Articles by Elizabeth D. Kirby in JoVE

Stereotaxic Surgery for Excitotoxic Lesion of Specific Brain Areas in the Adult Rat

JoVE 4079 7/19/2012

Elizabeth D. Kirby¹, Kelly Jensen², Ki A. Goosens³, Daniela Kaufer^1,4

¹Helen Wills Neuroscience Institute, University of California Berkeley, ²Office of Laboratory Animal Care, University of California Berkeley, ³McGovern Institute for Brain Research & The Department of Brain and Cognitive Science, Massachusetts Institute of Technology, ⁴Integrative Biology Department, University of California Berkeley

Targeted ablation of specific brain region(s) by infusion of an excitotoxin using stereotaxic coordinates is described. This technique could also be adapted for infusion of other chemicals into the rat brain.