Jochen Klein Department of Pharmacology Goethe University of Frankfurt Biography Publications Institution JoVE Articles Jochen Klein has not added a biography. If you are Jochen Klein and would like to personalize this page please email our Author Liaison for assistance. Publications Role of Phospholipases D1 and 2 in Astroglial Proliferation: Effects of Specific Inhibitors and Genetic Deletion European Journal of Pharmacology. May, 2015 | Pubmed ID: 25967349 Detection and Site Localization of Phosphorylcholine-Modified Peptides by NanoLC-ESI-MS/MS Using Precursor Ion Scanning and Multiple Reaction Monitoring Experiments Journal of the American Society for Mass Spectrometry. Mar, 2015 | Pubmed ID: 25487775 Self-built Microdialysis Probes with Improved Recoveries of ATP and Neuropeptides Journal of Neuroscience Methods. Nov, 2014 | Pubmed ID: 25172804 Dynamics of Hippocampal Acetylcholine Release During Lithium-pilocarpine-induced Status Epilepticus in Rats Journal of Neurochemistry. Oct, 2014 | Pubmed ID: 24909269 Bitter Triggers Acetylcholine Release from Polymodal Urethral Chemosensory Cells and Bladder Reflexes Proceedings of the National Academy of Sciences of the United States of America. Jun, 2014 | Pubmed ID: 24843119 Impaired Brain Development and Reduced Cognitive Function in Phospholipase D-deficient Mice Neuroscience Letters. Jun, 2014 | Pubmed ID: 24813107 Choline Acetyltransferase and Organic Cation Transporters Are Responsible for Synthesis and Propionate-induced Release of Acetylcholine in Colon Epithelium European Journal of Pharmacology. Jun, 2014 | Pubmed ID: 24698650 Phospholipase D is a Target for Inhibition of Astroglial Proliferation by Ethanol Neuropharmacology. Apr, 2014 | Pubmed ID: 24262632 Neurodegeneration After Transient Brain Ischemia in Aged Mice: Beneficial Effects of Bilobalide Brain Research. Sep, 2013 | Pubmed ID: 23850645 Blood Gases and Energy Metabolites in Mouse Blood Before and After Cerebral Ischemia: the Effects of Anesthetics Experimental Biology and Medicine (Maywood, N.J.). Jan, 2013 | Pubmed ID: 23479767 Neuroprotective Effects of Lactate in Brain Ischemia: Dependence on Anesthetic Drugs Neurochemistry International. Feb, 2013 | Pubmed ID: 23298645 Mice Heterozygous for AChE Are More Sensitive to AChE Inhibitors but Do Not Respond to BuChE Inhibition Neuropharmacology. Apr, 2013 | Pubmed ID: 23147415 Near-complete Adaptation of the PRiMA Knockout to the Lack of Central Acetylcholinesterase Journal of Neurochemistry. Sep, 2012 | Pubmed ID: 22747514 Uptake of Lithium into Rat Brain After Acute and Chronic Administration Neuroscience Letters. Jul, 2012 | Pubmed ID: 22659074 Ginkgo Extract EGb761 Confers Neuroprotection by Reduction of Glutamate Release in Ischemic Brain Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques. 2012 | Pubmed ID: 22365091 Neuroprotective Effects of Bilobalide Are Accompanied by a Reduction of Ischemia-induced Glutamate Release in Vivo Brain Research. Nov, 2011 | Pubmed ID: 22032877 In Vivo Brain Microdialysis: Advances in Neuropsychopharmacology and Drug Discovery Expert Opinion on Drug Discovery. Feb, 2011 | Pubmed ID: 21532928 The Ketogenic Diet Changes Metabolite Levels in Hippocampal Extracellular Fluid Neurochemistry International. Jan, 2011 | Pubmed ID: 21070829 Acute Depression of Energy Metabolism After Microdialysis Probe Implantation is Distinct from Ischemia-induced Changes in Mouse Brain Neurochemical Research. Jan, 2011 | Pubmed ID: 20878232 Brain Permeability of Bilobalide As Probed by Microdialysis Before and After Middle Cerebral Artery Occlusion in Mice Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques. 2010 | Pubmed ID: 21486534 Lactate Levels in the Brain Are Elevated Upon Exposure to Volatile Anesthetics: a Microdialysis Study Neurochemistry International. Dec, 2010 | Pubmed ID: 20933036 Quantitative Determination of Acetylcholine and Choline in Microdialysis Samples by MALDI-TOF MS Analytical Chemistry. Feb, 2010 | Pubmed ID: 20058877 Metabolic and Transmitter Changes in Core and Penumbra After Middle Cerebral Artery Occlusion in Mice Brain Research. Feb, 2010 | Pubmed ID: 19961839 Nicotine Exacerbates Brain Edema During in Vitro and in Vivo Focal Ischemic Conditions The Journal of Pharmacology and Experimental Therapeutics. Feb, 2010 | Pubmed ID: 19889792 Neurotransmitters and Energy Metabolites in Amyloid-bearing APP(SWE)xPSEN1dE9 Mouse Brain The Journal of Pharmacology and Experimental Therapeutics. Feb, 2010 | Pubmed ID: 19846589 Effects of Rivastigmine and Donepezil on Brain Acetylcholine Levels in Acetylcholinesterase-deficient Mice Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques. 2009 | Pubmed ID: 19470293 Metabolism of Boswellic