Frans van Roy Department of Biomedical Molecular Biology Ghent University Biography Publications Institution JoVE Articles Frans van Roy has not added a biography. If you are Frans van Roy and would like to personalize this page please email our Author Liaison for assistance. Publications Evolution and Diversity of Cadherins and Catenins Experimental Cell Research. Mar, 2017 | Pubmed ID: 28268172 Metazoan Evolution of the Armadillo Repeat Superfamily Cellular and Molecular Life Sciences : CMLS. Feb, 2017 | Pubmed ID: 27497926 Inactivation of P120 Catenin in Mice Disturbs Intrahepatic Bile Duct Development and Aggravates Liver Carcinogenesis European Journal of Cell Biology. Dec, 2016 | Pubmed ID: 27769530 Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma PloS One. 2016 | Pubmed ID: 27701444 P120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification PLoS Genetics. Aug, 2016 | Pubmed ID: 27556156 αT-catenin in Restricted Brain Cell Types and Its Potential Connection to Autism Journal of Molecular Psychiatry. 2016 | Pubmed ID: 27330745 Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog Current Biology : CB. Mar, 2016 | Pubmed ID: 26923788 Protocadherin-1 Binds to SMAD3 and Suppresses TGF-β1-induced Gene Transcription American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2015 | Pubmed ID: 26209277 Hematopoietic Plakophilin-3 Regulates Acute Tissue-specific and Systemic Inflammation in Mice European Journal of Immunology. Oct, 2015 | Pubmed ID: 26173741 TALEN-mediated Apc Mutation in Xenopus Tropicalis Phenocopies Familial Adenomatous Polyposis Oncoscience. 2015 | Pubmed ID: 26097888 NBPF1, a Tumor Suppressor Candidate in Neuroblastoma, Exerts Growth Inhibitory Effects by Inducing a G1 Cell Cycle Arrest BMC Cancer. May, 2015 | Pubmed ID: 25958384 The Human NANOS3 Gene Contributes to Lung Tumour Invasion by Inducing Epithelial-mesenchymal Transition The Journal of Pathology. Sep, 2015 | Pubmed ID: 25904364 The Cardiac Protein αT-catenin Contributes to Chemical-induced Asthma American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2015 | Pubmed ID: 25480337 Alpha-catenins Control Cardiomyocyte Proliferation by Regulating Yap Activity Circulation Research. Jan, 2015 | Pubmed ID: 25305307 Intercalated Discs and Arrhythmogenic Cardiomyopathy Circulation. Cardiovascular Genetics. Dec, 2014 | Pubmed ID: 25516623 Role of Cell-cell Adhesion Complexes in Embryonic Stem Cell Biology Journal of Cell Science. Jun, 2014 | Pubmed ID: 24931943 Beyond E-cadherin: Roles of Other Cadherin Superfamily Members in Cancer Nature Reviews. Cancer. Feb, 2014 | Pubmed ID: 24442140 PhysBinder: Improving the Prediction of Transcription Factor Binding Sites by Flexible Inclusion of Biophysical Properties Nucleic Acids Research. Jul, 2013 | Pubmed ID: 23620286 Molecular Biology of Cadherins. Preface Progress in Molecular Biology and Translational Science. 2013 | Pubmed ID: 23481207 Delta-protocadherins in Health and Disease Progress in Molecular Biology and Translational Science. 2013 | Pubmed ID: 23481195 New Insights into the Evolution of Metazoan Cadherins and Catenins Progress in Molecular Biology and Translational Science. 2013 | Pubmed ID: 23481191 Mutations in the Area Composita Protein αT-catenin Are Associated with Arrhythmogenic Right Ventricular Cardiomyopathy European Heart Journal. Jan, 2013 | Pubmed ID: 23136403 Ocular Anterior Segment Dysgenesis Upon Ablation of P120 Catenin in Neural Crest Cells Investigative Ophthalmology & Visual Science. Aug, 2012 | Pubmed ID: 22736606 Interaction of α-catulin with Dystrobrevin Contributes to Integrity of Dystrophin Complex in Muscle The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22577143 A Flexible Integrative Approach Based on Random Forest Improves Prediction of Transcription Factor Binding Sites Nucleic Acids Research. Aug, 2012 | Pubmed ID: 22492513 Loss of αT-catenin Alters the Hybrid Adhering Junctions in the Heart and Leads to Dilated Cardiomyopathy and Ventricular Arrhythmia Following Acute Ischemia Journal of Cell Science. Feb, 2012 | Pubmed ID: 22421363 Evolutionary Functional Analysis and Molecular Regulation of the ZEB Transcription Factors Cellular and