Hiroaki Taniguchi Department of Experimental Embryology Institute of Genetics and Animal Breeding of the Polish Academy of Sciences Biography Publications Institution JoVE Articles Hiroaki Taniguchi Hiroaki Taniguchi is an assistant professor and a team leader of laboratory for Genome Editing and Transcriptional Regulation at Institute of Genetics and Animal Breeding of the Polish Academy of Sciences. He received a Ph.D. from Université Laval (Faculty of Medicine, CANADA). His current research focuses on CRISPR-mediated gene editing and transcriptional gene regulation in the field of regenerative medicine, reproductive biology, and cancer biology. Publications Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse Andrology. Feb,2019 | Pubmed ID: 30793514Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum Eur J Med Chem. Jun,2018 | Pubmed ID: 29133056Phytochemicals as potent modulators of autophagy for cancer therapy Cancer Lett. Jun,2018 | Pubmed ID: 29474859Transplantation of dedifferentiated fat cell-derived micromass pellets contributed to cartilage repair in the rat osteochondral defect model J Orthop Sci. Jul,2018 | Pubmed ID: 29571958Application of CRISPR/Cas9 Genome Editing Technology for the Improvement of Crops Cultivated in Tropical Climates: Recent Progress, Prospects, and Challenges Front Plant Sci. May,2018 | Pubmed ID: 29868073Cancer whole-genome sequencing: present and future Oncogene. Dec,2015 | Pubmed ID: 25823020Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer Oncotarget. May,2018 | Pubmed ID: 29899848Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements Through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men International Journal of Molecular Sciences. Mar,2018 | Pubmed ID: 29494521Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold J Vis Exp. Oct,2018 | Pubmed ID: 30417883Possible Roles of the Transcription Factor Nrf1 (NFE2L1) in Neural Homeostasis by Regulating the Gene Expression of Deubiquitinating Enzymes Biochemical and Biophysical Research Communications. Jan,2017 | Pubmed ID: 28088524Imaging of Cell Shape Alteration and Cell Movement in Drosophila Gastrulation Using DE-cadherin Reporter Transgenic Flies J Vis Exp. Dec,2016 | Pubmed ID: 28060321USP15 Stabilizes the Transcription Factor Nrf1 in the Nucleus, Promoting the Proteasome Gene Expression Biochemical and Biophysical Research Communications. Sep,2016 | Pubmed ID: 27416755An Efficient Method to Obtain Dedifferentiated Fat Cells J Vis Exp. Jul,2016 | Pubmed ID: 27500409Erratum: Whole-genome Mutational Landscape and Characterization of Noncoding and Structural Mutations in Liver Cancer Nature Genetics. May,2016 | Pubmed ID: 27230686Systematic Analysis of Mutation Distribution in Three Dimensional Protein Structures Identifies Cancer Driver Genes Scientific Reports. May,2016 | Pubmed ID: 27225414Whole-genome Mutational Landscape and Characterization of Noncoding and Structural Mutations in Liver Cancer Nature Genetics. May,2016 | Pubmed ID: 27064257Selective Autophagic Receptor P62 Regulates the Abundance of Transcriptional Coregulator ARIP4 During Nutrient Starvation Scientific Reports. Sept,2015 | Pubmed ID: 26412716Constitutive Activation of Drosophila CncC Transcription Factor Reduces Lipid Formation in the Fat Body Biochemical and Biophysical Research Communications. Aug,2015 | Pubmed ID: 26049108Inhibitory Mechanism of FAT4 Gene Expression in Response to Actin Dynamics During Src-induced Carcinogenesis PloS One. Feb,2015 | Pubmed ID: 25679223Chromatin Regulators in Neurodevelopment and Disease: Analysis of Fly Neural Circuits Provides Insights: Networks of Chromatin Regulators and Transcription Factors Underlie Drosophila Neurogenesis and Cognitive Defects in Intellectual Disability and Neuropsychiatric Disorder ModelsBioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Sep,2014 | Pubmed ID: 25067789Whole mount immunolabeling of olfactory receptor neurons in the Drosophila antenna J Vis Exp. May,2014 | Pubmed ID: 24834898The Casein Kinase 2-nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression Molecular and Cellular Biology. Sep,2013 | Pubmed ID: 23816881Chromatin Modification of Notch Targets in Olfactory Receptor Neuron Diversification Nature Neuroscience. Dec,2011 | Pubmed ID: 22197833The Efficacy of IGF-I Receptor Monoclonal Antibody Against Human Gastrointestinal Carcinomas is Independent of K-ras Mutation Status Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug,2011 | Pubmed ID: 21642381Co-expression of Laminin β3 and γ2 Chains and Epigenetic Inactivation of Laminin α3 Chain in Gastric Cancer International Journal of Oncology. Sep,2011 | Pubmed ID: 21617852Epigenetic Inactivation of Calcium-sensing Receptor in Colorectal CarcinogenesisModern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jun,2011 | Pubmed ID: 21317879Serum Resistin Levels and Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention Journal of Atherosclerosis and Thrombosis. Nov,2011 | Pubmed ID: 21071880Lipopolysaccharide-activated Alveolar Macrophages Having Cytotoxicity Toward Lung Tumor Cells Through Cell-to-cell Binding-dependent Mechanism Anticancer Research. Aug,2010 | Pubmed ID: 20871035Cytotoxic Effects of Activated Alveolar Macrophages on Lung Carcinoma Cells Via Cell-to-cell Contact and Nitric Oxide Anticancer Research. Aug,2010 | Pubmed ID: 20871032Antitumor Effect of Inhalatory Lipopolysaccharide and Synergetic Effect in Combination with Cyclophosphamide Anticancer Research. Aug,2010 | Pubmed ID: 20871031Association of Glypican-3 Expression with Growth Signaling Molecules in Hepatocellular Carcinoma World Journal of Gastroenterology. Jul,2010 | Pubmed ID: 20653060Epidermal Growth Factor Receptor is an Obligatory Intermediate for Oxytocin-induced Cyclooxygenase 2 Expression and Prostaglandin F2 Alpha Production in Bovine Endometrial Epithelial Cells Endocrinology. Mar,2010 | Pubmed ID: 20080869The Expression of the Nuclear Receptors NR5A1 and NR5A2 and Transcription Factor GATA6 Correlates with Steroidogenic Gene Expression in the Bovine Corpus Luteum Molecular Reproduction and Development. Sep,2009 | Pubmed ID: 19455657The Effect of Human GATA4 Gene Mutations on the Activity of Target Gonadal Promoters Journal of Molecular Endocrinology. Feb,2009 | Pubmed ID: 19008335A GATA4/WT1 Cooperation Regulates Transcription of Genes Required for Mammalian Sex Determination and Differentiation BMC Molecular Biology. Apr,2008 | Pubmed ID: 18445271LRH-1/NR5A2 Cooperates with GATA Factors to Regulate Inhibin Alpha-subunit Promoter Activity Molecular and Cellular Endocrinology. Sep,2006 | Pubmed ID: 16893604Protein Kinase A-dependent Synergism Between GATA Factors and the Nuclear Receptor, Liver Receptor Homolog-1, Regulates Human Aromatase (CYP19) PII Promoter Activity in Breast Cancer Cells Endocrinology. Nov,2005 | Pubmed ID: 16109788GATA Factors and the Nuclear Receptors, Steroidogenic Factor 1/liver Receptor Homolog 1, Are Key Mutual Partners in the Regulation of the Human 3beta-hydroxysteroid Dehydrogenase Type 2 PromoterMolecular Endocrinology (Baltimore, Md.). Sep,2005 | Pubmed ID: 15928316Role of the GATA Family of Transcription Factors in Andrology Journal of Andrology. Jul-Aug,2004 | Pubmed ID: 15223831Fas-Fas Ligand System Mediates Luteal Cell Death in Bovine Corpus Luteum Biology of Reproduction. Mar,2002 | Pubmed ID: 11870083The Lipoxygenase Pathways Are Involved in LH-stimulated Progesterone Production in Bovine Corpus LuteumProstaglandins & Other Lipid Mediators. Jan,2002 | Pubmed ID: 11789897Therapeutic potential of songorine, a diterpenoid alkaloid of the genus