Jacqueline Cloos Department of Hematology VU University Medical Center Biography Publications Institution JoVE Articles Jacqueline Cloos has not added a biography. If you are Jacqueline Cloos and would like to personalize this page please email our Author Liaison for assistance. Publications Proteasome Inhibition and Mechanism of Resistance to a Synthetic, Library-based Hexapeptide Investigational New Drugs. Feb, 2018 | Pubmed ID: 29442210 Minimal/measurable Residual Disease in AML: Consensus Document from ELN MRD Working Party Blood. Jan, 2018 | Pubmed ID: 29330221 Positioning of Proteasome Inhibitors in Therapy of Solid Malignancies Cancer Chemotherapy and Pharmacology. Feb, 2018 | Pubmed ID: 29184971 The Interference of Genetic Associations in Establishing the Prognostic Value of the Immunophenotype in Acute Myeloid Leukemia Cytometry. Part B, Clinical Cytometry. Jan, 2018 | Pubmed ID: 28646564 Trimethylation of H3K27 During Human Cerebellar Development in Relation to Medulloblastoma Oncotarget. Oct, 2017 | Pubmed ID: 29108280 Leukaemic Stem Cell Load at Diagnosis Predicts the Development of Relapse in Young Acute Myeloid Leukaemia Patients British Journal of Haematology. Oct, 2017 | Pubmed ID: 29076143 (Immuno)proteasomes As Therapeutic Target in Acute Leukemia Cancer Metastasis Reviews. Dec, 2017 | Pubmed ID: 29071527 Bortezomib Resistance in Multiple Myeloma is Associated with Increased Serine Synthesis Cancer & Metabolism. 2017 | Pubmed ID: 28855983 Leukemic Stem Cells: Identification and Clinical Application International Journal of Hematology. May, 2017 | Pubmed ID: 28357569 Genomic Landscape of Retinoblastoma in Rbp130mice Resembles Human Retinoblastoma Genes, Chromosomes & Cancer. Mar, 2017 | Pubmed ID: 27750399 Proteasome Subunit Expression Analysis and Chemosensitivity in Relapsed Paediatric Acute Leukaemia Patients Receiving Bortezomib-containing Chemotherapy Journal of Hematology & Oncology. 09, 2016 | Pubmed ID: 27599459 Exocytosis of Polyubiquitinated Proteins in Bortezomib-resistant Leukemia Cells: a Role for MARCKS in Acquired Resistance to Proteasome Inhibitors Oncotarget. Nov, 2016 | Pubmed ID: 27542283 Somatic Genomic Alterations in Retinoblastoma Beyond RB1 Are Rare and Limited to Copy Number Changes Scientific Reports. 04, 2016 | Pubmed ID: 27126562 A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression PloS One. 2016 | Pubmed ID: 27115612 The Association of Aberrant Folylpolyglutamate Synthetase Splicing with Ex Vivo Methotrexate Resistance and Clinical Outcome in Childhood Acute Lymphoblastic Leukemia Haematologica. Jul, 2016 | Pubmed ID: 27036162 A Chemical Screen for Medulloblastoma Identifies Quercetin As a Putative Radiosensitizer Oncotarget. Jun, 2016 | Pubmed ID: 26967057 Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis Molecular & Cellular Proteomics : MCP. Apr, 2016 | Pubmed ID: 26801919 MiR Expression Profiling at Diagnosis Predicts Relapse in Pediatric Precursor B-cell Acute Lymphoblastic Leukemia Genes, Chromosomes & Cancer. Apr, 2016 | Pubmed ID: 26684414 Folylpolyglutamate Synthetase Splicing Alterations in Acute Lymphoblastic Leukemia Are Provoked by Methotrexate and Other Chemotherapeutics and Mediate Chemoresistance International Journal of Cancer. Apr, 2016 | Pubmed ID: 26547381 Multifactorial Resistance to Aminopeptidase Inhibitor Prodrug CHR2863 in Myeloid Leukemia Cells: Down-regulation of Carboxylesterase 1, Drug Sequestration in Lipid Droplets and Pro-survival Activation ERK/Akt/mTOR Oncotarget. Feb, 2016 | Pubmed ID: 26496029 Pharmacodynamic Monitoring of (immuno)proteasome Inhibition During Bortezomib Treatment of a Critically Ill Patient with Lupus Nephritis and Myocarditis Lupus Science & Medicine. 