Deepak Shukla Department of Ophthalmology and Visual Sciences University of Illinois at Chicago Biography Publications Institution JoVE Articles Deepak Shukla has not added a biography. If you are Deepak Shukla and would like to personalize this page please email our Author Liaison for assistance. Publications COVID-19 and Oral Diseases: Assessing Manifestations of a New Pathogen in Oral Infections International Reviews of Immunology. Sep, 2021 | Pubmed ID: 34525891 OPTN is a Host Intrinsic Restriction Factor Against Neuroinvasive HSV-1 Infection Nature Communications. Sep, 2021 | Pubmed ID: 34518549 Histatin-1 Attenuates LPS-Induced Inflammatory Signaling in RAW264.7 Macrophages International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34360629 Prophylactic Treatment with BX795 Blocks Activation of AKT and Its Downstream Targets to Protect Vaginal Keratinocytes and Vaginal Epithelium from HSV-2 Infection Antiviral Research. Oct, 2021 | Pubmed ID: 34303747 Histatin-1 is an Endogenous Ligand of the Sigma-2 Receptor The FEBS Journal. Jul, 2021 | Pubmed ID: 34233061 Heparan Sulfate Binding Cationic Peptides Restrict SARS-CoV-2 Entry Pathogens (Basel, Switzerland). Jun, 2021 | Pubmed ID: 34202835 Role of Tunneling Nanotubes in Viral Infection, Neurodegenerative Disease, and Cancer Frontiers in Immunology. Month, 2021 | Pubmed ID: 34194434 Emerging Roles of Heparan Sulfate Proteoglycans in Viral Pathogenesis Seminars in Thrombosis and Hemostasis. Apr, 2021 | Pubmed ID: 33851373 Entry Receptor Bias in Evolutionarily Distant HSV-1 Clinical Strains Drives Divergent Ocular and Nervous System Pathologies The Ocular Surface. Jul, 2021 | Pubmed ID: 33766740 Dissociation of DNA Damage Sensing by Endoglycosidase HPSE IScience. Mar, 2021 | Pubmed ID: 33748723 Disruption of Innate Defense Responses by Endoglycosidase HPSE Promotes Cell Survival JCI Insight. 04, 2021 | Pubmed ID: 33621216 Pathobiology and Treatment of Viral Keratitis Experimental Eye Research. 04, 2021 | Pubmed ID: 33556334 Dysregulation of Cell Signaling by SARS-CoV-2 Trends in Microbiology. 03, 2021 | Pubmed ID: 33451855 The 3--sulfation of Heparan Sulfate Modulates Protein Binding and Lyase Degradation Proceedings of the National Academy of Sciences of the United States of America. 01, 2021 | Pubmed ID: 33441484 Infection-Induced Porcine Ex Vivo Corneal Wound Model to Study the Efficacy of Herpes Simplex Virus-1 Entry and Replication Inhibitors Methods in Molecular Biology (Clifton, N.J.). Month, 2021 | Pubmed ID: 32808270 Herpes Simplex Virus Cell Entry Mechanisms: An Update Frontiers in Cellular and Infection Microbiology. Month, 2020 | Pubmed ID: 33537244 Standalone or Combinatorial Phenylbutyrate Therapy Shows Excellent Antiviral Activity and Mimics CREB3 Silencing Science Advances. Dec, 2020 | Pubmed ID: 33277262 Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity Against HSV-1 and HSV-2 and Synergy with Antiviral Drugs ACS Infectious Diseases. 11, 2020 | Pubmed ID: 33078609 and Activity, Tolerability, and Mechanism of Action of BX795 As an Antiviral Against Herpes Simplex Virus 2 Genital Infection Antimicrobial Agents and Chemotherapy. 08, 2020 | Pubmed ID: 32601167 Vaccines and Therapies in Development for SARS-CoV-2 Infections Journal of Clinical Medicine. Jun, 2020 | Pubmed ID: 32560227 Heparanase, Cell Signaling, and Viral Infections Cellular and Molecular Life Sciences : CMLS. Dec, 2020 | Pubmed ID: 32462405 BX795 Demonstrates Potent Antiviral Benefits Against Herpes Simplex Virus-1 Infection of Human Cell Lines Antiviral Research. 