Craig M. Crews Department of Molecular, Cellular, and Developmental Biology Yale University Biography Publications Institution JoVE Articles Craig M. Crews has not added a biography. If you are Craig M. Crews and would like to personalize this page please email our Author Liaison for assistance. Publications Multiplex CRISPR/Cas Screen in Regenerating Haploid Limbs of Chimeric Axolotls ELife. Jan, 2020 | Pubmed ID: 31989926 Proteolysis-Targeting Chimeras As Therapeutics and Tools for Biological Discovery Cell. Jan, 2020 | Pubmed ID: 31955850 Design, Synthesis and Biological Evaluation of Proteolysis Targeting Chimeras (PROTACs) As a BTK Degraders with Improved Pharmacokinetic Properties Bioorganic & Medicinal Chemistry Letters. Feb, 2020 | Pubmed ID: 31879210 Targeted Protein Degradation: Expanding the Toolbox Nature Reviews. Drug Discovery. 12, 2019 | Pubmed ID: 31666732 Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs ACS Central Science. Oct, 2019 | Pubmed ID: 31660436 Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation Cancer Research. Sep, 2019 | Pubmed ID: 31311809 Targeted Protein Internalization and Degradation by ENDosome TArgeting Chimeras (ENDTACs) ACS Central Science. Jun, 2019 | Pubmed ID: 31263767 PROteolysis TArgeting Chimeras (PROTACs) - Past, Present and Future Drug Discovery Today. Technologies. Apr, 2019 | Pubmed ID: 31200855 Protein Folding State-dependent Sorting at the Golgi Apparatus Molecular Biology of the Cell. 08, 2019 | Pubmed ID: 31166830 RUNX1-targeted Therapy for AML Expressing Somatic or Germline Mutation in RUNX1 Blood. 07, 2019 | Pubmed ID: 31023702 Targeted Protein Degradation: Elements of PROTAC Design Current Opinion in Chemical Biology. 06, 2019 | Pubmed ID: 31004963 BETP Degradation Simultaneously Targets Acute Myelogenous Leukemia Stem Cells and the Microenvironment The Journal of Clinical Investigation. 05, 2019 | Pubmed ID: 30829648 Evolving Rules for Protein Degradation? Insights from the Zinc Finger Degrome Biochemistry. 02, 2019 | Pubmed ID: 30681837 Differential PROTAC Substrate Specificity Dictated by Orientation of Recruited E3 Ligase Nature Communications. 01, 2019 | Pubmed ID: 30631068 Targeting Nuclear β-catenin As Therapy for Post-myeloproliferative Neoplasm Secondary AML Leukemia. 06, 2019 | Pubmed ID: 30575820 MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity Via Simultaneous Degradation of BRD4 and Stabilization of P53 Cancer Research. 01, 2019 | Pubmed ID: 30385614 Addressing Kinase-Independent Functions of Fak Via PROTAC-Mediated Degradation Journal of the American Chemical Society. 12, 2018 | Pubmed ID: 30444612 Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion Journal of the American Chemical Society. 12, 2018 | Pubmed ID: 30427680 Androgen Receptor Degradation by the Proteolysis-targeting Chimera ARCC-4 Outperforms Enzalutamide in Cellular Models of Prostate Cancer Drug Resistance Communications Biology. 2018 | Pubmed ID: 30271980 Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure-Degradation Relationships ChemMedChem. 08, 2018 | Pubmed ID: 29870139 Targeted Protein Unfolding Uncovers a Golgi-specific Transcriptional Stress Response Molecular Biology of the Cell. 06, 2018 | Pubmed ID: 29851555 Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation Biochemistry. 07, 2018 | Pubmed ID: 29851337 Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins Are Active Against Pre-clinical Models of Multiple Myeloma Leukemia. 10, 2018 | Pubmed ID: 29581547 Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead Cell Chemical Biology. 01, 2018 | Pubmed ID: 29129718 The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study Cell Chemical Biology. 01, 2018 | Pubmed ID: 29129716 Lineage Tracing of Genome-edited Alleles Reveals High Fidelity Axolotl Limb Regeneration ELife. 09, 2017 | Pubmed ID: 28917058 The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target ACS Central Science. Aug, 2017 | Pubmed ID: 28852696 Small-Molecule Modulation of Protein Homeostasis Chemical Reviews. Sep, 2017 | Pubmed ID: 28777566 Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation ACS Chemical Biology. 10, 2017 | Pubmed ID: 28767222 Targeted Protein Degradation: from Chemical Biology to Drug Discovery Cell Chemical Biology. Sep, 2017 | Pubmed ID: 28648379 Targeted Protein Knockdown Using Small Molecule Degraders Current Opinion in Chemical Biology. Aug, 2017 | Pubmed ID: 28605671 Waste Disposal-An Attractive Strategy for Cancer Therapy Science (New York, N.Y.). 