Fabio Cominelli Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute Case Western Reserve University Biography Publications Institution JoVE Articles Fabio Cominelli has not added a biography. If you are Fabio Cominelli and would like to personalize this page please email our Author Liaison for assistance. Publications A Guiding Map for Inflammation Nature Immunology. Jul, 2017 | Pubmed ID: 28722720 Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model? Cellular and Molecular Gastroenterology and Hepatology. Jul, 2017 | Pubmed ID: 28560286 A Novel Model of Colitis-associated Cancer in SAMP1/YitFc Mice with Crohn's Disease-like Ileitis PloS One. 2017 | Pubmed ID: 28301579 Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis Inflammatory Bowel Diseases. Mar, 2017 | Pubmed ID: 28146004 Mesenchymal Stem/stromal Cell Therapy for Inflammatory Bowel Disease: an Updated Review with Maintenance of Remission Current Opinion in Gastroenterology. Jan, 2017 | Pubmed ID: 28134690 Our Vision for the Future of Inflammatory Bowel Diseases: Research, Innovations, and Controversies Inflammatory Bowel Diseases. Jan, 2017 | Pubmed ID: 28002124 Fucosylation Deficiency in Mice Leads to Colitis And Adenocarcinoma Gastroenterology. Jan, 2017 | Pubmed ID: 27639802 Cytokines and Intestinal Inflammation Current Opinion in Gastroenterology. Nov, 2016 | Pubmed ID: 27673380 Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis Cancer Research. Nov, 2016 | Pubmed ID: 27634763 Clinical Effects of Gamma-Radiation-Resistant Aspergillus Sydowii on Germ-Free Mice Immunologically Prone to Inflammatory Bowel Disease Journal of Pathogens. 2016 | Pubmed ID: 27630775 Mucosal Interactions Between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease Frontiers in Immunology. 2016 | Pubmed ID: 27531998 A Novel Role for TL1A/DR3 in Protection Against Intestinal Injury and Infection Journal of Immunology (Baltimore, Md. : 1950). Jul, 2016 | Pubmed ID: 27233964 Colitis-Associated and Sporadic Colon Cancers: Different Diseases, Different Mutations? Gastroenterology. Apr, 2016 | Pubmed ID: 26924087 IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis The American Journal of Pathology. Apr, 2016 | Pubmed ID: 26908008 Pathway-based Approaches to the Treatment of Inflammatory Bowel Disease Translational Research : the Journal of Laboratory and Clinical Medicine. Jan, 2016 | Pubmed ID: 26408803 Role of Type 2 Immunity in Intestinal Inflammation Current Opinion in Gastroenterology. Nov, 2015 | Pubmed ID: 26376478 Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis Inflammatory Bowel Diseases. Nov, 2015 | Pubmed ID: 26348447 Dysregulated Intrahepatic CD4(+) T-cell Activation Drives Liver Inflammation in Ileitis-prone SAMP1/YitFc Mice Cellular and Molecular Gastroenterology and Hepatology. Jul, 2015 | Pubmed ID: 26213712 Stereomicroscopic 3D-pattern Profiling of Murine and Human Intestinal Inflammation Reveals Unique Structural Phenotypes Nature Communications. Jul, 2015 | Pubmed ID: 26154811 TISSUE REGENERATION. Inhibition of the Prostaglandin-degrading Enzyme 15-PGDH Potentiates Tissue Regeneration Science (New York, N.Y.). Jun, 2015 | Pubmed ID: 26068857 SAMP1/YitFc Mice Develop Ileitis Via Loss of CCL21 and Defects in Dendritic Cell Migration Gastroenterology. Apr, 2015 | Pubmed ID: 25620669 Ulcerative Colitis: What is the Optimal Treatment Goal and How Do We Achieve It? Current Treatment Options in Gastroenterology. Mar, 2015 | Pubmed ID: 25619458 Safety Considerations when Using Anti-TNFα Therapy to Treat Crohn's Disease Expert Opinion on Drug Safety. Jan, 2015 | Pubmed ID: 25400161 In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25213858 Cytokines and Mucosal Immunity Current Opinion in Gastroenterology. Nov, 2014 | Pubmed ID: 25203451 The Dual Role of Nod-like Receptors in Mucosal Innate Immunity and Chronic Intestinal Inflammation Frontiers in Immunology. 