Dihua Yu Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Biography Publications Institution JoVE Articles Dihua Yu has not added a biography. If you are Dihua Yu and would like to personalize this page please email our Author Liaison for assistance. Publications Brain Metastasis: Unique Challenges and Open Opportunities Biochimica Et Biophysica Acta. Jan, 2017 | Pubmed ID: 27939792 Advances in Decoding Breast Cancer Brain Metastasis Cancer Metastasis Reviews. Dec, 2016 | Pubmed ID: 27873078 Deubiquitination and Stabilization of PD-L1 by CSN5 Cancer Cell. Dec, 2016 | Pubmed ID: 27866850 Glycosylation and Stabilization of Programmed Death Ligand-1 Suppresses T-cell Activity Nature Communications. Aug, 2016 | Pubmed ID: 27572267 Downregulation of GLUT4 Contributes to Effective Intervention of Estrogen Receptor-negative/HER2-overexpressing Early Stage Breast Disease Progression by Lapatinib American Journal of Cancer Research. 2016 | Pubmed ID: 27293993 Upregulation of Lactate Dehydrogenase a by 14-3-3ζ Leads to Increased Glycolysis Critical for Breast Cancer Initiation and Progression Oncotarget. Jun, 2016 | Pubmed ID: 27150057 Selective Expression of Constitutively Active Pro-apoptotic Protein BikDD Gene in Primary Mammary Tumors Inhibits Tumor Growth and Reduces Tumor Initiating Cells American Journal of Cancer Research. 2015 | Pubmed ID: 26885451 Fluoxetine Induces Cytotoxic Endoplasmic Reticulum Stress and Autophagy in Triple Negative Breast Cancer World Journal of Clinical Oncology. Dec, 2015 | Pubmed ID: 26677444 Microenvironment-induced PTEN Loss by Exosomal MicroRNA Primes Brain Metastasis Outgrowth Nature. Nov, 2015 | Pubmed ID: 26479035 Src Inhibition Blocks C-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer Cancer Research. Sep, 2015 | Pubmed ID: 26383165 Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases Stem Cells (Dayton, Ohio). Oct, 2015 | Pubmed ID: 26260958 PI3K-independent MTOR Activation Promotes Lapatinib Resistance and IAP Expression That Can Be Effectively Reversed by MTOR and Hsp90 Inhibition Cancer Biology & Therapy. 2015 | Pubmed ID: 25692408 14-3-3ζ Turns TGF-β's Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from P53 to Gli2 Cancer Cell. Feb, 2015 | Pubmed ID: 25670079 Heregulin-HER3-HER2 Signaling Promotes Matrix Metalloproteinase-dependent Blood-brain-barrier Transendothelial Migration of Human Breast Cancer Cell Lines Oncotarget. Feb, 2015 | Pubmed ID: 25668816 HER Family Kinase Domain Mutations Promote Tumor Progression and Can Predict Response to Treatment in Human Breast Cancer Molecular Oncology. Mar, 2015 | Pubmed ID: 25435280 S6K1 Promotes Invasiveness of Breast Cancer Cells in a Model of Metastasis of Triple-negative Breast Cancer American Journal of Translational Research. 2014 | Pubmed ID: 25075253 MDM2-mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer Science Signaling. Jul, 2014 | Pubmed ID: 25074979 Cooperativity of Oncogenic K-ras and Downregulated P16/INK4A in Human Pancreatic Tumorigenesis PloS One. 2014 | Pubmed ID: 25029561 Definition of PKC-α, CDK6, and MET As Therapeutic Targets in Triple-negative Breast Cancer Cancer Research. Sep, 2014 | Pubmed ID: 24970481 Biomarker-guided Sequential Targeted Therapies to Overcome Therapy Resistance in Rapidly Evolving Highly Aggressive Mammary Tumors Cell Research. May, 2014 | Pubmed ID: 24675532 Enhanced PI3K P110α Signaling Confers Acquired Lapatinib Resistance That Can Be Effectively Reversed by a P110α-selective