Acids in Vitro and in Vivo Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jun, 2008 | Pubmed ID: 18356270 Role of Glycine Receptors and Glycine Release for the Neuroprotective Activity of Bilobalide Brain Research. Mar, 2008 | Pubmed ID: 18325484 Neuroprotection in Mice by NGP1-01 After Transient Focal Brain Ischemia Brain Research. Feb, 2008 | Pubmed ID: 18234166 Choline Availability and Acetylcholine Synthesis in the Hippocampus of Acetylcholinesterase-deficient Mice Neurochemistry International. May, 2008 | Pubmed ID: 18023504 Phenserine Expert Opinion on Investigational Drugs. Jul, 2007 | Pubmed ID: 17594192 Excessive Hippocampal Acetylcholine Levels in Acetylcholinesterase-deficient Mice Are Moderated by Butyrylcholinesterase Activity Journal of Neurochemistry. Mar, 2007 | Pubmed ID: 17212694 Role of GABAergic Antagonism in the Neuroprotective Effects of Bilobalide Brain Research. Jan, 2007 | Pubmed ID: 17134681 Effects of Chloride Flux Modulators in an in Vitro Model of Brain Edema Formation Brain Research. Nov, 2006 | Pubmed ID: 17014830 NMDA Receptor-antagonistic Properties of Hyperforin, a Constituent of St. John's Wort Journal of Pharmacological Sciences. Sep, 2006 | Pubmed ID: 16936454 NGP1-01 is a Brain-permeable Dual Blocker of Neuronal Voltage- and Ligand-operated Calcium Channels Neurochemical Research. Mar, 2006 | Pubmed ID: 16733815 Functions and Pathophysiological Roles of Phospholipase D in the Brain Journal of Neurochemistry. Sep, 2005 | Pubmed ID: 16042758 NGP1-01, a Lipophilic Polycyclic Cage Amine, is Neuroprotective in Focal Ischemia Neuroscience Letters. Jul 22-29, 2005 | Pubmed ID: 15936510 Microarray Analysis and Response of the Lungs to Inhaled Insulin Diabetes Technology & Therapeutics. Jun, 2005 | Pubmed ID: 15929684 Cross-talk Between Phosphatidic Acid and Ceramide During Ethanol-induced Apoptosis in Astrocytes BMC Pharmacology. Feb, 2005 | Pubmed ID: 15694004 Glycerophosphocholine is Elevated in Cerebrospinal Fluid of Alzheimer Patients Neurobiology of Aging. Nov-Dec, 2004 | Pubmed ID: 15465626 Effects of Norepinephrine and Cardiotrophin-1 on Phospholipase D Activity and Incorporation of Myristic Acid into Phosphatidylcholine in Rat Heart Journal of Pharmacological Sciences. Jul, 2004 | Pubmed ID: 15272209 Stimulation of Hippocampal Acetylcholine Release by Hyperforin, a Constituent of St. John's Wort Neuroscience Letters. Jul, 2004 | Pubmed ID: 15196674 Mitogenic Effects of Phospholipase D and Phosphatidic Acid in Transiently Permeabilized Astrocytes: Effects of Ethanol Journal of Neurochemistry. Oct, 2003 | Pubmed ID: 12969256 Intestinal Ischaemia During Cardiac Arrest and Resuscitation: Comparative Analysis of Extracellular Metabolites by Microdialysis Resuscitation. Aug, 2003 | Pubmed ID: 12909384 Nitrergic Modulation of Hippocampal Acetylcholine Release is Independent of Endothelial NO Synthase Activity Neurochemical Research. Apr, 2003 | Pubmed ID: 12675148 Effects of Septal Grafts on Acetylcholine Release from Rat Hippocampus After 192 IgG-saporin Lesion Neurochemical Research. Apr, 2003 | Pubmed ID: 12675132 ADP-ribosylation Factor-dependent Phospholipase D2 Activation is Required for Agonist-induced Mu-opioid Receptor Endocytosis The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12519790 NMDA-induced Acetylcholine Release in Mouse Striatum: Role of NO Synthase Isoforms Journal of Neurochemistry. Sep, 2002 | Pubmed ID: 12354305 Stability of Phospholipase D in Primary Astrocytes Biochemical and Biophysical Research Communications. Sep, 2002 | Pubmed ID: 12270129 Breakdown of Choline-containing Phospholipids in Rat Brain During Severe Weight Loss Neuroscience Letters. Jun, 2002 | Pubmed ID: 12052529 Dual Modulation of Striatal Acetylcholine Release by Hyperforin, a Constituent of St. John's Wort The Journal of Pharmacology and Experimental Therapeutics. May, 2002 | Pubmed ID: 11961077 A Homeostatic Mechanism Counteracting K(+) -evoked Choline Release in Adult Brain Journal of Neurochemistry. Mar, 2002 | Pubmed ID: 11948248 Custom-made Microdialysis Probe Design Jana Lietsche1, Jan Gorka2, Stefanie Hardt3, Michael Karas2, Jochen Klein1 1Department of Pharmacology, Goethe University of Frankfurt, 2Department of Pharmaceutical Chemistry, Goethe University of Frankfurt, 3Department of Clinical Pharmacology, Goethe University of Frankfurt JoVE 53048 Neuroscience
Custom-made Microdialysis Probe Design Jana Lietsche1, Jan Gorka2, Stefanie Hardt3, Michael Karas2, Jochen Klein1 1Department of Pharmacology, Goethe University of Frankfurt, 2Department of Pharmaceutical Chemistry, Goethe University of Frankfurt, 3Department of Clinical Pharmacology, Goethe University of Frankfurt JoVE 53048 Neuroscience