2014 | Pubmed ID: 25071778 Occurrence of Spontaneous Periodontal Disease in the SAMP1/YitFc Murine Model of Crohn Disease Journal of Periodontology. Dec, 2014 | Pubmed ID: 25019175 Inflammatory Bowel Disease Immunology Letters. Oct, 2014 | Pubmed ID: 24938525 Functional Defects in NOD2 Signaling in Experimental and Human Crohn Disease Gut Microbes. May-Jun, 2014 | Pubmed ID: 24637801 The Tumor Necrosis Factor-like Cytokine 1A/death Receptor 3 Cytokine System in Intestinal Inflammation Current Opinion in Gastroenterology. Nov, 2013 | Pubmed ID: 24100723 Dysregulated NOD2 Predisposes SAMP1/YitFc Mice to Chronic Intestinal Inflammation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 24082103 Intestinal-Specific TNFα Overexpression Induces Crohn's-Like Ileitis in Mice PloS One. 2013 | Pubmed ID: 23977323 Inhibition of Leukocyte Trafficking in Inflammatory Bowel Disease The New England Journal of Medicine. Aug, 2013 | Pubmed ID: 23964940 RIP2 Activity in Inflammatory Disease and Implications for Novel Therapeutics Journal of Leukocyte Biology. Jun, 2013 | Pubmed ID: 23794710 Vercirnon for the Treatment of Crohn's Disease Expert Opinion on Investigational Drugs. Jul, 2013 | Pubmed ID: 23627683 Probiotic Bacteria Regulate Intestinal Epithelial Permeability in Experimental Ileitis by a TNF-dependent Mechanism PloS One. 2012 | Pubmed ID: 22848704 New Insights into the Dichotomous Role of Innate Cytokines in Gut Homeostasis and Inflammation Cytokine. Sep, 2012 | Pubmed ID: 22795953 Spontaneous, Immune-mediated Gastric Inflammation in SAMP1/YitFc Mice, a Model of Crohn's-like Gastritis Gastroenterology. Nov, 2011 | Pubmed ID: 21704001 Cepa De Ratón SAMP1/YitFc: Un Modelo Espontáneo De La Ileitis Como Enfermedad De Crohn Inflammatory Bowel Diseases. Dec, 2011 | Pubmed ID: 21557393 Deficiencia De Integrina Beta7 Suprime Células B Autoguiado Hacia El Blanco Y Atenúa La Ileitis Crónica En Ratones SAMP1/YitFc Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20926792 Probiotics Promote Gut Health Through Stimulation of Epithelial Innate Immunity Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20018654 Emerging Drugs for the Treatment of Ulcerative Colitis Expert Opinion on Emerging Drugs. Sep, 2009 | Pubmed ID: 19656075 AGA Institute Future Trends Committee Report: the Future of Gastroenterology Training Programs in the United States Gastroenterology. Nov, 2008 | Pubmed ID: 19009690 Commensal Bacteria and "oncologic Surveillance": Suggestions from an Experimental Model Journal of Clinical Gastroenterology. Sep, 2008 | Pubmed ID: 18685507 Early and Late Gut Immune Responses in IBD Journal of Pediatric Gastroenterology and Nutrition. Apr, 2008 | Pubmed ID: 18354325 A CD8+/CD103high T Cell Subset Regulates TNF-mediated Chronic Murine Ileitis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2008 | Pubmed ID: 18250468 MNK Kinases Regulate Multiple TLR Pathways and Innate Proinflammatory Cytokines in Macrophages American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2008 | Pubmed ID: 18032482 Una Experiencia Retrospectivo Multicéntrico De Infliximab En Pacientes Con Enfermedad De Crohn: Tasas De Reacción En El Tratamiento Y La Persistencia Gastroenterology & Hepatology. May, 2007 | Pubmed ID: 21960854 Innate and Adaptive Immune Responses Related to IBD Pathogenesis Current Gastroenterology Reports. Dec, 2007 | Pubmed ID: 18377804 Resistin-like Molecule Beta (RELMbeta/FIZZ2) is Highly Expressed in the Ileum of SAMP1/YitFc Mice and is Associated with Initiation of Ileitis Journal of Immunology (Baltimore, Md. : 1950). Nov, 2007 | Pubmed ID: 17982092 Immunopathogenesis of Inflammatory Bowel Disease: Current Concepts Current Opinion in Gastroenterology. Jul, 2007 | Pubmed ID: 17545770 Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force Gastroenterology. May, 2007 | Pubmed ID: 17498517 Cloning IL-1 and the Birth of a New Era in Cytokine Biology Journal of Immunology (Baltimore, Md. : 1950). May, 2007 | Pubmed ID: 17442919 The Attrition of Young Physician-scientists: Problems and Potential Solutions Gastroenterology. Feb, 2007 | Pubmed ID: 17258744 Commensal Bacteria Exacerbate Intestinal Inflammation but Are Not Essential for the Development of Murine Ileitis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2007 | Pubmed ID: 17237431 Cytokine Therapy for Crohn's Disease: Advances in Translational Research Annual Review of Medicine. 