08, 2020 | Pubmed ID: 32380150 Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration Molecular Therapy. Methods & Clinical Development. Jun, 2020 | Pubmed ID: 32346548 Bacterial Pigment Prodigiosin Demonstrates a Unique Antiherpesvirus Activity That Is Mediated Through Inhibition of Prosurvival Signal Transducers Journal of Virology. 06, 2020 | Pubmed ID: 32295926 Heparanase, Heparan Sulfate and Viral Infection Advances in Experimental Medicine and Biology. Month, 2020 | Pubmed ID: 32274736 Heparanase-Regulated Syndecan-1 Shedding Facilitates Herpes Simplex Virus 1 Egress Journal of Virology. 02, 2020 | Pubmed ID: 31827001 Prior Inhibition of AKT Phosphorylation by BX795 Can Define a Safer Strategy to Prevent Herpes Simplex Virus-1 Infection of the Eye The Ocular Surface. 04, 2020 | Pubmed ID: 31770600 Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections Microorganisms. Oct, 2019 | Pubmed ID: 31658632 Drug-encapsulated Carbon (DECON): A Novel Platform for Enhanced Drug Delivery Science Advances. 08, 2019 | Pubmed ID: 31453334 CRISPR-Cas Based Targeting of Host and Viral Genes As an Antiviral Strategy Seminars in Cell & Developmental Biology. 12, 2019 | Pubmed ID: 30953741 Pathological Processes Activated by Herpes Simplex Virus-1 (HSV-1) Infection in the Cornea Cellular and Molecular Life Sciences : CMLS. Feb, 2019 | Pubmed ID: 30327839 Pathogenesis of Herpes Simplex Keratitis: The Host Cell Response and Ocular Surface Sequelae to Infection and Inflammation The Ocular Surface. 01, 2019 | Pubmed ID: 30317007 Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease? Frontiers in Immunology. Month, 2018 | Pubmed ID: 30319604 Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells Journal of Virology. 12, 2018 | Pubmed ID: 30232188 Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures Journal of Virology. 10, 2018 | Pubmed ID: 30045986 Prediction of Cellular Gene Targets of Herpesvirus Encoded MicroRNAs Data in Brief. Aug, 2018 | Pubmed ID: 29892642 Viral MiRNAs Alter Host Cell MiRNA Profiles and Modulate Innate Immune Responses Frontiers in Immunology. Month, 2018 | Pubmed ID: 29559974 Herpesvirus-encoded MicroRNAs Detected in Human Gingiva Alter Host Cell Transcriptome and Regulate Viral Infection Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. May, 2018 | Pubmed ID: 29550353 Targeting Herpes Simplex Virus-1 GD by a DNA Aptamer Can Be an Effective New Strategy to Curb Viral Infection Molecular Therapy. Nucleic Acids. Dec, 2017 | Pubmed ID: 29246315 Emerging Roles of Heparanase in Viral Pathogenesis Pathogens (Basel, Switzerland). Sep, 2017 | Pubmed ID: 28927006 Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1 Cell Reports. 07, 2017 | Pubmed ID: 28700944 Effects of Histatin-1 Peptide on Human Corneal Epithelial Cells PloS One. Month, 2017 | Pubmed ID: 28542418 Zinc Oxide Tetrapods Inhibit Herpes Simplex Virus Infection of Cultured Corneas Molecular Vision. Month, 2017 | Pubmed ID: 28275313 Cultured Corneas Show Dendritic Spread and Restrict Herpes Simplex Virus Infection That is Not Observed with Cultured Corneal Cells Scientific Reports. 02, 2017 | Pubmed ID: 28198435 Role of Metal and Metal Oxide Nanoparticles As Diagnostic and Therapeutic Tools for Highly Prevalent Viral Infections Nanomedicine : Nanotechnology, Biology, and Medicine. 01, 2017 | Pubmed ID: 27575283 Genital Herpes: Insights into Sexually Transmitted Infectious Disease Microbial Cell (Graz, Austria). Jun, 2016 | Pubmed ID: 28357380 Could Zinc Oxide Tetrapod Nanoparticles Be Used As an Effective Immunotherapy Against HSV-2? Nanomedicine (London, England). 