David A. Tuveson Cold Spring Harbor Laboratory Biography Publications Institution JoVE Articles David A. Tuveson has not added a biography. If you are David A. Tuveson and would like to personalize this page please email our Author Liaison for assistance. Publications Suppression of Tumor-associated Neutrophils by Lorlatinib Attenuates Pancreatic Cancer Growth and Improves Treatment with Immune Checkpoint Blockade Nature Communications. 06, 2021 | Pubmed ID: 34099731 Oncogenic KRAS Engages an RSK1/NF1 Pathway to Inhibit Wild-type RAS Signaling in Pancreatic Cancer Proceedings of the National Academy of Sciences of the United States of America. 05, 2021 | Pubmed ID: 34021083 Fighting the Sixth Decade of the Cancer War with Better Cancer Models Cancer Discovery. 04, 2021 | Pubmed ID: 33811115 Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 04, 2021 | Pubmed ID: 33495315 Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, STRA Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 01, 2021 | Pubmed ID: 33093149 Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer Gastroenterology. 01, 2021 | Pubmed ID: 33039466 Diversity and Biology of Cancer-Associated Fibroblasts Physiological Reviews. 01, 2021 | Pubmed ID: 32466724 Single-Pass Vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation Of Pancreatic Adenocarcinoma Organoids Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 04, 2021 | Pubmed ID: 32119924 Vestigial-like 1 is a Shared Targetable Cancer-placenta Antigen Expressed by Pancreatic and Basal-like Breast Cancers Nature Communications. 10, 2020 | Pubmed ID: 33087697 KrasP34R and KrasT58I Mutations Induce Distinct RASopathy Phenotypes in Mice JCI Insight. 11, 2020 | Pubmed ID: 32990679 Pancreatic Cancer SLUGged The Journal of Experimental Medicine. 09, 2020 | Pubmed ID: 32813872 Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes Cancer Discovery. 10, 2020 | Pubmed ID: 32703770 Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer Annals of Surgery. 09, 2020 | Pubmed ID: 32657929 Dissecting Cell-type-specific Metabolism in Pancreatic Ductal Adenocarcinoma ELife. 07, 2020 | Pubmed ID: 32648540 SOAT1 Promotes Mevalonate Pathway Dependency in Pancreatic Cancer The Journal of Experimental Medicine. 09, 2020 | Pubmed ID: 32633781 Famotidine Use and Quantitative Symptom Tracking for COVID-19 in Non-hospitalised Patients: a Case Series Gut. 09, 2020 | Pubmed ID: 32499303 SIRT1-NOX4 Signaling Axis Regulates Cancer Cachexia The Journal of Experimental Medicine. 07, 2020 | Pubmed ID: 32441762 The Era of COVID-19 and the Rise of Science Collectivism in Cancer Research Cancer Discovery. 07, 2020 | Pubmed ID: 32404307 Squamous Trans-differentiation of Pancreatic Cancer Cells Promotes Stromal Inflammation ELife. 04, 2020 | Pubmed ID: 32329713 Roadmap for the Emerging Field of Cancer Neuroscience Cell. 04, 2020 | Pubmed ID: 32302564 ILC2s Amplify PD-1 Blockade by Activating Tissue-specific Cancer Immunity Nature. 03, 2020 | Pubmed ID: 32076273 Author Correction: Transcription Phenotypes of Pancreatic Cancer Are Driven by Genomic Events During Tumor Evolution Nature Genetics. Apr, 2020 | Pubmed ID: 32051610 Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma Cancer Research. 04, 2020 | Pubmed ID: 32029550 Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer Cancer Cell. 02, 2020 | Pubmed ID: 31983610 A Framework for Advancing Our Understanding of Cancer-associated Fibroblasts Nature Reviews. Cancer. 03, 2020 | Pubmed ID: 31980749 Transcription Phenotypes of Pancreatic Cancer Are Driven by Genomic Events During Tumor Evolution Nature Genetics. 02, 2020 | Pubmed ID: 31932696 Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism Cell Reports. Oct, 2019 | Pubmed ID: 31665640 Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 12, 2019 | Pubmed ID: 31527169 Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 11, 2019 | Pubmed ID: 31492749 Proteomic Analyses of ECM During Pancreatic Ductal Adenocarcinoma Progression Reveal Different Contributions by Tumor and Stromal Cells Proceedings of the National Academy of Sciences of the United States of America. 