisa Case1, Colleen Brophy3, Kyle Hocking2,3 1Department of Anesthesiology, Vanderbilt University Medical Center, 2Department of Biomedical Engineering, Vanderbilt University, 3Department of Surgery, Vanderbilt University Medical Center, 4Ohio University Heritage College of Osteopathic Medicine JoVE 65967 Medicine
Author Spotlight: Exploring Venous Waveforms for Non-Invasive Respiratory Monitoring in Pigs Bret D. Alvis1,2, Colleen Brophy3, Joyce Cheung-Flynn3, Marisa Case1, Kyle Hocking2,3 1Department of Anesthesiology, Vanderbilt University Medical Center, 2Department of Biomedical Engineering, Vanderbilt University, 3Department of Surgery, Vanderbilt University Medical Center JoVE 65963 Medicine
Adult and Pediatric Porcine Model of Acute Volume Overload Bret D. Alvis1,2, Jenna Helmer Sobey1, Lexie Vaughn3, Christina Jelly1, Dawson Wervey4, Joyce Cheung-Flynn3, Marisa Case1, Colleen Brophy3, Kyle Hocking2,3 1Department of Anesthesiology, Vanderbilt University Medical Center, 2Department of Biomedical Engineering, Vanderbilt University, 3Department of Surgery, Vanderbilt University Medical Center, 4Ohio University Heritage College of Osteopathic Medicine JoVE 65967 Medicine