09, 2016 | Pubmed ID: 27527812 Filopodia and Viruses: An Analysis of Membrane Processes in Entry Mechanisms Frontiers in Microbiology. Month, 2016 | Pubmed ID: 27014223 Extended Release of an Anti-Heparan Sulfate Peptide From a Contact Lens Suppresses Corneal Herpes Simplex Virus-1 Infection Investigative Ophthalmology & Visual Science. Jan, 2016 | Pubmed ID: 26780322 Cell Entry Mechanisms of HSV: What We Have Learned in Recent Years Future Virology. Oct, 2015 | Pubmed ID: 27066105 Heparanase is a Host Enzyme Required for Herpes Simplex Virus-1 Release from Cells Nature Communications. Apr, 2015 | Pubmed ID: 25912399 A Role for 3-O-sulfated Heparan Sulfate in Promoting Human Cytomegalovirus Infection in Human Iris Cells Journal of Virology. May, 2015 | Pubmed ID: 25717110 Diversity of Heparan Sulfate and HSV Entry: Basic Understanding and Treatment Strategies Molecules (Basel, Switzerland). Month, 2015 | Pubmed ID: 25665065 Corneal Lymphangiogenesis in Herpetic Stromal Keratitis Survey of Ophthalmology. Jan-Feb, 2015 | Pubmed ID: 25444520 Characterization of a Proteolytically Stable D-peptide That Suppresses Herpes Simplex Virus 1 Infection: Implications for the Development of Entry-based Antiviral Therapy Journal of Virology. Feb, 2015 | Pubmed ID: 25428865 Comprehensive Analysis of Herpes Simplex Virus 1 (HSV-1) Entry Mediated by Zebrafish 3-O-Sulfotransferase Isoforms: Implications for the Development of a Zebrafish Model of HSV-1 Infection Journal of Virology. Nov, 2014 | Pubmed ID: 25142596 Zebrafish 3-O-sulfotransferase-4 Generated Heparan Sulfate Mediates HSV-1 Entry and Spread PloS One. Month, 2014 | Pubmed ID: 24498308 Zebrafish: Modeling for Herpes Simplex Virus Infections Zebrafish. Feb, 2014 | Pubmed ID: 24266790 Inhibition of Myosin Light Chain Kinase Can Be Targeted for the Development of New Therapies Against Herpes Simplex Virus Type-1 Infection Antiviral Therapy. Month, 2014 | Pubmed ID: 23813409 An Investigative Peptide-acyclovir Combination to Control Herpes Simplex Virus Type 1 Ocular Infection Investigative Ophthalmology & Visual Science. Sep, 2013 | Pubmed ID: 23989188 Exploiting Herpes Simplex Virus Entry for Novel Therapeutics Viruses. Jun, 2013 | Pubmed ID: 23752649 Role of Filopodia in HSV-1 Entry into Zebrafish 3-O-Sulfotransferase-3-Expressing Cells The Open Virology Journal. Month, 2013 | Pubmed ID: 23667409 Recent Advances in Vaccine Development for Herpes Simplex Virus Types I and II Human Vaccines & Immunotherapeutics. Apr, 2013 | Pubmed ID: 23442925 Glycoprotein Targeted Therapeutics: a New Era of Anti-herpes Simplex Virus-1 Therapeutics Reviews in Medical Virology. May, 2013 | Pubmed ID: 23440920 Role of Heparan Sulfate in Ocular Diseases Experimental Eye Research. May, 2013 | Pubmed ID: 23410824 Members of 3-O-Sulfotransferases (3-OST) Family: A Valuable Tool from Zebrafish to Humans for Understanding Herpes Simplex Virus Entry The Open Virology Journal. Month, 2013 | Pubmed ID: 23358893 Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry Journal of Virology. Apr, 2013 | Pubmed ID: 23345512 Increased Axonal Expression of Nectin-1 in Multiple Sclerosis Plaques Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. Apr, 2013 | Pubmed ID: 22460696 Tin Oxide Nanowires Suppress Herpes Simplex Virus-1 Entry and Cell-to-cell Membrane Fusion PloS One. Month, 2012 | Pubmed ID: 23110193 Prophylactic, Therapeutic and Neutralizing Effects of Zinc Oxide Tetrapod Structures Against Herpes Simplex Virus Type-2 Infection Antiviral Research. Dec, 2012 | Pubmed ID: 23047013 Role of Heparan Sulfate in Sexually Transmitted Infections Glycobiology. Nov, 2012 | Pubmed ID: 22773448 Herpes Simplex Epithelial and Stromal Keratitis: an Epidemiologic Update Survey of Ophthalmology. Sep, 2012 | Pubmed ID: 22542912 A 3-O-sulfated