PI3K Inhibitor Molecular Cancer Therapeutics. Jan, 2014 | Pubmed ID: 24249715 14-3-3ζ Orchestrates Mammary Tumor Onset and Progression Via MiR-221-mediated Cell Proliferation Cancer Research. Jan, 2014 | Pubmed ID: 24197133 Inhibition of Type I Insulin-like Growth Factor Receptor Signaling Attenuates the Development of Breast Cancer Brain Metastasis PloS One. 2013 | Pubmed ID: 24039934 Needle-based Fluorescence Endomicroscopy Via Structured Illumination with a Plastic, Achromatic Objective Journal of Biomedical Optics. Sep, 2013 | Pubmed ID: 24002190 SRC Family Kinases As Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases Cancer Research. Sep, 2013 | Pubmed ID: 23913825 Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-resistant Breast Cancer Cancer Research. Sep, 2012 | Pubmed ID: 22773664 Growth Factor Signaling in Metastasis: Current Understanding and Future Opportunities Cancer Metastasis Reviews. Dec, 2012 | Pubmed ID: 22706845 The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis Cell. May, 2012 | Pubmed ID: 22632973 Evidence That GTP-binding Domain but Not Catalytic Domain of Transglutaminase 2 is Essential for Epithelial-to-mesenchymal Transition in Mammary Epithelial Cells Breast Cancer Research : BCR. Jan, 2012 | Pubmed ID: 22225906 Targeting Src Family Kinases in Anti-cancer Therapies: Turning Promise into Triumph Trends in Pharmacological Sciences. Dec, 2011 | Pubmed ID: 22153719 Nucleolin Protein Interacts with Microprocessor Complex to Affect Biogenesis of MicroRNAs 15a and 16 The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 22049078 BikDD Eliminates Breast Cancer Initiating Cells and Synergizes with Lapatinib for Breast Cancer Treatment Cancer Cell. Sep, 2011 | Pubmed ID: 21907925 Phase I/II Study of Trastuzumab in Combination with Everolimus (RAD001) in Patients with HER2-overexpressing Metastatic Breast Cancer Who Progressed on Trastuzumab-based Therapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2011 | Pubmed ID: 21730275 Microenvironment Determinants of Brain Metastasis Cell & Bioscience. 2011 | Pubmed ID: 21711688 Evidence That Aberrant Expression of Tissue Transglutaminase Promotes Stem Cell Characteristics in Mammary Epithelial Cells PloS One. 2011 | Pubmed ID: 21687668 Pilot and Feasibility Study: Prospective Proteomic Profiling of Mammary Epithelial Cells from High-risk Women Provides Evidence of Activation of Pro-survival Pathways Breast Cancer Research and Treatment. Jun, 2011 | Pubmed ID: 21647677 Cancer Cell Migration: Integrated Roles of Matrix Mechanics and Transforming Potential PloS One. 2011 | Pubmed ID: 21647371 Combating Trastuzumab Resistance by Targeting SRC, a Common Node Downstream of Multiple Resistance Pathways Nature Medicine. Apr, 2011 | Pubmed ID: 21399647 P53 Regulates Epithelial-mesenchymal Transition and Stem Cell Properties Through Modulating MiRNAs Nature Cell Biology. Mar, 2011 | Pubmed ID: 21336307 Protein Microarray Analysis of Mammary Epithelial Cells from Obese and Nonobese Women at High Risk for Breast Cancer: Feasibility Data Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Mar, 2011 | Pubmed ID: 21242333 Cytokine Receptor CXCR4 Mediates Estrogen-independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer Cancer Research. Jan, 2011 | Pubmed ID: 21123450 14-3-3ζ As a Prognostic Marker and Therapeutic Target for Cancer Expert Opinion on Therapeutic Targets. Dec, 2010 | Pubmed ID: 21058923 Activation of P21(CIP1/WAF1) in Mammary Epithelium