09, 2019 | Pubmed ID: 31484774 Perspectives on the Role of Wnt Biology in Cancer Science Signaling. 07, 2019 | Pubmed ID: 31289213 Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer Cancer Discovery. 09, 2019 | Pubmed ID: 31263025 The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer in Mice Science (New York, N.Y.). 06, 2019 | Pubmed ID: 31221853 Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts Cancer Discovery. 08, 2019 | Pubmed ID: 31197017 Cancer Modeling Meets Human Organoid Technology Science (New York, N.Y.). Jun, 2019 | Pubmed ID: 31171691 Oral Mucosal Organoids As a Potential Platform for Personalized Cancer Therapy Cancer Discovery. 07, 2019 | Pubmed ID: 31053628 A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth Cancer Discovery. May, 2019 | Pubmed ID: 31043410 Organoid Models for Translational Pancreatic Cancer Research Current Opinion in Genetics & Development. 02, 2019 | Pubmed ID: 30844513 Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30378048 Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30378047 IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma Cancer Discovery. 02, 2019 | Pubmed ID: 30366930 Stromal Biology and Therapy in Pancreatic Cancer: Ready for Clinical Translation? Gut. 01, 2019 | Pubmed ID: 30177543 Deciphering Cancer Fibroblasts The Journal of Experimental Medicine. 12, 2018 | Pubmed ID: 30470718 TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma Cell Reports. 11, 2018 | Pubmed ID: 30428345 Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine Cancer Discovery. 09, 2018 | Pubmed ID: 29903880 Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer Cancer Discovery. 09, 2018 | Pubmed ID: 29853643 Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer Cancer Research. 08, 2018 | Pubmed ID: 29789416 Successful Creation of Pancreatic Cancer Organoids by Means of EUS-guided Fine-needle Biopsy Sampling for Personalized Cancer Treatment Gastrointestinal Endoscopy. Jun, 2018 | Pubmed ID: 29325707 Transcriptional Regulation by Nrf2 Antioxidants & Redox Signaling. 12, 2018 | Pubmed ID: 28899199 Soils and Seeds That Initiate Pancreatic Cancer Metastasis Cancer Discovery. 10, 2017 | Pubmed ID: 28974531 Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis Cell. Aug, 2017 | Pubmed ID: 28757253 Recurrent Noncoding Regulatory Mutations in Pancreatic Ductal Adenocarcinoma Nature Genetics. Jun, 2017 | Pubmed ID: 28481342 ROS in Cancer: The Burning Question Trends in Molecular Medicine. 05, 2017 | Pubmed ID: 28427863 Untangling the Genetics from the Epigenetics in Pancreatic Cancer Metastasis Nature Genetics. Feb, 2017 | Pubmed ID: 28232730 Distinct Populations of Inflammatory Fibroblasts and Myofibroblasts in Pancreatic Cancer The Journal of Experimental Medicine. 03, 2017 | Pubmed ID: 28232471 Rapid and Tunable Method to Temporally Control Gene Editing Based on Conditional Cas9 Stabilization Nature Communications. 02, 2017 | Pubmed ID: 28224990 Cancer: Double Trouble for Tumours Nature. 02, 2017 | Pubmed ID: 28099410 ROS in Translation: Chink in the Armor Cell Cycle (Georgetown, Tex.). 02, 2017 | Pubmed ID: 27636545 Challenges and Opportunities in Modeling Pancreatic Cancer Cold Spring Harbor Symposia on Quantitative Biology. 2016 | Pubmed ID: 28289164 Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors Cancer Research. 12, 2016 | Pubmed ID: 27742686 NRF2 Promotes Tumor Maintenance by Modulating MRNA Translation in Pancreatic Cancer Cell. Aug, 2016 | Pubmed ID: 27477511 Model Organoids Provide New Research Opportunities for Ductal Pancreatic Cancer Molecular & Cellular Oncology. Jan, 2016 | Pubmed ID: 27308531 Conjugation to the Sigma-2 Ligand SV119 Overcomes Uptake Blockade and Converts Dm-Erastin into a Potent Pancreatic Cancer Therapeutic Oncotarget. Jun, 2016 | Pubmed ID: 27244881 Pancreatic Cancer Nature Reviews. Disease Primers. 04, 2016 | Pubmed ID: 27158978 Modeling Pancreatic Cancer with Organoids Trends in Cancer. Apr, 2016 | Pubmed ID: 27135056 Macrophage-secreted Granulin Supports Pancreatic Cancer Metastasis by Inducing Liver Fibrosis Nature Cell Biology. 