2007 | Pubmed ID: 17217333 Bloqueo De Anticuerpo De CCL25/CCR9 Mejora Temprano Pero No Tarde Ileitis Murina Crónica Gastroenterology. Nov, 2006 | Pubmed ID: 17101325 Absence of Bacterially Induced RELMbeta Reduces Injury in the Dextran Sodium Sulfate Model of Colitis The Journal of Clinical Investigation. Nov, 2006 | Pubmed ID: 17024245 Do Patient Preferences Influence Decisions on Treatment for Patients with Steroid-refractory Ulcerative Colitis? Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Sep, 2006 | Pubmed ID: 16829206 Novel Strategies to Attenuate Immune Activation in Crohn's Disease Current Opinion in Pharmacology. Aug, 2006 | Pubmed ID: 16753341 Role of TL1A and Its Receptor DR3 in Two Models of Chronic Murine Ileitis Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16698931 Papel Crítico De Endotelial Selectina P Glicoproteína Ligando 1 En Crónica Ileitis Murina The Journal of Experimental Medicine. Apr, 2006 | Pubmed ID: 16567389 El Defecto Primario En Ileitis Experimental Proviene De Una Fuente De Nonhematopoietic The Journal of Experimental Medicine. Mar, 2006 | Pubmed ID: 16505137 Dirigidas a La Molécula De Adhesión Celular Histórico Mucosa (MAdCAM) -1 a La Imagen De Forma No Invasiva De Crohn Experimental Gastroenterology. Jan, 2006 | Pubmed ID: 16401463 New Concepts in the Pathophysiology of Inflammatory Bowel Disease Annals of Internal Medicine. Dec, 2005 | Pubmed ID: 16365470 Activation of A2A Adenosine Receptor Attenuates Intestinal Inflammation in Animal Models of Inflammatory Bowel Disease Gastroenterology. Jul, 2005 | Pubmed ID: 16012931 Altered Epithelial Cell Lineage Allocation and Global Expansion of the Crypt Epithelial Stem Cell Population Are Associated with Ileitis in SAMP1/YitFc Mice The American Journal of Pathology. Apr, 2005 | Pubmed ID: 15793286 Proinflammatory Effects of TH2 Cytokines in a Murine Model of Chronic Small Intestinal Inflammation Gastroenterology. Mar, 2005 | Pubmed ID: 15765401 L-selectina, Alfa 4 Beta 1 Y Alfa 4 Beta 7 Integrinas Participaron En El Reclutamiento De Células T CD4 + a Inflamación Crónica Del Intestino Journal of Immunology (Baltimore, Md. : 1950). Feb, 2005 | Pubmed ID: 15699171 Acoplamiento a Peroxisome Proliferator-activado-gama Del Receptor En Ratones SAMP1/YitFc Y Enfermedad De Crohn Humana Gastroenterology. Feb, 2005 | Pubmed ID: 15685547 Cytokine-based Therapies for Crohn's Disease--new Paradigms The New England Journal of Medicine. Nov, 2004 | Pubmed ID: 15537904 Expanded B Cell Population Blocks Regulatory T Cells and Exacerbates Ileitis in a Murine Model of Crohn Disease The Journal of Clinical Investigation. Aug, 2004 | Pubmed ID: 15286805 Differential Contribution of IL-1Ra Isoforms to Allele-specific IL-1Ra MRNA Accumulation Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Apr, 2004 | Pubmed ID: 15144571 Optimal Dosing of 5-aminosalicylic Acid: 5 Decades of Choosing Between Politicians Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Jan, 2003 | Pubmed ID: 15017510 Effect of Digestive Health Care Services Integration on Resource Use and Outcomes in Patients with Digestive Disorders Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. Mar, 2003 | Pubmed ID: 15017507 The Th1 Immune Pathway As a Therapeutic Target in Crohn's Disease Current Opinion in Investigational Drugs (London, England : 2000). Nov, 2003 | Pubmed ID: 14758766 Future Therapies for Inflammatory Bowel Disease Current Gastroenterology Reports. Dec, 2003 | Pubmed ID: 14602063 Expresión, Localización Y Actividad Funcional De TL1A, Una Citocina Th1-polarización Novela En Enfermedad Inflamatoria Intestinal Journal of Immunology (Baltimore, Md. : 1950). Nov, 2003 | Pubmed ID: 14568967 Identification of a Quantitative Trait Locus for Ileitis in a Spontaneous Mouse Model of Crohn's Disease: SAMP1/YitFc Gastroenterology. Aug, 