Accelerates Mammary Tumorigenesis and Promotes Lung Metastasis Biochemical and Biophysical Research Communications. Dec, 2010 | Pubmed ID: 21040707 Tissue Transglutaminase Promotes Drug Resistance and Invasion by Inducing Mesenchymal Transition in Mammary Epithelial Cells PloS One. 2010 | Pubmed ID: 20967228 Cancer Cell Stiffness: Integrated Roles of Three-dimensional Matrix Stiffness and Transforming Potential Biophysical Journal. Oct, 2010 | Pubmed ID: 20923638 Activation of Murine Double Minute 2 by Akt in Mammary Epithelium Delays Mammary Involution and Accelerates Mammary Tumorigenesis Cancer Research. Oct, 2010 | Pubmed ID: 20841468 PTEN, PIK3CA, P-AKT, and P-p70S6K Status: Association with Trastuzumab Response and Survival in Patients with HER2-positive Metastatic Breast Cancer The American Journal of Pathology. Oct, 2010 | Pubmed ID: 20813970 PI(3)king Apart PTEN's Role in Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2010 | Pubmed ID: 20622047 Invasive Breast Cancer Development: "fatal Accident" from Malfunctions in Both "motor" and "brake" Cell Cycle (Georgetown, Tex.). Feb, 2010 | Pubmed ID: 20090417 Molecular Predictors of Response to Trastuzumab and Lapatinib in Breast Cancer Nature Reviews. Clinical Oncology. Feb, 2010 | Pubmed ID: 20027191 Upregulation of Neutrophil Gelatinase-associated Lipocalin by ErbB2 Through Nuclear Factor-kappaB Activation Cancer Research. Dec, 2009 | Pubmed ID: 19951994 14-3-3zeta Cooperates with ErbB2 to Promote Ductal Carcinoma in Situ Progression to Invasive Breast Cancer by Inducing Epithelial-mesenchymal Transition Cancer Cell. Sep, 2009 | Pubmed ID: 19732720 Breast Cancer Metastasis: Challenges and Opportunities Cancer Research. Jun, 2009 | Pubmed ID: 19470768 ErbB2-mediated Src and Signal Transducer and Activator of Transcription 3 Activation Leads to Transcriptional Up-regulation of P21Cip1 and Chemoresistance in Breast Cancer Cells Molecular Cancer Research : MCR. Apr, 2009 | Pubmed ID: 19372587 14-3-3zeta/tau Heterodimers Regulate Slingshot Activity in Migrating Keratinocytes Biochemical and Biophysical Research Communications. Jun, 2009 | Pubmed ID: 19371722 14-3-3zeta Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival Cancer Research. Apr, 2009 | Pubmed ID: 19318578 Oxygen Sensor Boosts Growth Factor Signaling Nature Medicine. Mar, 2009 | Pubmed ID: 19265822 Mitotic Deregulation by Survivin in ErbB2-overexpressing Breast Cancer Cells Contributes to Taxol Resistance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2009 | Pubmed ID: 19228734 Ph.D. Training in Cancer Biology Cancer Research. Nov, 2008 | Pubmed ID: 19010881 14-3-3 Zeta Down-regulates P53 in Mammary Epithelial Cells and Confers Luminal Filling Cancer Research. Mar, 2008 | Pubmed ID: 18339856 ERK Promotes Tumorigenesis by Inhibiting FOXO3a Via MDM2-mediated Degradation Nature Cell Biology. Feb, 2008 | Pubmed ID: 18204439 Loss of Trimethylation at Lysine 27 of Histone H3 is a Predictor of Poor Outcome in Breast, Ovarian, and Pancreatic Cancers Molecular Carcinogenesis. Sep, 2008 | Pubmed ID: 18176935 Novel Approaches for Chemosensitization of Breast Cancer Cells: the E1A Story Advances in Experimental Medicine and Biology. 2007 | Pubmed ID: 17993239 Molecular Mechanisms of ErbB2-mediated Breast Cancer Chemoresistance Advances in Experimental Medicine and Biology. 