Molecular Life Sciences : CMLS. Aug, 2012 | Pubmed ID: 22349261 Functions of P120ctn Isoforms in Cell-cell Adhesion and Intracellular Signaling Frontiers in Bioscience (Landmark Edition). Jan, 2012 | Pubmed ID: 22201829 Functions of P120ctn in Development and Disease Frontiers in Bioscience (Landmark Edition). Jan, 2012 | Pubmed ID: 22201773 Efficient and User-friendly Pluripotin-based Derivation of Mouse Embryonic Stem Cells Stem Cell Reviews. Sep, 2012 | Pubmed ID: 22011883 ARVCF Depletion Cooperates with Tbx1 Deficiency in the Development of 22q11.2DS-like Phenotypes in Xenopus Developmental Dynamics : an Official Publication of the American Association of Anatomists. Dec, 2011 | Pubmed ID: 22028109 ConTra V2: a Tool to Identify Transcription Factor Binding Sites Across Species, Update 2011 Nucleic Acids Research. Jul, 2011 | Pubmed ID: 21576231 New Insights into the Evolution of Metazoan Cadherins Molecular Biology and Evolution. Jan, 2011 | Pubmed ID: 20817718 Direct Control of Hoxd1 and Irx3 Expression by Wnt/beta-catenin Signaling During Anteroposterior Patterning of the Neural Axis in Xenopus The International Journal of Developmental Biology. 2010 | Pubmed ID: 20979027 Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development Cancer Research. Nov, 2010 | Pubmed ID: 20889723 The Transcriptional Repressor Kaiso Localizes at the Mitotic Spindle and is a Constituent of the Pericentriolar Material PloS One. Feb, 2010 | Pubmed ID: 20169156 Chibby Interacts with NBPF1 and Clusterin, Two Candidate Tumor Suppressors Linked to Neuroblastoma Experimental Cell Research. Apr, 2010 | Pubmed ID: 20096688 Involvement of Members of the Cadherin Superfamily in Cancer Cold Spring Harbor Perspectives in Biology. Dec, 2009 | Pubmed ID: 20457567 The NBPF1 Promoter Has Been Recruited from the Unrelated EVI5 Gene Before Simian Radiation Molecular Biology and Evolution. Jun, 2009 | Pubmed ID: 19282512 TRIP6, a Novel Molecular Partner of the MAGI-1 Scaffolding Molecule, Promotes Invasiveness FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2009 | Pubmed ID: 19017743 Molecular Evolution of the Cadherin Superfamily The International Journal of Biochemistry & Cell Biology. Feb, 2009 | Pubmed ID: 18848899 Variant HNF1 Modulates Epithelial Plasticity of Normal and Transformed Ovary Cells Neoplasia (New York, N.Y.). Dec, 2008 | Pubmed ID: 19048126 Endoplasmic Reticulum Quality Control: a New Mechanism of E-cadherin Regulation and Its Implication in Cancer Human Molecular Genetics. Nov, 2008 | Pubmed ID: 18772194 Expression of Protocadherin-1 (Pcdh1) During Mouse Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Sep, 2008 | Pubmed ID: 18729229 Low Nucleosome Occupancy is Encoded Around Functional Human Transcription Factor Binding Sites BMC Genomics. Jul, 2008 | Pubmed ID: 18627598 Canonical Wnt Signaling Controls Proliferation of Retinal Stem/progenitor Cells in Postembryonic Xenopus Eyes Stem Cells (Dayton, Ohio). Aug, 2008 | Pubmed ID: 18556512 A Constitutional Translocation T(1;17)(p36.2;q11.2) in a Neuroblastoma Patient Disrupts the Human NBPF1 and ACCN1 Genes PloS One. May, 2008 | Pubmed ID: 18493581 ConTra: a Promoter Alignment Analysis Tool for Identification of Transcription Factor Binding Sites Across Species Nucleic Acids Research. Jul, 2008 | Pubmed ID: 18453628 Chicken Beta-globin Insulator Overcomes Variegation of Transgenes in Xenopus Embryos FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2008 | Pubmed ID: 18359926 Continuous Cell Injury Promotes Hepatic Tumorigenesis in Cdc42-deficient Mouse Liver Gastroenterology. Mar, 2008 | Pubmed ID: 18325391 Plakophilin-3-deficient Mice Develop Hair Coat Abnormalities and Are Prone to Cutaneous Inflammation The Journal of Investigative Dermatology. Jun, 2008 | Pubmed ID: 18079750 Insulin-like Growth Factor-I Receptor, E-cadherin and Alpha V Integrin Form a Dynamic Complex Under the Control of Alpha-catenin International Journal of Cancer. Feb, 2008 | Pubmed ID: 17955485 A Unique and Specific Interaction Between AlphaT-catenin and Plakophilin-2 in the Area Composita, the Mixed-type Junctional Structure of Cardiac Intercalated Discs Journal of Cell Science. Jun, 2007 | Pubmed ID: 17535849 A Distance Difference Matrix Approach to Identifying Transcription Factors That Regulate Differential Gene Expression Genome Biology. 