Elizabeth M. Jaffee The Sidney Kimmel Comprehensive Cancer Center The Johns Hopkins University School of Medicine Biography Publications Institution JoVE Articles Elizabeth M. Jaffee has not added a biography. If you are Elizabeth M. Jaffee and would like to personalize this page please email our Author Liaison for assistance. Publications Vaccines for Pancreatic Cancer Cancer Journal (Sudbury, Mass.). Nov, 2012 | Pubmed ID: 23187853 Targeting the Right Regulatory T-cell Population for Tumor Immunotherapy Oncoimmunology. Oct, 2012 | Pubmed ID: 23170276 Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-resistant Breast Cancer Cancer Research. Sep, 2012 | Pubmed ID: 22773664 Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: a Current Perspective Cancer Research. Jul, 2012 | Pubmed ID: 22761338 Annexin A2 is a New Antigenic Target for Pancreatic Cancer Immunotherapy Oncoimmunology. Jan, 2012 | Pubmed ID: 22720228 Whole Cell Vaccines--past Progress and Future Strategies Seminars in Oncology. Jun, 2012 | Pubmed ID: 22595050 Development of a Novel Preclinical Pancreatic Cancer Research Model: Bioluminescence Image-guided Focal Irradiation and Tumor Monitoring of Orthotopic Xenografts Translational Oncology. Apr, 2012 | Pubmed ID: 22496923 The Determinants of Tumour Immunogenicity Nature Reviews. Cancer. Apr, 2012 | Pubmed ID: 22378190 Trafficking of High Avidity HER-2/neu-specific T Cells into HER-2/neu-expressing Tumors After Depletion of Effector/memory-like Regulatory T Cells PloS One. 2012 | Pubmed ID: 22359647 A Live-attenuated Listeria Vaccine (ANZ-100) and a Live-attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012 | Pubmed ID: 22147941 Defining the Critical Hurdles in Cancer Immunotherapy Journal of Translational Medicine. 2011 | Pubmed ID: 22168571 Increased Expression of DNA Repair Genes in Invasive Human Pancreatic Cancer Cells Pancreas. Jul, 2011 | Pubmed ID: 21633318 Tyrosine 23 Phosphorylation-dependent Cell-surface Localization of Annexin A2 is Required for Invasion and Metastases of Pancreatic Cancer PloS One. 2011 | Pubmed ID: 21572519 Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer Journal of Translational Medicine. 2011 | Pubmed ID: 21569425 Nondominant CD8 T Cells Are Active Players in the Vaccine-induced Antitumor Immune Response Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21346233 CD8⺠Foxp3⺠Tumor Infiltrating Lymphocytes Accumulate in the Context of an Effective Anti-tumor Response International Journal of Cancer. Journal International Du Cancer. Aug, 2011 | Pubmed ID: 20857491 Tumor Antigen-targeted, Monoclonal Antibody-based Immunotherapy: Clinical Response, Cellular Immunity, and Immunoescape Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2010 | Pubmed ID: 20697078 Cellular Vaccine Approaches Cancer Journal (Sudbury, Mass.). Jul-Aug, 2010 | Pubmed ID: 20693840 Paclitaxel Enhances Early Dendritic Cell Maturation and Function Through TLR4 Signaling in Mice Cellular Immunology. 2010 | Pubmed ID: 20346445 Timed Sequential Treatment with Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-macrophage Colony-stimulating Factor-secreting Breast Tumor Vaccine: a Chemotherapy Dose-ranging Factorial Study of Safety and Immune Activation Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2009 | Pubmed ID: 19805669 SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009 | Pubmed ID: 19584151 OX40 Costimulation Can Abrogate Foxp3+ Regulatory T Cell-mediated Suppression of Antitumor Immunity International Journal of Cancer. Journal