2003 | Pubmed ID: 12891551 TNF-alpha Neutralization Ameliorates the Severity of Murine Crohn's-like Ileitis by Abrogation of Intestinal Epithelial Cell Apoptosis Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12832622 Mouse Models for the Study of Crohn's Disease Trends in Molecular Medicine. May, 2003 | Pubmed ID: 12763527 Emergence of Perianal Fistulizing Disease in the SAMP1/YitFc Mouse, a Spontaneous Model of Chronic Ileitis Gastroenterology. Apr, 2003 | Pubmed ID: 12671894 Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor-induced Crohn's-like Inflammatory Bowel Disease The Journal of Experimental Medicine. Dec, 2002 | Pubmed ID: 12486099 Down-regulation of Intestinal Lymphocyte Activation and Th1 Cytokine Production by Antibiotic Therapy in a Murine Model of Crohn's Disease Journal of Immunology (Baltimore, Md. : 1950). Nov, 2002 | Pubmed ID: 12391251 Effect of Misoprostol on Ibuprofen-induced Renal Dysfunction in Patients with Decompensated Cirrhosis: Results of a Double-blind Placebo-controlled Parallel Group Study The American Journal of Gastroenterology. Aug, 2002 | Pubmed ID: 12190173 A Possible Role of IL-1ra 3'-untranslated Region in Modulation of Protein Production Cytokine. Jan, 2002 | Pubmed ID: 11886177 Intestinal Ischemia and Peripheral Gangrene in a Patient with Chronic Renal Failure Gastroenterology. Feb, 2002 | Pubmed ID: 11832463 Guiado por ecografía intracardiaca inyección de células madre mesenquimales humanas para aumentar autoguiado hacia el blanco en el intestino para su uso en modelos murinos de enfermedades de intestino inflamatorias experimentales Maneesh Dave1, Paola Menghini1, Keiki Sugi2,3, Rodrigo A. Somoza5, Zhenghong Lee4, Mukesh Jain2,3, Arnold Caplan5, Fabio Cominelli1 1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University, 2Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, 3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 4Department of Radiology, University Hospitals Case Medical Center, 5Department of Biology - Skeletal Research Center, Case Western Reserve University JoVE 55367 Medicine La colonoscopia flexible en ratones para evaluar la gravedad de la colitis y colorrectal tumores utilizando un sistema validado de puntuación endoscópica Tomohiro Kodani*1,3, Alex Rodriguez-Palacios*1,3, Daniele Corridoni1,3, Loris Lopetuso2,3, Luca Di Martino1,3, Brian Marks1,3, James Pizarro1,3, Theresa Pizarro2,3, Amitabh Chak1,3, Fabio Cominelli1,3 1Division of Gastroenterology, Case Western Reserve University School of Medicine, Cleveland, 2Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, 3Digestive Health Research Center, Case Western Reserve University School of Medicine, Cleveland JoVE 50843 Medicine
Guiado por ecografía intracardiaca inyección de células madre mesenquimales humanas para aumentar autoguiado hacia el blanco en el intestino para su uso en modelos murinos de enfermedades de intestino inflamatorias experimentales Maneesh Dave1, Paola Menghini1, Keiki Sugi2,3, Rodrigo A. Somoza5, Zhenghong Lee4, Mukesh Jain2,3, Arnold Caplan5, Fabio Cominelli1 1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University, 2Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, 3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 4Department of Radiology, University Hospitals Case Medical Center, 5Department of Biology - Skeletal Research Center, Case Western Reserve University JoVE 55367 Medicine
La colonoscopia flexible en ratones para evaluar la gravedad de la colitis y colorrectal tumores utilizando un sistema validado de puntuación endoscópica Tomohiro Kodani*1,3, Alex Rodriguez-Palacios*1,3, Daniele Corridoni1,3, Loris Lopetuso2,3, Luca Di Martino1,3, Brian Marks1,3, James Pizarro1,3, Theresa Pizarro2,3, Amitabh Chak1,3, Fabio Cominelli1,3 1Division of Gastroenterology, Case Western Reserve University School of Medicine, Cleveland, 2Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, 3Digestive Health Research Center, Case Western Reserve University School of Medicine, Cleveland JoVE 50843 Medicine
