Gino Villetti Corporate Preclinical R&D Chiesi Farmaceutici S.p.A. Biography Publications Institution JoVE Articles Gino Villetti has not added a biography. If you are Gino Villetti and would like to personalize this page please email our Author Liaison for assistance. Publications Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives As Inhaled PDE4 Inhibitors for Respiratory Diseases Journal of Medicinal Chemistry. Dec, 2017 | Pubmed ID: 29200281 The PDE4 Inhibitor CHF-6001 and LAMAs Inhibit Bronchoconstriction-induced Remodelling in Lung Slices American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2017 | Pubmed ID: 28596292 Longitudinal Assessment of Bleomycin-induced Lung Fibrosis by Micro-CT Correlates with Histological Evaluation in Mice Multidisciplinary Respiratory Medicine. 2017 | Pubmed ID: 28400960 Heterologous Matrix Metalloproteinase Gene Promoter Activity Allows In Vivo Real-time Imaging of Bleomycin-Induced Lung Fibrosis in Transiently Transgenized Mice Frontiers in Immunology. 2017 | Pubmed ID: 28298912 Physiological, Biochemical, and Biophysical Characterization of the Lung-Lavaged Spontaneously-Breathing Rabbit As a Model for Respiratory Distress Syndrome PloS One. 2017 | Pubmed ID: 28060859 In Vivo Monitoring of Lung Inflammation in CFTR-deficient Mice Journal of Translational Medicine. Jul, 2016 | Pubmed ID: 27468800 Anti-inflammatory Effects of the Novel Inhaled Phosphodiesterase Type 4 Inhibitor CHF6001 on Virus-inducible Cytokines Pharmacology Research & Perspectives. Feb, 2016 | Pubmed ID: 26977295 Assessment of Asthmatic Inflammation Using Hybrid Fluorescence Molecular Tomography-x-ray Computed Tomography Journal of Biomedical Optics. Jan, 2016 | Pubmed ID: 26803669 Monitoring Inflammation and Airway Remodeling by Fluorescence Molecular Tomography in a Chronic Asthma Model Journal of Translational Medicine. Oct, 2015 | Pubmed ID: 26496719 In Vivo Imaging of the Lung Inflammatory Response to Pseudomonas Aeruginosa and Its Modulation by Azithromycin Journal of Translational Medicine. Aug, 2015 | Pubmed ID: 26239109 CHF6001 I: a Novel Highly Potent and Selective Phosphodiesterase 4 Inhibitor with Robust Anti-inflammatory Activity and Suitable for Topical Pulmonary Administration The Journal of Pharmacology and Experimental Therapeutics. Mar, 2015 | Pubmed ID: 25576075 CHF6001 II: a Novel Phosphodiesterase 4 Inhibitor, Suitable for Topical Pulmonary Administration--in Vivo Preclinical Pharmacology Profile Defines a Potent Anti-inflammatory Compound with a Wide Therapeutic Window The Journal of Pharmacology and Experimental Therapeutics. Mar, 2015 | Pubmed ID: 25576073 Azithromycin Inhibits Nuclear Factor-κB Activation During Lung Inflammation: an in Vivo Imaging Study Pharmacology Research & Perspectives. Oct, 2014 | Pubmed ID: 25505605 Enlightened Mannhemia Haemolytica Lung Inflammation in Bovinized Mice Veterinary Research. Jan, 2014 | Pubmed ID: 24460618 Novel Class of Benzoic Acid Ester Derivatives As Potent PDE4 Inhibitors for Inhaled Administration in the Treatment of Respiratory Diseases Journal of Medicinal Chemistry. Feb, 2014 | Pubmed ID: 24400806 Multi-target Action of the Novel Anti-Alzheimer Compound CHF5074: in Vivo Study of Long Term Treatment in Tg2576 Mice BMC Neuroscience. Apr, 2013 | Pubmed ID: 23560952 Receptor for Advanced Glycation End Products Contributes to Postnatal Pulmonary Development and Adult Lung Maintenance Program in Mice American Journal of Respiratory Cell and Molecular Biology. Feb, 2013 | Pubmed ID: 23144333 In Vivo Imaging of Transiently Transgenized Mice with a Bovine Interleukin 8 (CXCL8) Promoter/luciferase Reporter