2007 | Pubmed ID: 17504544 Description and Mapping of the Resistance of DBA/2 Mice to TNF-induced Lethal Shock Journal of Immunology (Baltimore, Md. : 1950). Apr, 2007 | Pubmed ID: 17404289 Insertion of an HERV(K) LTR in the Intron of NBPF3 is Not Required for Its Transcriptional Activity Virology. May, 2007 | Pubmed ID: 17391723 The Transcription Factor ZEB1 (deltaEF1) Represses Plakophilin 3 During Human Cancer Progression FEBS Letters. Apr, 2007 | Pubmed ID: 17391671 Truncated Isoform of Mouse AlphaT-catenin is Testis-restricted in Expression and Function FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2007 | Pubmed ID: 17185752 Diverse Functions of P120ctn in Tumors Biochimica Et Biophysica Acta. Jan, 2007 | Pubmed ID: 17030444 E-cadherin Regulates Human Nanos1, Which Interacts with P120ctn and Induces Tumor Cell Migration and Invasion Cancer Research. Oct, 2006 | Pubmed ID: 17047063 Writing Readable Prose: when Planning a Scientific Manuscript, Following a Few Simple Rules Has a Large Impact EMBO Reports. Sep, 2006 | Pubmed ID: 16953194 The Wild-derived Inbred Mouse Strain SPRET/Ei is Resistant to LPS and Defective in IFN-beta Production Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16455798 A New Generation of JASPAR, the Open-access Repository for Transcription Factor Binding Site Profiles Nucleic Acids Research. Jan, 2006 | Pubmed ID: 16381983 In Vivo Tracing of Canonical Wnt Signaling in Xenopus Tadpoles by Means of an Inducible Transgenic Reporter Tool FEBS Letters. Jan, 2006 | Pubmed ID: 16376877 SIP1/ZEB2 Induces EMT by Repressing Genes of Different Epithelial Cell-cell Junctions Nucleic Acids Research. 2005 | Pubmed ID: 16314317 A Role for Kaiso-p120ctn Complexes in Cancer? Nature Reviews. Cancer. Dec, 2005 | Pubmed ID: 16294216 Nuclear Translocation of AlphaN-catenin by the Novel Zinc Finger Transcriptional Repressor ZASC1 Experimental Cell Research. Nov, 2005 | Pubmed ID: 16182284 A Novel Gene Family NBPF: Intricate Structure Generated by Gene Duplications During Primate Evolution Molecular Biology and Evolution. Nov, 2005 | Pubmed ID: 16079250 The Transcription Factor Snail Induces Tumor Cell Invasion Through Modulation of the Epithelial Cell Differentiation Program Cancer Research. Jul, 2005 | Pubmed ID: 16024625 Expression and Nuclear Location of the Transcriptional Repressor Kaiso is Regulated by the Tumor Microenvironment Cancer Research. Mar, 2005 | Pubmed ID: 15781635 Unraveling Signalling Cascades for the Snail Family of Transcription Factors Cellular Signalling. May, 2005 | Pubmed ID: 15683729 Implication of the MAGI-1b/PTEN Signalosome in Stabilization of Adherens Junctions and Suppression of Invasiveness FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2005 | Pubmed ID: 15629897 Cadherin-mediated Cell-cell Adhesion in the Testis Frontiers in Bioscience : a Journal and Virtual Library. Jan, 2005 | Pubmed ID: 15574378 Differential Downregulation of AlphaT-catenin Expression in Placenta: Trophoblast Cell Type-dependent Imprinting of the CTNNA3 Gene Gene Expression Patterns : GEP. Nov, 2004 | Pubmed ID: 15533819 Global Inhibition of Lef1/Tcf-dependent Wnt Signaling at Its Nuclear End Point Abrogates Development in Transgenic Xenopus Embryos The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15371453 Response of TNF-hyporesponsive SPRET/Ei Mice in Models of Inflammatory Disorders Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jul, 2004 | Pubmed ID: 15366373 GATA-4 and MEF2C Transcription Factors Control the Tissue-specific Expression of the AlphaT-catenin Gene CTNNA3 Nucleic Acids Research. 2004 | Pubmed ID: 15302915 P120 Catenin is Required for Morphogenetic Movements Involved in the Formation of the Eyes and the Craniofacial Skeleton in Xenopus Journal of Cell Science. Aug, 2004 | Pubmed ID: 15292404 Breaking the Species Barrier: Derivation of Germline-competent Embryonic Stem Cells from Mus Spretus X C57BL/6 Hybrids Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 15277691 Alpha-T-catenin is Expressed in Human Brain and Interacts with the Wnt Signaling Pathway but is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease Neuromolecular Medicine. 