2007 | Pubmed ID: 17993237 Preclinical Testing of Clinically Applicable Strategies for Overcoming Trastuzumab Resistance Caused by PTEN Deficiency Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2007 | Pubmed ID: 17908983 Rad51 Overexpression Contributes to Chemoresistance in Human Soft Tissue Sarcoma Cells: a Role for P53/activator Protein 2 Transcriptional Regulation Molecular Cancer Therapeutics. May, 2007 | Pubmed ID: 17513613 High Prevalence of P53 Exon 4 Mutations in Soft Tissue Sarcoma Cancer. Jun, 2007 | Pubmed ID: 17429838 Tumor Progression and Metastasis from Genetic to Microenvironmental Determinants: a Workshop of the Tumor Progression and Metastasis NIH Study Section in Honor of Dr. Martin L. Padarathsingh, May 31, 2006, Georgetown, Washington, DC Cancer Biology & Therapy. Dec, 2006 | Pubmed ID: 17224636 Adenoviral-Vector Based SiRNA for Mutant K-ras As a Promising Tool for Lung Cancer Gene Therapy: A License to Kill Cancer Biology & Therapy. Dec, 2006 | Pubmed ID: 17224631 Wild-type P53 Inhibits Nuclear Factor-kappaB-induced Matrix Metalloproteinase-9 Promoter Activation: Implications for Soft Tissue Sarcoma Growth and Metastasis Molecular Cancer Research : MCR. Nov, 2006 | Pubmed ID: 17077165 Cytoplasmic Expression of P21CIP1/WAF1 is Correlated with IKKbeta Overexpression in Human Breast Cancers International Journal of Oncology. Nov, 2006 | Pubmed ID: 17016640 Vascular Endothelial Growth Factor Overexpression by Soft Tissue Sarcoma Cells: Implications for Tumor Growth, Metastasis, and Chemoresistance Cancer Research. Sep, 2006 | Pubmed ID: 16951193 Mechanisms of Disease: Understanding Resistance to HER2-targeted Therapy in Human Breast Cancer Nature Clinical Practice. Oncology. May, 2006 | Pubmed ID: 16683005 Selective Inhibition of ErbB2-overexpressing Breast Cancer in Vivo by a Novel TAT-based ErbB2-targeting Signal Transducers and Activators of Transcription 3-blocking Peptide Cancer Research. Apr, 2006 | Pubmed ID: 16585203 Synthetic Triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic Acid Induces Growth Arrest in HER2-overexpressing Breast Cancer Cells Molecular Cancer Therapeutics. Feb, 2006 | Pubmed ID: 16505105 ErbB2 Increases Vascular Endothelial Growth Factor Protein Synthesis Via Activation of Mammalian Target of Rapamycin/p70S6K Leading to Increased Angiogenesis and Spontaneous Metastasis of Human Breast Cancer Cells Cancer Research. Feb, 2006 | Pubmed ID: 16489002 Prostate Tumor Cells Infected with a Recombinant Influenza Virus Expressing a Truncated NS1 Protein Activate Cytolytic CD8+ Cells to Recognize Noninfected Tumor Cells Journal of Virology. Jan, 2006 | Pubmed ID: 16352563 Mechanisms of Trastuzumab Resistance and Their Clinical Implications Annals of the New York Academy of Sciences. Nov, 2005 | Pubmed ID: 16382045 A Knotty Turnabout?: Akt1 As a Metastasis Suppressor Cancer Cell. Dec, 2005 | Pubmed ID: 16338656 ErbB2 Promotes Src Synthesis and Stability: Novel Mechanisms of Src Activation That Confer Breast Cancer Metastasis Cancer Research. Mar, 2005 | Pubmed ID: 15753384 A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2005 | Pubmed ID: 15671549 Expression of Receptor Tyrosine Kinases Epidermal Growth Factor Receptor and HER-2/neu in Synovial Sarcoma Cancer. Feb, 2005 | Pubmed ID: 15641030 Transcriptional Repression of Protein Kinase Calpha Via Sp1 by Wild Type P53 is Involved in Inhibition of Multidrug Resistance 1 P-glycoprotein Phosphorylation The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15563462 Upregulation of CXCR4 is Essential for HER2-mediated Tumor Metastasis Cancer Cell. Nov, 2004 | Pubmed ID: 15542430 