Hugo J. Bellen Program in Developmental Biology Baylor College of Medicine Biography Publications Institution JoVE Articles Hugo J. Bellen has not added a biography. If you are Hugo J. Bellen and would like to personalize this page please email our Author Liaison for assistance. Publications Cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis Cell Reports. Aug, 2019 | Pubmed ID: 31412248 De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia American Journal of Human Genetics. Aug, 2019 | Pubmed ID: 31327508 The Fruit Fly at the Interface of Diagnosis and Pathogenic Mechanisms of Rare and Common Human Diseases Human Molecular Genetics. Jun, 2019 | Pubmed ID: 31227826 Loss of Proteins Associated with Amyotrophic Lateral Sclerosis Affects Lysosomal Acidification Via Different Routes Autophagy. Aug, 2019 | Pubmed ID: 31032688 Ubiquilins Regulate Autophagic Flux Through MTOR Signalling and Lysosomal Acidification Nature Cell Biology. 03, 2019 | Pubmed ID: 30804504 VAMP Associated Proteins Are Required for Autophagic and Lysosomal Degradation by Promoting a PtdIns4P-mediated Endosomal Pathway Autophagy. Jul, 2019 | Pubmed ID: 30741620 Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism Trends in Endocrinology and Metabolism: TEM. 02, 2019 | Pubmed ID: 30528460 Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis Cell. Dec, 2018 | Pubmed ID: 30550790 Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins Neuron. 12, 2018 | Pubmed ID: 30467080 Interactions Between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits Neuron. 12, 2018 | Pubmed ID: 30467079 Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease The New England Journal of Medicine. 11, 2018 | Pubmed ID: 30304647 Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts American Journal of Human Genetics. 10, 2018 | Pubmed ID: 30290152 An Expanded Toolkit for Gene Tagging Based on MiMIC and Scarless CRISPR Tagging in ELife. 08, 2018 | Pubmed ID: 30091705 IRF2BPL Is Associated with Neurological Phenotypes American Journal of Human Genetics. 08, 2018 | Pubmed ID: 30057031 The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders Cell. 07, 2018 | Pubmed ID: 30053424 Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain Cell Metabolism. 10, 2018 | Pubmed ID: 29909971 Using to Study Mechanisms of Hereditary Hearing Loss Disease Models & Mechanisms. 05, 2018 | Pubmed ID: 29853544 Visual Impairment and Progressive Phthisis Bulbi Caused by Recessive Pathogenic Variant in MARK3 Human Molecular Genetics. May, 2018 | Pubmed ID: 29771303 Functional Variants in TBX2 Are Associated with a Syndromic Cardiovascular and Skeletal Developmental Disorder Human Molecular Genetics. 07, 2018 | Pubmed ID: 29726930 Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms Developmental Cell. 04, 2018 | Pubmed ID: 29689197 A Gene-specific Library for ELife. 03, 2018 | Pubmed ID: 29565247 The Expanding Neurological Phenotype of DNM1L-related Disorders Brain : a Journal of Neurology. 04, 2018 | Pubmed ID: 29529134 Biallelic Mutations in ATP5F1D, Which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder American Journal of Human Genetics. Mar, 2018 | Pubmed ID: 29478781 A Kinase-dependent Feedforward Loop Affects CREBB Stability and Long Term Memory Formation ELife. 02, 2018 | Pubmed ID: 29473541 Pleiotropic Neuropathological and Biochemical Alterations Associated with Myo5a Mutation in a Rat Model Brain Research. 01, 2018 | Pubmed ID: 29217155 Genetic Strategies to Tackle Neurological Diseases in Fruit Flies Current Opinion in Neurobiology. 