Frank Reimann Metabolic Research Laboratories and MRC Metabolic Diseases Unit Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge Biography Publications Institution JoVE Articles Frank Reimann has not added a biography. If you are Frank Reimann and would like to personalize this page please email our Author Liaison for assistance. Publications Signalling in the Gut Endocrine Axis Physiology & Behavior. Feb, 2017 | Pubmed ID: 28257936 Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight Diabetes. Apr, 2017 | Pubmed ID: 28057699 Scaling It Down: New in Vitro Tools to Get the Balance Right The Biochemical Journal. Jan, 2017 | Pubmed ID: 28008090 Gut Hormone Regulation and Secretion Via FFA1 and FFA4 Handbook of Experimental Pharmacology. 2017 | Pubmed ID: 27873089 Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia Endocrinology. Oct, 2016 | Pubmed ID: 27547850 Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans Endocrinology. Oct, 2016 | Pubmed ID: 27447725 Transcriptomic Profiling of Pancreatic Alpha, Beta and Delta Cell Populations Identifies Delta Cells As a Principal Target for Ghrelin in Mouse Islets Diabetologia. Oct, 2016 | Pubmed ID: 27390011 Mechanisms Underlying Glucose-dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 Secretion Journal of Diabetes Investigation. Apr, 2016 | Pubmed ID: 27186350 Preproglucagon Neurons in the Hindbrain Have IL-6 Receptor-α and Show Ca2+ Influx in Response to IL-6 American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2016 | Pubmed ID: 27097661 Role of Enteroendocrine L-cells in Arginine Vasopressin-mediated Inhibition of Colonic Anion Secretion The Journal of Physiology. Sep, 2016 | Pubmed ID: 27037495 Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance PloS One. 2016 | Pubmed ID: 27010458 The Incretin Hormone Glucagon-like Peptide 1 Increases Mitral Cell Excitability by Decreasing Conductance of a Voltage-dependent Potassium Channel The Journal of Physiology. May, 2016 | Pubmed ID: 26931093 Stimulation of Incretin Secreting Cells Therapeutic Advances in Endocrinology and Metabolism. Feb, 2016 | Pubmed ID: 26885360 Peptide Production and Secretion in GLUTag, NCI-H716, and STC-1 Cells: a Comparison to Native L-cells Journal of Molecular Endocrinology. Apr, 2016 | Pubmed ID: 26819328 G Protein-coupled Receptors As New Therapeutic Targets for Type 2 Diabetes Diabetologia. Feb, 2016 | Pubmed ID: 26661410 Galanin Inhibits GLP-1 and GIP Secretion Via the GAL1 Receptor in Enteroendocrine L and K Cells British Journal of Pharmacology. Mar, 2016 | Pubmed ID: 26661062 The Effect of Encapsulated Glutamine on Gut Peptide Secretion in Human Volunteers Peptides. Mar, 2016 | Pubmed ID: 26541888 GLP1- and GIP-producing Cells Rarely Overlap and Differ by Bombesin Receptor-2 Expression and Responsiveness The Journal of Endocrinology. Jan, 2016 | Pubmed ID: 26483393 Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium Annual Review of Physiology. 2016 | Pubmed ID: 26442437 The Effect of Bariatric Surgery on Gastrointestinal and Pancreatic Peptide Hormones Peptides. Mar, 2016 | Pubmed ID: 26344355 Signalling Pathways Involved in the Detection of Peptones by Murine Small Intestinal Enteroendocrine L-cells Peptides. Mar, 2016 | Pubmed ID: 26215048 High Fat Diet Impairs the Function of Glucagon-like Peptide-1 Producing L-cells Peptides. Mar, 2016 | Pubmed ID: 26145551 Lipid Derivatives Activate GPR119 and Trigger GLP-1 Secretion in Primary Murine L-cells Peptides. Mar, 2016 | Pubmed ID: 26144594 Distribution and Characterisation of Glucagon-like Peptide-1 Receptor Expressing Cells in the Mouse Brain Molecular Metabolism. Oct, 2015 | Pubmed ID: 26500843 Limited Impact on Glucose Homeostasis of Leptin Receptor Deletion from Insulin- or Proglucagon-expressing Cells Molecular Metabolism. Sep, 2015 | Pubmed ID: 26413468 