2015 | Pubmed ID: 26719810 Clinical Impact of Additional Cytogenetic Aberrations, CKIT and RAS Mutations, and Treatment Elements in Pediatric T(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2015 | Pubmed ID: 26573082 Loss of Photoreceptorness and Gain of Genomic Alterations in Retinoblastoma Reveal Tumor Progression EBioMedicine. Jul, 2015 | Pubmed ID: 26288838 Methotrexate Resistance in Relation to Treatment Outcome in Childhood Acute Lymphoblastic Leukemia Journal of Hematology & Oncology. May, 2015 | Pubmed ID: 26022503 Gene Expression Profiles Associated with Pediatric Relapsed AML PloS One. 2015 | Pubmed ID: 25849371 Molecular Basis of Resistance to Proteasome Inhibitors in Hematological Malignancies Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. Jan, 2015 | Pubmed ID: 25670156 Pre-mRNA Splicing in Cancer: the Relevance in Oncogenesis, Treatment and Drug Resistance Expert Opinion on Drug Metabolism & Toxicology. May, 2015 | Pubmed ID: 25495223 Relevance of Leukemic Stem Cells in Acute Myeloid Leukemia: Heterogeneity and Influence on Disease Monitoring, Prognosis and Treatment Design Expert Review of Hematology. Dec, 2014 | Pubmed ID: 25242511 Antileukemic Activity and Mechanism of Drug Resistance to the Marine Salinispora Tropica Proteasome Inhibitor Salinosporamide A (Marizomib) Molecular Pharmacology. Jul, 2014 | Pubmed ID: 24737138 RB1 Mutation Spectrum in a Comprehensive Nationwide Cohort of Retinoblastoma Patients Journal of Medical Genetics. Jun, 2014 | Pubmed ID: 24688104 Anti-leukemic Activity and Mechanisms Underlying Resistance to the Novel Immunoproteasome Inhibitor PR-924 Biochemical Pharmacology. May, 2014 | Pubmed ID: 24552657 Pre-B-cell Leukemia Homeobox Interacting Protein 1 is Overexpressed in Astrocytoma and Promotes Tumor Cell Growth and Migration Neuro-oncology. Jul, 2014 | Pubmed ID: 24470547 Interferon-γ-induced Upregulation of Immunoproteasome Subunit Assembly Overcomes Bortezomib Resistance in Human Hematological Cell Lines Journal of Hematology & Oncology. Jan, 2014 | Pubmed ID: 24418325 High Resolution SNP Array Profiling Identifies Variability in Retinoblastoma Genome Stability Genes, Chromosomes & Cancer. Jan, 2014 | Pubmed ID: 24249257 How to Assess Minimal Residual Disease in Pediatric and Adult Acute Myeloid Leukemia? Translational Pediatrics. Apr, 2013 | Pubmed ID: 26835296 Higher Ratio Immune Versus Constitutive Proteasome Level As Novel Indicator of Sensitivity of Pediatric Acute Leukemia Cells to Proteasome Inhibitors Haematologica. Dec, 2013 | Pubmed ID: 24056819 Proteasome Inhibitors in Acute Leukemia Expert Review of Anticancer Therapy. Mar, 2013 | Pubmed ID: 23477519 Randomized Double Blind Trial of Ciprofloxacin Prophylaxis During Induction Treatment in Childhood Acute Lymphoblastic Leukemia in the WK-ALL Protocol in Indonesia Journal of Blood Medicine. 2013 | Pubmed ID: 23403504 Overcoming Bortezomib Resistance in Human B Cells by Anti-CD20/rituximab-mediated Complement-dependent Cytotoxicity and Epoxyketone-based Irreversible Proteasome Inhibitors Experimental Hematology & Oncology. Jan, 2013 | Pubmed ID: 23305345 Myeloid Antigen Expression in Childhood Acute Lymphoblastic Leukemia and Its Relevance for Clinical Outcome in Indonesian ALL-2006 Protocol Journal of Oncology. 