06, 2018 | Pubmed ID: 29128849 The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission Cell Reports. 12, 2017 | Pubmed ID: 29281828 Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila Genetics. Oct, 2017 | Pubmed ID: 28978772 The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia Via APOE/D Cell Metabolism. Nov, 2017 | Pubmed ID: 28965825 Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research Genetics. 09, 2017 | Pubmed ID: 28874452 Clinically Severe CACNA1A Alleles Affect Synaptic Function and Neurodegeneration Differentially PLoS Genetics. Jul, 2017 | Pubmed ID: 28742085 Peroxisomal Biogenesis is Genetically and Biochemically Linked to Carbohydrate Metabolism in Drosophila and Mouse PLoS Genetics. Jun, 2017 | Pubmed ID: 28640802 Building Dialogues Between Clinical and Biomedical Research Through Cross-species Collaborations Seminars in Cell & Developmental Biology. 10, 2017 | Pubmed ID: 28579453 Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages Cell Host & Microbe. Jun, 2017 | Pubmed ID: 28579255 A Cell Cycle-independent, Conditional Gene Inactivation Strategy for Differentially Tagging Wild-type and Mutant Cells ELife. 05, 2017 | Pubmed ID: 28561736 MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome American Journal of Human Genetics. Jun, 2017 | Pubmed ID: 28502612 Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models Scientific Reports. 01, 2017 | Pubmed ID: 28112163 Amyotrophic Lateral Sclerosis Pathogenesis Converges on Defects in Protein Homeostasis Associated with TDP-43 Mislocalization and Proteasome-Mediated Degradation Overload Current Topics in Developmental Biology. 2017 | Pubmed ID: 28057298 Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes MTORC1 Activation and Neurodegeneration Neuron. Jan, 2017 | Pubmed ID: 28017472 A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3 American Journal of Human Genetics. Jan, 2017 | Pubmed ID: 28017372 Loss of Frataxin Activates the Iron/sphingolipid/PDK1/Mef2 Pathway in Mammals ELife. 11, 2016 | Pubmed ID: 27901468 Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease PLoS Genetics. Oct, 2016 | Pubmed ID: 27764101 Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes American Journal of Human Genetics. Oct, 2016 | Pubmed ID: 27640307 Loss of Frataxin Induces Iron Toxicity, Sphingolipid Synthesis, and Pdk1/Mef2 Activation, Leading to Neurodegeneration ELife. 06, 2016 | Pubmed ID: 27343351 Uncoupling Neuronal Death and Dysfunction in Drosophila Models of Neurodegenerative Disease Acta Neuropathologica Communications. 06, 2016 | Pubmed ID: 27338814 The E3 Ligase Ubr3 Regulates Usher Syndrome and MYH9 Disorder Proteins in the Auditory Organs of Drosophila and Mammals ELife. 06, 2016 | Pubmed ID: 27331610 NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies PLoS Biology. 06, 2016 | Pubmed ID: 27254664 Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 Through Poly-ubiquitination PLoS Genetics. 05, 2016 | Pubmed ID: 27195754 Drosophila Tools and Assays for the Study of Human Diseases Disease Models & Mechanisms. Mar, 2016 | Pubmed ID: 26935102 Missense Variants in the Middle Domain of DNM1L in Cases of Infantile Encephalopathy Alter Peroxisomes and Mitochondria when Assayed in Drosophila Human Molecular Genetics. 