AconitumEur J Med Chem. Jun,2018 | Pubmed ID: 29133056Phytochemicals as potent modulators of autophagy for cancer therapyCancer Lett. Jun,2018 | Pubmed ID: 29474859Transplantation of dedifferentiated fat cell-derived micromass pellets contributed to cartilage repair in the rat osteochondral defect modelJ Orthop Sci. Jul,2018 | Pubmed ID: 29571958Application of CRISPR/Cas9 Genome Editing Technology for the Improvement of Crops Cultivated in Tropical Climates: Recent Progress, Prospects, and ChallengesFront Plant Sci. May,2018 | Pubmed ID: 29868073Cancer whole-genome sequencing: present and futureOncogene. Dec,2015 | Pubmed ID: 25823020Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancerOncotarget. May,2018 | Pubmed ID: 29899848Whole mount immunolabeling of olfactory receptor neurons in the Drosophila antennaJ Vis Exp. May,2014 | Pubmed ID: 24834898An Efficient Method to Obtain Dedifferentiated Fat CellsJ Vis Exp. Jul,2016 | Pubmed ID: 27500409Imaging of Cell Shape Alteration and Cell Movement in Drosophila Gastrulation Using DE-cadherin Reporter Transgenic FliesJ Vis Exp. Dec,2016 | Pubmed ID: 28060321Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial ScaffoldJ Vis Exp. Oct,2018 | Pubmed ID: 30417883Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouseAndrology. Feb,2019 | Pubmed ID: 30793514 Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements Through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men International Journal of Molecular Sciences. 03, 2018 | Pubmed ID: 29494521 Possible Roles of the Transcription Factor Nrf1 (NFE2L1) in Neural Homeostasis by Regulating the Gene Expression of Deubiquitinating Enzymes Biochemical and Biophysical Research Communications. Jan, 2017 | Pubmed ID: 28088524 USP15 Stabilizes the Transcription Factor Nrf1 in the Nucleus, Promoting the Proteasome Gene Expression Biochemical and Biophysical Research Communications. Sep, 2016 | Pubmed ID: 27416755 Erratum: Whole-genome Mutational Landscape and Characterization of Noncoding and Structural Mutations in Liver Cancer Nature Genetics. May, 2016 | Pubmed ID: 27230686 Systematic Analysis of Mutation Distribution in Three Dimensional Protein Structures Identifies Cancer Driver Genes Scientific Reports. Month, 2016 | Pubmed ID: 27225414 Whole-genome Mutational Landscape and Characterization of Noncoding and Structural Mutations in Liver Cancer Nature Genetics. May, 2016 | Pubmed ID: 27064257 Selective Autophagic Receptor P62 Regulates the Abundance of Transcriptional Coregulator ARIP4 During Nutrient Starvation Scientific Reports. Month, 2015 | Pubmed ID: 26412716 Constitutive Activation of Drosophila CncC Transcription Factor Reduces Lipid Formation in the Fat Body Biochemical and Biophysical Research Communications. Aug, 2015 | Pubmed ID: 26049108 Inhibitory Mechanism of FAT4 Gene Expression in Response to Actin Dynamics During Src-induced Carcinogenesis PloS One. Month, 2015 | Pubmed ID: 25679223 Chromatin Regulators in Neurodevelopment and Disease: Analysis of Fly Neural Circuits Provides Insights: Networks of Chromatin Regulators and Transcription Factors Underlie Drosophila Neurogenesis and Cognitive Defects in Intellectual Disability and Neuropsychiatric Disorder Models BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Sep, 2014 | Pubmed ID: 25067789 The Casein Kinase 2-nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression Molecular and Cellular Biology. Sep, 2013 | Pubmed ID: 23816881 Chromatin Modification of Notch Targets in Olfactory Receptor Neuron Diversification Nature Neuroscience. Month, 2011 | Pubmed ID: 22197833 The Efficacy of IGF-I Receptor Monoclonal Antibody Against Human Gastrointestinal Carcinomas is Independent of K-ras Mutation Status Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21642381 Co-expression