Can Encapsulated Glutamine Increase GLP-1 Secretion, Improve Glucose Tolerance, and Reduce Meal Size in Healthy Volunteers? A Randomised, Placebo-controlled, Cross-over Trial Lancet (London, England). Feb, 2015 | Pubmed ID: 26312890 Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors Endocrinology. Nov, 2015 | Pubmed ID: 26280129 A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium Endocrinology. Nov, 2015 | Pubmed ID: 26241122 Corrigendum: Transcriptional Regulator PRDM12 is Essential for Human Pain Perception Nature Genetics. Aug, 2015 | Pubmed ID: 26220135 Farnesoid X Receptor Inhibits Glucagon-like Peptide-1 Production by Enteroendocrine L Cells Nature Communications. Jul, 2015 | Pubmed ID: 26134028 Effect of Reducing Portion Size at a Compulsory Meal on Later Energy Intake, Gut Hormones, and Appetite in Overweight Adults Obesity (Silver Spring, Md.). Jul, 2015 | Pubmed ID: 26054049 Transcriptional Regulator PRDM12 is Essential for Human Pain Perception Nature Genetics. Jul, 2015 | Pubmed ID: 26005867 Novel SCN9A Mutations Underlying Extreme Pain Phenotypes: Unexpected Electrophysiological and Clinical Phenotype Correlations The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2015 | Pubmed ID: 25995458 Submembrane ATP and Ca2+ Kinetics in α-cells: Unexpected Signaling for Glucagon Secretion FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2015 | Pubmed ID: 25911612 LKB1 and AMPKα1 Are Required in Pancreatic Alpha Cells for the Normal Regulation of Glucagon Secretion and Responses to Hypoglycemia Molecular Metabolism. Apr, 2015 | Pubmed ID: 25830091 Activation of the GLP-1 Receptors in the Nucleus of the Solitary Tract Reduces Food Reward Behavior and Targets the Mesolimbic System PloS One. 2015 | Pubmed ID: 25793511 Inhibition of the Malate-aspartate Shuttle in Mouse Pancreatic Islets Abolishes Glucagon Secretion Without Affecting Insulin Secretion The Biochemical Journal. May, 2015 | Pubmed ID: 25731850 Gut Chemosensing Mechanisms The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25664852 Targeting Development of Incretin-producing Cells Increases Insulin Secretion The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500886 Stimulation of GLP-1 Secretion Downstream of the Ligand-gated Ion Channel TRPA1 Diabetes. Apr, 2015 | Pubmed ID: 25325736 Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells Cell Reports. Nov, 2014 | Pubmed ID: 25456122 The Melanocortin-4 Receptor is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 in Vivo Cell Metabolism. Dec, 2014 | Pubmed ID: 25453189 Clocking Up GLP-1: Considering Intestinal Rhythms in the Incretin Effect Diabetes. Nov, 2014 | Pubmed ID: 25342730 The Role of Gut Endocrine Cells in Control of Metabolism and Appetite Experimental Physiology. Sep, 2014 | Pubmed ID: 25210110 The Peutz-Jeghers Kinase LKB1 Suppresses Polyp Growth from Intestinal Cells of a Proglucagon-expressing Lineage in Mice Disease Models & Mechanisms. Nov, 2014 | Pubmed ID: 25190708 Na+ Current Properties in Islet α- and β-cells Reflect Cell-specific Scn3a and Scn9a Expression The Journal of Physiology. Nov, 2014 | Pubmed ID: 25172946 Reversible Changes in Pancreatic Islet Structure and Function Produced by Elevated Blood Glucose Nature Communications. Aug, 2014 | Pubmed ID: 25145789 Diabetes Recovery by Age-dependent Conversion of Pancreatic δ-cells into Insulin Producers Nature. Oct, 2014 | Pubmed ID: 25141178 GLP-1 Receptor Stimulation of the Lateral Parabrachial Nucleus Reduces Food Intake: Neuroanatomical, Electrophysiological, and Behavioral Evidence Endocrinology. Nov, 2014 | Pubmed ID: 25116706 LKB1 and AMPK Differentially Regulate Pancreatic β-cell Identity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2014 | Pubmed ID: 25070369 Insulin-like Peptide 5 is an Orexigenic Gastrointestinal