Construct PloS One. 2012 | Pubmed ID: 22761878 Therapeutic Effect of CHF5074, a New γ-secretase Modulator, in a Mouse Model of Scrapie Prion. Jan-Mar, 2012 | Pubmed ID: 22453180 Unbalanced Oxidant-induced DNA Damage and Repair in COPD: a Link Towards Lung Cancer Thorax. Jun, 2011 | Pubmed ID: 21460372 The γ-secretase Modulator CHF5074 Restores Memory and Hippocampal Synaptic Plasticity in Plaque-free Tg2576 Mice Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 21321397 Acetaminophen, Via Its Reactive Metabolite N-acetyl-p-benzo-quinoneimine and Transient Receptor Potential Ankyrin-1 Stimulation, Causes Neurogenic Inflammation in the Airways and Other Tissues in Rodents FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2010 | Pubmed ID: 20720158 Evaluation of Lung Inflammation Induced by Intratracheal Administration of LPS in Mice: Comparison Between MRI and Histology Magma (New York, N.Y.). Apr, 2010 | Pubmed ID: 20386954 CHF5074, a Novel Gamma-secretase Modulator, Restores Hippocampal Neurogenesis Potential and Reverses Contextual Memory Deficit in a Transgenic Mouse Model of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20164581 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel Gamma-secretase Modulator, Reduces Brain Beta-amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease Without Causing Peripheral Toxicity The Journal of Pharmacology and Experimental Therapeutics. Dec, 2007 | Pubmed ID: 17895400 Discovery of Diaryl Imidazolidin-2-one Derivatives, a Novel Class of Muscarinic M3 Selective Antagonists (Part 2) Journal of Medicinal Chemistry. Apr, 2007 | Pubmed ID: 17352463 Discovery of Diaryl Imidazolidin-2-one Derivatives, a Novel Class of Muscarinic M3 Selective Antagonists (Part 1) Journal of Medicinal Chemistry. Apr, 2007 | Pubmed ID: 17352462 Formoterol and Beclomethasone Dipropionate Interact Positively in Antagonising Bronchoconstriction and Inflammation in the Lung Pharmacological Research. May, 2007 | Pubmed ID: 17336541 In Vitro and in Vivo Profiling of CHF5022 and CHF5074 Two Beta-amyloid1-42 Lowering Agents Pharmacological Research. Apr, 2007 | Pubmed ID: 17292621 Conformation-sensitive Antibodies Against Alzheimer Amyloid-beta by Immunization with a Thioredoxin-constrained B-cell Epitope Peptide The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17267402 Structural Determinants of Torpedo Californica Acetylcholinesterase Inhibition by the Novel and Orally Active Carbamate Based Anti-alzheimer Drug Ganstigmine (CHF-2819) Journal of Medicinal Chemistry. Aug, 2006 | Pubmed ID: 16913695 Pharmacological Assessment of the Duration of Action of Glycopyrrolate Vs Tiotropium and Ipratropium in Guinea-pig and Human Airways British Journal of Pharmacology. Jun, 2006 | Pubmed ID: 16565730 Synthesis and Anticonvulsant Activity of a Class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide Derivatives Bioorganic & Medicinal Chemistry. May, 2006 | Pubmed ID: 16460950 Synthesis and Biological Activity of Flurbiprofen Analogues As Selective Inhibitors of Beta-amyloid(1)(-)(42) Secretion Journal of Medicinal Chemistry. Sep, 2005 | Pubmed ID: 16134939 CHF3381, a Novel Antinociceptive Agent, Attenuates Capsaicin-induced Pain in Rats European Journal of Pharmacology. Sep, 2005 | Pubmed ID: 16125167 High Throughput Screening of Beta-amyloid Secretion Inhibitors Using Homogenous Time-resolved Fluorescence Combinatorial Chemistry & High Throughput Screening. Dec, 2004 | Pubmed ID: 15578936 Ganstigmine and Donepezil Improve Neurodegeneration in AD11 Antinerve Growth Factor Transgenic Mice American Journal of Alzheimer's Disease and Other Dementias. May-Jun, 