Karthik Nagapudi Small Molecule Pharmaceutical Sciences Genentech, Inc. Biography Publications Institution JoVE Articles Karthik Nagapudi has not added a biography. If you are Karthik Nagapudi and would like to personalize this page please email our Author Liaison for assistance. Publications High-throughput Screening and Scale-up of Cocrystals Using Resonant Acoustic Mixing International Journal of Pharmaceutics. Apr, 2017 | Pubmed ID: 28229947 Humidity Induced Phase Transformation of Poloxamer 188 and Its Effect on Physical Stability of Amorphous Solid Dispersion of AMG 579, a PDE10A Inhibitor International Journal of Pharmaceutics. Apr, 2017 | Pubmed ID: 28163226 Control Strategies for Drug Product Continuous Direct Compression-State of Control, Product Collection Strategies, and Startup/Shutdown Operations for the Production of Clinical Trial Materials and Commercial Products Journal of Pharmaceutical Sciences. Apr, 2017 | Pubmed ID: 28069357 A Rational Approach Towards Development of Amorphous Solid Dispersions: Experimental and Computational Techniques International Journal of Pharmaceutics. Mar, 2017 | Pubmed ID: 28063904 Application of (19) F Time-domain NMR to Measure Content in Fluorine-containing Drug Products Magnetic Resonance in Chemistry : MRC. Jun, 2016 | Pubmed ID: 25773191 Investigation of Phase Mixing in Amorphous Solid Dispersions of AMG 517 in HPMC-AS Using DSC, Solid-State NMR, and Solution Calorimetry Molecular Pharmaceutics. Nov, 2015 | Pubmed ID: 26457879 Conformational Isomerism in Solid State of AMG 853--structure Studies Using Solid-state Nuclear Magnetic Resonance and X-ray Diffraction Journal of Pharmaceutical Sciences. Jul, 2015 | Pubmed ID: 25912152 Amorphous Solid Dispersions: a Robust Platform to Address Bioavailability Challenges Therapeutic Delivery. Feb, 2015 | Pubmed ID: 25690090 Sorbitol Crystallization-induced Aggregation in Frozen MAb Formulations Journal of Pharmaceutical Sciences. Feb, 2015 | Pubmed ID: 25219372 Application of Twin Screw Extrusion to the Manufacture of Cocrystals: Scale-up of AMG 517-sorbic Acid Cocrystal Production Faraday Discussions. 2014 | Pubmed ID: 25406487 Structural Studies of a Non-stoichiometric Channel Hydrate Using High Resolution X-ray Powder Diffraction, Solid-state Nuclear Magnetic Resonance, and Moisture Sorption Methods Journal of Pharmaceutical Sciences. Sep, 2014 | Pubmed ID: 24470123 Effect of PH and Excipients on Structure, Dynamics, and Long-term Stability of a Model IgG1 Monoclonal Antibody Upon Freeze-drying Pharmaceutical Research. Apr, 2013 | Pubmed ID: 23184227 Crystal Structure Study and Investigation of Solid-state Cyclization for AMG 222, a Channel Hydrate International Journal of Pharmaceutics. Jan, 2013 | Pubmed ID: 23182974 High-throughput 96-well Solvent Mediated Sonic Blending Synthesis and On-plate Solid/solution Stability Characterization of Pharmaceutical Cocrystals International Journal of Pharmaceutics. Jan, 2013 | Pubmed ID: 23178596 Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies Pharmaceutics. Aug, 2011 | Pubmed ID: 24310598 Manufacture and Performance Evaluation of a Stable Amorphous Complex of an Acidic Drug Molecule and Neusilin Journal of Pharmaceutical Sciences. Aug, 2011 | Pubmed ID: 21520086 Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth Molecular Cancer Therapeutics. Aug, 2010 | Pubmed ID: 20663930 Fast Surface Crystallization of Amorphous Griseofulvin Below T G Pharmaceutical Research. Aug, 2010 | Pubmed ID: 20414704 Manufacture of Pharmaceutical Co-crystals Using Twin Screw Extrusion: a Solvent-less and Scalable Process Journal of Pharmaceutical Sciences. Apr, 2010 | Pubmed ID: 19774652 Quantification of Compaction-induced Crystallinity Reduction of a Pharmaceutical Solid Using 19F Solid-state NMR and Powder X-ray Diffraction Drug Development and Industrial Pharmacy. Aug, 2009 | Pubmed ID: 19360510 Alterations in Physical Cross-linking Modulate Mechanical Properties of Two-phase Protein Polymer Networks Biomacromolecules. Nov-Dec, 2005 | Pubmed ID: 16283724 Viscoelastic and Mechanical Behavior of Recombinant Protein Elastomers Biomaterials. Aug, 2005 | Pubmed ID: 15763249 Photo-cross-linking of Type I Collagen Gels in the Presence of Smooth Muscle Cells: Mechanical Properties, Cell Viability, and Function Biomacromolecules. Jul-Aug, 2003 | Pubmed ID: 12857069 Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products Maria Victoria Silva Elipe1, Lan Li1, Karthik Nagapudi2, Alan M. Kook3, Carlos Cobas4, Isaac Iglesias4, Chen Peng4 1Department of Attribute Sciences, Amgen, Inc., 2Small Molecule Pharmaceutical Sciences, Genentech, Inc., 3NMR Service + Consulting, 4Mestrelab Research JoVE 55850 Chemistry
Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products Maria Victoria Silva Elipe1, Lan Li1, Karthik Nagapudi2, Alan M. Kook3, Carlos Cobas4, Isaac Iglesias4, Chen Peng4 1Department of Attribute Sciences, Amgen, Inc., 2Small Molecule Pharmaceutical Sciences, Genentech, Inc., 3NMR Service + Consulting, 4Mestrelab Research JoVE 55850 Chemistry