Hormone Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 25028498 Fructose Stimulates GLP-1 but Not GIP Secretion in Mice, Rats, and Humans American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2014 | Pubmed ID: 24525020 Identification and Characterization of GLP-1 Receptor-expressing Cells Using a New Transgenic Mouse Model Diabetes. Apr, 2014 | Pubmed ID: 24296712 Generation of L Cells in Mouse and Human Small Intestine Organoids Diabetes. Feb, 2014 | Pubmed ID: 24130334 Role of KATP Channels in Glucose-regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes Cell Metabolism. Dec, 2013 | Pubmed ID: 24315372 Towards the Harnessing of Gut Feelings Current Opinion in Pharmacology. Dec, 2013 | Pubmed ID: 24140240 A Tag to Track Short Chain Fatty Acid Sensors Endocrinology. Oct, 2013 | Pubmed ID: 24058154 Oligopeptides Stimulate Glucagon-like Peptide-1 Secretion in Mice Through Proton-coupled Uptake and the Calcium-sensing Receptor Diabetologia. Dec, 2013 | Pubmed ID: 24045836 Molecular Mechanisms of Incretin Hormone Secretion Current Opinion in Pharmacology. Dec, 2013 | Pubmed ID: 24035446 The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23269670 PPARβ/δ Affects Pancreatic β Cell Mass and Insulin Secretion in Mice The Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 23093780 Neurochemical Characterization of Body Weight-regulating Leptin Receptor Neurons in the Nucleus of the Solitary Tract Endocrinology. Oct, 2012 | Pubmed ID: 22869346 Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry Endocrinology. Jul, 2012 | Pubmed ID: 22685263 G-protein-coupled Receptors in Intestinal Chemosensation Cell Metabolism. Apr, 2012 | Pubmed ID: 22482725 Intestinal Sensing of Nutrients Handbook of Experimental Pharmacology. 2012 | Pubmed ID: 22249821 Short-chain Fatty Acids Stimulate Glucagon-like Peptide-1 Secretion Via the G-protein-coupled Receptor FFAR2 Diabetes. Feb, 2012 | Pubmed ID: 22190648 Nutrient Detection by Incretin Hormone Secreting Cells Physiology & Behavior. Jun, 2012 | Pubmed ID: 22182802 Na(+)-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-dependent Incretin Secretion Diabetes. Jan, 2012 | Pubmed ID: 22124465 Interleukin-6 Enhances Insulin Secretion by Increasing Glucagon-like Peptide-1 Secretion from L Cells and Alpha Cells Nature Medicine. Oct, 2011 | Pubmed ID: 22037645 CCK Stimulation of GLP-1 Neurons Involves α1-adrenoceptor-mediated Increase in Glutamatergic Synaptic Inputs Diabetes. Nov, 2011 | Pubmed ID: 21885869 Glutamine Triggers and Potentiates Glucagon-like Peptide-1 Secretion by Raising Cytosolic Ca2+ and CAMP Endocrinology. Feb, 2011 | Pubmed ID: 21209017 Role of Phosphodiesterase and Adenylate Cyclase Isozymes in Murine Colonic Glucagon-like Peptide 1 Secreting Cells British Journal of Pharmacology. May, 2011 | Pubmed ID: 21054345 Congenital Insensitivity to Pain: Novel SCN9A Missense and In-frame Deletion Mutations Human Mutation. Sep, 2010 | Pubmed ID: 20635406 Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius: Electrical Properties of Glucagon-like Peptide 1 Neurons Diabetes. Aug, 2010 | Pubmed ID: 20522593 GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-type Ca2+ Channel-dependent Exocytosis Cell Metabolism. Jun, 2010 | Pubmed ID: 20519125 Pain Perception is Altered by a Nucleotide Polymorphism in SCN9A Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20212137 Molecular Mechanisms Underlying Nutrient Detection by Incretin-secreting Cells International Dairy Journal. Apr, 2010 | Pubmed ID: 20204054 Increased Liver Stiffness in Alcoholic Liver Disease: Differentiating Fibrosis from Steatohepatitis World Journal of Gastroenterology. Feb, 2010 | Pubmed ID: 20180235 Molecular Mechanisms Underlying Nutrient-stimulated Incretin Secretion Expert Reviews in Molecular Medicine. Jan, 2010 | Pubmed ID: 20047700 Hypogonadotropic