2004 | Pubmed ID: 15214201 Mechanisms of Action of CHF3381 in the Forebrain British Journal of Pharmacology. Aug, 2003 | Pubmed ID: 12890713 Antinociceptive Activity of the N-methyl-D-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain The Journal of Pharmacology and Experimental Therapeutics. Aug, 2003 | Pubmed ID: 12750440 The Protective Effect of Ganstigmine Against Amyloid Beta 25-35 Neurotoxicity on Chicken Cortical Neurons is Independent from the Cholinesterase Inhibition Neuroscience Letters. May, 2003 | Pubmed ID: 12697278 Neuroprotective Activity of CHF3381, a Putative N-methyl-D-aspartate Receptor Antagonist Neuroreport. Nov, 2002 | Pubmed ID: 12438928 יחידנית או משולבת הדמיה גישה המבוססת על מיקרו-CT וקרינה פלואורסצנטית טומוגרפיה מולקולרית להערכת האורך של ריאות הנגרמת Bleomycin פיברוזיס בעכברים Francesca Ruscitti1, Francesca Ravanetti2, Gaetano Donofrio2, Yanto Ridwan3, Paula van Heijningen3, Jeroen Essers4, Gino Villetti1, Antonio Cacchioli2, Wim Vos5, Franco Fabio Stellari1 1Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 2Department of Veterinary Science, University of Parma, 3Department of Molecular Genetics, Erasmus MC, 4Department of Molecular Genetics, Vascular Surgery, Radiation Oncology, Erasmus MC, 5Fluidda NV JoVE 56443 Immunology and Infection דגם IL-8 עכבר transgenized חולף עבור Gabriella Bergamini*1, Fabio Stellari*2, Angela Sandri*3, Maria M. Lleo3, Gaetano Donofrio4, Francesca Ruscitti5,2, Federico Boschi6, Andrea Sbarbati7, Gino Villetti2, Paola Melotti8, Claudio Sorio1 1Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory "D. Lissandrini", University of Verona, 2Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 3Department of Diagnostic and Public Health, Microbiology Division, University of Verona, 4Dipartimento di Scienze Medico-Veterinarie, University of Parma, 5Department of Biomedical Biotechnological and Translational Sciences, University of Parma, 6Department of Computer Science, University of Verona, 7Department of Neurological, Biomedical and Movement Sciences, University of Verona, 8Cystic Fibrosis Regional Center (CFC), AOUI Verona JoVE 55499 Immunology and Infection
יחידנית או משולבת הדמיה גישה המבוססת על מיקרו-CT וקרינה פלואורסצנטית טומוגרפיה מולקולרית להערכת האורך של ריאות הנגרמת Bleomycin פיברוזיס בעכברים Francesca Ruscitti1, Francesca Ravanetti2, Gaetano Donofrio2, Yanto Ridwan3, Paula van Heijningen3, Jeroen Essers4, Gino Villetti1, Antonio Cacchioli2, Wim Vos5, Franco Fabio Stellari1 1Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 2Department of Veterinary Science, University of Parma, 3Department of Molecular Genetics, Erasmus MC, 4Department of Molecular Genetics, Vascular Surgery, Radiation Oncology, Erasmus MC, 5Fluidda NV JoVE 56443 Immunology and Infection
דגם IL-8 עכבר transgenized חולף עבור Gabriella Bergamini*1, Fabio Stellari*2, Angela Sandri*3, Maria M. Lleo3, Gaetano Donofrio4, Francesca Ruscitti5,2, Federico Boschi6, Andrea Sbarbati7, Gino Villetti2, Paola Melotti8, Claudio Sorio1 1Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory "D. Lissandrini", University of Verona, 2Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 3Department of Diagnostic and Public Health, Microbiology Division, University of Verona, 4Dipartimento di Scienze Medico-Veterinarie, University of Parma, 5Department of Biomedical Biotechnological and Translational Sciences, University of Parma, 6Department of Computer Science, University of Verona, 7Department of Neurological, Biomedical and Movement Sciences, University of Verona, 8Cystic Fibrosis Regional Center (CFC), AOUI Verona JoVE 55499 Immunology and Infection