05, 2016 | Pubmed ID: 27088855 Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2016 | Pubmed ID: 26573598 MRI with Hyperpolarised [1-13C]pyruvate Detects Advanced Pancreatic Preneoplasia Prior to Invasive Disease in a Mouse Model Gut. Mar, 2016 | Pubmed ID: 26347531 BAG3 Promotes Pancreatic Ductal Adenocarcinoma Growth by Activating Stromal Macrophages Nature Communications. Nov, 2015 | Pubmed ID: 26522614 Pre-clinical Models of Pancreatic Ductal Adenocarcinoma The Journal of Pathology. Sep, 2015 | Pubmed ID: 26419819 Mouse Models of Pancreatic Ductal Adenocarcinoma Hematology/oncology Clinics of North America. Aug, 2015 | Pubmed ID: 26226900 The Utilization of Extracellular Proteins As Nutrients Is Suppressed by MTORC1 Cell. Jul, 2015 | Pubmed ID: 26144316 A Minimally Invasive, Lentiviral Based Method for the Rapid and Sustained Genetic Manipulation of Renal Tubules Scientific Reports. Jun, 2015 | Pubmed ID: 26046460 Stromal Biology and Therapy in Pancreatic Cancer: a Changing Paradigm Gut. Sep, 2015 | Pubmed ID: 25994217 ADAM8 As a Drug Target in Pancreatic Cancer Nature Communications. Jan, 2015 | Pubmed ID: 25629724 BRAF Inhibitor Resistance Mediated by the AKT Pathway in an Oncogenic BRAF Mouse Melanoma Model Proceedings of the National Academy of Sciences of the United States of America. Feb, 2015 | Pubmed ID: 25624498 Identification of Novel Vascular Projections with Cellular Trafficking Abilities on the Microvasculature of Pancreatic Ductal Adenocarcinoma The Journal of Pathology. Jun, 2015 | Pubmed ID: 25561062 Organoid Models of Human and Mouse Ductal Pancreatic Cancer Cell. Jan, 2015 | Pubmed ID: 25557080 P53 Mutations Change Phosphatidylinositol Acyl Chain Composition Cell Reports. Jan, 2015 | Pubmed ID: 25543136 Vitamin D Receptor-mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy Cell. Sep, 2014 | Pubmed ID: 25259922 The RAS and YAP1 Dance, Who is Leading? The EMBO Journal. Nov, 2014 | Pubmed ID: 25257311 Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment BioMed Research International. 2014 | Pubmed ID: 25147816 SPARC Independent Drug Delivery and Antitumour Effects of Nab-paclitaxel in Genetically Engineered Mice Gut. Jun, 2014 | Pubmed ID: 24067278 Emerging Concepts in Pancreatic Cancer Medicine: Targeting the Tumor Stroma OncoTargets and Therapy. Dec, 2013 | Pubmed ID: 24379681 SCRIB Expression is Deregulated in Human Prostate Cancer, and Its Deficiency in Mice Promotes Prostate Neoplasia The Journal of Clinical Investigation. Nov, 2011 | Pubmed ID: 21965329 Imaging intravitale longitudinale tramite finestre in silicone trasparente Laura Maiorino*1,2,3, Margaret Shevik*1,4,5, José M. Adrover1, Xiao Han1,6, Elias Georgas7,8, John Erby Wilkinson9, Harrison Seidner1, Leonie Foerschner1, David A. Tuveson1, Yi-Xian Qin8, Mikala Egeblad1 1Cold Spring Harbor Laboratory, 2Cold Spring Harbor Laboratory School of Biological Sciences, 3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 4Medical Scientist Training Program, School of Medicine, Stony Brook University, 5Graduate Program in Pharmacology, Stony Brook University, 6Graduate Program in Genetics, Stony Brook University, 7Graduate Program in Biomedical Engineering, Stony Brook University, 8Department of Biomedical Engineering, Stony Brook University, 9Department of Pathology, University of Michigan JoVE 62757 Cancer Research
Imaging intravitale longitudinale tramite finestre in silicone trasparente Laura Maiorino*1,2,3, Margaret Shevik*1,4,5, José M. Adrover1, Xiao Han1,6, Elias Georgas7,8, John Erby Wilkinson9, Harrison Seidner1, Leonie Foerschner1, David A. Tuveson1, Yi-Xian Qin8, Mikala Egeblad1 1Cold Spring Harbor Laboratory, 2Cold Spring Harbor Laboratory School of Biological Sciences, 3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 4Medical Scientist Training Program, School of Medicine, Stony Brook University, 5Graduate Program in Pharmacology, Stony Brook University, 6Graduate Program in Genetics, Stony Brook University, 7Graduate Program in Biomedical Engineering, Stony Brook University, 8Department of Biomedical Engineering, Stony Brook University, 9Department of Pathology, University of Michigan JoVE 62757 Cancer Research