Hypogonadism Due to a Novel Missense Mutation in the First Extracellular Loop of the Neurokinin B Receptor The Journal of Clinical Endocrinology and Metabolism. Oct, 2009 | Pubmed ID: 19755480 Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-associated Variants Diabetes. Sep, 2009 | Pubmed ID: 19542200 TAC3 and TACR3 Mutations in Familial Hypogonadotropic Hypogonadism Reveal a Key Role for Neurokinin B in the Central Control of Reproduction Nature Genetics. Mar, 2009 | Pubmed ID: 19079066 Oral Glutamine Increases Circulating Glucagon-like Peptide 1, Glucagon, and Insulin Concentrations in Lean, Obese, and Type 2 Diabetic Subjects The American Journal of Clinical Nutrition. Jan, 2009 | Pubmed ID: 19056578 Nutritional Regulation of Glucagon-like Peptide-1 Secretion The Journal of Physiology. Jan, 2009 | Pubmed ID: 19001044 Dissociation Between Sensing and Metabolism of Glucose in Sugar Sensing Neurones The Journal of Physiology. Jan, 2009 | Pubmed ID: 18981030 Glucose Sensing in L Cells: a Primary Cell Study Cell Metabolism. Dec, 2008 | Pubmed ID: 19041768 Extrahepatic Cholestasis Increases Liver Stiffness (FibroScan) Irrespective of Fibrosis Hepatology (Baltimore, Md.). Nov, 2008 | Pubmed ID: 18836992 No Differences in Mortality Between Users of Pancreatic-specific and Non-pancreatic-specific Sulphonylureas: a Cohort Analysis Diabetes, Obesity & Metabolism. Apr, 2008 | Pubmed ID: 18093208 An SCN9A Channelopathy Causes Congenital Inability to Experience Pain Nature. Dec, 2006 | Pubmed ID: 17167479 Sodium-coupled Glucose Cotransporters Contribute to Hypothalamic Glucose Sensing Diabetes. Dec, 2006 | Pubmed ID: 17130483 Mucolipin-1 is a Lysosomal Membrane Protein Required for Intracellular Lactosylceramide Traffic Traffic (Copenhagen, Denmark). Oct, 2006 | Pubmed ID: 16978393 Relapsing Diabetes Can Result from Moderately Activating Mutations in KCNJ11 Human Molecular Genetics. Apr, 2005 | Pubmed ID: 15718250 Constitutive Ras Activity Induces Hippocampal Hypertrophy and Remodeling of Pyramidal Neurons in SynRas Mice Journal of Neuroscience Research. Sep, 2004 | Pubmed ID: 15352209 Open to Control--new Hope for Patients with Neonatal Diabetes The New England Journal of Medicine. Apr, 2004 | Pubmed ID: 15115828 A Novel Missense Mutation in AE1 Causing Autosomal Dominant Distal Renal Tubular Acidosis Retains Normal Transport Function but is Mistargeted in Polarized Epithelial Cells The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14734552 A Novel Glucose-sensing Mechanism Contributing to Glucagon-like Peptide-1 Secretion from the GLUTag Cell Line Diabetes. May, 2003 | Pubmed ID: 12716745 Differential Selectivity of Insulin Secretagogues: Mechanisms, Clinical Implications, and Drug Interactions Journal of Diabetes and Its Complications. Mar-Apr, 2003 | Pubmed ID: 12623163 Analysis of the Differential Modulation of Sulphonylurea Block of Beta-cell and Cardiac ATP-sensitive K+ (K(ATP)) Channels by Mg-nucleotides The Journal of Physiology. Feb, 2003 | Pubmed ID: 12562963 A New Subtype of Autosomal Dominant Diabetes Attributable to a Mutation in the Gene for Sulfonylurea Receptor 1 Lancet (London, England). Jan, 2003 | Pubmed ID: 12559865 Sulfonylurea Stimulation of Insulin Secretion Diabetes. Dec, 2002 | Pubmed ID: 12475777 Glucose-sensing in Glucagon-like Peptide-1-secreting Cells Diabetes. Sep, 2002 | Pubmed ID: 12196469 Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells Arianna Psichas*1, Gwen Tolhurst*1, Cheryl A. Brighton1, Fiona M. Gribble1, Frank Reimann1 1Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge JoVE 55687 Biology
Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells Arianna Psichas*1, Gwen Tolhurst*1, Cheryl A. Brighton1, Fiona M. Gribble1, Frank Reimann1 1Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge JoVE 55687 Biology