International Du Cancer. Aug, 2009 | Pubmed ID: 19455675 Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer Cancer Research. Apr, 2009 | Pubmed ID: 19351817 Exomic Sequencing Identifies PALB2 As a Pancreatic Cancer Susceptibility Gene Science (New York, N.Y.). Apr, 2009 | Pubmed ID: 19264984 Use of Tumour-responsive T Cells As Cancer Treatment Lancet. Feb, 2009 | Pubmed ID: 19231634 Effective Depletion of Regulatory T Cells Allows the Recruitment of Mesothelin-specific CD8 T Cells to the Antitumor Immune Response Against a Mesothelin-expressing Mouse Pancreatic Adenocarcinoma Clinical and Translational Science. Dec, 2008 | Pubmed ID: 20357913 Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses Science (New York, N.Y.). Sep, 2008 | Pubmed ID: 18772397 Antibody Association with HER-2/neu-targeted Vaccine Enhances CD8 T Cell Responses in Mice Through Fc-mediated Activation of DCs The Journal of Clinical Investigation. May, 2008 | Pubmed ID: 18398507 Vaccine Impedes the Development of Reflux-induced Esophageal Cancer in a Surgical Rat Model: Efficacy of the Vaccine in a Post-Barrett's Esophagus Setting Digestive Diseases and Sciences. Nov, 2008 | Pubmed ID: 18343998 Vaccine Impedes the Development of Reflux-induced Esophageal Cancer in a Surgical Rat Model: Efficacy of the Vaccine in a Pre-Barrett's Esophagus Setting Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract. Jan, 2008 | Pubmed ID: 17957441 Preclinical Evaluation of MORAb-009, a Chimeric Antibody Targeting Tumor-associated Mesothelin Cancer Immunity. 2007 | Pubmed ID: 18088084 Alteration of Cellular and Humoral Immunity by Mutant P53 Protein and Processed Mutant Peptide in Head and Neck Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056201 Alphaviral Vector-transduced Dendritic Cells Are Successful Therapeutic Vaccines Against Neu-overexpressing Tumors in Wild-type Mice Vaccine. Sep, 2007 | Pubmed ID: 17675184 A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity Through an Immune-based Mechanism Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2007 | Pubmed ID: 17606729 Cancer Immunologists and Cancer Biologists: Why We Didn't Talk then but Need to Now Cancer Research. Apr, 2007 | Pubmed ID: 17413003 OX40 Costimulation Synergizes with GM-CSF Whole-cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16393983 Genes to Vaccines for Immunotherapy: How the Molecular Biology Revolution Has Influenced Cancer Immunology Molecular Cancer Therapeutics. Nov, 2005 | Pubmed ID: 16275985 Cancer Vaccines in Combination with Multimodality Therapy Cancer Treatment and Research. 2005 | Pubmed ID: 16211873 Leveraging the Activity of Tumor Vaccines with Cytotoxic Chemotherapy Cancer Research. Sep, 2005 | Pubmed ID: 16166275 Fusion to Listeriolysin O and Delivery by Listeria Monocytogenes Enhances the Immunogenicity of HER-2/neu and Reveals Subdominant Epitopes in the FVB/N Mouse Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148111 Allergies and the Risk of Pancreatic Cancer: a Meta-analysis with Review of Epidemiology and Biological Mechanisms Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Aug, 2005 | Pubmed ID: 16103436 Immunotherapy for Pancreatic Cancer - Science Driving Clinical Progress Nature Reviews. Cancer. Jun, 2005 | Pubmed ID: 15905855 Recruitment of Latent Pools of High-avidity CD8(+) T Cells to the Antitumor Immune Response The Journal of Experimental Medicine. May, 2005 | Pubmed ID: 15883172 Diverse CD8+ T-cell Responses to Renal Cell Carcinoma Antigens in Patients Treated with an Autologous Granulocyte-macrophage Colony-stimulating Factor Gene-transduced Renal Tumor Cell Vaccine Cancer Research. Feb, 2005 | Pubmed ID: 15705910 Tumor-specific CD4+ T Cells from a Patient with Renal Cell Carcinoma Recognize Diverse Shared Antigens International Journal of Cancer. Journal International Du Cancer. Jul, 2005 | Pubmed ID: 15704175 Development of a Cytokine-modified Allogeneic Whole Cell Pancreatic Cancer Vaccine Methods in Molecular Medicine. 