Activation of the Akt/mammalian Target of Rapamycin/4E-BP1 Pathway by ErbB2 Overexpression Predicts Tumor Progression in Breast Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2004 | Pubmed ID: 15501954 PTEN Activation Contributes to Tumor Inhibition by Trastuzumab, and Loss of PTEN Predicts Trastuzumab Resistance in Patients Cancer Cell. Aug, 2004 | Pubmed ID: 15324695 PI3K: Missense Mutation Motivates Malignancy Cancer Biology & Therapy. Aug, 2004 | Pubmed ID: 15280668 Lineage Infidelity of MDA-MB-435 Cells: Expression of Melanocyte Proteins in a Breast Cancer Cell Line Cancer Research. May, 2004 | Pubmed ID: 15150101 Liposomal Mediated Transfer of ErbB2 Antisense DNA: Coming of Age in the War Against Cancer Cancer Biology & Therapy. Feb, 2004 | Pubmed ID: 14764991 Silibinin: a Thorny Therapeutic for EGF-R Expressing Tumors? Cancer Biology & Therapy. Sep-Oct, 2003 | Pubmed ID: 14614321 Combined Trastuzumab and Paclitaxel Treatment Better Inhibits ErbB-2-mediated Angiogenesis in Breast Carcinoma Through a More Effective Inhibition of Akt Than Either Treatment Alone Cancer. Oct, 2003 | Pubmed ID: 14508823 ErbB2 Overexpression in Human Breast Carcinoma is Correlated with P21Cip1 Up-regulation and Tyrosine-15 Hyperphosphorylation of P34Cdc2: Poor Responsiveness to Chemotherapy with Cyclophoshamide Methotrexate, and 5-fluorouracil is Associated with Erb2 Overexpression and with P21Cip1 Overexpression Cancer. Sep, 2003 | Pubmed ID: 12973835 Enhanced Sensitization to Taxol-induced Apoptosis by Herceptin Pretreatment in ErbB2-overexpressing Breast Cancer Cells Cancer Research. Oct, 2002 | Pubmed ID: 12384528 Characterization of 11 Human Sarcoma Cell Strains: Evaluation of Cytogenetics, Tumorigenicity, Metastasis, and Production of Angiogenic Factors Cancer. Oct, 2002 | Pubmed ID: 12237927 ErbB2 Overexpression Correlates with Increased Expression of Vascular Endothelial Growth Factors A, C, and D in Human Breast Carcinoma Cancer. Jun, 2002 | Pubmed ID: 12115372 Phosphorylation on Tyrosine-15 of P34(Cdc2) by ErbB2 Inhibits P34(Cdc2) Activation and is Involved in Resistance to Taxol-induced Apoptosis Molecular Cell. May, 2002 | Pubmed ID: 12049736 Combined Anti-fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis Cancer Research. Apr, 2002 | Pubmed ID: 11929822 Early Placenta Insulin-like Growth Factor (pro-EPIL) is Overexpressed and Secreted by C-erbB-2-positive Cells with High Invasion Potential Cancer Research. Feb, 2002 | Pubmed ID: 11861376 Intracarotid حقن الخلية السرطانية لإنتاج نماذج الماوس من الدماغ الانبثاث Chenyu Zhang1, Frank J. Lowery1, Dihua Yu1 1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center JoVE 55085 Cancer Research ذات دقة عالية الألياف الضوئية للMicroendoscopy في الموقع الخلوية التصوير Mark Pierce1, Dihua Yu2, Rebecca Richards-Kortum1 1Department of Bioengineering, Rice University, 2Department of Molecular and Cellular Oncology, The Univeristy of Texas M. D. Anderson Cancer Center JoVE 2306 Bioengineering
Intracarotid حقن الخلية السرطانية لإنتاج نماذج الماوس من الدماغ الانبثاث Chenyu Zhang1, Frank J. Lowery1, Dihua Yu1 1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center JoVE 55085 Cancer Research
ذات دقة عالية الألياف الضوئية للMicroendoscopy في الموقع الخلوية التصوير Mark Pierce1, Dihua Yu2, Rebecca Richards-Kortum1 1Department of Bioengineering, Rice University, 2Department of Molecular and Cellular Oncology, The Univeristy of Texas M. D. Anderson Cancer Center JoVE 2306 Bioengineering