of Laminin β3 and γ2 Chains and Epigenetic Inactivation of Laminin α3 Chain in Gastric Cancer International Journal of Oncology. Sep, 2011 | Pubmed ID: 21617852 Epigenetic Inactivation of Calcium-sensing Receptor in Colorectal Carcinogenesis Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jun, 2011 | Pubmed ID: 21317879 Serum Resistin Levels and Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention Journal of Atherosclerosis and Thrombosis. Month, 2011 | Pubmed ID: 21071880 Lipopolysaccharide-activated Alveolar Macrophages Having Cytotoxicity Toward Lung Tumor Cells Through Cell-to-cell Binding-dependent Mechanism Anticancer Research. Aug, 2010 | Pubmed ID: 20871035 Cytotoxic Effects of Activated Alveolar Macrophages on Lung Carcinoma Cells Via Cell-to-cell Contact and Nitric Oxide Anticancer Research. Aug, 2010 | Pubmed ID: 20871032 Antitumor Effect of Inhalatory Lipopolysaccharide and Synergetic Effect in Combination with Cyclophosphamide Anticancer Research. Aug, 2010 | Pubmed ID: 20871031 Association of Glypican-3 Expression with Growth Signaling Molecules in Hepatocellular Carcinoma World Journal of Gastroenterology. Jul, 2010 | Pubmed ID: 20653060 Epidermal Growth Factor Receptor is an Obligatory Intermediate for Oxytocin-induced Cyclooxygenase 2 Expression and Prostaglandin F2 Alpha Production in Bovine Endometrial Epithelial Cells Endocrinology. Mar, 2010 | Pubmed ID: 20080869 The Expression of the Nuclear Receptors NR5A1 and NR5A2 and Transcription Factor GATA6 Correlates with Steroidogenic Gene Expression in the Bovine Corpus Luteum Molecular Reproduction and Development. Sep, 2009 | Pubmed ID: 19455657 The Effect of Human GATA4 Gene Mutations on the Activity of Target Gonadal Promoters Journal of Molecular Endocrinology. Feb, 2009 | Pubmed ID: 19008335 A GATA4/WT1 Cooperation Regulates Transcription of Genes Required for Mammalian Sex Determination and Differentiation BMC Molecular Biology. Month, 2008 | Pubmed ID: 18445271 LRH-1/NR5A2 Cooperates with GATA Factors to Regulate Inhibin Alpha-subunit Promoter Activity Molecular and Cellular Endocrinology. Sep, 2006 | Pubmed ID: 16893604 Protein Kinase A-dependent Synergism Between GATA Factors and the Nuclear Receptor, Liver Receptor Homolog-1, Regulates Human Aromatase (CYP19) PII Promoter Activity in Breast Cancer Cells Endocrinology. Nov, 2005 | Pubmed ID: 16109788 GATA Factors and the Nuclear Receptors, Steroidogenic Factor 1/liver Receptor Homolog 1, Are Key Mutual Partners in the Regulation of the Human 3beta-hydroxysteroid Dehydrogenase Type 2 Promoter Molecular Endocrinology (Baltimore, Md.). Sep, 2005 | Pubmed ID: 15928316 Role of the GATA Family of Transcription Factors in Andrology Journal of Andrology. Jul-Aug, 2004 | Pubmed ID: 15223831 Fas-Fas Ligand System Mediates Luteal Cell Death in Bovine Corpus Luteum Biology of Reproduction. Mar, 2002 | Pubmed ID: 11870083 The Lipoxygenase Pathways Are Involved in LH-stimulated Progesterone Production in Bovine Corpus Luteum Prostaglandins & Other Lipid Mediators. Jan, 2002 | Pubmed ID: 11789897 使用P19胚胎癌细胞的神经发生 Paweł Leszczyński1, Magdalena Śmiech1, Aamir S. Teeli1, Aleksandra Zołocińska2, Anna Słysz2, Zygmunt Pojda2, Mariusz Pierzchała3, Hiroaki Taniguchi1 1Department of Experimental Embryology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, 2Department of Regenerative Medicine, Maria Skłodowska-Curie Institute - Oncology Center, 3Department of Genomics and Biodiversities, Institute of Genetics and Animal Breeding, Polish Academy of Sciences JoVE 58225 Developmental Biology 操纵活细胞构建稳定的3D 蜂窝组件, 无需人工支架 Takehiro Yamazaki*1, Hiroaki Taniguchi*2, Shoto Tsuji1, Shiho Sato1, Takahiro Kenmotsu1, Kenichi Yoshikawa1, Koichiro Sadakane1 1Faculty of Life and Medical Sciences, Doshisha University, 2The Institute of Genetics and Animal