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Articles by Danielle L. Michell in JoVE
Vasküler Endotel Yüksek Lumen Basıncı Görüntüleme Lökosit Adezyon
Danielle L. Michell, Karen L. Andrews, Kevin J. Woollard, Jaye P.F. Chin-Dusting
Vascular Pharmacology Laboratory, Baker IDI Heart and Diabetes Institute, Monash University
Bu hasat basınçlı kaplar endotele lökosit yapışma görselleştirmek için bir yöntemdir. Bu teknik, bu nedenle yüksek kan basıncı fizyopatolojik koşullardaki taklit-200 mmHg intralüminal basınca kadar farklı kayma akışı altında vasküler yapışma eğitimi sağlar.
Other articles by Danielle L. Michell on PubMed
Frontiers in Bioscience (Scholar Edition). 2011 | Pubmed ID: 21622244
Essential hypertension is the leading risk factor for mortality worldwide, accountable for 13% of deaths globally. Despite numerous therapies available uncontrolled hypertension is still very prevalent today and a large subset are shown to have treatment resistant hypertension. Several cardiovascular diseases including hypertension result in endothelial dysfunction and inflammation. Once thought of as a passive barrier between blood flow and tissue the endothelium is now considered a main hub for maintaining vascular tone, structure and haemostasis. Several pathways occur in the endothelium that can result in dysfunction and altered vascular stasis. Such pathways include the impairment of the vasodilator nitric oxide (NO), increases in pro-inflammatory pathways such as ROS (reactive oxygen species) production and also recent reports suggest that the enzyme arginase, associated with the L-arginine-urea cycle, may be an important factor that is increased in hypertension. These pathways may offer alternative mechanisms to treat the complications associated with hypertension rather than the conventional therapies that aim to lower blood pressure.