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In JoVE (1)
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Articles by Judy Coleman in JoVE
JoVE General
ऐ से midgut और लार की गिल्टी के विच्छेदन. aegypti मच्छरों
1Department of Molecular Biology and Biochemistry, University of California, Irvine (UCI), 2Department of Molecular Biology and Biochemistry, Department of Microbiology and Molecular Genetics, University of California, Irvine (UCI)
मच्छर midgut और लार की गिल्टी चाबी प्रविष्टि और प्लाज्मोडियम फाल्सीपेरम और डेंगू वायरस की तरह वेक्टर रोगज़नक़ों के लिए बाहर निकलें अंक हैं. यह वीडियो एडीज aegypti मच्छरों से midgut और लार ग्रंथियों को हटाने के लिए विच्छेदन तकनीक को दर्शाता है.
Other articles by Judy Coleman on PubMed
Genetic Control of Malaria Parasite Transmission: Threshold Levels for Infection in an Avian Model System
Genetic strategies for controlling malaria transmission based on engineering pathogen resistance in Anopheles mosquitoes are being tested in a number of animal models. A key component is the effector molecule and the efficiency with which it reduces parasite transmission. Single-chain antibodies (scFvs) that bind the circumsporozoite protein of the avian parasite, Plasmodium gallinaceum, can reduce mean intensities of sporozoite infection of salivary glands by two to four orders of magnitude in transgenic Aedes aegypti. Significantly, mosquitoes with as few as 20 sporozoites in their salivary glands are infectious for a vertebrate host, Gallus gallus. Although scFvs hold promise as effector molecules, they will have to reduce mean intensities of infection to zero to prevent parasite transmission and disease. We conclude that similar endpoints must be reached with human pathogens if we are to expect an effect on disease transmission.
Spatial Mapping of Gene Expression in the Salivary Glands of the Dengue Vector Mosquito, Aedes Aegypti
Aedes aegypti mosquitoes are the main vectors of dengue viruses to humans. Understanding their biology and interactions with the pathogen are prerequisites for development of dengue transmission control strategies. Mosquito salivary glands are organs involved directly in pathogen transmission to vertebrate hosts. Information on the spatial distribution of gene expression in these organs is expected to assist in the development of novel disease control strategies, including those that entail the release of transgenic mosquitoes with impaired vector competence.