05, 2016 | Pubmed ID: 26931468 WAC Regulates MTOR Activity by Acting As an Adaptor for the TTT and Pontin/Reptin Complexes Developmental Cell. Jan, 2016 | Pubmed ID: 26812014 Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins Cell. Dec, 2015 | Pubmed ID: 26687361 Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila Cell. Dec, 2015 | Pubmed ID: 26687360 Morgan's Legacy: Fruit Flies and the Functional Annotation of Conserved Genes Cell. Sep, 2015 | Pubmed ID: 26406362 Increased COUP-TFII Expression in Adult Hearts Induces Mitochondrial Dysfunction Resulting in Heart Failure Nature Communications. 2015 | Pubmed ID: 26356605 FlyVar: a Database for Genetic Variation in Drosophila Melanogaster Database : the Journal of Biological Databases and Curation. 2015 | Pubmed ID: 26289428 BIOSAFETY. Safeguarding Gene Drive Experiments in the Laboratory Science (New York, N.Y.). Aug, 2015 | Pubmed ID: 26229113 The Retromer Complex in Development and Disease Development (Cambridge, England). Jul, 2015 | Pubmed ID: 26199408 Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress PLoS Biology. Jul, 2015 | Pubmed ID: 26176594 A Genetic Toolkit for Tagging Intronic MiMIC Containing Genes ELife. Jun, 2015 | Pubmed ID: 26102525 A Library of MiMICs Allows Tagging of Genes and Reversible, Spatial and Temporal Knockdown of Proteins in Drosophila ELife. Mar, 2015 | Pubmed ID: 25824290 A Voltage-gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and is Required for Neuronal Homeostasis PLoS Biology. Mar, 2015 | Pubmed ID: 25811491 Huntingtin Functions As a Scaffold for Selective Macroautophagy Nature Cell Biology. Mar, 2015 | Pubmed ID: 25686248 Fruit Flies in Biomedical Research Genetics. Mar, 2015 | Pubmed ID: 25624315 Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration Cell. Jan, 2015 | Pubmed ID: 25594180 A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission Neuron. Nov, 2014 | Pubmed ID: 25451193 Survival of the Fittest Tools Genetics. Oct, 2014 | Pubmed ID: 25316776 Mitochondrial Fusion but Not Fission Regulates Larval Growth and Synaptic Development Through Steroid Hormone Production ELife. Oct, 2014 | Pubmed ID: 25313867 A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases Cell. Sep, 2014 | Pubmed ID: 25259927 Large-scale Identification of Chemically Induced Mutations in Drosophila Melanogaster Genome Research. Oct, 2014 | Pubmed ID: 25258387 Introduction to Notch Signaling Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25053477 A Mitocentric View of Parkinson's Disease Annual Review of Neuroscience. 2014 | Pubmed ID: 24821430 The Retromer Complex is Required for Rhodopsin Recycling and Its Loss Leads to Photoreceptor Degeneration PLoS Biology. Apr, 2014 | Pubmed ID: 24781186 Shared Mechanisms Between Drosophila Peripheral Nervous System Development and Human Neurodegenerative Diseases Current Opinion in Neurobiology. Aug, 2014 | Pubmed ID: 24762652 Chemical Mutagens, Transposons, and Transgenes to Interrogate Gene Function in Drosophila Melanogaster Methods (San Diego, Calif.). Jun, 2014 | Pubmed ID: 24583113 Drosophila Tempura, a Novel Protein Prenyltransferase α Subunit, Regulates Notch Signaling Via Rab1 and Rab11 PLoS Biology. Jan, 2014 | Pubmed ID: 24492843 The Amyotrophic Lateral Sclerosis 8 Protein, VAP, is Required for ER Protein Quality Control Human Molecular Genetics. Apr, 2014 | Pubmed ID: 24271015 MiR-9a Minimizes the Phenotypic Impact of Genomic Diversity by Buffering a Transcription Factor Cell. Dec, 2013 | Pubmed ID: 24360277 VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis Elegans PLoS Genetics. 