Breeding, Polish Academy of Sciences JoVE 57815 Biochemistry A蛋白制备方法在蛋白质与核余子交互使用LC-MS / MS分析的高通量鉴定 Megumi Tsuchiya*1, M. Rezaul Karim*2, Taro Matsumoto3, Hidesato Ogawa1, Hiroaki Taniguchi3,4,5 1Graduate School of Frontier Biosciences, Osaka University, 2Department of Biotechnology and Genetic Engineering, Jahangirnagar University, 3Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University, 4Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 5Graduate School of Life and Medical Sciences, Doshisha University JoVE 55077 Biochemistry 细胞形态改变与细胞运动的影像 M. Rezaul Karim1, Tomohiro Haruta2, Taro Matsumoto3, Hiroki Oda2, Hiroaki Taniguchi3,4,5 1Biotechnology and Genetic Engineering Department, Jahangirnagar University, 2JT Biohistory Research Hall, 3Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University, 4Graduate School of Life and Medical Sciences, Doshisha University, 5Institute of Genetics and Animal Breeding of the Polish Academy of Sciences Developmental Biology 一个有效的方法获取反分化脂肪细胞 Hiroaki Taniguchi*1, Tomohiko Kazama*1, Kazuhiro Hagikura*1, Chii Yamamoto1, Minako Kazama1, Yuki Nagaoka1, Taro Matsumoto1 1Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University Developmental Biology 嗅觉受体神经元在全山免疫标记 M. Rezaul Karim1, Keita Endo2, Adrian W Moore3, Hiroaki Taniguchi1 1Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, 2Laboratory for Circuit Mechanisms of Sensory Perception, RIKEN Brain Science Institute, 3Disease Mechanism Research Core, RIKEN Brain Science Institute Neuroscience
使用P19胚胎癌细胞的神经发生 Paweł Leszczyński1, Magdalena Śmiech1, Aamir S. Teeli1, Aleksandra Zołocińska2, Anna Słysz2, Zygmunt Pojda2, Mariusz Pierzchała3, Hiroaki Taniguchi1 1Department of Experimental Embryology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, 2Department of Regenerative Medicine, Maria Skłodowska-Curie Institute - Oncology Center, 3Department of Genomics and Biodiversities, Institute of Genetics and Animal Breeding, Polish Academy of Sciences JoVE 58225 Developmental Biology
操纵活细胞构建稳定的3D 蜂窝组件, 无需人工支架 Takehiro Yamazaki*1, Hiroaki Taniguchi*2, Shoto Tsuji1, Shiho Sato1, Takahiro Kenmotsu1, Kenichi Yoshikawa1, Koichiro Sadakane1 1Faculty of Life and Medical Sciences, Doshisha University, 2The Institute of Genetics and Animal Breeding, Polish Academy of Sciences JoVE 57815 Biochemistry
A蛋白制备方法在蛋白质与核余子交互使用LC-MS / MS分析的高通量鉴定 Megumi Tsuchiya*1, M. Rezaul Karim*2, Taro Matsumoto3, Hidesato Ogawa1, Hiroaki Taniguchi3,4,5 1Graduate School of Frontier Biosciences, Osaka University, 2Department of Biotechnology and Genetic Engineering, Jahangirnagar University, 3Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University, 4Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 5Graduate School of Life and Medical Sciences, Doshisha University JoVE 55077 Biochemistry
细胞形态改变与细胞运动的影像 M. Rezaul Karim1, Tomohiro Haruta2, Taro Matsumoto3, Hiroki Oda2, Hiroaki Taniguchi3,4,5 1Biotechnology and Genetic Engineering Department, Jahangirnagar University, 2JT Biohistory Research Hall, 3Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University, 4Graduate School of Life and Medical Sciences, Doshisha University, 5Institute of Genetics and Animal Breeding of the Polish Academy of Sciences Developmental Biology
一个有效的方法获取反分化脂肪细胞 Hiroaki Taniguchi*1, Tomohiko Kazama*1, Kazuhiro Hagikura*1, Chii Yamamoto1, Minako Kazama1, Yuki Nagaoka1, Taro Matsumoto1 1Division of Cell Regeneration and Transplantation, School of Medicine, Nihon University Developmental Biology
嗅觉受体神经元在全山免疫标记 M. Rezaul Karim1, Keita Endo2, Adrian W Moore3, Hiroaki Taniguchi1 1Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, 2Laboratory for Circuit Mechanisms of Sensory Perception, RIKEN Brain Science Institute, 3Disease Mechanism Research Core, RIKEN Brain Science Institute Neuroscience