Heparan Sulfate Binding Peptide Preferentially Targets Herpes Simplex Virus 2-infected Cells Journal of Virology. Jun, 2012 | Pubmed ID: 22491462 Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells Clinical & Developmental Immunology. Month, 2012 | Pubmed ID: 22481969 Stem Cell Marker CD271 is Expressed by Vasculogenic Mimicry-forming Uveal Melanoma Cells in Three-dimensional Cultures Molecular Vision. Month, 2012 | Pubmed ID: 22419851 Early Events in Herpes Simplex Virus Lifecycle with Implications for an Infection of Lifetime The Open Virology Journal. Month, 2012 | Pubmed ID: 22291864 Herpes Simplex Virus Infects Most Cell Types in Vitro: Clues to Its Success Virology Journal. Oct, 2011 | Pubmed ID: 22029482 An Important Role for Syndecan-1 in Herpes Simplex Virus Type-1 Induced Cell-to-cell Fusion and Virus Spread PloS One. Month, 2011 | Pubmed ID: 21957484 Virostatic Potential of Micro-nano Filopodia-like ZnO Structures Against Herpes Simplex Virus-1 Antiviral Research. Nov, 2011 | Pubmed ID: 21893101 Corneal Latency and Transmission of Herpes Simplex Virus-1 Future Virology. Jan, 2011 | Pubmed ID: 21436960 Chronic Progressive Deficits in Neuron Size, Density and Number in the Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus Brain Pathology (Zurich, Switzerland). Sep, 2011 | Pubmed ID: 21371157 Syndecan-1 and Syndecan-2 Play Key Roles in Herpes Simplex Virus Type-1 Infection The Journal of General Virology. Apr, 2011 | Pubmed ID: 21148276 HSV-1 Infection of Human Corneal Epithelial Cells: Receptor-mediated Entry and Trends of Re-infection Molecular Vision. Month, 2010 | Pubmed ID: 21139972 Phosphoinositide 3 Kinase Signalling May Affect Multiple Steps During Herpes Simplex Virus Type-1 Entry The Journal of General Virology. Dec, 2010 | Pubmed ID: 20810749 Mediators and Mechanisms of Herpes Simplex Virus Entry into Ocular Cells Current Eye Research. Jun, 2010 | Pubmed ID: 20465436 In Vitro Antiviral Activity of Neem (Azardirachta Indica L.) Bark Extract Against Herpes Simplex Virus Type-1 Infection Phytotherapy Research : PTR. Aug, 2010 | Pubmed ID: 20041417 Expanding the Role of 3-O Sulfated Heparan Sulfate in Herpes Simplex Virus Type-1 Entry Virology. Feb, 2010 | Pubmed ID: 20004926 A Role for Heparan Sulfate in Viral Surfing Biochemical and Biophysical Research Communications. Jan, 2010 | Pubmed ID: 19909728 Expression of Herpes Virus Entry Mediator (HVEM) in the Cornea and Trigeminal Ganglia of Normal and HSV-1 Infected Mice Current Eye Research. Oct, 2009 | Pubmed ID: 19895317 Viral Entry Mechanisms: Simplicity Drives Complexity The FEBS Journal. Dec, 2009 | Pubmed ID: 19878309 Viral Entry Mechanisms: Cellular and Viral Mediators of Herpes Simplex Virus Entry The FEBS Journal. Dec, 2009 | Pubmed ID: 19878306 An Unusual Dependence of Human Herpesvirus-8 Glycoproteins-induced Cell-to-cell Fusion on Heparan Sulfate Biochemical and Biophysical Research Communications. Dec, 2009 | Pubmed ID: 19747451 A Sugar Binding Protein Cyanovirin-N Blocks Herpes Simplex Virus Type-1 Entry and Cell Fusion Antiviral Research. Oct, 2009 | Pubmed ID: 19665490 Role of Nectin-1, HVEM, and PILR-alpha in HSV-2 Entry into Human Retinal Pigment Epithelial Cells Investigative Ophthalmology & Visual Science. Jun, 2009 | Pubmed ID: 19234349 The Importance of Heparan Sulfate in Herpesvirus Infection Virologica Sinica. Dec, 2008 | Pubmed ID: 19956628 Antiviral Activity of Phytochemicals: a Comprehensive Review Mini Reviews in Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18855727 Herpes Simplex Virus Type 1 Induces Filopodia in Differentiated P19 Neural Cells to Facilitate Viral Spread Neuroscience