2013 | Pubmed ID: 24039594 Rhodopsin Homeostasis and Retinal Degeneration: Lessons from the Fly Trends in Neurosciences. Nov, 2013 | Pubmed ID: 24012059 NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors Trends in Neurosciences. Nov, 2013 | Pubmed ID: 23968695 Protein Phosphatase 1ß Limits Ring Canal Constriction During Drosophila Germline Cyst Formation PloS One. 2013 | Pubmed ID: 23936219 Drosophila EHBP1 Regulates Scabrous Secretion During Notch-mediated Lateral Inhibition Journal of Cell Science. Aug, 2013 | Pubmed ID: 23788431 The C8ORF38 Homologue Sicily is a Cytosolic Chaperone for a Mitochondrial Complex I Subunit The Journal of Cell Biology. Mar, 2013 | Pubmed ID: 23509070 The Dynamin-binding Domains of Dap160/intersectin Affect Bulk Membrane Retrieval in Synapses Journal of Cell Science. Feb, 2013 | Pubmed ID: 23321638 Crag is a GEF for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells PLoS Biology. 2012 | Pubmed ID: 23226104 A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands Science (New York, N.Y.). Nov, 2012 | Pubmed ID: 23197537 An Assay to Detect in Vivo Y Chromosome Loss in Drosophila Wing Disc Cells G3 (Bethesda, Md.). Sep, 2012 | Pubmed ID: 22973547 Spectraplakins Promote Microtubule-mediated Axonal Growth by Functioning As Structural Microtubule-associated Proteins and EB1-dependent +TIPs (tip Interacting Proteins) The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2012 | Pubmed ID: 22764224 Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans PLoS Biology. 2012 | Pubmed ID: 22448145 Genome-wide Manipulations of Drosophila Melanogaster with Transposons, Flp Recombinase, and ΦC31 Integrase Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22367874 Secreted VAPB/ALS8 Major Sperm Protein Domains Modulate Mitochondrial Localization and Morphology Via Growth Cone Guidance Receptors Developmental Cell. Feb, 2012 | Pubmed ID: 22264801 DEHBP1 Controls Exocytosis and Recycling of Delta During Asymmetric Divisions The Journal of Cell Biology. Jan, 2012 | Pubmed ID: 22213802 Stringent Analysis of Gene Function and Protein-Protein Interactions Using Fluorescently Tagged Genes Genetics. Dec, 2011 | Pubmed ID: 22174071 Dueling Ca2+ Sensors in Neurotransmitter Release Cell. Oct, 2011 | Pubmed ID: 22036557 Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly Neuron. Oct, 2011 | Pubmed ID: 22017985 MiMIC: a Highly Versatile Transposon Insertion Resource for Engineering Drosophila Melanogaster Genes Nature Methods. Sep, 2011 | Pubmed ID: 21985007 Drosophila P Elements Preferentially Transpose to Replication Origins Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21896744 Drosophila Ten-m and Filamin Affect Motor Neuron Growth Cone Guidance PloS One. 2011 | Pubmed ID: 21857973 Rich Regulates Target Specificity of Photoreceptor Cells and N-cadherin Trafficking in the Drosophila Visual System Via Rab6 Neuron. Aug, 2011 | Pubmed ID: 21835342 The Drosophila Gene Disruption Project: Progress Using Transposons with Distinctive Site Specificities Genetics. Jul, 2011 | Pubmed ID: 21515576 The BMP Signaling Pathway at the Drosophila Neuromuscular Junction and Its Links to Neurodegenerative Diseases Current Opinion in Neurobiology. Feb, 2011 | Pubmed ID: 20832291 A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 As an Evolutionarily Conserved Pain Gene Cell. Nov, 2010 | Pubmed ID: 21074052 A Molecularly Defined Duplication Set for the X Chromosome of Drosophila Melanogaster Genetics. Dec, 2010 | Pubmed ID: 20876565 Endocytosis and Intracellular Trafficking of Notch and Its Ligands Current Topics in Developmental Biology. 