03, 2017 | Pubmed ID: 28302825 Proteolysis-Targeting Chimeras: Induced Protein Degradation As a Therapeutic Strategy ACS Chemical Biology. 04, 2017 | Pubmed ID: 28263557 Targeted Protein Degradation by PROTACs Pharmacology & Therapeutics. Jun, 2017 | Pubmed ID: 28223226 Novel BET Protein Proteolysis-targeting Chimera Exerts Superior Lethal Activity Than Bromodomain Inhibitor (BETi) Against Post-myeloproliferative Neoplasm Secondary (s) AML Cells Leukemia. 09, 2017 | Pubmed ID: 28042144 Induced Protein Degradation: an Emerging Drug Discovery Paradigm Nature Reviews. Drug Discovery. 02, 2017 | Pubmed ID: 27885283 Targeted Protein Degradation by Small Molecules Annual Review of Pharmacology and Toxicology. 01, 2017 | Pubmed ID: 27732798 Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane As an Acetylene Equivalent European Journal of Organic Chemistry. Aug, 2016 | Pubmed ID: 28781577 PROTAC-induced BET Protein Degradation As a Therapy for Castration-resistant Prostate Cancer Proceedings of the National Academy of Sciences of the United States of America. 06, 2016 | Pubmed ID: 27274052 Inducing Protein Degradation As a Therapeutic Strategy Journal of Medicinal Chemistry. 06, 2016 | Pubmed ID: 27199030 Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells ACS Chemical Biology. 06, 2016 | Pubmed ID: 27121275 Small-Molecule PROTACS: New Approaches to Protein Degradation Angewandte Chemie (International Ed. in English). Feb, 2016 | Pubmed ID: 26756721 Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL Angewandte Chemie (International Ed. in English). Jan, 2016 | Pubmed ID: 26593377 Development of Small Molecules Targeting the Pseudokinase Her3 Bioorganic & Medicinal Chemistry Letters. Aug, 2015 | Pubmed ID: 26094118 Small-Molecule-Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging Angewandte Chemie (International Ed. in English). Aug, 2015 | Pubmed ID: 26083457 Catalytic in Vivo Protein Knockdown by Small-molecule PROTACs Nature Chemical Biology. Aug, 2015 | Pubmed ID: 26075522 HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins ACS Chemical Biology. Aug, 2015 | Pubmed ID: 26070106 Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4 Chemistry & Biology. Jun, 2015 | Pubmed ID: 26051217 Generating and Identifying Axolotls with Targeted Mutations Using Cas9 RNA-guided Nuclease Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25740494 Pharmacological Targeting of the Pseudokinase Her3 Nature Chemical Biology. Dec, 2014 | Pubmed ID: 25326665 Targeted Protein Destabilization Reveals an Estrogen-mediated ER Stress Response Nature Chemical Biology. Nov, 2014 | Pubmed ID: 25242550 Highly Efficient Targeted Mutagenesis in Axolotl Using Cas9 RNA-guided Nuclease Development (Cambridge, England). May, 2014 | Pubmed ID: 24764077 Small-molecule Control of Intracellular Protein Levels Through Modulation of the Ubiquitin Proteasome System Angewandte Chemie (International Ed. in English). Feb, 2014 | Pubmed ID: 24459094 A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins ACS Chemical Biology. Oct, 2013 | Pubmed ID: 23978068 Posttranslational Protein Knockdown Coupled to Receptor Tyrosine Kinase Activation with PhosphoPROTACs Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23674677 From Epoxomicin to Carfilzomib: Chemistry, Biology, and Medical Outcomes Natural Product Reports. May, 2013 | Pubmed ID: 23575525 Dissecting Fragment-based Lead Discovery at the Von Hippel-Lindau Protein:hypoxia Inducible Factor 1α Protein-protein Interface Chemistry & Biology. Oct, 2012 | Pubmed ID: 23102223 Small-molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α Angewandte Chemie (International Ed. in English). Nov, 2012 | Pubmed ID: 23065727 Microarray Analysis of MicroRNA Expression During Axolotl Limb Regeneration PloS One. 2012 | Pubmed ID: 23028429 A HaloTag-based Small Molecule Microarray Screening Methodology with Increased Sensitivity and Multiplex Capabilities ACS Chemical Biology. Dec, 2012 | Pubmed ID: 23013033 Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the VHL/HIF-1α Interaction Journal of the American Chemical Society. Mar, 2012 | Pubmed ID: 22369643 Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins Chembiochem : a European Journal of Chemical Biology. Mar, 2012 | Pubmed