Letters. Aug, 2008 | Pubmed ID: 18554796 HVEM and Nectin-1 Are the Major Mediators of Herpes Simplex Virus 1 (HSV-1) Entry into Human Conjunctival Epithelium Investigative Ophthalmology & Visual Science. Sep, 2008 | Pubmed ID: 18502984 Using a 3-O-sulfated Heparin Octasaccharide to Inhibit the Entry of Herpes Simplex Virus Type 1 Biochemistry. May, 2008 | Pubmed ID: 18457417 Herpes Simplex Virus Type 1 Infection Induces Oxidative Stress and the Release of Bioactive Lipid Peroxidation By-products in Mouse P19N Neural Cell Cultures Journal of Neurovirology. Oct, 2007 | Pubmed ID: 17994426 Role of 3-O-sulfated Heparan Sulfate in Virus-induced Polykaryocyte Formation FEBS Letters. Sep, 2007 | Pubmed ID: 17765228 Herpes Simplex Virus Type 2 Entry into Cultured Human Corneal Fibroblasts is Mediated by Herpesvirus Entry Mediator The Journal of General Virology. Aug, 2007 | Pubmed ID: 17622611 Viral Inhibition Studies on Sulfated Lignin, a Chemically Modified Biopolymer and a Potential Mimic of Heparan Sulfate Biomacromolecules. May, 2007 | Pubmed ID: 17439173 Soluble 3-O-sulfated Heparan Sulfate Can Trigger Herpes Simplex Virus Type 1 Entry into Resistant Chinese Hamster Ovary (CHO-K1) Cells The Journal of General Virology. Apr, 2007 | Pubmed ID: 17374750 A Novel Role for Phagocytosis-like Uptake in Herpes Simplex Virus Entry The Journal of Cell Biology. Sep, 2006 | Pubmed ID: 17000878 Role for 3-O-sulfated Heparan Sulfate As the Receptor for Herpes Simplex Virus Type 1 Entry into Primary Human Corneal Fibroblasts Journal of Virology. Sep, 2006 | Pubmed ID: 16940509 Expression of Nectin-1 in Normal and Herpes Simplex Virus Type 1-infected Murine Brain Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication of the Society for Applied Immunohistochemistry. Sep, 2006 | Pubmed ID: 16932027 A Role for Heparan Sulfate 3-O-sulfotransferase Isoform 2 in Herpes Simplex Virus Type 1 Entry and Spread Virology. Mar, 2006 | Pubmed ID: 16336986 A Role for 3-O-sulfotransferase Isoform-4 in Assisting HSV-1 Entry and Spread Biochemical and Biophysical Research Communications. Dec, 2005 | Pubmed ID: 16259945 A Role for Herpesvirus Entry Mediator As the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells Journal of Virology. Oct, 2005 | Pubmed ID: 16189018 Spinoculation of Heparan Sulfate Deficient Cells Enhances HSV-1 Entry, but Does Not Abolish the Need for Essential Glycoproteins in Viral Fusion Journal of Virological Methods. Sep, 2005 | Pubmed ID: 15908019 Characterization of Heparan Sulphate 3-O-sulphotransferase Isoform 6 and Its Role in Assisting the Entry of Herpes Simplex Virus Type 1 The Biochemical Journal. Jan, 2005 | Pubmed ID: 15303968 Herpes Simplex Virus Entry Receptor Nectin-1 is Widely Expressed in the Murine Eye Current Eye Research. Oct-Nov, 2004 | Pubmed ID: 15590476 A Role for 3-O-sulfated Heparan Sulfate in Cell Fusion Induced by Herpes Simplex Virus Type 1 The Journal of General Virology. Apr, 2004 | Pubmed ID: 15039523 Cellular Expression of GH Confers Resistance to Herpes Simplex Virus Type-1 Entry Virology. Jul, 2003 | Pubmed ID: 12890617 Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals Tejabhiram Yadavalli1, Ipsita Volety1, Deepak Shukla1,2 1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 2Department of Microbiology and Immunology, University of Illinois at Chicago JoVE 62195 Immunology and Infection
Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals Tejabhiram Yadavalli1, Ipsita Volety1, Deepak Shukla1,2 1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, 2Department of Microbiology and Immunology, University of Illinois at Chicago JoVE 62195 Immunology and Infection