2004 | Pubmed ID: 15075440 Stability of Dendritic Spines and Synaptic Contacts is Controlled by Alpha N-catenin Nature Neuroscience. Apr, 2004 | Pubmed ID: 15034585 Combined Subtractive CDNA Cloning and Array CGH: an Efficient Approach for Identification of Overexpressed Genes in DNA Amplicons BMC Genomics. Feb, 2004 | Pubmed ID: 15018647 Alpha-catenin is Required for IGF-I-induced Cellular Migration but Not Invasion in Human Colonic Cancer Cells Oncogene. Feb, 2004 | Pubmed ID: 14961074 Functional and Molecular Characterization of the Epithelioid to Round Transition in Human Colorectal Cancer LoVo Cells Oncogene. Oct, 2003 | Pubmed ID: 14562048 E-Cadherin Mediates MMP Down-regulation in Highly Invasive Bronchial Tumor Cells The American Journal of Pathology. Aug, 2003 | Pubmed ID: 12875984 The Protein Kinase Akt Induces Epithelial Mesenchymal Transition and Promotes Enhanced Motility and Invasiveness of Squamous Cell Carcinoma Lines Cancer Research. May, 2003 | Pubmed ID: 12727836 Defining Desmosomal Plakophilin-3 Interactions The Journal of Cell Biology. Apr, 2003 | Pubmed ID: 12707304 Assessment of the CTNNA3 Gene Encoding Human Alpha T-catenin Regarding Its Involvement in Dilated Cardiomyopathy Human Genetics. Mar, 2003 | Pubmed ID: 12596047 A Novel Role for P120 Catenin in E-cadherin Function The Journal of Cell Biology. Nov, 2002 | Pubmed ID: 12427869 Localization of the 17q Breakpoint of a Constitutional 1;17 Translocation in a Patient with Neuroblastoma Within a 25-kb Segment Located Between the ACCN1 and TLK2 Genes and Near the Distal Breakpoints of Two Microdeletions in Neurofibromatosis Type 1 Patients Genes, Chromosomes & Cancer. Oct, 2002 | Pubmed ID: 12203774 Smad4 Induces the Tumor Suppressor E-cadherin and P-cadherin in Colon Carcinoma Cells Oncogene. Sep, 2002 | Pubmed ID: 12203117 Hyporesponsiveness of SPRET/Ei Mice to Lethal Shock Induced by Tumor Necrosis Factor and Implications for a TNF-based Antitumor Therapy Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002 | Pubmed ID: 12089334 The Human AlphaE-catenin Gene CTNNA1: Mutational Analysis and Rare Occurrence of a Truncated Splice Variant Biochimica Et Biophysica Acta. Apr, 2002 | Pubmed ID: 11997091 Medial Meniscocapsular Separation: MR Imaging Criteria and Diagnostic Pitfalls European Journal of Radiology. Mar, 2002 | Pubmed ID: 11861099 Protein Binding and Functional Characterization of Plakophilin 2. Evidence for Its Diverse Roles in Desmosomes and Beta -catenin Signaling The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11790773 Isolation and Characterization of XKaiso, a Transcriptional Repressor That Associates with the Catenin Xp120(ctn) in Xenopus Laevis The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11751886 Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange Tim Pieters1,2,3,4, Lieven Haenebalcke1,2, Kenneth Bruneel1,2,4, Niels Vandamme1,2,4, Tino Hochepied1,2, Jolanda van Hengel5, Dagmar Wirth6, Geert Berx1,2,4, Jody J. Haigh7, Frans van Roy1,2,4, Steven Goossens1,2,3,4 1Department of Biomedical Molecular Biology, Ghent University, 2Inflammation Research Center, VIB, 3Center for Medical Genetics, Ghent University Hospital, 4Cancer Research Institute Ghent (CRIG), 5Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, 6Helmholtz Center for Infection Research, 7Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre JoVE 55575 Developmental Biology
Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange Tim Pieters1,2,3,4, Lieven Haenebalcke1,2, Kenneth Bruneel1,2,4, Niels Vandamme1,2,4, Tino Hochepied1,2, Jolanda van Hengel5, Dagmar Wirth6, Geert Berx1,2,4, Jody J. Haigh7, Frans van Roy1,2,4, Steven Goossens1,2,3,4 1Department of Biomedical Molecular Biology, Ghent University, 2Inflammation Research Center, VIB, 3Center for Medical Genetics, Ghent University Hospital, 4Cancer Research Institute Ghent (CRIG), 5Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, 6Helmholtz Center for Infection Research, 7Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre JoVE 55575 Developmental Biology