2012 | Pubmed ID: 23227046 Proteasome-based Mechanisms of Intrinsic and Acquired Bortezomib Resistance in Non-small Cell Lung Cancer Biochemical Pharmacology. Jan, 2012 | Pubmed ID: 22027222 PARP Inhibition Sensitizes Childhood High Grade Glioma, Medulloblastoma and Ependymoma to Radiation Oncotarget. Dec, 2011 | Pubmed ID: 22184287 Integrative Analysis of Type-I and Type-II Aberrations Underscores the Genetic Heterogeneity of Pediatric Acute Myeloid Leukemia Haematologica. Oct, 2011 | Pubmed ID: 21791472 Cell Sensitivity Assays: the MTT Assay Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21516412 Down-regulation of MiR-101 in Endothelial Cells Promotes Blood Vessel Formation Through Reduced Repression of EZH2 PloS One. Jan, 2011 | Pubmed ID: 21297974 Evaluation of Gene Expression Signatures Predictive of Cytogenetic and Molecular Subtypes of Pediatric Acute Myeloid Leukemia Haematologica. Feb, 2011 | Pubmed ID: 20971820 MiR-101 is Down-regulated in Glioblastoma Resulting in EZH2-induced Proliferation, Migration, and Angiogenesis Oncotarget. Dec, 2010 | Pubmed ID: 21321380 In Silico Analysis of Kinase Expression Identifies WEE1 As a Gatekeeper Against Mitotic Catastrophe in Glioblastoma Cancer Cell. Sep, 2010 | Pubmed ID: 20832752 High-frequency Type I/II Mutational Shifts Between Diagnosis and Relapse Are Associated with Outcome in Pediatric AML: Implications for Personalized Medicine Blood. Oct, 2010 | Pubmed ID: 20592250 Strategies for the Analysis of in Vitro Radiation Sensitivity and Prediction of Interaction with Potential Radiation Modifying Agents International Journal of Radiation Biology. Jun, 2010 | Pubmed ID: 20470196 FLT3 and KIT Mutated Pediatric Acute Myeloid Leukemia (AML) Samples Are Sensitive in Vitro to the Tyrosine Kinase Inhibitor SU11657 Leukemia Research. Oct, 2010 | Pubmed ID: 20435347 Attenuated AMPA Receptor Expression Allows Glioblastoma Cell Survival in Glutamate-rich Environment PloS One. Jun, 2009 | Pubmed ID: 19536293 Role of Tyrosine Phosphatase Inhibitors in Cancer Treatment with Emphasis on SH2 Domain-containing Tyrosine Phosphatases (SHPs) Anti-cancer Agents in Medicinal Chemistry. Feb, 2009 | Pubmed ID: 19199865 Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features PloS One. Aug, 2008 | Pubmed ID: 18769486 Molecular Basis of Bortezomib Resistance: Proteasome Subunit Beta5 (PSMB5) Gene Mutation and Overexpression of PSMB5 Protein Blood. Sep, 2008 | Pubmed ID: 18565852 Methylenetetrahydrofolate Reductase (MTHFR) C677T and Thymidylate Synthase Promoter (TSER) Polymorphisms in Indonesian Children with and Without Leukemia Leukemia Research. Jan, 2008 | Pubmed ID: 17395259 Sulfasalazine Sensitises Human Monocytic/macrophage Cells for Glucocorticoids by Upregulation of Glucocorticoid Receptor Alpha and Glucocorticoid Induced Apoptosis Annals of the Rheumatic Diseases. Oct, 2007 | Pubmed ID: 17267514 Stability and Prognostic Influence of FLT3 Mutations in Paired Initial and Relapsed AML Samples Leukemia. Jul, 2006 | Pubmed ID: 16642044 Microarray Analysis of Bleomycin-exposed Lymphoblastoid Cells for Identifying Cancer Susceptibility Genes Molecular Cancer Research : MCR. Feb, 2006 | Pubmed ID: 16513838 Acquired Resistance to Chloroquine in Human CEM T Cells is Mediated by Multidrug Resistance-associated Protein 1 and Provokes High Levels of Cross-resistance to Glucocorticoids Arthritis and Rheumatism. Feb, 2006 | Pubmed ID: 16447232 The Effect of G-CSF on the in Vitro