ID: 22271667 Disruption of Wnt Planar Cell Polarity Signaling by Aberrant Accumulation of the MetAP-2 Substrate Rab37 Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035799 Small-molecule Hydrophobic Tagging-induced Degradation of HaloTag Fusion Proteins Nature Chemical Biology. Aug, 2011 | Pubmed ID: 21725302 A Genetic Interaction Network of Five Genes for Human Polycystic Kidney and Liver Diseases Defines Polycystin-1 As the Central Determinant of Cyst Formation Nature Genetics. Jun, 2011 | Pubmed ID: 21685914 Triptolide Directly Inhibits DCTP Pyrophosphatase Chembiochem : a European Journal of Chemical Biology. Jul, 2011 | Pubmed ID: 21671327 Gene Expression Profile of the Regeneration Epithelium During Axolotl Limb Regeneration Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21648017 Natural Product Inhibitors of the Ubiquitin-proteasome Pathway Current Drug Targets. Oct, 2011 | Pubmed ID: 21561423 Unexpected Stereochemical Tolerance for the Biological Activity of Tyroscherin Bioorganic & Medicinal Chemistry. Mar, 2011 | Pubmed ID: 21315614 HIV Protease-mediated Activation of Sterically Capped Proteasome Inhibitors and Substrates Journal of the American Chemical Society. Feb, 2011 | Pubmed ID: 21186803 Total Synthesis and Biological Evaluation of Tyroscherin Organic Letters. Oct, 2010 | Pubmed ID: 20831175 Targeting the Undruggable Proteome: the Small Molecules of My Dreams Chemistry & Biology. Jun, 2010 | Pubmed ID: 20609404 Reversal of TNP-470-induced Endothelial Cell Growth Arrest by Guanine and Guanine Nucleosides The Journal of Pharmacology and Experimental Therapeutics. Sep, 2010 | Pubmed ID: 20571059 Activation of the Planar Cell Polarity Formin DAAM1 Leads to Inhibition of Endothelial Cell Proliferation, Migration, and Angiogenesis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20351293 Chemical Inducers of Targeted Protein Degradation The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20147751 Triptolide Reduces Cyst Formation in a Neonatal to Adult Transition Pkd1 Model of ADPKD Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jul, 2010 | Pubmed ID: 20139063 Identification and Characterization of a Peptidic Ligand for Ras Chembiochem : a European Journal of Chemical Biology. Mar, 2010 | Pubmed ID: 20082398 Total Synthesis and Structure-activity Investigation of the Marine Natural Product Neopeltolide Journal of the American Chemical Society. Sep, 2009 | Pubmed ID: 19663512 Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One ACS Chemical Biology. Nov, 2008 | Pubmed ID: 19112665 A Role for Planar Cell Polarity Signaling in Angiogenesis Angiogenesis. 2008 | Pubmed ID: 18798004 Targeted Intracellular Protein Degradation Induced by a Small Molecule: En Route to Chemical Proteomics Bioorganic & Medicinal Chemistry Letters. Nov, 2008 | Pubmed ID: 18752944 Triptolide Reduces Cystogenesis in a Model of ADPKD Journal of the American Society of Nephrology : JASN. Sep, 2008 | Pubmed ID: 18650476 Triptolide-induced Transcriptional Arrest is Associated with Changes in Nuclear Substructure Cancer Research. Jul, 2008 | Pubmed ID: 18593926 Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis Chemistry & Biology. May, 2008 | Pubmed ID: 18482702 Chemical Genetics: Exploring the Role of the Proteasome in Cell Biology Using Natural Products and Other Small Molecule Proteasome Inhibitors Journal of Medicinal Chemistry. May, 2008 | Pubmed ID: 18393403 Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials Cell. Sep, 2007 | Pubmed ID: 17803898 Synthesis of the C3-C18 Fragment of Amphidinolides G and H Organic Letters. Aug, 2007 | Pubmed ID: 17616200 Triptolide is a Traditional Chinese Medicine-derived Inhibitor of Polycystic Kidney Disease Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360534 A Chemical and Genetic Approach to the Mode of Action of Fumagillin Chemistry & Biology. Sep, 2006 | Pubmed ID: 16984890 Myriaporone 3/4 Structure--activity Relationship Studies Define a Pharmacophore Targeting Eukaryotic Protein Synthesis Molecular BioSystems. Aug, 2006 | Pubmed ID: 16880957 Targeted Gene Disruption of Methionine Aminopeptidase 2 Results in an Embryonic Gastrulation Defect and Endothelial Cell Growth Arrest Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16790550 Neurotrophic Peptide Aldehydes: Solid Phase Synthesis of Fellutamide B and a Simplified Analog Bioorganic & Medicinal Chemistry Letters. Jul, 2006 | Pubmed ID: 16697191 Synthetic Studies on Amphidinolide B1 Organic Letters. Feb, 2006 | Pubmed ID: 16435851 Studies on Calcium Dependence Reveal Multiple Modes of Action for Triptolide Chemistry & Biology. Dec, 2005 | Pubmed ID: 16356843 Development and Characterization of Proteasome Inhibitors Methods in Enzymology. 