2005 | Pubmed ID: 15542914 Fatty Acid Synthase Inhibitors Are Chemopreventive for Mammary Cancer in Neu-N Transgenic Mice Oncogene. Jan, 2005 | Pubmed ID: 15489885 Augmenting the Potency of Breast Cancer Vaccines: Combined Modality Immunotherapy Breast Disease. 2004 | Pubmed ID: 15687703 Mesothelin-specific CD8(+) T Cell Responses Provide Evidence of in Vivo Cross-priming by Antigen-presenting Cells in Vaccinated Pancreatic Cancer Patients The Journal of Experimental Medicine. Aug, 2004 | Pubmed ID: 15289501 Toward a Breast Cancer Vaccine: Work in Progress Oncology (Williston Park, N.Y.). Sep, 2003 | Pubmed ID: 14569849 Cancer Vaccines: an Old Idea Comes of Age Cancer Biology & Therapy. Jul-Aug, 2003 | Pubmed ID: 14508095 HER-2/neu-specific Monoclonal Antibodies Collaborate with HER-2/neu-targeted Granulocyte Macrophage Colony-stimulating Factor Secreting Whole Cell Vaccination to Augment CD8+ T Cell Effector Function and Tumor-free Survival in Her-2/neu-transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). Aug, 2003 | Pubmed ID: 12902523 Lentivirus-mediated Gene Transfer and Expression in Established Human Tumor Antigen-specific Cytotoxic T Cells and Primary Unstimulated T Cells Human Gene Therapy. Jul, 2003 | Pubmed ID: 12885348 Major Histocompatibility Complex Class II-restricted Presentation of a Cytosolic Antigen by Autophagy European Journal of Immunology. May, 2003 | Pubmed ID: 12731050 Identification and Characterization of the Immunodominant Rat HER-2/neu MHC Class I Epitope Presented by Spontaneous Mammary Tumors from HER-2/neu-transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2003 | Pubmed ID: 12682262 Apoptotic, but Not Necrotic, Tumor Cell Vaccines Induce a Potent Immune Response in Vivo International Journal of Cancer. Journal International Du Cancer. Jan, 2003 | Pubmed ID: 12455034 Cytokine Modified Tumor Vaccines Surgical Oncology Clinics of North America. Jul, 2002 | Pubmed ID: 12487062 To Live or Not to Live: That Depends on GAGE? Cancer Biology & Therapy. Jul-Aug, 2002 | Pubmed ID: 12432252 Pancreatic Cancer Current Problems in Cancer. Jul-Aug, 2002 | Pubmed ID: 12399802 Focus on Pancreas Cancer Cancer Cell. Jul, 2002 | Pubmed ID: 12150822 Cytokine Gene-modified Cell-based Cancer Vaccines Methods in Molecular Medicine. 2002 | Pubmed ID: 11987781 Иммуногистохимического окрашивания B7-H1 (PD-L1) на Парафиновые Слайды из ткани поджелудочной железы аденокарцинома Elaine Bigelow1,2, Katherine M. Bever1,2, Haiying Xu1,2,3, Allison Yager1, Annie Wu1,2,4, Janis Taube3,5, Lieping Chen6, Elizabeth M. Jaffee1,2,5,7,8, Robert A. Anders1,2,5,8, Lei Zheng1,2,4,5,7 1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine JoVE 4059 Medicine
Иммуногистохимического окрашивания B7-H1 (PD-L1) на Парафиновые Слайды из ткани поджелудочной железы аденокарцинома Elaine Bigelow1,2, Katherine M. Bever1,2, Haiying Xu1,2,3, Allison Yager1, Annie Wu1,2,4, Janis Taube3,5, Lieping Chen6, Elizabeth M. Jaffee1,2,5,7,8, Robert A. Anders1,2,5,8, Lei Zheng1,2,4,5,7 1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine JoVE 4059 Medicine