Cytotoxicity of Cytarabine and Fludarabine in the FLAG Combination in Pediatric Acute Myeloid Leukemia International Journal of Oncology. Dec, 2004 | Pubmed ID: 15547723 Umfassendes Protokoll zur Probe und Prozess des Knochenmarks zur Messung von messbaren Resterkrankung und leukämischen Stammzellen in der akuten myeloischen Leukämie Jacqueline Cloos*1,2, Jeffrey R. Harris*3, Jeroen J.W.M. Janssen1, Angele Kelder1, F. Huang3, Gerrit Sijm1, Maike Vonk1, Alexander N. Snel1, Jennifer R. Scheick1, Willemijn J. Scholten1, Jannemieke Carbaat-Ham1, Dennis Veldhuizen1, Diana Hanekamp1, Yvonne J.M. Oussoren-Brockhoff1, Gertjan J.L. Kaspers2,4, Gerrit J. Schuurhuis1, A. Kate Sasser3, Gert Ossenkoppele1 1Department of Hematology, VU University Medical Center, 2Pediatric Oncology/Hematology, VU University Medical Center, 3Janssen Research & Development, LLC, 4Princess Máxima Center for Pediatric Oncology JoVE 56386 Cancer Research Mit RNA-Sequenzierung Neuartige Splice-Varianten zu Arzneimittelresistenz mit Bezug zu erkennen in Rocco Sciarrillo1,2,3, Anna Wojtuszkiewicz1, Irsan E. Kooi4, Valentina E. Gómez3, Ugo Boggi5, Gerrit Jansen6, Gert-Jan Kaspers1,7, Jacqueline Cloos*1, Elisa Giovannetti*3,8,9 1Department of Pediatric Oncology/Hematology, VU University Medical Center, 2Department of Hematology, VU University Medical Center, 3Department of Medical Oncology, VU University Medical Center, 4Department of Clinical Genetics, VU University Medical Center, 5Division of General and Transplant Surgery, Azienda Ospedaliera Universitaria Pisana, Universita’ di Pisa, 6Amsterdam Immunology and Rheumatology Center, VU University Medical Center, 7Princess Máxima Center for Pediatric Oncology, 8Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, 9Institute of Nanoscience and Nanotechnology, CNR-Nano JoVE 54714 Cancer Research
Umfassendes Protokoll zur Probe und Prozess des Knochenmarks zur Messung von messbaren Resterkrankung und leukämischen Stammzellen in der akuten myeloischen Leukämie Jacqueline Cloos*1,2, Jeffrey R. Harris*3, Jeroen J.W.M. Janssen1, Angele Kelder1, F. Huang3, Gerrit Sijm1, Maike Vonk1, Alexander N. Snel1, Jennifer R. Scheick1, Willemijn J. Scholten1, Jannemieke Carbaat-Ham1, Dennis Veldhuizen1, Diana Hanekamp1, Yvonne J.M. Oussoren-Brockhoff1, Gertjan J.L. Kaspers2,4, Gerrit J. Schuurhuis1, A. Kate Sasser3, Gert Ossenkoppele1 1Department of Hematology, VU University Medical Center, 2Pediatric Oncology/Hematology, VU University Medical Center, 3Janssen Research & Development, LLC, 4Princess Máxima Center for Pediatric Oncology JoVE 56386 Cancer Research
Mit RNA-Sequenzierung Neuartige Splice-Varianten zu Arzneimittelresistenz mit Bezug zu erkennen in Rocco Sciarrillo1,2,3, Anna Wojtuszkiewicz1, Irsan E. Kooi4, Valentina E. Gómez3, Ugo Boggi5, Gerrit Jansen6, Gert-Jan Kaspers1,7, Jacqueline Cloos*1, Elisa Giovannetti*3,8,9 1Department of Pediatric Oncology/Hematology, VU University Medical Center, 2Department of Hematology, VU University Medical Center, 3Department of Medical Oncology, VU University Medical Center, 4Department of Clinical Genetics, VU University Medical Center, 5Division of General and Transplant Surgery, Azienda Ospedaliera Universitaria Pisana, Universita’ di Pisa, 6Amsterdam Immunology and Rheumatology Center, VU University Medical Center, 7Princess Máxima Center for Pediatric Oncology, 8Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, 9Institute of Nanoscience and Nanotechnology, CNR-Nano JoVE 54714 Cancer Research