2005 | Pubmed ID: 16338383 Stereoselective Assembly of a 1,3-diene Via Coupling Between an Allenic Acetate and a (B)-alkylborane: Synthetic Studies on Amphidinolide B1 Organic Letters. Aug, 2005 | Pubmed ID: 16092840 Developing Microcolin A Analogs As Biological Probes Bioorganic & Medicinal Chemistry Letters. Sep, 2005 | Pubmed ID: 15993592 Chemical Approaches to Controlling Intracellular Protein Degradation Chembiochem : a European Journal of Chemical Biology. Jan, 2005 | Pubmed ID: 15532104 Total Synthesis of TMC-95A and -B Via a New Reaction Leading to Z-enamides. Some Preliminary Findings As to SAR Journal of the American Chemical Society. May, 2004 | Pubmed ID: 15149232 Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation Journal of the American Chemical Society. Mar, 2004 | Pubmed ID: 15038727 A Single Amino Acid Residue Defines the Difference in Ovalicin Sensitivity Between Type I and II Methionine Aminopeptidases The Journal of Biological Chemistry. Mar, 2004 | Pubmed ID: 14676204 Small-molecule Inhibitors of the Cell Cycle: an Overview Progress in Cell Cycle Research. 2003 | Pubmed ID: 14593706 Feeding the Machine: Mechanisms of Proteasome-catalyzed Degradation of Ubiquitinated Proteins Current Opinion in Chemical Biology. Oct, 2003 | Pubmed ID: 14580555 Chemical Genetics: Adding to the Developmental Biology Toolbox Developmental Cell. Jul, 2003 | Pubmed ID: 12852848 Simplified Synthetic TMC-95A/B Analogues Retain the Potency of Proteasome Inhibitory Activity Chembiochem : a European Journal of Chemical Biology. Jun, 2003 | Pubmed ID: 12794861 Chemical Genetics: a Small Molecule Approach to Neurobiology Neuron. Nov, 2002 | Pubmed ID: 12441047 Inhibitors of NF-kappaB Signaling: Design and Synthesis of a Biotinylated Isopanepoxydone Affinity Reagent Bioorganic & Medicinal Chemistry Letters. Dec, 2002 | Pubmed ID: 12419384 Total Synthesis of Luminacin D Organic Letters. Sep, 2002 | Pubmed ID: 12201723 Characterization of a Novel Mammalian Phosphatase Having Sequence Similarity to Schizosaccharomyces Pombe PHO2 and Saccharomyces Cerevisiae PHO13 Biochemistry. Jun, 2002 | Pubmed ID: 12056916 Protacs: Chimeric Molecules That Target Proteins to the Skp1-Cullin-F Box Complex for Ubiquitination and Degradation Proceedings of the National Academy of Sciences of the United States of America. Jul, 2001 | Pubmed ID: 11438690 The Ubiquitin-proteasome Pathway and Proteasome Inhibitors Medicinal Research Reviews. Jul, 2001 | Pubmed ID: 11410931 Cells Adapted to the Proteasome Inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl Sulfone Require Enzymatically Active Proteasomes for Continued Survival Proceedings of the National Academy of Sciences of the United States of America. Jan, 2001 | Pubmed ID: 11149939 The Antiangiogenic Agent TNP-470 Requires P53 and P21CIP/WAF for Endothelial Cell Growth Arrest Proceedings of the National Academy of Sciences of the United States of America. Nov, 2000 | Pubmed ID: 11070090 The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up- or Down-regulate Antigen Presentation at Nontoxic Doses Journal of Immunology (Baltimore, Md. : 1950). Jun, 2000 | Pubmed ID: 10843664 Epoxomicin, a Potent and Selective Proteasome Inhibitor, Exhibits in Vivo Antiinflammatory Activity Proceedings of the National Academy of Sciences of the United States of America. Aug, 1999 | Pubmed ID: 10468620 The Anti-angiogenic Agent Fumagillin Covalently Binds and Inhibits the Methionine Aminopeptidase, MetAP-2 Proceedings of the National Academy of Sciences of the United States of America. Jun, 1997 | Pubmed ID: 9177176 جيل من الأناكسولوت الشيميري مع أطراف هابلويد متحولة من خلال التطعيم الجنيني Lucas D. Sanor1, G. Parker Flowers1, Craig M. Crews1 1Department of Molecular, Cellular, and Developmental Biology, Yale University JoVE 60156 Genetics
جيل من الأناكسولوت الشيميري مع أطراف هابلويد متحولة من خلال التطعيم الجنيني Lucas D. Sanor1, G. Parker Flowers1, Craig M. Crews1 1Department of Molecular, Cellular, and Developmental Biology, Yale University JoVE 60156 Genetics