Davide Trotti Jefferson Weinberg ALS Center Thomas Jefferson University Biography Publications Institution JoVE Articles Davide Trotti has not added a biography. If you are Davide Trotti and would like to personalize this page please email our Author Liaison for assistance. Publications Proteostatic Imbalance and Protein Spreading in Amyotrophic Lateral Sclerosis The EMBO Journal. May, 2021 | Pubmed ID: 33792056 Synaptic Dysfunction Induced by Glycine-alanine Dipeptides in C9orf72-ALS/FTD is Rescued by SV2 Replenishment EMBO Molecular Medicine. 05, 2020 | Pubmed ID: 32347002 Excess Glutamate Secreted from Astrocytes Drives Upregulation of P-glycoprotein in Endothelial Cells in Amyotrophic Lateral Sclerosis Experimental Neurology. 06, 2019 | Pubmed ID: 30974102 Repeat-associated Non-AUG Translation in C9orf72-ALS/FTD is Driven by Neuronal Excitation and Stress EMBO Molecular Medicine. 02, 2019 | Pubmed ID: 30617154 MiR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption Via a Non-Cell-Autonomous Mechanism in ALS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 06, 2018 | Pubmed ID: 29773756 Haploinsufficiency Leads to Neurodegeneration in C9ORF72 ALS/FTD Human Induced Motor Neurons Nature Medicine. 03, 2018 | Pubmed ID: 29400714 EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis Advances in Neurobiology. 2017 | Pubmed ID: 28828608 Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies The AAPS Journal. 11, 2017 | Pubmed ID: 28779378 Mutation of the Caspase-3 Cleavage Site in the Astroglial Glutamate Transporter EAAT2 Delays Disease Progression and Extends Lifespan in the SOD1-G93A Mouse Model of ALS Experimental Neurology. 06, 2017 | Pubmed ID: 28342750 Pathogenic Determinants and Mechanisms of ALS/FTD Linked to Hexanucleotide Repeat Expansions in the C9orf72 Gene Neuroscience Letters. 01, 2017 | Pubmed ID: 27619540 Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD Cell Reports. 10, 2016 | Pubmed ID: 27732842 Astrocytes Drive Upregulation of the Multidrug Resistance Transporter ABCB1 (P-Glycoprotein) in Endothelial Cells of the Blood-brain Barrier in Mutant Superoxide Dismutase 1-linked Amyotrophic Lateral Sclerosis Glia. 08, 2016 | Pubmed ID: 27158936 Regulation of ABC Efflux Transporters at Blood-brain Barrier in Health and Neurological Disorders Brain Research. Dec, 2015 | Pubmed ID: 26187753 ABC Transporter-driven Pharmacoresistance in Amyotrophic Lateral Sclerosis Brain Research. May, 2015 | Pubmed ID: 25175835 Inhibiting Drug Efflux Transporters Improves Efficacy of ALS Therapeutics Annals of Clinical and Translational Neurology. Dec, 2014 | Pubmed ID: 25574474 Role of Mitochondria in Mutant SOD1 Linked Amyotrophic Lateral Sclerosis Biochimica Et Biophysica Acta. Aug, 2014 | Pubmed ID: 24568860 Sumoylation of Critical Proteins in Amyotrophic Lateral Sclerosis: Emerging Pathways of Pathogenesis Neuromolecular Medicine. Dec, 2013 | Pubmed ID: 24062161 Small Peptides Against the Mutant SOD1/Bcl-2 Toxic Mitochondrial Complex Restore Mitochondrial Function and Cell Viability in Mutant SOD1-mediated ALS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2013 | Pubmed ID: 23843527 Selective Increase of Two ABC Drug Efflux Transporters at the Blood-spinal Cord Barrier Suggests Induced Pharmacoresistance in ALS Neurobiology of Disease. Aug, 2012 | Pubmed ID: 22521463 An Over-oxidized Form of Superoxide Dismutase Found in Sporadic Amyotrophic Lateral Sclerosis with Bulbar Onset Shares a Toxic Mechanism with Mutant SOD1 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012 | Pubmed ID: 22416121 Motor Neuron Impairment Mediated by a Sumoylated Fragment of the Glial Glutamate Transporter EAAT2 Glia. Nov, 2011 | Pubmed ID: 21769946 Voltage-dependent Inwardly Rectifying Potassium Conductance in the Outer Membrane of Neuronal Mitochondria The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20551319 ALS-linked Mutant SOD1 Damages Mitochondria by Promoting Conformational Changes in Bcl-2 Human Molecular Genetics. Aug, 2010 | Pubmed ID: 20460269 Glutamate Transporters and the Excitotoxic Path to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Antioxidants & Redox Signaling. Jul, 2009 | Pubmed ID: 19413484 Nordihydroguaiaretic Acid Increases Glutamate Uptake in Vitro and in Vivo: Therapeutic Implications for Amyotrophic Lateral Sclerosis Experimental Neurology. Sep, 2008 | Pubmed ID: 18625223 A Caspase-3-cleaved Fragment of the Glial Glutamate Transporter EAAT2 is Sumoylated and Targeted to Promyelocytic Leukemia Nuclear Bodies in Mutant SOD1-linked Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17823119 Astrocytes Expressing ALS-linked Mutant FUS Induce Motor Neuron Death Through Release of Tumor Necrosis Factor-alpha Glia. | Pubmed ID: 29380416 Antisense Proline-arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates That Initiate in Vitro and in Vivo Neuronal Death Neuron. | Pubmed ID: 25521377 מדידה פלואורסצנטית בזמן אמת של פונקציות סינפטיות במודלים של טרשת אמיוטרופית לרוחב Karthik Krishnamurthy*1, Davide Trotti1, Piera Pasinelli1, Brigid Jensen*1 1Jefferson Weinberg ALS Center, Thomas Jefferson University JoVE 62813 Neuroscience
מדידה פלואורסצנטית בזמן אמת של פונקציות סינפטיות במודלים של טרשת אמיוטרופית לרוחב Karthik Krishnamurthy*1, Davide Trotti1, Piera Pasinelli1, Brigid Jensen*1 1Jefferson Weinberg ALS Center, Thomas Jefferson University JoVE 62813 Neuroscience