2010 | Pubmed ID: 20816395 100 Years of Drosophila Research and Its Impact on Vertebrate Neuroscience: a History Lesson for the Future Nature Reviews. Neuroscience. Jul, 2010 | Pubmed ID: 20383202 Cell Adhesion, the Backbone of the Synapse: "vertebrate" and "invertebrate" Perspectives Cold Spring Harbor Perspectives in Biology. Oct, 2009 | Pubmed ID: 20066100 Rab3 GTPase Lands Bruchpilot Neuron. Dec, 2009 | Pubmed ID: 20005815 Tilting the Balance Between Facilitatory and Inhibitory Functions of Mammalian and Drosophila Complexins Orchestrates Synaptic Vesicle Exocytosis Neuron. Nov, 2009 | Pubmed ID: 19914185 A Synaptic Vesicle-associated Ca2+ Channel Promotes Endocytosis and Couples Exocytosis to Endocytosis Cell. Sep, 2009 | Pubmed ID: 19737521 Tweek, an Evolutionarily Conserved Protein, is Required for Synaptic Vesicle Recycling Neuron. Jul, 2009 | Pubmed ID: 19640479 The Drosophila Deoxyhypusine Hydroxylase Homologue Nero and Its Target EIF5A Are Required for Cell Growth and the Regulation of Autophagy The Journal of Cell Biology. Jun, 2009 | Pubmed ID: 19546244 The Arp2/3 Complex and WASp Are Required for Apical Trafficking of Delta into Microvilli During Cell Fate Specification of Sensory Organ Precursors Nature Cell Biology. Jul, 2009 | Pubmed ID: 19543274 A Novel Neuronal Pathway for Visually Guided Escape in Drosophila Melanogaster Journal of Neurophysiology. Aug, 2009 | Pubmed ID: 19474177 Versatile P[acman] BAC Libraries for Transgenesis Studies in Drosophila Melanogaster Nature Methods. Jun, 2009 | Pubmed ID: 19465919 Sequoia Regulates Cell Fate Decisions in the External Sensory Organs of Adult Drosophila EMBO Reports. Jun, 2009 | Pubmed ID: 19444309 Importin 13 Regulates Neurotransmitter Release at the Drosophila Neuromuscular Junction The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19403829 A Notch Updated The Journal of Cell Biology. Mar, 2009 | Pubmed ID: 19255248 Ero1L, a Thiol Oxidase, is Required for Notch Signaling Through Cysteine Bridge Formation of the Lin12-Notch Repeats in Drosophila Melanogaster The Journal of Cell Biology. Sep, 2008 | Pubmed ID: 18809725 The Amyotrophic Lateral Sclerosis 8 Protein VAPB is Cleaved, Secreted, and Acts As a Ligand for Eph Receptors Cell. Jun, 2008 | Pubmed ID: 18555774 Straightjacket is Required for the Synaptic Stabilization of Cacophony, a Voltage-gated Calcium Channel Alpha1 Subunit The Journal of Cell Biology. Apr, 2008 | Pubmed ID: 18391075 NAD Synthase NMNAT Acts As a Chaperone to Protect Against Neurodegeneration Nature. Apr, 2008 | Pubmed ID: 18344983 Rumi is a CAP10 Domain Glycosyltransferase That Modifies Notch and is Required for Notch Signaling Cell. Jan, 2008 | Pubmed ID: 18243100 Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-length Huntingtin Accumulating in the Cytoplasm Neuron. Jan, 2008 | Pubmed ID: 18184562 V-ATPase V0 Sector Subunit A1 in Neurons is a Target of Calmodulin The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17933871 Huntingtin-interacting Protein 14, a Palmitoyl Transferase Required for Exocytosis and Targeting of CSP to Synaptic Vesicles The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18158335 Transgenesis Upgrades for Drosophila Melanogaster Development (Cambridge, England). Oct, 2007 | Pubmed ID: 17905790 Eps15 and Dap160 Control Synaptic Vesicle Membrane Retrieval and Synapse Development The Journal of Cell Biology. Jul, 2007 | Pubmed ID: 17620409 Thirty-one Flavors of Drosophila Rab Proteins Genetics. Jun, 2007 | Pubmed ID: 17409086 P[acman]: a BAC Transgenic Platform for Targeted Insertion of Large DNA Fragments in D. Melanogaster Science (New York, N.Y.). Dec, 2006 | Pubmed ID: 17138868 Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity PLoS Biology. Nov, 2006 | Pubmed ID: 17132048 Activity-independent Prespecification of Synaptic Partners in the Visual Map of Drosophila Current Biology : CB. Sep, 2006 | Pubmed ID: 16979562 Senseless Physically Interacts with Proneural Proteins and Functions As a Transcriptional Co-activator Development (Cambridge, England). May, 2006 | Pubmed ID: 16624856 Internalization is Required for Proper Wingless Signaling in Drosophila Melanogaster The Journal of Cell Biology. Apr, 2006 | Pubmed ID: 16606693 Senseless and Daughterless Confer Neuronal Identity to Epithelial Cells in the Drosophila Wing Margin Development (Cambridge, England). May, 2006 | Pubmed ID: 16554363 The Nicotinic Acetylcholine Receptor Dalpha7 is Required for an Escape Behavior in Drosophila PLoS Biology. Mar, 2006 | Pubmed ID: 16494528 Fighting Anthrax with Flies Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16492749 Gfi1 Functions Downstream of Math1 to Control Intestinal Secretory Cell Subtype Allocation and Differentiation Genes & Development. Oct, 2005 | Pubmed ID: 16230531 Sec15 Interacts with Rab11 Via a Novel Domain and Affects Rab11 Localization in Vivo Nature Structural & Molecular Biology. Oct, 2005 | Pubmed ID: 16155582 Sec15, a Component of the Exocyst, Promotes Notch Signaling During the Asymmetric Division of Drosophila Sensory Organ Precursors Developmental Cell. Sep, 2005 | Pubmed ID: 16137928 The AXH Domain of Ataxin-1 Mediates Neurodegeneration Through Its Interaction with Gfi-1/Senseless Proteins Cell. Aug, 2005 | Pubmed ID: 16122429 Synaptic Mitochondria Are Critical for Mobilization of Reserve Pool Vesicles at Drosophila Neuromuscular Junctions Neuron. Aug, 2005 | Pubmed ID: 16055061 Aberrant Lysosomal Carbohydrate Storage Accompanies Endocytic Defects and Neurodegeneration in Drosophila Benchwarmer The Journal of Cell Biology. Jul, 2005 | Pubmed ID: 15998804 The V-ATPase V0 Subunit A1 is Required for a Late Step in Synaptic Vesicle Exocytosis in Drosophila Cell. May, 2005 | Pubmed ID: 15907473 Mutations in Drosophila Sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components Neuron. Apr, 2005 | Pubmed ID: 15848801 Emerging Technologies for Gene Manipulation in Drosophila Melanogaster Nature Reviews. Genetics. Mar, 2005 | Pubmed ID: 15738961 Gfi/Pag-3/senseless Zinc Finger Proteins: a Unifying Theme? Molecular and Cellular Biology. Oct, 2004 | Pubmed ID: 15456856 The Architecture of the Active Zone in the Presynaptic Nerve Terminal Physiology (Bethesda, Md.). Oct, 2004 | Pubmed ID: 15381754 Dap160/intersectin Acts As a Stabilizing Scaffold Required for Synaptic Development and Vesicle Endocytosis Neuron. Jul, 2004 | Pubmed ID: 15260956 The BDGP Gene Disruption Project: Single Transposon Insertions Associated with 40% of Drosophila Genes Genetics. Jun, 2004 | Pubmed ID: 15238527 Hugo J. Bellen Current Biology : CB. Mar, 2004 | Pubmed ID: 15043825 The Ins and Outs of Wingless Signaling Trends in Cell Biology. Jan, 2004 | Pubmed ID: 14729180 Senseless Acts As a Binary Switch During Sensory Organ Precursor Selection Genes & Development. Dec, 2003 | Pubmed ID: 14665671 Synaptojanin is Recruited by Endophilin to Promote Synaptic Vesicle Uncoating Neuron. Nov, 2003 | Pubmed ID: 14622578 Mapping Drosophila Mutations with Molecularly Defined P Element Insertions Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 12960394 Quantitative Analysis of Bristle Number in Drosophila Mutants Identifies Genes Involved in Neural Development Current Biology : CB. Aug, 2003 | Pubmed ID: 12932322 Synaptotagmin I, a Ca2+ Sensor for Neurotransmitter Release Trends in Neurosciences. Aug, 2003 | Pubmed ID: 12900172 The Zinc Finger Transcription Factor Gfi1, Implicated in Lymphomagenesis, is Required for Inner Ear Hair Cell Differentiation and Survival Development (Cambridge, England). Jan, 2003 | Pubmed ID: 12441305 Drosophila Atonal Fully Rescues the Phenotype of Math1 Null Mice: New Functions Evolve in New Cellular Contexts Current Biology : CB. Sep, 2002 | Pubmed ID: 12372255 Drosophila VAP-33A Directs Bouton Formation at Neuromuscular Junctions in a Dosage-dependent Manner Neuron. Jul, 2002 | Pubmed ID: 12160747 Meaningless Minis? Mechanisms of Neurotransmitter-receptor Clustering Trends in Neurosciences. Aug, 2002 | Pubmed ID: 12127745 When Cell Biology Meets Development: Endocytic Regulation of Signaling Pathways Genes & Development. Jun, 2002 | Pubmed ID: 12050111 Drosophila Crumbs is a Positional Cue in Photoreceptor Adherens Junctions and Rhabdomeres Nature. Mar, 2002 | Pubmed ID: 11850624 Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila Cell. Jan, 2002 | Pubmed ID: 11832215 Mapping and Identification of Essential Gene Functions on the X Chromosome of Drosophila EMBO Reports. Jan, 2002 | Pubmed ID: 11751581 Bonus, a Drosophila Homolog of TIF1 Proteins, Interacts with Nuclear Receptors and Can Inhibit BetaFTZ-F1-dependent Transcription Molecular Cell. Apr, 2001 | Pubmed ID: 11336699 Untying the Gordian Knot of Cytokinesis. Role of Small G Proteins and Their Regulators The Journal of Cell Biology. Mar, 2000 | Pubmed ID: 10704435 A Putative Exchange Factor for Rho1 GTPase is Required for Initiation of Cytokinesis in Drosophila Genes & Development. Sep, 1999 | Pubmed ID: 10485851 Pavarotti Encodes a Kinesin-like Protein Required to Organize the Central Spindle and Contractile Ring for Cytokinesis Genes & Development. May, 1998 | Pubmed ID: 9585508 Deciphering the Function of Neurexins at Cellular Junctions The Journal of Cell Biology. May, 1997 | Pubmed ID: 9151682 Primordium Specific Requirement of the Homeotic Gene Fork Head in the Developing Gut of the Drosophila Embryo Roux's Archives of Developmental Biology : the Official Organ of the EDBO. Nov, 1989 | Pubmed ID: 28305483 İnsan Genomik ve Model Organizma Genetiği Bilgilerini Entegre Eden Web Tabanlı Bir Araç olan MARRVEL'de Gezinme Julia Wang1,2, Zhandong Liu3,4, Hugo J. Bellen1,4,5,6,7, Shinya Yamamoto1,4,5,6 1Program in Developmental Biology, Baylor College of Medicine, 2Medical Scientist Training Program, Baylor College of Medicine, 3Department of Pediatrics, Baylor College of Medicine, 4Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, 5Department of Molecular and Human Genetics, Baylor College of Medicine, 6Department of Neuroscience, Baylor College of Medicine, 7Howard Hughes Medical Institute, Baylor College of Medicine JoVE 59542 Genetics
İnsan Genomik ve Model Organizma Genetiği Bilgilerini Entegre Eden Web Tabanlı Bir Araç olan MARRVEL'de Gezinme Julia Wang1,2, Zhandong Liu3,4, Hugo J. Bellen1,4,5,6,7, Shinya Yamamoto1,4,5,6 1Program in Developmental Biology, Baylor College of Medicine, 2Medical Scientist Training Program, Baylor College of Medicine, 3Department of Pediatrics, Baylor College of Medicine, 4Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, 5Department of Molecular and Human Genetics, Baylor College of Medicine, 6Department of Neuroscience, Baylor College of Medicine, 7Howard Hughes Medical Institute, Baylor College of Medicine JoVE 59542 Genetics